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主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    28 February 2016, Volume 39 Issue 2 Previous Issue    Next Issue
    Understanding WANG Qingren’s theory of “supplementing and supporting yang” and “restoring yang”*
    ZHANG Zaikang, FENG Ruixue, ZHANG Ziwei
    2016, 39 (2):  93-96.  doi: 10.3969/j.issn.1006-2157.2016.02.001
    Abstract ( 547 )   PDF (1154KB) ( 716 )   Save
    From four aspects of connotation, indication of application, prescription and herbal medicine, this article elaborates on the authors'understanding of WANG Qingren’s theory of “supplementing and supporting yang” and “restoring yang”.Supplementing and supporting yang is a featured approach of replenishing original qi, indicated for pattern of qi deficiency.WANG Qingren composed ten famous qi-tonifying formulas.Sheng Huangqi (raw astragalus) and Dangshen(codonopsispilosula) are the most commonly used qi-tonifying medicinals.Restoring yang is directed against the pattern of yang deficiency, with two formulas.Pao Fuzi (processed aconite root) is the primary herb to restore yang. WANG Qingren's theory of “supplementing and supporting yang” and “restoring yang”has an important role in guiding TCM internal medicine,surgery,gynecology,pediatrics, facial features,and dermatology etc.They are worthy of inheritance and further development.
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    Research on plasma metabolites of chronic heart failure patients with blood stasis pattern*
    WANG Juan, ZHAO Huihui, CHEN Jianxin, DENG Dong, GUO Shuzhen, LI Zhongfeng, LUO Liangtao, WANG Wei
    2016, 39 (2):  101-105.  doi: 10.3969/j.issn.1006-2157.2016.02.003
    Abstract ( 429 )   PDF (1749KB) ( 457 )   Save
    Objective To study the changes of metabolites in chronic heart failure (CHF) patients of blood stasis pattern by applying nuclear magnetic resonance (NMR). Methods Demographic data were collected from CHF patients of blood stasis pattern using cross-section survey. Their blood samples were also obtained and then magnetic resonance spectrum with pattern recognition techniques were used for integral calculation and normalization based on chemical shift. All data were imputed into SIMCA-P software and the Results were analyzed by using orthogonal projections to latent structures-discriminant analysis (OPLS-DA) model. Results The OPLS-DA analysis of plasma samples could differentiate and predict blood stasis pattern. Increased levels of lactate, alanine, and pyruvic acid with decreased levels of histidine, glycine, valineas, and other metabolites constitute the metabolomics profile of blood stasis pattern. Conclusion This study showed a profile of altered metabolites related to energy utilization and fatty acid metabolism in plasma samples of CHF patients with blood stasis pattern, which could offer a new approach to the diagnosis and treatment of CHF.
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    Effects of qi supplementing, blood activating,and blood stasis resolving medicinals on differentiation of bone mesenchymal stem cells to cardiomyocyte-like cells in microenvironment of rat myocardium: a laboratory study in vitro*
    ZHANG Jinsheng, ZHANG Baoxia, DU Meimei, ZHU Huifang, ZHANG Yangyang
    2016, 39 (2):  106-112.  doi: 10.3969/j.issn.1006-2157.2016.02.004
    Abstract ( 376 )   PDF (2879KB) ( 386 )   Save
    Objective To investigate the effects of different therapeutic formulas on the differentiation of bone marrow mesenchymal stem cells (BMSC) to cardiomyocyte-like cells in rat myocardium of in vitro micro-environment. Methods 40 SD rats randomly divided into blood-activating stasis-resolving group, qi supplementing blood-activating group, qi supplementing group, and blank group were administered orally Chinese medicinals to obtain madicated serum; another 60 SD rats were used to extract, incubate, isolate and purify BMSC; SD newborn rats were used to extract and incubate myocardial cell, then to establish an external myocardial micro-environment. MTT assay was used to select the optimal compounding concentration of each treatment group. Flow cytometry was used to measure the proliferation of CD105+-BMSC of each treatment group. Immunocytochemical method was used to test the CD105+-BMSC’s expression of myocardium protein CTNT, GATA-4 while immunofluorescence technique was used to measure the expression of MHC. Results The doubling time of CD105+-BMSC of each treatment group was 24 h. The cells numbers in blood-activating and stasis-resolving group were significantly higher than those in control group and other treatment groups from the 2nd day, and remained steady. All the proliferation index of blood-activating and stasis-resolving group at every time point were the highest except the 1st day. The number of cell division was also significantly more than other groups: qi-supplementing and blood-activating group, qi-supplementing group, blood activating and stasis resolving group. From the 2nd day to 5th day, the expressions in the blood-activating stasis-resolving group, qi-supplementing blood-activating group, qi-supplementing group increased markedly with statistical significance compared with the blank group (P<0.05), blood-activating stasis-resolving group was superior to the other two groups(P<0.05). There were no statistical significance between the qi-supplementing blood-activating group and qi-supplementing group (P>0.05). Conclusion Under the external mimic myocardial micro-environment condition, all therapeutic formulas could promote CD105+-BMSC’s differentiation. They also could promote CD105+-BMSC’s metaplasia to the cardiomyocyte-like cells, however, the blood-activating stasis-resolving medicinal appears to be most effective.
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    Effects of Yiqi Huoxue Huatan Formula on proliferation and differentiation of rat embryonic neural stem cells*
    GAO Luan, WANG Jian, CHENG Fafeng, TANG Wei
    2016, 39 (2):  113-118.  doi: 10.3969/j.issn.1006-2157.2016.02.005
    Abstract ( 349 )   PDF (3693KB) ( 356 )   Save
    Objective To study the effects of Yiqi Huoxue Huatan (qi-replenishing blood-activating phlegm-resolving)Formula on proliferation and differentiation of rat embryonic neural stem cells (NSC). Methods The rat NSC were divided into five groups, including blank serum group, drug serum group, blank serum + LY294002 group, drug serum + LY294002 group, and culture medium control group. The effects of drug serum on cell proliferation and differentiation were evaluated by cell culturing, serum pharmacology, immunofluorescence techniques. Morphological changes were observed by phase contrast microscope. Nestin, neuron-specific enolase(NES) and glial fibrillary acidic protein(GFAP) were measured by using immunofluorescence staining. Results Morphologically, drug serum was non-toxic to neural stem cells and promoted the differentiation of neural stem cells. Immunofluorescence staining showed that nestin expression increased within 24 h yet decreased significantly after 72 h incubation. NES and GFAP positive cells increased significantly in the drug serum group, compared with control group. Conclusion The serum from the rats treated with Yiqi Huoxue Huatan Formula has significant effects on differentiation and proliferationof NSC.
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    Correlation between meteorological factors in autumn and cough in winter*
    ZHANG Tianxing, HAO Yu, HE Juan
    2016, 39 (2):  119-121.  doi: 10.3969/j.issn.1006-2157.2016.02.006
    Abstract ( 364 )   PDF (1078KB) ( 295 )   Save
    Objective To analyze the relationship between meteorological factors in autumn and incidence of cough (pulmonary infection) in winter, and establish regression forecast equations to estimate pulmonary infection incidence in Beijing. Methods 1 093 case records of pulmonary infection from 1999 to 2011 were collected from Beijing Dongzhimen Hospital and data of meteorological factors (including daily average temperature, wind speed, precipitation, relative humidity, and vapor pressure) during the same period were also collected from Beijing Meteorological Observatory. The Spearman correlation and stepwise multiple regression were adopted to analyze the data. Results The incidence of pulmonary infection was related to average temperature and average vapor pressure in autumn. Average vapor pressure and average wind speed in autumn were elected into the equation. The equation was Y=-424.971+45.117X1-76.290X2 (X1 stands for average vapor pressure while X2 stands for average wind speed). Conclusion The incidence of pulmonary infection in winter in Beijing area was related to average vapor pressure and average wind speed in autumn, which verifies the theory in Huangdi Neijing (Huangdi’s Internal Classic) that damp pathogens (shi xie) in autumn can lead to occurrence of cough in winter.
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    Toll-like receptor-8 gene rs3764880 polymorphism and ischemic stroke risk in patients of Han Chinese males*
    GU Lian, ZHOU Jinying, TAN Jinjing, LIANG Baoyun, YAN yan, CHEN Qing, XIE Juanjuan, TANG Nong
    2016, 39 (2):  122-127.  doi: 10.3969/j.issn.1006-2157.2016.02.007
    Abstract ( 380 )   PDF (1114KB) ( 293 )   Save
    Objective To explore the association between Toll-like receptor-8(TLR8) genetic polymorphisms and susceptibility to ischemic stroke (IS) in patients of different traditional Chinese medicine (TCM) patterns. Methods 311 IS patients of wind-phlegm stasis-obstruction pattern, 284 IS patients of qi-deficiency blood-stasis pattern and 605 controls were recruited. The real-time PCR technology was used to detect TLR8 gene expression levels. TLR8 rs3764880 single nucleotide polymorphism(SNPs) were genotyped using the Sequenom Mass ARRAY platform. Levels of inflammatory cytokines were measured by using ELISA. Statistical analyses were carried out by using PLINK and SPSS 16.0 software. Results TLR8 gene variant rs3764880 polymorphism was significantly associated with wind-phlegm stasis-obstruction pattern in IS males patients in the allele model (P<0.05). In IS male patients of qi-deficiency blood-stasis pattern , level of IL-8 was higher in the GG genotype carriers than the AA+AG genotype carriers (P<0.05). The GG+AG genotype carriers had higher levels of TNF-α and IL-8 than the AA genotype carriers(P<0.05) . TLR8 gene variant rs3764880 polymorphism was significantly associated with the levels of TC (βb=-0.03, Padj=0.001) and LDL (βb=-0.25, Padj=0.018) in additive model in qi-deficiency blood-stasis pattern in Han Chinese IS male patients. Conclusion TLR8 gene rs3764880 polymorphism might be associated with the susceptibility to IS in patients of wind-phlegm stasis-obstruction and affect inflammatory reaction and lipid metabolism in Han Chinese males of qi-deficiency blood-stasis pattern.
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    Timing characteristics analysis of the tranquilizing effects of Imaginary Working based on the alpha band electroencephalogram power*
    HU Qingchuan, LI Shenyi, WANG Weiwei, ZHANG Haibo, WANG Yanping, JIA Dexian, ZHANG Weibo, WEI Yulong
    2016, 39 (2):  128-131.  doi: 10.3969/j.issn.1006-2157.2016.02.008
    Abstract ( 432 )   PDF (1480KB) ( 313 )   Save
    Objective To explore the tranquilizing effects of Imaginary Working by investigating the timing characteristics of the alpha band electroencephalogram(EEG) power. Methods College students as volunteer subjects were recruited and randomly divided into experimental group and control group at 1∶1 ratio. The experimental group received Imaginary Working intervention while the control group did not receive any intervention. After Imaginary Working intervention training, the alpha band absolute power of two groups was measured to compare and analyze. Results Alpha band EEG absolute power in the two groups were statistically different at all time periods (P<0.05). The absolute power value of the experimental group was higher than the control group, appeared more steady than the control group at each time point. Conclusion Imaginary Working can induce the alpha band rhythm response and maintain the effects with time as a subsequent effect. Imaginary Working presents with an apparent tranquilizing effect.
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    Neuroprotective effects of kidney-tonifying and blood-activating medicinals on optical nerve in glaucomatous eyes after filtering surgery*
    WANG Wei, LI Yan , LIU Hongji, ZHU Xinping , LI Xiang
    2016, 39 (2):  132-135.  doi: 10.3969/j.issn.1006-2157.2016.02.009
    Abstract ( 415 )   PDF (1088KB) ( 393 )   Save
    Objective To observe the neuroprotective effects of kidney-tonifying and blood-activating medicinals on optical nerve in glaucomatous eyes after filtering surgery with intraocular pressure(IOP) under control. Methods A prospective study was conducted to enroll 36 cases of primary glaucoma after filtering surgery with IOP under control. The subjects were randomly divided into control group and treatment group. The control group received monitoring and IOP control management only while the treatment group was added oral intake of kidney-tonifying and blood-activating medicinals for three treatment courses (each course lasts two months with a total of six months). Visual acuity, IOP, visual field, optic nerve scanning, and VEP were evaluated before and after treatment. Results The visual acuity and IOP of two group showed no significant changes before and after treatment. After treatment,mean sensitivity (MS), mean defect (MD), loss variance (LV), average retinal nerve fiber layer thickness (RNFL), and pattern visual evoked potential (LP100, AP100) were significantly improved in the treatment group (P<0.05).There was no significant change in C/D and RA in the treatment group after treatment (P>0.05). There were no significant changes in all parameters in the control group after treatment (P>0.05). Compared with the control group, MS , MD, LV, average RNFL’s thickness, LP100, and AP100 of two groups were statistically significant after treatment (P<0.05). Conclusion Kidney-tonifying and blood-activating medicinals could improve vision, VEP and RNFL thickness in primary glaucomatous eyes after filtering surgery thereby protecting the optic nerve and visual function in glaucomatous patients.
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    Pattern distribution at different stages of bronchial asthma: a descriptive study*
    WANG Zhiwan, LI Jiansheng, YU Xueqing, ZHANG Zhaowang
    2016, 39 (2):  136-139.  doi: 10.3969/j.issn.1006-2157.2016.02.010
    Abstract ( 371 )   PDF (1078KB) ( 316 )   Save
    Objective To describe the distribution of patterns at acute attack stage, chronic persistent stage and remission stage of bronchial asthma. Methods Bronchial asthma patients’ data from 17 Class-A Top-Level TCM hospitals were collected. The database was established using SPSS18.0 for frequency description and chi-square test. Results Of 2 500 questionnaires given out, 2 481 were returned with 2 428 valid ones identified. Patterns of bronchial asthma during the acute attack stage were mainly excess patterns, including patterns of exogenous cold and internal fluid-retention, turbid phlegm obstructing the lung, phlegm-heat obstructing the lung, wind-phlegm retention in the lung, and blood stasis. Patterns during the chronic persistent stage were mostly complex patterns of deficiency and excess. Patterns at the remission stage were mainly deficiency patterns, including patterns of lung qi deficiency, deficiency of lung and spleen, deficiency of kidney and lung, deficiency of lung-kidney qi and Yin, deficiency of kidney and lung Yang. Conclusion The rules of different pattern distribution at different stages of bronchial asthma provide the basis for the prevention and cure.
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    Study of TCM patterns and mechanism for pediatric pneumonia based on symptom correlation*
    AI Jun, WANG Shouchuan, DAI Ming, LUO Jun, CHEN Jirui, HUANG Yiling, HUANG Biling
    2016, 39 (2):  140-143.  doi: 10.3969/j.issn.1006-2157.2016.02.011
    Abstract ( 392 )   PDF (1083KB) ( 477 )   Save
    Objective To study TCM patterns and mechanism for pediatric pneumonia with the approach of symptom correlation analysis. Methods 480 cases records of pediatric pneumonia were collected from multiple centers as a large sample data source. Correlation analysis was conducted to analyze both the total dataset and subgroups by patterns under the guidance of TCM theory and clinical practice so as to study TCM patterns and mechanism for pediatric pneumonia. Results More than 30 000 association rules were mined from the total samples, from which the basic pathogenesis of pediatric pneumonia was confirmed to be heat, stagnation and phiegm. And over 100 000 association rules were obtained from the subgroups. Heat pattern is the primary underlying one. Compared with the pattern of wind heat invading lung, the support and confidence of the pathogenesis related to heat were higher than the pattern of phlegm-heat obstructing lung, while those of the pathogenesis related to stagnation, to phlegm, were lower than the pattern of phlegm-heat. Conclusion The approach of symptom correlation analysis could be used for a more standard, Objective, and scientific TCM development as it is consistent with the spirit of evidence based practice.
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    Effects of Chinese medicine on proteinuria in patients with early diabetic nephropathy: a meta-analysis*
    DAI Xiaoying, ZHANG Yan, YI Jing, TANG LI Ling, HE Lifang
    2016, 39 (2):  144-150.  doi: 10.3969/j.issn.1006-2157.2016.02.012
    Abstract ( 436 )   PDF (3734KB) ( 602 )   Save
    Objective To evaluate the effects of Traditional Chinese Medicine (TCM) on proteinuria in patients with early diabetic nephropathy (DN) by using meta-analysis. Methods All publications of randomized controlled trials (RCTs) studying traditional Chinese medicine in the treatment of early diabetic nephropathy were searched and identified from Medline, PubMed, Cochrane Library, CBM, VIP and CNKI. The quality of included studies were evaluated by using revised Jadad scale. Rev. Man 5.3 software was used for meta-analysis. Results A total of 27 RCTs involving 1 824 patients with early DN were included. Meta-analysis Results showed that TCM treatment group could reduce the level of urine albumin excretion rate (UAER) and 24h urine albumin level with or without using angiotensin converting enzyme inhibitor and angiotensin receptor blocker (ACEI/ARB), when compared to control group using ACEI/ARB only. No serious adverse reactions were observed in TCM treatment groups.Conclusion It was proved that the efficiency and safety of traditional Chinese medicine on proteinuria in patients with early diabetic nephropathy.
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    Optimization of extraction technology for total saponins from Rhizoma Panacis Majoris using orthogonal test *
    LI Fengying, WANG Yingzi, WANG Qing, ZHANG Xiuting, ZHANG Chunni, LI Wenhua, LUO Shengxiu
    2016, 39 (2):  151-154.  doi: 10.3969/j.issn.1006-2157.2016.02.013
    Abstract ( 417 )   PDF (1141KB) ( 607 )   Save
    Objective To optimize extraction technology for total saponins from Rhizoma Panacis Majoris(zhuzishen) and provide a theoretical basis for development and utilization of saponins from Rhizoma Panacis Majoris. Methods Ultraviolet spectrophotometry was employed to detect content of total saponins from Rhizoma Panacis Majoris with detection wave length set at 540 nm. And effects of ethanol concentration, solvent quantity, extraction time and extraction times on extraction process were investigated by using orthogonal test design. Results Linear range of total saponins from Rhizoma Panacis Majoris was 0.052~0.182 mg, and the average recovery rate was 98.64%. The best extraction technology for total saponins from Rhizoma Panacis Majoris was to extract 3 times with 10 times treatment of 70% ethanol for 1 h per time. The average yield rate of total saponins from Rhizoma Panacis Majoris was 12.32%. Conclusion This established ultraviolet spectrophotometry was accurate and reliable to detect contents of total saponins from Rhizoma Panacis Majoris. At the same time, this optimized extraction technology of total saponins from Rhizoma Panacis Majoris was simple, stable and feasible.
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    Percutaneous penetration enhancement effects of azone on TCM active ingredients with different lipophilicity*
    WANG Jingyan, LAN Yi, RU Qingguo, WANG Yifei, LIU Yan, YU Jingxin, WU Qing
    2016, 39 (2):  155-161.  doi: 10.3969/j.issn.1006-2157.2016.02.014
    Abstract ( 450 )   PDF (1573KB) ( 328 )   Save
    Objective To investigate the effects of azone on transdermal absorption of TCM active ingredients with different lipophilicity, and further explore its percutaneous penetration enhancement effects on the complex TCM active ingredients. Methods Five model drugs, namely osthole, tetramethylpyrazine,ferulic acid, puerarin and geniposide, were selected based on their lipophilicity determined by logKo/w, and then tested using in vitro permeation studies in which Franz diffusion cellsand rat skin were employed.Meanwhile, the association between the logKo/w values of model drugs and enhancement ratio(ER) was established. Results Different concentrations of azone could significantly promote the transdermal absorption of all model drugs. The ER value gradually increased with the increase of the azone concentration withina certain concentration range. It, however, started to decrease when exceedinga certain concentration level. The penetration enhancement ratio was roughly in parabolic curve relation with the drug lipophilicity after treatment with azone, and azone could achieve the optimal permeation effect for moderate hydrophilic drugs (an estimated logKo/w value of -0.5). Conclusion azone could significantly promote the transdermal absorption of TCM components with different lipophilicity, and its penetration enhancement ratio was in parabolic curve relation with the drug lipophilicity.
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    Studies on the serum pharmacochemistry of Yinchenhao Decoction*
    XU Bo, DOU Zhihua, LUO Lin, GU Wei, MENG Ping, LIU Qingqing, WANG Zhengyu
    2016, 39 (2):  162-168.  doi: 10.3969/j.issn.1006-2157.2016.02.015
    Abstract ( 391 )   PDF (1920KB) ( 384 )   Save
    Objective To analyze the constituents of Yinchenhao Decoction (YCHD) absorbed into blood by serum pharmacochemistry. Methods SD rats were used as donor and serum containing drugs were prepared after intragastric administration of YCHD, YCHD without one of the component herbs, and individual herbs of YCHD. HPLC fingerprints of serum containing drug were established. By comparing the fingerprints of serum containing YCHD with the one of control serum, drug-induced constituents in blood were distinguished. By comparing the fingerprint of serum containing YCHD with the ones of serum containing YCHD without either one of the component herbs, and individual herbs of YCHD, the sources of drug-induced constituents were analyzed. By comparing the retention time and spectrograms of chromatographic peaks in fingerprint of serum containing YCHD with the ones of YCHD and reference substances, drug-induced constituents in blood were identified. Results 23 drug-induced constituents in serum containing YCHD were detected. 6 of them were original compounds, other 17 were metabolites. 3 constituents out of 6 original compounds were identified as geniposidic acid and geniposide (iridoids from Gardeniae Fructus), and rhein (anthraquinone from Rhei Radix et Rhizoma), other three original compounds were identified as anthraquinone from Rhei Radix et Rhizoma(RRR) and 2 crocetin derivatives from Gardeniae Fructus(GF). Out of 17 metabolites, 1 was identified as the metabolite of iridoid, 7 were identified as the metabolites of anthraquinone, and 9 were identified as the metabolites of crocetin derivatives. Conclusion Drug-induced constituents in serum containing YCHD include original form of anthraquinones from RRR, original form of iridoids and crocetin derivatives from GF, and the metabolites of the constituents mentioned above. All these drug-induced constituents may be the pharmacodynamic material basis for hepatoprotective effects of YCHD.
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    Effects of acupuncture on embryo quality in superovulating mice*
    ZHANG Yuanyuan, DING Deguang, ZHU Shuxiu
    2016, 39 (2):  169-172.  doi: 10.3969/j.issn.1006-2157.2016.02.016
    Abstract ( 376 )   PDF (1162KB) ( 507 )   Save
    Objective To explore effects of electroacupuncture on embryo quality in superovulating mice. Methods 60 female mice were randomly divided into natural group, negative control group, superovulating group and electroacupuncture group. Acupuncture group was treated with electroacupuncture on Sanyinjiao(SP6), Guanyuan(RN3) and Zhongji(RN4). Embryonic quality was evaluated based on the embryonic development status and blastula evaluation system. Results Superovulating group presented with the most number of embryos. High-quality embryo rate was relatively low. Moreover, the rate of Grade 3~6 blastocyst was the lowest in superovulating group. Compared with superovulating group, blastocyst rate in the electroacupuncture group was not significantly different (P>0.05). However, rates of high-quality blastocyst and Grade 3~6 blastocyst were higher than the superovulating group with statistical significance (P<0.05). Conclusion Acupuncture can improve embryo quality in superovulating mice and possibly improve implantation rate.
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    Effects of acupuncture along meridians on the expression of Toll-like receptor 4 protein in myocardium of myocardial ischemic rats*
    CHENG Zedong, YU Songzai, CHEN Yiguo
    2016, 39 (2):  173-176.  doi: 10.3969/j.issn.1006-2157.2016.02.017
    Abstract ( 330 )   PDF (1393KB) ( 522 )   Save
    Objective To study the effects of electro acupuncture (EA) on selected acupoints along meridians on cardiac Toll-like receptor 4 (TLR4) in SD rats with myocardial ischemia induced by isoprenaline hydrochloride (ISO). Methods 50 male SD rats were randomly divided into five groups (n=10 each). ISO was subcutaneously injected in all groups except the blank group to establish the myocardial ischemia model. After successful modeling, EA was applied at corresponding acupuncture point for rats in the Neiguan (PC6) group, the Lieque (LU7) group and the non-acupoint (mid-point between RN8 and ST25) group. Myocardial tissue of the rats were obtained after the final EA. Superoxide dismutase (SOD) activities, creative kinase (CK-MB), morphology of cardiac tissue and cardiac TLR4 protein expression were evaluated. Results Compared with the model group, the rats of PC6 group myocardial fibers were arranged more and appeared more orderly with complete structure; cell interstitial infiltration of inflammatory cells was not apparent. The serum SOD contents were significantly increased, while the levels of CK-MB and TLR4 protein in myocardial tissue were significantly decreased. There were no significant differences between the above parameters in the non acupoint group and the LU7 group when compared to model group. Conclusion The mechanism of the therapeutic effect of EA at Neiguan (PC6) on myocardial ischemia is probably by regulating the expression of myocardial tissue TLR4 protein.
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