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主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 December 2015, Volume 38 Issue 12 Previous Issue    Next Issue
    Analysis of the procedure and hierarchy of imagery thinking in traditional Chinese medicine*
    XU Yincong, WANG Xiaoping
    2015, 38 (12):  797-800.  doi: 10.3969/j.issn.1006-2157.2015.12.001
    Abstract ( 404 )   PDF (1059KB) ( 408 )   Save
    Based on comprehensive review and analysis of the cognitive process in imagery thinking, the overall procedure of imagery thinking is generalized as “perceiving”, “filtering”, “constructing”, “comparing”, “forming” and “validating”, as well as “prior establishing” the image before imagery thinking and “presenting” the image afterwards. TCM is closely connected with the whole process of imagery thinking in theoretical study and clinical practice. With the development of thinking process, the image presents with five hierarchies of different implications and functions, which are initial image by perceiving and filtering, concrete image by constructing, concrete image series by comparing, imagery thinking by forming the image, general image by presenting the imagery thinking, for the purpose of providing methodological basis for the analysis of cognitive process and hierarchy of TCM imagery thinking.
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    Effects of Jiangya Tongluo Formula on adrenomedullin in rats with hypertensive nephrosclerosis*
    QIN Jianguo, HAN Lin, Wang Yuanyuan, GAO Yushan, ZHANG Xiaoyu, GUO Yi, SONG Linmei, LUO Yanni, CHI Xiaoyi
    2015, 38 (12):  801-805.  doi: 10.3969/j.issn.1006-2157.2015.12.002
    Abstract ( 369 )   PDF (1101KB) ( 210 )   Save
    Objective To observe the effects of Jiangya Tongluo Formula (blood pressure-lowering collateral-unblocking formula, JYTLF) on adrenomedullin (ADM) in rats with hypertensive nephrosclerosis and to investigate its protective effect on kidney. Method Twenty-one 16-week-old spontaneous hypertensive rats (SHR) were used as subjects and randomly divided into model group (SHR group), valsartan group, and JYTLF group. Seven healthy Wistar Kyoto (WKY) rats were used as the blank control group. JYTLF group was orally given Jiangya Tongluo Formula (14.2 g/kg/d) while valsartan group received valsartan (10 mg/kg/d), both by intragastric gavage. The control group and the model group were given saline at the same dosage. Blood pressure of these rats was measured before treatment and at 2, 4, 8 weeks after treatment. 24-hour urinary albumin, kidney function parameters and histopathological changes of kidney tissue in four groups were measured as well. ADM protein levels in kidney were also measured to correlate with the blood pressure levels. Results Levels of blood pressure, 24-hour urinary albumin, serum creatine (Scr), and blood urea nitrogen (BUN) were significantly higher in the model group, valsartan group, and JYTLF group when compared with those in the blank control group. These levels in valsartan and JYTLF groups were lower than those in model group (P<0.01), yet there was no significant difference between the two treatment groups. Kidney ADM levels decreased markedly (P<0.01) in the model group, valsartan group and JYTLF group when compared with the normal control group. ADM levels in valsartan group and JYTLF group were higher than those in the model group (P<0.01) and there was an inverse correlation between ADM and blood pressure levels (γ=-0.740,P<0.001), yet no significant difference was observed between two treatment groups. HE staining showed that Jiangya Tongluo Formula significantly improved the renal arteries and glomerular sclerosis, thus promoted the recovery of kidney tissue. Conclusion Jiangya Tongluo Formula could up-regulate the level of ADM in kidneys in rats with hypertensive nephrosclerosis, dilate renal blood vessels and renal ischemia, which may play an important role in protecting renal function.
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    Effects of Wuzi Yanzong Pill on the expression of Cox7a2 gene and ERK phosphorylation in rats with kidney essence deficiency pattern*
    ZHANG Xiuping, LIU Baoxing, QIN Mao, CUI Tianwei
    2015, 38 (12):  806-810.  doi: 10.3969/j.issn.1006-2157.2015.12.003
    Abstract ( 352 )   PDF (1075KB) ( 241 )   Save
    Objective To observe the effects of Wuzi Yanzong Pill (Five-Seed Progeny Pill, WZYZP)on Cox7a2 gene and extracellular signal-regulated kinase (ERK) phosphorylation level in rats with kidney essence deficiency pattern. Methods Sprague-Dawley (SD) male rats were randomly divided into five groups (n=5 in each group): blank control group, model group, low-dose WZWZP (WZWZP-L) group, mid-dose WZWZP (WZWZP-M) group, and high-dose WZWZP (WZWZP-H). The blank control group were given sodium carboxy methyl cellulose (NaCMC) via intragastric gavage. The model group and three WZWZP groups received intragastric gavage of Leigongteng (Tripterygium Wilfordii) glycosides (GTW) alone (20 mg/kg) or GTW followed by WZWZP (low dose of 0.5g/kg, medium dose of 1.0g/kg, or high dose of 2.0 g/kg daily) respectively for 30 consecutive days. Cox7a2 mRNA expression in testis was determined by using real-time reverse transcriptase polymerase chain reaction (RTPCR). The extracellular signal-regulated kinase1/2 (ERK1/2) phosphorylation level was assessed with Western blot assay. Histopathological changes in the testes were evaluated using Johnsen’s scale. Results GTW induced an increase in Cox7a2 mRNA expression and an activation of ERK as well as a decline of Johnsen’s score and significant decrease in testicular spermatogenesis. Compared with GTW group, ERK phosphorylation level in high-dose WZWZP group decreased markedly while high-dose and mid-dose WZWZP downregulated Cox7a2 mRNA levels. Furthermore, Johnsen’s score in all WZWZP groups increased significantly. Conclusion WZWZP could protect the impaired spermatogenesis, probably by mediating mitochondrial energy metabolism via ERK pathway.
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    Effects of polysaccharide in angelica and hedysari combination on mitochondrial apoptosis pathway in radiation-injured myocardial cells*
    ZHU Beibei, CHANG Yanna, LI Yingdong, SUN Shaobo, LIU Kai
    2015, 38 (12):  811-816.  doi: 10.3969/j.issn.1006-2157.2015.12.004
    Abstract ( 431 )   PDF (1070KB) ( 232 )   Save
    Objective To investigate the effects of polysaccharide in angelica (Danggui, Radix Angelicae Sinensis) and hedysari (Hongqi, Radix Hedysari) combination on the pathway of mitochondrial apoptosis caused by radiation injury induced oxidative stress in myocardial cells of neonatal rats. Method Myocardial cells of Wistar neonatal rats were obtained from in vitro primary culture and radiation injury model was established by using direct X-ray exposure. Different concentrations of angelica and hedysari polysaccharide were administered as intervention. Cells were randomly divided into five groups: normal control group, radiation injury model group (5Gy exposure dose), low-dose polysaccharide intervention group (25 mg/L, DGHQ-L group), mid-dose polysaccharide intervention group (50 mg/L, DGHQ-M group), and high-dose polysaccharide intervention group (100 mg/L, DGHQ-H group). Growth inhibition rates of cells were measured with tetrazolium (MTT) Colorimetric assay while levels of reactive oxygen species (ROS) were assessed with fluorescent probe DCFH-DA. Mitochondrial membrane potential was measured with confocal scanning laser microscopy and expression levels of cytochrome C (CytC), caspases-3, and caspases-9 were detected with Western blot assay. Results Compared with the normal control group, growth inhibition rate of rat myocardial cells in the radiation injury model group was significantly increased, with a marked decrease in mitochondrial potential (ΔΨm) and a significant elevation in the expression levels of ROS, CytC, caspases-3, and caspases-9 (P<0.05) in the model group as well. Compared with the model group, growth inhibition rates of rat myocardial cells were significantly decreased in all DGHQ groups. Mitochondrial potential (ΔΨm) increased while the expression levels of ROS, CytC, caspases-3, and caspases-9 decreased (P<0.05). Conclusion The activation of mitochondrial apoptosis pathway is one of the main mechanism of myocardial cell apoptosis induced by X ray radiation. Angelica and hedysari polysaccharide can regulate and control the pathway, and exhibit protective effects against myocardial cell apoptosis.
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    Correlation between AT1R gene polymorphism and environmental factors and its implication for TCM patterns in essential hypertension*
    WU Chuanyun, ZHOU Xuemei, DONG Mei, HUANG Kaiquan, XU Hui, SU Yu, WANG Li, CHEN Xuegong, ZHANG Hongmei, DONG Changwu
    2015, 38 (12):  817-822.  doi: 10.3969/j.issn.1006-2157.2015.12.005
    Abstract ( 349 )   PDF (1017KB) ( 260 )   Save
    Objective To reveal the correlation between angiotensin II-l receptor (AT1R) gene polymorphism and environmental factors and its implication for different TCM patterns in essential hypertension by analyzing the correlation between two genetic loci of AT1R and environmental factors. Methods Four groups of EH patients with different TCM patterns and one healthy control group were selected (n=100 in each group). Gene locus polymorphism of A1166C and T573C of AT1R gene was detected by using multiple high temperature ligase detection reaction genotyping technique (iMLDR) while the effects of correlation between the AT1R gene polymorphism and environmental factors on different TCM patterns in essential hypertension were assessed by using Multifactor Dimensionality Reduction (MDR). Results The Results indicated the optimal diagnostic model of excessive phlegm-dampness pattern and yin-yang deficiency pattern were the combination of low-density lipoprotein cholesterol (LDL-C), body mass index (BMI), salt intake and alcohol consumption with T573C locus of AT1R gene. The optimal diagnostic model of liver-fire hyperactivity pattern was the combination of LDL-C and BMI. The optimal diagnostic model of yin deficiency with yang hyperactivity pattern was mono-factor model of dietary habit. It showed that there was a close correlation among LDL-C, salt intake, alcohol consumption with AT1R T573C gene locus in excessive phlegm-dampness pattern. Meanwhile, it also showed a close interaction of LDL-C, BMI, and dietary habit with AT1R T573C gene locus in yin-yang deficiency group. Conclusion Correlation between internal and external factors of human may be used to signify different patterns of EH. The correlation between environment factors and T573C locus of AT1R gene may be important to the formation of excessive phlegm-dampness pattern and yin-yang deficiency pattern.
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    Effects of Yiqi Yangyin Chujie Formula combined with cisplatin on the growth and apoptosis of human lung adenocarcinoma cell A549*
    LIU Chang, QIAN Yanfang, HU Jinghong, ZHU Yuting, WEI Zhen, ZHANG Xiuxia, ZHAO Jiayi, SUN Hongmei
    2015, 38 (12):  823-828.  doi: 10.3969/j.issn.1006-2157.2015.12.006
    Abstract ( 294 )   PDF (1026KB) ( 226 )   Save
    Objective To investigate the effects of Yiqi Yangyin Chujie Formula (qi-tonifying yin-nourishing mass-eliminating formula) combined with cisplatin on the apoptosis of human lung adenocarcinoma cell A549. Methods Human lung adenocarcinoma cell line A549 was cultured in vitro and then divided into four groups: blank control group, Yiqi Yangyin Chujie Formula group (TCM group), cisplatin group and combined treatment group. The blank control group received no intervention. TCM group was treated with Yiqi Yangyin Chujie Formula at doses of 1 000 mg/L, 500 mg/L, 200 mg/L, 100 mg/L, 50 mg/L and 20 mg/L respectively. Cisplatin doses were set at 4 mg/L or 8 mg/L while the combined treatment group was treated with both cisplatin and TCM formula at dose combinations mentioned above. Then cell proliferation inhibition was tested by using tetrazolium (MTT) colorimetric assay. Terminally labeled transferase technique (TUNNEL) apoptosis of A549 cells was applied. Expression of Bcl-2 and Caspase-3 were determined by using immunocytochemistry technique. Results MTT assay showed that the inhibition rates of experiment group were significantly higher than those of control group (P<0.05~P<0.001) with the combined group (200 mg/L TCM +4 mg/L cisplatin) topping the list. TUNNEL showed that numbers of apoptotic cells in the experiment groups were significantly higher than that of the control group (P<0. 01~P<0.001) with the highest number observed in the combined treatment group (200 mg/L TCM +4 mg/L cisplatin). Expression of Bcl-2 decreased in all experiment groups compared with that of control group. The reduction was significant (P<0. 01) in cisplatin group (4 mg/L) and combined treatment group (200 mg/L TCM +4 mg/L cisplatin). Expression of Caspase-3 increased in all experiment groups compared with that of control group. The increase (P<0. 05, P<0. 01) was significant in TCM group (200 mg/L) and combined treatment group (200 mg/L TCM+4 mg/L cisplatin). Conclusion Yiqi Yangyin Chujie Formula could inhibit the proliferation of A549 cell through inducing apoptosis of A549, which appears to be more effective when combined with cisplatin. Its mechanism may be related with the suppression of Bcl-2 and enhancement of Caspase-3 expression.
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    Changes of cardiac functions in rats with spleen-yang deficiency pattern and its underlying mechanism*
    JIANG Xiaolin, ZHANG Lide
    2015, 38 (12):  829-833.  doi: 10.3969/j.issn.1006-2157.2015.12.007
    Abstract ( 380 )   PDF (1152KB) ( 226 )   Save
    Objective To explore the changes of cardiac functions in rats with spleen-yang deficiency pattern and its underlying mechanism. Methods 30 Sprage Dawley (SD) rats were randomly divided into two groups: the blank control group and spleen-yang deficiency model group. After successful modeling with improper diet, exhaustive swimming and intragastric gavage of senna leaf (Fanxieye), changes of cardiac functions in the two groups were determined by using ultrasonic imaging with a high-resolution in vivo imaging system. Protein expression of brain natriuretic peptide (BNP) in the myocardium was assessed by using Western blotting and immunohistochemistry. Contents of BNP and cyclic adenosine monophosphate (cAMP) in the serum and myocardium were measured with Enzyme-linked Immuno Sorbent Assay (ELISA). The mRNA expression of Basic Fibroblast Growth Factor (bFGF) and protein kinase A (PKA) were detected by using Reverse Transcription-polymerase Chain Reaction (RT-PCR). Results Compared with the blank control group, Stroke Volume (SV) and Ejection Fraction (EF) decreased (P<0.05) while the contents of cAMP and BNP in serum and myocardium increased (P<0.05). BNP protein expression and mRNA expression of bFGF and PKA increased (P<0.05) in the model group. Conclusion Cardiac function seems to decline in spleen-yang deficiency rats. Contents of BNP and cAMP, and expression of PKA and bFGF all appears to have increased in the model group.
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    Distribution of Yunqi in birth dates of patients with cerebral infarction*
    ZHANG Xuan, LIU Yixuan, HE Juan
    2015, 38 (12):  834-837.  doi: 10.3969/j.issn.1006-2157.2015.12.009
    Abstract ( 407 )   PDF (997KB) ( 241 )   Save
    Objective To study the distribution of yunqi (five circuits and six qi) in birth dates of patients with cerebral infarction (CI). Methods Descriptive statistics was used to describe the features of heavenly stems, circuits of year, dominant qi and guest qi in birth years of 3,222 CI cases, and then Chi-square test was adopted to determine differences among them. Results Distribution of heavenly stems and dominant qi in birth years of CI patients showed some significant differences (P<0.05). Specifically, the highest incidence of CI was associated with the year of Yi (lack of metal circuit) while the lowest incidence of CI was related to the year of Ji (lack of earth circuit). Additionally, the highest incidence of CI occurred in the period of the 4th qi (referring to damp qi in the theory of five circuits and six qi) while the lowest incidence of CI appeared in the period of 6th qi (referring to cold qi in the theory of five circuits and six qi) (P<0.05). Conclusion Distribution of heavenly stems and dominant qi in birth years may have some influence on the risk of CI.
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    Improvement of life quality in patients with diabetic kidney disease receiving chronic illness management intervention combined with TCM treatment upon pattern identification by stage: a clinical trial*
    LI Tongxia, ZHANG Ning, CHEN Feifei, JIANG Xia, ZHOU Peiyi, LU Chen, SHA Sha
    2015, 38 (12):  838-841.  doi: 10.3969/j.issn.1006-2157.2015.12.009
    Abstract ( 243 )   PDF (1001KB) ( 356 )   Save
    Objective To evaluate the effects of chronic illness management intervention and TCM treatment based on pattern identification by stage on the quality of life in patients with diabetic kidney disease (DKD). Methods 120 DKD patients were randomly divided into the observation group and control group (n=60 in each group). Comprehensive conventional treatment was offered in both groups. Intervention of chronic illness management and TCM treatment by stage was added to the control group for a course of 24 months and one follow-up every 6 months afterwards. SF-36 Quality of Life (QoL SF-36) was used to measure changes of physiological function, psychological condition and overall life quality. Results The physiological function, psychological condition and general life quality were all improved in the two groups at different stages during the 24-month period when compared with baseline data in each group (P<0.05); Compared with the control group, the observation group started to exhibit more improvement in physiological function and general life quality at the end of 12 month (P<0.05) and maintained the superiority in psychological and social dimension between 18 and 24 months (P<0.05). Conclusion The combined intervention of chronic illness management and TCM treatment based on pattern identification at different stages may improve psychological and social functions of DKD patients on the basis of improving physiological functions, with an overall benefit of their life quality.
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    Effects of electroacupuncture on serum myelin basic protein and its antibody in rats with sciatic nerve injury*
    LI Xiaoqin, YU Tianyuan, YU Yue, PAN Fan, WU Jiancong, GAO Yufeng, LU Mengqian, WANG Lei, GEN Nan, YAO Binbin, XIAN Sitong, ZHANG Linfeng
    2015, 38 (12):  842-846.  doi: 10.3969/j.issn.1006-2157.2015.12.010
    Abstract ( 333 )   PDF (1008KB) ( 242 )   Save
    Objective To explore the effects of electroacupuncture (EA) on sciatic nerve injury (SNI) from the perspective of myelin sheath repair. Methods Sprague-Dawley (SD) rats were randomly divided into 5 groups, including normal group, sham-operation group, model group, model control group and EA group. SNI model was established by clamping sciatic nerve in all groups except normal group and sham operation group. EA group received treatment using EA device with electrical current set at 2mA and 5HZ in dilatational wave mode. Points used were Huantiao (GB30), Yinmen (BL37), Yanglingquan (GB34) and Chengshan (BL57) on the affected side. Rats in the model control group were treated for 10 minutes once a day for two treatment courses with one course lasting ten sessions, starting from when electroacupuncture was offered in EA group. No intervention was offered to the normal group, sham operation group and model group. Injury and repair of spinal cord and sciatic nerve myelin sheath were observed after tissue staining. Enzyme-linked immunosorbent assay (ELISA) was used to detect the expression level of Myelin Basic Protein (MBP) and MBP antibody in the serum. Results After 20 sessions of intervention, myelin in the white matter of spinal cord appeared to be loose in the model group and model control group with lower degree of myelination while the structural integrity of myelin and axons was maintained in EA group with higher degree of myelination. The concentration of serum MBP and MBP antibody in the model group and model control group were significantly higher than those in the normal group (P<0.05). The concentration of MBP and MBP antibody in EA group were significantly lower than those in the model group and model control group (P<0.05). The expression of MBP and MBP antibody in EA group were close to yet slightly higher than those in the normal group. Conclusion Electroacupuncture seems to decrease the expression of serum MBP to alleviate the destruction of axons and myelin sheath. Electroacupuncture may decrease the expression of MBP antibody in serum to reduce the autoimmune reaction of rats so that it could protect myelin sheath from the secondary damage. Therefore, electroacupuncture may protect the myelin sheath and promote the repair of injury of sciatic nerve.
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    Effects of electroacupuncture on gastrointestinal hormones in rats with diabetic gastroparesis*
    LIN Yaping, HE Feng’e, PENG Yan, WAN Quanquan, SHEN Jing
    2015, 38 (12):  847-851.  doi: 10.3969/j.issn.1006-2157.2015.12.011
    Abstract ( 323 )   PDF (1010KB) ( 207 )   Save
    Objective To observe the effects of electro-acupuncture on gastrointestinal hormones in rats with diabetic gastroparesis (DGP), and explore possible mechanism underlying therapeutic effects. Methods Sixty Sprague Dawley (SD) rats were randomly divided into 5 groups: blank control group, DGP model group, electroacupuncture point group, electroacupuncture non-point group and metoclopramide group. The animal DGP model was established with intraperitoneal injection of 2% Streptozotocin (STZ) in combination with a high-sucrose/high-fat diet for 8 weeks. OneTouch glucose meter was used to measure blood sugar; test-tape was used to test glycosuria, and phenol red lavage method, to measure gastric emptying rate and intestinal migration rate. GH and Ghrelin were determined with ELISA. Results Compared with the blank group, gastrointestinal emptying, GH and ghrelin levels all decreased significantly (P<0.05 or P<0.01) in the DGP model group, whereas glycemia and glycosuria were significantly more prominent (P<0.01). Meanwhile, gastro-intestinal emptying, GH level and Ghrelin levels in the electroacupuncture group were increased significantly (P<0.05 or P<0.01) compared with the DGP model group, whereas its glycaemia and glycosuria were improved significantly (P<0.05). Conclusion Electroacupuncture could regulate blood sugar level, promote gastro-intestinal emptying, and relieve DGP symptoms. Its underlying mechanism may be through increasing growth hormone and ghrelin levels.
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    Anti-obesity effects of electroacupuncture on rats with diet-induced obesity and its mechanism*
    QU Yating, LIU Xia, HE Junfeng, LIU Zhijun, PU Qingyang, GUO Shengtong, DU Jia, JIANG Pengfei
    2015, 38 (12):  852-856.  doi: 10.3969/j.issn.1006-2157.2015.12.012
    Abstract ( 380 )   PDF (1059KB) ( 270 )   Save
    Objective To observe the effects of electroacupuncture (EA) on body weight, insulin resistance (IR), hypothalamic protein tyrosine phosphatase 1B (PTP1B) and insulin receptor substrate 1 (IRS1) in diet-induced obesity (DIO) rats, as well as its mechanism. Methods 50 SD male rats were randomly divided into low-fat diet (LFD) group (n=10) and high-fat diet (HFD) group (n=40). When the DIO model was successfully established in HFD group, DIO rats were randomly divided into model group, EA group, and Orlistat (OLST) group (n=10 in each group). EA was applied to Zusanli (ST36) and Quchi (LI11) and the stimulation was retained for 20 minutes each time for 28 consecutive days in the EA group. Rats in OLST group was orally administered with Orlistat by daily intragastric gavage (32.4 mg/kg). No intervention was offered to rats in LFD and HFD groups. After 4 weeks, all rats were sacrificed to measure the levels of fasting plasma glucose (FPG) using biochemistry technique, fasting insulin (FINS) using radioimmunoassay, PTP1B and IRS1 using Western blotting assay and morphological changes of adipocytes using HE staining. Results Body weights, levels of FPG, FINS, HOMA-IR and diameter of adipocyte in rats of EA and OLST groups were all significantly lower than those in HFD group (P<0.05). But there were no significant difference between EA, OLST and HFD groups in IRS1 (P>0.05). Rats in OLST group showed watery stools, decreased activity, mental fatigue and withered fur, while those in EA group had regular stools and lustrous fur. Conclusion EA exhibits an anti-obesity effect, probably by inhibiting the expression of PTP1B, relieving IR, reducing the weight and shrinking adipocyte, which may be the mechanism for losing weight. EA seems to be superior to Orlistat as anti-obesity therapy with less side effects.
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    Rules for selecting acupoints in acupuncture and moxibustion treatment of peripheral nerve injury based on current literature*
    ZHANG Mingxing, WANG Rui, LIU Yangyang, LIU Jianwei, GUO Yi
    2015, 38 (12):  857-864.  doi: 10.3969/j.issn.1006-2157.2015.12.013
    Abstract ( 483 )   PDF (1201KB) ( 382 )   Save
    Objective To review literature on acupuncture and moxibustion treatment of peripheral nerve injury (PNI) in the past fifteen years, and sum up rules for selectinga cupoints as references for clinicians. Methods "acupuncture" OR "electropuncture" OR "moxa-moxibustion" OR"acupuncture-point injection" OR"catgut implantation at acupoint"AND "nerve injury" OR"peripheral nerve" were used as search words in CNKI, Wanfang and VIP database to retrieve the relevant literature. Search Results were entered into NoteExpress software. After removing irrelevant papers,included stndies were lvere classified into nine categories according to the nervous involved: brachial plexus, ulnar nerve, radial nerve, median nerve, superior clunial nerve, caudal nerve, sciatic nerve, tibial nerve and nervus peroneus communls; acupuncture points used in the remaining studies were extracted and analyzed. Results Acupuncture points used for peripheral nerve injury of upper limb were mostly selected from the Large Intestine Meridian (LI), Small Intestine Meridian (SI) and Sanjiao Meridian (TE), with the most frequently used acupoints being LI15, LI11, LI4, Li10, SJ5, SI3, SI8, SI7, SI4, PC6, and PC3. Points for peripheral nerve injury of lower limb were mostly selected from Stomach Meridian (ST), Bladder Meridian (BL) and Gall Bladder Meridian (GB), with the mostfrequently used acupoints being ST36, ST31, ST41, GB34, GB30, BL54, BL23, BL40, BL33, BL32, RN1and SP9. Conclusion The selection of acupoints for the treatment of peripheral nerve injury is mainly based on the meridians near the nerve, coupled with local and distal acupoints.
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