主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 April 2016, Volume 39 Issue 4 Previous Issue    Next Issue
    Researching thoughts of quantitative diagnostic criteria of TCM syndromes of sub-health*
    ZHAO Hui, WANG Dawei, JIANG Youming, XUE Feifei, LI Chun
    2016, 39 (4):  269-272.  doi: 10.3969/j.issn.1006-2157.2016.04.001
    Abstract ( 365 )   PDF (1149KB) ( 431 )   Save
    Based on the analysis of TCM syndromes of sub-health for the present studies on quantitative diagnostic criteria, and on the point of methodology,this article puts forward the idea of establishing the quantitative diagnostic criteria of TCM syndromes of sub-health with four steps:taking the “single syndrome” of sub-health as the research unit, using the structural equation model to establish the corresponding model between syndromes and symptoms,applying the receiver-operating characteristic curve to confirm the critical value of diagnosis,and through the clinical curative effect to evaluate the authenticity and objectivity of diagnostic criteria. The quantitative criteria will provide new ideas for the research of diagnostic criteria of TCM syndromes of sub-health.
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    Establishment of precise states control system: the route that brings TCM to precision medicine (2)
    YUAN Bing
    2016, 39 (4):  273-276.  doi: 10.3969/j.issn.1006-2157.2016.04.002
    Abstract ( 440 )   PDF (1067KB) ( 617 )   Save
    The “precise” identification of various aspects of the human condition, the “precise” understanding of the function of drugs, and the “precise” selection of medication form the indispensable links to achieve “Precision Medicine” (PM). Based on the “precise” body states description system, the use of drug and prescription and its effects on the human body may be “precisely” comprehended. Therefore, a more “precise” treatment plan can be actualized according to an individual. This paper discusses in detail how to use artificial intelligence and big data analysis techniques to precisely grasp the function of drugs. It also further elaborates that, based on the “precise” diagnosis and the “precise” understanding of the function of drugs, an optimal individualized treatment plan may be devised.
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    Application of Xiang Thinking in traditional Chinese medicine
    BI Siling,ZHANG Yuzhong
    2016, 39 (4):  277-280.  doi: 10.3969/j.issn.1006-2157.2016.04.003
    Abstract ( 446 )   PDF (1072KB) ( 489 )   Save
    Xiang Thinking,one of human basic thinking, is also the important thinking way in traditional Chinese medicine(TCM), from which the theories linked to TCM were largely derived. Xiang Thinking integrates each aspect of the construction of TCM theories and TCM clinical application-basic theory, diagnosis, prescription drugs and regimen. TCM is a great achievement of rational knowledge got by Xiang Thinking, and the establishment of TCM theoretical system is the fruit of rich experiences and philosophical thinking in the process of TCM clinical practice.
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    Effects of Bushen Huoxue Formula on estrogen receptor and Cyclin B in uteri of ovariectomized rats*
    TANG Yuqing, ZHANG Dongwei, SUN Xuejiao, GUO Yubo, WANG Lili, MA Rufeng, LI Cheng, LIU Yi, LI Yu
    2016, 39 (4):  281-287.  doi: 10.3969/j.issn.1006-2157.2016.04.004
    Abstract ( 403 )   PDF (1405KB) ( 404 )   Save
    Objective To explore the effects of Bushen Huoxue (nourishing kidney and activating blood) Formula on estrogen receptor (ER) and Cyclin B in ovariectomized rats’ uteri, so as to study the mechanism of Bushen Huoxue Formula (TCM) on perimenopausal syndrome. Methods Total 54 female SD rats were randomly divided into sham group, model group, estradiol group, TCM group, TCM + estradiol group, TCM + sham group (n=9 each). Rat model of perimenopausal syndrome was induced by bilateral ovariectomy. After 40 days’ intragastrical administration, all the rats were sacrificed. Rats’ uteri were dissected and weighed. The serum contents of estrogen (E2), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were detected by using ELISA; the endometrial thickness and pathological changes were measured using HE staining; the distribution and the expression of ERα and ERβ in endometrial tissue were observed by immunohistochemical method; the protein expression of Cyclin B was detected by Western Blot. Results Compared with the model group, the serum content of LH and FSH decreased significantly(P<0.05,P<0.01)and that of E2 increased in TCM group(P<0.05);while the index of uterus, endometrial thickness and the protein expressions of ERα, ERβ and Cyclin B increased remarkably(P<0.05). The estrogen-like effects of Bushen Huoxue Formula was weaker than estrogen. And each indicator of TCM + sham group showed no difference with that of sham group(P>0.05). Conclusion The estrogen-like effects of Bushen Huoxue Formula were proved to be weaker than that of E2, with no significant impact on uteri tissue of healthy rats.
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    Effects of paeoniflorin on phosphodiesterase subtypes in the hippocampus CA1 zone of rats with syndrome of blood deficiency and liver stagnation*
    ZHOU Tiantian, WANG Linyuan, WANG Jingxia, ZHU Yingli, ZHAO Danping, ZHANG Jianjun
    2016, 39 (4):  288-292.  doi: 10.3969/j.issn.1006-2157.2016.04.005
    Abstract ( 378 )   PDF (1306KB) ( 411 )   Save
    Objective To observe the effects of paeoniflorin on the protein expression of phosphodiesterase (PDE) subtypes in the hippocampus CA1 zone of rats with syndrome of blood deficiency and liver stagnation. Methods The rats were divided into blank group, model group, low dose and high dose of paeoniflorin (low-, high-dose) group. Each group had been intragastrically administered since the first day of modeling—low-dose group with 20 mg/kg paeoniflorin, high-dose group with 40 mg/kg, blank group and model group with pure water, for consecutive 21 days. After perfusion fixation, the brains of all rats were dissected and paraffin-emedded sections of brains were studied. The protein expression of PDE1A, PDE2A, PDE4A, PDE5A, PDE9A and PDE10A were detected using immunohistochemistrical methods. Results Compared with blank group, the protein expression of PDE1A, PDE2A, PDE5A and PDE9A of the model group increased significantly(P<0.05,P<0.01,P<0.01,P<0.01),and that of PDE4A, PDE10A declined(P<0.01,P<0.05). Paeoniflorin down-regulated the protein expression of PDE1A, PDE2A, PDE5A and PDE9A remarkably(P<0.05,P<0.01,P<0.01,P<0.01),and up-regulated that of PDE4A, PDE10A(P<0.05). Conclusion The protein expressions of PDE subtypes of rat model with syndrome of blood deficiency and liver stagnation changed remarkably due to the double stimulations of radiation and restraint. The effect of nourishing blood and liver of White Peony Root (Radix Paeoniae Alba, Baishao) suggested be a dynamic balance of multi-target with multi-path, which was proved by the regulations of paeoniflorin on substrates hydrolases resulted in the concentration of the two nucleotides.
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    Inhibitory effects of supercritical fluid extraction of Mulberry Leaf extract on human umbilical endothelial cells co-cultured with breast cancer cells MDA-MB-231*
    WANG Zhixiong, ZHANG Junli, MIAO Weiwei
    2016, 39 (4):  293-297.  doi: 10.3969/j.issn.1006-2157.2016.04.006
    Abstract ( 394 )   PDF (1145KB) ( 451 )   Save
    Objective To study the effects of proliferation, migration and apoptosis of Mulberry Leaf (Folium Mori, Sangye) on the human umbilical endothelial cells (HUVEC-2C) co-cultured with breast cancer cells MDA-MB-231. Methods The model of MDA-MB-231 cells co-cultured with HUVEC-2C was developed using Transwell. By using CCK-8 kit, the proliferation effect was studied from HUVEC-2C group, MDA-MB-231 cells co-cultured with HUVEC-2C (co-cultured) group, high dose, middle dose and low dose mulberry leaf (high-, mid-, low- dose )groups. By observing the co-cultured group and high-dose group, the migration of HUVEC-2C was studied using 24 orifice-transwell small plate. The apoptosis of HUVEC-2C was detected by flow cytometry instrument (FCM). From co-cultured group and high-dose, mid-dose and low-dose groups, the expression of VEGF was tested by ELISA. Results Inhibition of Mulberry Leaf fluid on the proliferation of HUVEC-2C increased with the concentration increased; compared with the co-cultured group, the inhibitive effect of Mulberry Leaf fluid (0.1, 0.05, 0.025 g/mL) increased significantly (P<0.05), with the dose of 0.1 g/mL the greatest. The effect of limitation of the fluids on the migration of HUVEC-2C was observed, compared with the co-cultured group. The fluids promoted apoptosis of HUVEC-2C and inhibited the expression of VEGF in the co-culture system. Conclusion Mulberry Leaf could inhibit the proliferation, migration and promote the apoptosis of HUVEC-2C co-cultured with tumor cells to inhibit the angiogenesis of the tumor. The potential mechanism would be linked to the inhibitory effect on VEGF expression.
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    Components in Radix Aconiti before and after processing by using HPLC-MS*
    QIN Yuxin, ZHANG Xianling, WANG Lei, ZHANG Yufan, WANG Xin, TAN Peng, LI Fei
    2016, 39 (4):  298-303.  doi: 10.3969/j.issn.1006-2157.2016.04.007
    Abstract ( 430 )   PDF (1321KB) ( 532 )   Save
    Objective To contrast the components in Radix Aconiti (Common Monkshood Mother Root, Chuanwutou) before and after processing, so as to provide primary evidence for interpreting the processing principles of Radix Aconiti. Methods HPLC analysis was performed on Thermo SCIENTIFIC high performance liquid chromatograph, with Agilent Extend-C18 column eluted with acetonitrile and 0.2% ammonia in a gradient program at wavelength 240 nm, and mass spectrum(MS) method was conducted in the positive ion mode. Results Total 99 components were detected in unprocessed Radix Aconiti, and 106 components were included in Radix Aconiti Praeparata. There were 53 in common. After processing, 46 components disappeared with 53 more were detected. And 64 components were identified in unprocessed Radix Aconiti. Conclusion The change of components of Radix Aconiti before and after processing was proved by the method of HPLC-MS, which was more effective and comprehensive than the method of HPLC detecting six alkaloids.
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    Optimization of determination method of typhaneoside and isorhamnetin-3-O-neohesperidoside in Pollen Typhae*
    CHEN Luxiao, LIU Bin, GUO Fengxia, JIANG Yanyan
    2016, 39 (4):  304-307.  doi: 10.3969/j.issn.1006-2157.2016.04.008
    Abstract ( 397 )   PDF (1093KB) ( 442 )   Save
    Objective To establish the determination method of typhaneoside and isorhamnetin-3-O-neohesperidoside in Pollen Typhae, Puhuang. Methods Single-factor test method was used to optimize the procedure of sample preparation. HPLC was used to detect the contents of typhaneoside and isorhamnetin-3-O-neohesperidoside in Pollen Typhae, Waters SunFireTM C18 (4.6 mm×250 mm, 5 μm) column at 20℃ and 254 nm detection wavelength, with mobile phase of acetonitrile-0.05% phosphoric acid (V/V) and flow rate of 1 mL/min. Results The sample solution was prepared by extracting from Pollen Typhae with 80 times amount of methanol for refluxing 1.5 h. Typhaneoside showed a good linear relationship at the range of 0.245 2~1.471 0 μg (r = 0.999 9), with the recovery of 98.47% (RSD=2.05%, n=6). Isorhamnetin-3-O-neohesperidoside showed a good linear relationship at the range of 0.191 2~1.147 4 μg (r = 0.999 7), with the recovery of 100.56% (RSD = 2.56%, n=6). Conclusion The method established is simple, rapid, accurate and repeatable, which built up a good basis for the quality control and evaluation of Pollen Typhae.
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    Quality representation and correlation analysis of Aurea Helianthus based on characteristic chromatogram of drug system*
    FENG Duo, TAN Li, PENG Ping, SHEN Lifeng, XU Shuya, LV Shan, ZHANG Yuanyuan, CHEN Wei, ZHANG Fang, SHI Renbing
    2016, 39 (4):  308-315.  doi: 10.3969/j.issn.1006-2157.2016.04.009
    Abstract ( 504 )   PDF (1265KB) ( 416 )   Save
    Objective To establish quality representation and correlation analysis method based on the characteristic chromatograms of drug system of Aurea helianthus (Jinhuakui), so as to evaluate quality of Aurea helianthus effectively and accurately. Methods Using HPLC-PDA method to characterize the 19 characteristic peaks and their chemical types in specific chromatograms of Aurea helianthus to represent the quality of altoghther 15 batches of Aurea helianthus. The quantitative representation of the 15 batches of Aurea helianthus was based on the contents of 5 characteristic index component-chlorogenic acid, rutinum, hyperoside, isoquercitrin, quercetin, phenylpropionic acids (represented by chlorogenic acid) and flavonoids ( represented by hyperoside). Correlation analysis of quality and quantity representations was then performed based on reference. Results Total 19 characteristic peaks (3 peaks of phenylpropionic acids and 16 peaks of flavonoids) appeared in the chromatogram of all the 15 batches. By taking Batch 1 as the reference, the total contents of the effective index components of Batch 10, 14, 8, 11, 6 and 5 were higher than the reference, and the highest correlation with the reference showed in Batch 5, 6, 3, 7, 2, 11 and 12. So the quality of Batch 5, 6, 11, 3, 7 and 2 were superio to the others. Conclusion The quality characterization correlation analysis model established for Aurea helianthus, concerning on systemic correlation and application validity, evaluated the quality of Aurea helianthus effectively and accurately.
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    Comparison of serum level of methylglyoxal, adiponectin and vascular endothelial growth factor in patients with diabetic kidney disease at early stage and at clinical stage*
    ZHANG Xiangwei, LIU Hongfang, CUI Zhaoli, ZHU Ying
    2016, 39 (4):  316-319.  doi: 10.3969/j.issn.1006-2157.2016.04.010
    Abstract ( 339 )   PDF (1080KB) ( 319 )   Save
    Objective To study the differences of serum methylglyoxal (MGO),adiponectin (APN)and vascular endothelial growth factor (VEGF)in patients with diabetic kidney disease (DKD)at early stage and at clinical stage. Methods Patients with DKD collected from 2012 to 2014 in the hospitals were grouped by stage (early stage group: 152 cases, clinical stage group: 56 cases). All the patients were treated with conventional therapy, including hypoglycemic drugs and antihypertensive drugs. Serum of all patients was collected and detected at the beginning (baseline) and after six months. Serum MGO, APN and VEGF were measured using ELISA and compared inter-group and intra-group. Results Compared with the early stage group, the levels of serum MGO and VEGF in clinical stage group were higher at the beginning and after six months(P<0.05), while the level of APN showed no difference. In the early stage group, the level of serum APN got higher after six months than that at the beginning(P<0.05),with no significant change in MGO, VEGF. There were no significant difference in MGO, APN and VEGF in clinical stage group in six months(P>0.05). Conclusion The increasing of serum MGO and VEGF which suggested the progression of early DKD, may provide some references for risk assessment of DKD patients at early stage.
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    Effects of Yiqi Yangyin Formula on the outcome of controlled ovarian hyperstimulation in poor ovarian responders*
    HONG Yanli, NIE Xiaowei, TAN Yong, ZHOU Huifang, YIN Yanyun
    2016, 39 (4):  320-324.  doi: 10.3969/j.issn.1006-2157.2016.04.011
    Abstract ( 405 )   PDF (1107KB) ( 428 )   Save
    Objective To observe the effects of Yiqi Yangyin(supplementing qi and nourishing yin) Formula on the embryo quality and pregnancy outcome in poor ovarian responders treated with controlled ovarian hyperstimulation (COH), and to study its effects on growth differentiation factor-9 (GDF-9)and bone morphogenetic protein-15 (BMP-15) in serum and follicular fluid. Methods Total 94 cycles of poor ovarian responders undergoing IVF-ET were grouped by the first day of COH: on odd dates into control group(n=48), on even dates into treatment group(n=46). Two groups were both stimulated by minimal stimulation protocol, in addition, the treatment group took Yiqi Yangyin Formula from the second day of the menstrual cycle to the day of HCG injection. Then the total dosage of Gn, the days of Gn stimulation, number of retrieval oocytes, fertilization rate, transplant rate, pregnancy rate and cycle cancellation rate were recorded. And the levels of GDF-9 and BMP-15 of serum and follicular fluid were detected using ELISA, and the protein expression were measured by Western blot. Results Compared with the control group, the total dosage of Gn and cycle cancellation rate decreased significantly in the treatment group, while the estradiol level, thickness of endometrium, retrieval oocytes, pregnancy rate were all increased(P<0.05). The protein expressions of GDF-9 and BMP-15 in granulose cells in treatment group were significantly higher than those in the control group(P<0.05). Conclusion Yiqi Yangyin Formula can collaborate with exogenous sexual hormones to improve the ovarian respond, so as to increase the poor ovarian responders’ retrieval oocytes and pregnancy rate. The potential mechanism is linked to the effects of Yiqi Yangyin Formula on regulating the expression of GDF-9 and BMP-15 in ovaries.
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    Correlation between TCM constitution and metabolic syndrome: a systematic review and Meta-analysis*
    LUO Hui, WANG Qi
    2016, 39 (4):  325-334.  doi: 10.3969/j.issn.1006-2157.2016.04.012
    Abstract ( 474 )   PDF (1409KB) ( 578 )   Save
    Objective Based on the current studies of the correlation between TCM constitution and metabolic syndrome (MS), to study the distribution rule of TCM constitution of patients with MS, so as to provide proof of evidence-based medicine (EBM) for prevention and treatment of MS. Methods After searching China National Knowledge Infrastructure (CNKI), Chongqing VIP Chinese Science and Technology Periodical Database (VIP), Wanfang Data, PubMed, and Embase, all clinical literature linked to the correlation between constitution and MS were included. The meta-analysis of cross-sectional studies was conducted using R version 3.2.2 software, and the Meta-analysis of case-control studies was finished using Review Manager 5.3 software with rate or odds ratio (OR) and 95% confidence interval (CI) as effect size. Results 13 cross-sectional studies and 2 case-control studies were eligible, with 6 742 MS patients and 3 576 of control group. The constitution of phlegm-dampness, qi-deficiency and damp-heat accounted for 30% (22%~40%), 19% (13%~28%) and 14% (10%~20%) of MS patients respectively. The meta-analysis of case-control studies showed that OR of occurrance risk of MS in patients with constitution of phlegm-dampness, qi-deficiency, damp-heat were 5.87 (1.94~17.79), 1.17 (1.01~1.37) and 1.96 (1.65~2.33) respectively. Each of the three TCM constitutions mentioned above took up the highest proportion in MS patients of North China, the lowest proportion in East China, and the middle in South China. There was no gender difference on the rate of phlegm-dampness constitute, while the rate of qi-deficiency constitution in female was higher than male with damp-heat constitution reversely. The methodological quality of the two case-control studies was high, and that of the cross-sectional studies was low with higher bias risk. Conclusion The constitution of phlegm-dampness, qi-deficiency and damp-heat were the primary types in patients with MS, which were believed to be the risk factors of the incidence of MS,furthermore, the phlegm-dampness constitution was the closest with MS. We suggest that the clinical study should conduct and report in accordance with the consolidated standards to improve the study quality, so as to explore the correlation of constitutions and diseases, and to support the diagnosis and treatment model of “differentiation of constitution-pattern-disease”.
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    Evaluating the effectiveness of ring management on patients with chronic obstructive pulmonary disease: a study in tertiary hospital, community health service stations, family*
    YAO Xiaoqin, FENG Cuiling, XUE Guangwei, QI Ying, Zhang Xiaoya, Wang Yanning, Ma Jia, Cai Wei, Liu Hongxia
    2016, 39 (4):  335-340.  doi: 10.3969/j.issn.1006-2157.2016.04.013
    Abstract ( 424 )   PDF (1099KB) ( 509 )   Save
    Objective To evaluate the effectiveness of ring management – tertiary hospital, community health service stations and family, on patients with chronic obstructive pulmonary disease (COPD). Methods Eligible patients were randomly divided into management group (n=107) and control group (n=103). All the patients were treated with the routine clinical practice, besides, systematic intervention for those in the management in the ways of health education, exercise management and medication management, who were managed by using COPD e-files. Furthermore, the patients in the management group were subdivided into Ba Duan Jin group and other exercises group according to the way of physical exercises, or into inhalation group and non-inhalation group according to the Western medication. COPD Assessment Test (CAT), the modified Medical Research Council (mMRC) Dyspnea Scale, number of acute exacerbation and lung function were analyzed before, six months post- and twelve months post- ring management. Results After 12 months of ring management, CAT score of patients in the management group decreased 4.69, mMRC scale decreased 0.52, the number of acute exacerbation less than twice increased to 75.7%, which were superior to that of control group(P<0.05). Increasing score of CAT in Ba Duan Jin subgroup was much more than that in other exercise subgroup(P<0.05). Increasing of FEV1% Pred in inhalation subgroup was more than that in non-inhalation subgroup(P<0.05). Score of CAT and number of acute exacerbation in the management group both decreased significantly compared with those in the control group(P<0.05). Conclusion Ring management model for COPD which can alleviate the symptoms of patients with stable COPD, improve the life quality and reduce the risk of exacerbation, is more comprehensive than medication management.
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    Treatment strategies for male infertility caused by varicocele
    QIN Guozheng
    2016, 39 (4):  341-343.  doi: 10.3969/j.issn.1006-2157.2016.04.014
    Abstract ( 383 )   PDF (1060KB) ( 487 )   Save
    Based on the recent literature linking varicocele to male infertility treated by Chinese medicine or intergrative medicine, guided by basic theory of TCM, the author thinks that varicocele is not bound to male fertility decline. According to TCM, infertility caused by varicocele is resulted from blood stasis in superficial venules of essence room, and blood fails to generate essece. The principal treatment is the method of removing blood stasis from meridians with promoting blood circulation to generate essence. The patients who have operation indications should undergo surgery, combined timely the TCM treatment. Furthermore, the physicians should engage in improving the curative effects by strengthening Three Categories of Etiological Factor System (San Yin Zhi Yi), improving the patients’ treatment compliance, avoiding the influences of unfavorable factors.
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    Post-effects of electro-acupuncture intervention on the skin temperature of the acupoints areas of the rats with myocardial ischemia*
    ZHANG Ping, ZHAO Guozhen, LIU Yali, JI Bo, DAI Jian, LU Yawen, YAN Mingna, WANG Dan, BAI Hongxin, SUN Xiaomin, XU Yongsi
    2016, 39 (4):  344-349.  doi: 10.3969/j.issn.1006-2157.2016.04.015
    Abstract ( 369 )   PDF (1099KB) ( 247 )   Save
    Objective To observe the skin temperature at the area of acupoints —“Neiguan” (PC 6), “Ximen” (PC 4) and “Tianquan” (PC 2) before and after electro-acupuncturing at low and high frequency, so as to explore the post-effects of acupuncturing on the rats with myocardial ischemia. Methods Myocardial ischemia model was induced by coronary artery occlusion. Wistar female rats were divided randomly into blank group, sham group, model group, low-, and high- frequency of electro-acupuncture (low-frequency, high-frequency) groups(each n=10), with acupuncturing on the rats in low and high frequency group once daily . The infrared thermograms were recorded at immediately (0 min), 30 min and 60 min after needle withdrawl. Then the data were measured and analyzed. Results The skin temperature of all three acupoint areas of rat model increased; after acupuncturing, the skin temperature of the three acupoint areas decreased, with that of PC 2 and PC 4 near to the control group. The skin temperatures of bilateral PC 6, bilateral PC 4, left PC 2 at immediately after needle withdrawl in low-frequency group were nearer to that of control group; at 30 min, skin temperatures of bilateral PC 6 and PC 4 in high-frequency group were nearer to that of control group; at 60 min, the skin temperatures of bilateral PC 6, right PC 4 and right PC 2 were nearer to that of the control group. Conclusion The skin temperatures of acupoints at the Pericardium Meridian decreased after low or high frequency acupuncture treatment; low frequency electro-acupuncture evoked rapid effects and short duration, by contrast, high frequency electro-acupuncture was found slow onset and long duration.
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    Law of acupoints compatibility in Modern Disease Menu of Acupuncture and Moxibustion Therapy*
    LI Bo, Chen Bo, Chen Zelin, Guo Yi
    2016, 39 (4):  350-352.  doi: 10.3969/j.issn.1006-2157.2016.04.016
    Abstract ( 367 )   PDF (1070KB) ( 401 )   Save
    Objective Taking the diseases listed in Modern Diseases Menu of Acupuncture and Moxibustion Therapy as the subjects, to study the rules of acupoints compatibility. Methods Based on searching the literature, the tables of acupoints compatibility in acupuncture and moxibustion prescriptions were completed. From the tables, the number of times and frequency of distal-proximal points combination, local combination and other combination were analyzed. Results Altogether 16 categories of 252 diseases were included. The prescription of distal-proximal points combination accounted for 57% of all the prescriptions. Except for a few systemic diseases, the distal-proximal points combination was found in the prescription applied in the 16 categories of diseases with the frequency more than 60%. Conclusion In the book of Modern Diseases Menu of Acupuncture and Moxibustion Therapy, the distal-proximal points combination, one of the basic acupoints combinations, was also the most common method, with the most widely application in treating the diseases of musculoskeletal system, nervous system, digestive system and urogenital system. By contrast, local combination was applied in a limited scope with less application, but can be used as the supplement for the distal-proximal points combination.
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