主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 May 2016, Volume 39 Issue 5 Previous Issue    Next Issue
    Theory of qi transformation in Neijing*
    HAO Yu, HE Juan
    2016, 39 (5):  357-359.  doi: 10.3969/j.issn.1006-2157.2016.05.001
    Abstract ( 419 )   Save
    This article put forward a novel idea that the TCM term of qi transformation, based on its original meaning and interpretation in Neijing, whose subject referred to qi transformation of heaven and earth, was a vital academic scope extended from the understanding of human body by natural philosophy of qi-monism theory. The connotation of qi transformation in Neijing was reflected in two aspects: qi transformation of heaven and earth generating everything in the world, qi transformation of heaven and earth involving qi transformation of life. Qi transformation is characterized by sequence, direction and internal homeostasis, which plays an important role in guiding TCM clinical practices.
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    Using the holism concept of “yin-yang of four seasons and five zang-organs” theory to discuss the mechanism of Siwu Tang against blood troubles*
    ZHANG Na, YAO Xuan, KONG Yurong, GUO Xiazhen
    2016, 39 (5):  360-363.  doi: 10.3969/j.issn.1006-2157.2016.05.002
    Abstract ( 394 )   Save
    Traditional Chinese Medicine(TCM) is characterized by holism concept. Through Inner Canon of Huangdi, the theory of “yin-yang of four seasons and five zang-organs”is one of the academic thoughts which presents wholism concept of “correspondence between nature and human”. Siwu Tang has been appraised as the “saint prescription of gynecology”, directed at various blood troubles. This article tries to study the mechanism of Siwu Tang against blood troubles from the view of the wholism concept of“yin-yang of four seasons and five zang-organs”.
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    The comparative study of inhibitory effects of truncated therapy and conventional therapy on lung tissue inflammation of mice with pneumonia induced by influenza virus*
    CHEN Danjun, DONG Yingying, REN Ruifang, YOU Leiming, WU Jun, HAO Yu
    2016, 39 (5):  367-371.  doi: 10.3969/j.issn.1006-2157.2016.05.004
    Abstract ( 380 )   Save
    Objective To compare the effects of truncated therapy and conventional therapy on the lung tissue inflammation of mice with pneumonia induced by influenza virus,so as to explore the mechanism of truncated therapy superior to conventional therapy and its relationship with inflammatory cascade after viral infections. Methods 192 Balb/c mice were randomly divided into healthy group, model group, conventional therapy group and truncated therapy group. Except for the healthy group, the mice of the other three groups were infected with 50 μL 30 LD50 mouse lung-adapted influenza virus strain (FM1) by inoculating intranasally. After 1 h of inoculation, healthy group and model group were administered intragastrically (i.g.) distilled water; conventional therapy group was administered i.g. twice daily Yinqiao Powder for the first three days, then Xijiao Dihuang Decoction for the next four days (totae seven days); truncated therapy group was administered i.g. Xijiaodihuang Decoction twice daily for consecutive seven days. Then the mice were sacrificed by taking the eyeballs on the 2nd, 4th, 6th, and 8th day for sampling and detecting. The WBC count in bronchoalveolar lavage fluid (BALF) was detected, the levels of IL-1β and IL-18 in the supernatants of lung homogenate were measured by ELISA and NOD-like receptor family mem NOD-, LRR-and pyrin domain containing 3 (NLRP3) mRNA in the lung tissue were detected by quantitative realtime-PCR. Results Compared with the model group, the WBC counts of BALF, IL-1β, IL-18 and NLRP3 mRNA in truncated therapy group and conventional therapy group decreased(P<0.01). WBC counts , IL-1β and IL-18 began to show the remarkable differences from that of model group since the 2nd day, while conventional therapy group didn’t. On 8th day, WBC count in truncated group was lower significantly than that in the conventional group(P<0.01). On the 4th day of being infected, NLRP3 mRNA of mice lung tissue expressed highly in the model group , while decreased significantly in the truncated group only. Conclusion The truncated therapy which may inhibit the inflammatory reaction induced by innate immunity at the early phase of infection, can prevent the inflammatory cascade, and can truncate the progress of the disease. The potential mechanism is linked to inhibiting the formation of NLRP3 inflammasome, interfering the mature and secretion of IL-1β and IL-18 .
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    Experimental study on dermal safety of Majie Pingchuan cataplasm*
    ZHU Wenxiang, LIU Yuanjun, CHENG Fafeng, LI Changxiang, WANG Qingguo, WANG Xueqian
    2016, 39 (5):  372-375.  doi: 10.3969/j.issn.1006-2157.2016.05.005
    Abstract ( 395 )   Save
    Objective To investigate the safety of Majie Pingchuan cataplasm on skin. Methods ①Acute toxicity test. Twelve rabbits were randomly divided into three groups with hair removed and skin damaged, systemic poisoning situation was observed after patching blank matrix cataplasm and Majie Pingchuan cataplasm. ②Skin irritation test. Sixteen rabbits were randomly divided into four groups with hair removed and skin damaged, one twelfth of one sheet of blank matrix cataplasm and Majie Pingchuan cataplasm were separately patched on left or right side skin, erythema and edema were observed in single and repeated stimulation tests. ③Skin allegy test. Thirty guinea pigs were randomly divided into three groups, one twelfth of one sheet of blank matrix cataplasm, Majie Pingchuan cataplasm, 0.2 mL of 2,4-dinitrochlorobenzene were patched on the left side skin. On 28th day allergic reaction was observed after patching the same excitants six hours continuously on the right skin. Results In the acute toxicity test, there was no death and abnormal physiological conditions in rabbits. In the single stimulus test, erythema and edema did not appear. In the repeated stimulation tset, there was slight erythema disappearing in 48 h, and no edema. In allergy test, Majie Pingchuan cataplasm group did not appear erythema and edema, the sensitization rate was 0. Conclusion Majie Pingchuan Cataplasm had no acute toxicity and irritation on intacted or injured skin of rabbits. There was no allergic reaction in guinea pig skin. Majie Pingchuan cataplasm is safe and non-toxic.
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    Literature study on fecal class Chinese medicines and their application in the ancient prescriptions*
    SU Zeqi,ZHANG Wenjun,ZHANG Yushan,WANG Dechen,MENG Xiangmei,WANG Weixin,WU Jiarui,LI Jian,DING Xia
    2016, 39 (5):  376-382.  doi: 10.3969/j.issn.1006-2157.2016.05.006
    Abstract ( 392 )   Save
    Objective To summarize the basic characteristics of fecal class Chinese medicines in modern clinical practice, and to find out the application of them in ancient prescriptions. Methods Taking “feces”(Chinese: 粪便; pinyin: fènbiàn) and “Chinese medicines”(Chinese: 中药; pinyin: zhōngyào) as the keywords, we searched CNKI, Wangfang, CQVIP and CBM databases of relevant articles published since the time of establishment. Then the fecal class Chinese medicines were screened. What we obtained were where the official names came from, what their alternative names were at different times, which creatures they were excreted from, what property and flavor, meridian tropism, efficacy and indications they had. Furthermore, we searched the ancient prescriptions involving fecal class Chinese medicines using the database platform of Dictionary of Chinese Medicine Prescriptions, institute of Chinese Materia Medical of China Academy of Chinese Medical Sciences to get the common compatibility and potential rules of clinical application. Results Total eleven fecal class Chinese were common used in modern clinical practice, which were recorded in various monographs of Chinese medicine by numerous names, and were excreted from birds, mammals and worm. The nature of the medicines were hot or cold; the flavor coved sour, bitter, sweet, bitter, salty; the meridian tropism lied in meridian of liver (gall bladder),heart (cardiac), spleen (stomach), lung (intestine) and kidney (bladder); the various effects were listed as the following: resolving superficies, clearing heat, dispelling pathogenic wind and removing dampness, resolving stagnation, expelling blood stasisfor removing obstruction in collaterals, removing phlegm, relieving cough, calming endogenous wind, inducing resuscitation, removing toxicity, destroying parasites, relieve itching, eliminating necrotic tissues and promoting granulation. In addition, we extracted relevant 1 550 relevant prescriptions containing the eleven medicines which had the internal pharmaceutical compatibility and association rules. Conclusion The application of fecal class Chinese medicines has a long history. The further study and innovating application will be much of value of research and application in the intestinal microecology and the diagnosis and treatment of various diseases.
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    Antioxidant activities and chemical compositions of Thymus quinquecostatus Celak*
    YAN Cheng, CHEN Xiaoyi, SUI Hong, TIAN Yuxin, WANG Yan, BAI Shaojuan, ZHAO Yicheng, SHI Renbing, SHE Gaimei
    2016, 39 (5):  383-389.  doi: 10.3969/j.issn.1006-2157.2016.05.007
    Abstract ( 382 )   Save
    Objective To study the antioxidant activities and chemical compositions of Thymus quinquecostatus Celak (dijiao). Methods The antioxidant activities of five polar fractions of dijiao were screened and evaluated using DPPH and ABTS free radical scavenging assays. After the chemical compositions were separated and purified by using silica gel chromatography, Sephadex LH-20 chromatography and MCI GEL CHP-20P column chromatography, the chemical compositions were identified by MS and NMR spectrometers, and records of literature. Results From the EtOAc and n-BuOH fractions which showed high antioxidant activity, total 18 compositions were separated and identified: scutellarin (“1 ”short for peak No. 1, the same below), scutellarein (2), 5,6,7-trihydroxy-4′-methoxyflavone (3), xanthomicrol (4), apigenin (5), 4′-methoxyluteolin (6), luteolin-7-O-β-D-glucopyranoside (7), luteolin (8),and rutin (9), danshensu (10), vanillic acid (11), protocatechuic acid (12), chlorogenic acid (13), caffeic acid (14), ferulic acid (15), 2,6-dihydroxy-4-isopropylphenyl-β-D-glucopyranoside (16), olenolic cid (17) and daucosterol (18). Conclusion The composition 1,2, 3 and 16 were the first reported in the genus Thymus, and 4~8, 10~12, 14~15 and 17~18 were found first in dijiao.
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    Improving the quality standard for Jinlian Qingre Capsule*
    DIND Rui, HE Kai, ZHANG Haixu, WANG Qing
    2016, 39 (5):  390-394.  doi: 10.3969/j.issn.1006-2157.2016.05.008
    Abstract ( 373 )   Save
    Objective To improve the quality standard of Jinlian Qingre Capsule. Methods Chinese Globeflower Flower(Trollii Chinensis Flos, Jinlianhua),Dyers Woad Leaf(Folium Isatidis, Daqingye),Figwort Root(Srophulariae Radix, Xuanshen)and Bitter Apricot Seed(Semen Armeniacae Amarum, Kuxingren)in Jinlian Qingre Capsule were identified using thin layer chromdograph (TLC). The content of vitexin was detected using HPLC with a Phenomenex Luna C18 (2)100A column(250 mm×4.6 mm,5 μm), a mobile phase of acetonitrile- 0.4% ammonium acetate(15∶85)at the flow rate of 1.0 mL/min, detection wave length at 340 nm and the column temperature at 25 ℃. Results Main spots of Chinese Globeflower Flower,Dyers Woad Leaf,Figwort Root and Bitter Apricot Seed in TLC were clear and separated well. A good linearity was obtained for vitexin in the range of 0.06~0.57 μg(r=0.999 9)with mean sample recovery rate of 99.7% and RSD of 2.1%. Conclusion Method of TLC and HPLC established in this study which appears to be highly specific,accurate and repeatable can be used in the quality control of the Jinlian Qingre Capsule.
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    Effects of electro-acupuncture on activity of microglia in spinal dorsal horn in rat model of transplantation of autologous nucleus pulposus*
    JI Lili, GE Dongyu, REN Xiujun, ZHAO Liyun, LI Genmao, TU Ya
    2016, 39 (5):  399-405.  doi: 10.3969/j.issn.1006-2157.2016.05.01
    Abstract ( 383 )   Save
    Objective To study the different prescriptions of eletcro-acupuncture (distal-proximal acupoints, proximal acupoints and distal acupoints) on pain-related behaviors and expression of microglia marker OX42 and cyclooxygenase 2 (COX2) in spinal dorsal horn in rat model of transplantation of autologous nucleus pulposus, so as to provide experimental basis for the mechanism of the different prescriptions. Methods 54 healthy male SD rats were randomly divided into six groups (each n=9)-normal group, model group, sham operation group, distal-proximal acupoint group, proximal acupoint group, distal acupoint group. After modeling, the rats in three acupuncture groups were treated for 20 minutes, once daily for consecutive 7 days. Those in distal-proximal acupoint group were needled at bilateral “L5 Jiajixue” (Ex-B2), “Dachangshu” (BL 25), “Weizhong” (BL 40) and “Kunlun” (BL 60); those in proximal acupoint group were needled at bilateral “L5 Jiajixue” (Ex-B2)and “Dachangshu” (BL 25) ; the rats in distal acupoint group rats were needled at bilateral “Weizhong” (BL 40)and “Kunlun” (BL 60). Thermal withdrawal latencies were evaluated. The expressions of OX42 and COX2 in the left spinal dorsal horn were detected using immunohistochemical methods. Results Thermal withdrawal latencies and the expression of OX42 and COX2 increased in rat model of transplantation of autologous nucleus pulposus. After treatment, thermal pain threshold was improved (P<0.05), and the expression of OX42 and COX2 were inhibited (P<0.05). The inhibitory effects of distal-proximal acupoint group and proximal acupoint group were superior to that in distal acupoint group. Conclusion Each acupuncture prescription reduced anti-inflammatory effects by inhibiting inflammatory signaling pathways in spinal dorsal horn, with the prescription of distal-proximal acupoints and proximal acupoints superior to distal acupoints.
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    Effects of moxibustion at Zusanli(ST36)on endogenous protective factors and related proteins expression in gastric mucosal lesions rats after damaging nucleus tractus solitarii*
    XIANG Juan, CHEN Guo, OUYANG Lizhi, LI Fei, XIANG Liting, CHEN Ying, YU Jun, YANG Zhou, LI Tielang, PENG Liang
    2016, 39 (5):  406-412.  doi: 10.3969/j.issn.1006-2157.2016.05.011
    Abstract ( 344 )   Save
    Objective To study the role of nucleus tractus solitarii (NTS) on the protective effects of moxibustion on gastric mucosa lesion in the nervous pathway by investigating the effects of moxibustion at "Zusanli" (ST 36) on endogenous protective factors and gap-associated protein expression of gastric mucosal lesion rats after damaging their nucleus tractus solitarii (NTS). Methods 48 healthy SD rats, SPF grade, were divided into four groups using random number table(each n=12): normal group, model group, moxibustion group, moxibustion + NTS damaged group. Three days after bilateral NTS damaged in moxibustion + NTS damaged group, gastric mucosal lesion rat model was induced by intragastrical (i.g.) administration of anhydrous ethanol at dose of 6 mL/kg and aspirin mixed suspension at dose of 200 mg/kg for consecutive three days. The next day, rats in moxibustion group and moxibustion + NTS damaged group were treated by moxibustion at Zusanli (ST 36) twice daily for consecutive three days. All rats were sacrificed, then their serum and gastric tissue were collected. Ulcer index (UI) was calculated, and the expressions of epidermal growth factor (EGF), nitric oxide (NO), Bcl-2 anti-apoptotic proteins (Bcl-2) and pro-apoptotic protein (Bax) were detected. Results Compared with normal group, UI in model group increased significantly(P<0.05), decreased in moxibustion group(P<0.05). Compared with model group, content of EGF and NO in serum and gastric tissue increased remarkably in moxibustion group(P<0.05)which were higher than those in moxibustion + NTS damaged group(P<0.05). Protein expression of Bcl-2 increased significantly in moxibustion group and moxibustion + NTS damage group compared with model group, while expression of Bax protein decreased with increasing of AI (P<0.05). Conclusion Treatment of moxibustion at Zusanli (ST 36) can regulate the expression of endogenous protective factors and proteins to protect rats’ gastric mucosa, which was affected by damaging NTS. It is suggested that NTS be the important regulatory location in the signaling pathway of protective effects of moxibustion at Zusanli on gastric mucosal.
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    Effects of needle-knife surgery on plantar stress for treating calcaneodynia*
    YIN Yueshang, WANG Qingfu, MA Yufeng, QI Yinze ,YANG Lili ,SHI Zongting ,WANG Huan, ZHANG Dong
    2016, 39 (5):  413-416.  doi: 10.3969/j.issn.1006-2157.2016.05.012
    Abstract ( 367 )   Save
    Objective To study the difference of plantar pressure before and after needle-knife surgery on patients with calcaneodynia, so as to evaluate its efficacy and provide evidence to the clinical application of needle-knife therapy. Methods A total 70 patients with calcaneodynia were divided into two needle-knife therapy groups (treatment group, each n=35). After local anesthesia, the needle-knife was inserted into quickly guided by the plantar fascia scale, perpendicular to the direction of metatarsal fascia, then cut and separated the ligaments and fascia attached to the bone spur three to five times. In treatment group 1, the needle-knives were inserted to half of the scale, and in the treatment group 2, the needle-knives were inserted to quarter of the scale. 35 more patients were assigned to the control group who received blocking therapy. Peak pressure values of medial forefoot (MFF), lateral forefoot (LFF), midfoot (MF), medial heel (MHEEL) and lateral heel (LHEEL) were measured before and after treatment using Footscan USB2 System manufactured in RSscan Co. Ltd. Results There was no difference of MFF pressure in the two treatment groups before and after need-knife therapy, but pressures of LFF, MF, MHEEL and LHEEL showed significant differences between after and before treatement(P<0.05). In control group, the pressures of MFF, MF and MHEEL had no significant differences between before and after treatment, while that of LFF and LHEEL showed differences(P<0.05). Conclusion Needle-knife surgery can effectively attenuate the plantar stress changes of the patients with calcaneodynia, and be benefit for recovery the normal lines of force of patients’ feet.
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    Correlation between TCM patterns and bronchoscopy manifestation: a pilot study of primary bronchogenic carcinoma patients *
    FENG Feng, FENG Cuiling, ZHANG Li
    2016, 39 (5):  417-423.  doi: 10.3969/j.issn.1006-2157.2016.05.013
    Abstract ( 345 )   Save
    Objective Based on the distribution rules of TCM patterns of bronchogenic carcinoma patients at first visit, the correlation between TCM patterns and bronchoscopy manifestation was studied to attempt to expand the TCM theory of Microscopic Syndrome Differentiation in the field of bronchoscopy. Methods Before treatment, 176 patients were diagnosed using TCM Four Diagnostic Methods. Then the distribution of TCM patterns was got by using cluster analysis and factor analysis. 98 of 176 patients undergoing bronchoscopy were further studied to find out the correlation between their TCM patterns and bronchoscopy manifestation. Results The leading patterns of primary bronchogenic carcinoma were deficiency of qi and yin (35.2%), qi stagnation, blood stasis with dampness retention (24.4%), qi deficiency with phlegm-dampness (22.2%), yin deficiency(18.2 %). There were statistical differences of bronchoscopy manifestation in different patterns (P<0.05)—hyperplasia in pattern of qi deficiency with phlegm-dampness and pattern of qi stagnation, blood stasis with dampness retention, infiltration in pattern of yin deficiency and pattern of deficiency of qi and yin. Conclusion The differences of bronchoscopy manifestation in different TCM patterns were proved.
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    Quantitative analysis of CT images on lung volume, rating and integral on symptoms: a study on chronic obstructive pulmonary disease patients with syndrome of lung-qi deficiency*
    PENG Nan, LU Yao, ZHAO Jing, KANG Deqiang, GUO Hongli
    2016, 39 (5):  424-428.  doi: 10.3969/j.issn.1006-2157.2016.05.014
    Abstract ( 374 )   Save
    Objective To combine the functional quantitative indicators with the morphological imaging diagnosis by quantitative CT on chronic obstructive pulmonary disease (COPD) patients, so as to provide the objective and quantitative indicators for TCM differentiation and for degrees of lung parenchyma injury. Methods A total of 75 COPD patients at stable stage with syndrome of lung-qi deficiency were divided into three groups (mild, moderate, severe)in accordance with Clinical Guideline of New Drug for Traditional Chinese Medicine, and 20 more healthy people were recruited into healthy group. After lung CT scan, the multi-range imaging quantitative analysis was carried using the post-proceeding three-dimension technology. Then the CT quantitative indicators and the integral and rating of symptoms of patients were compared with the healthy subjects. Results Compared with the healthy group,the mean volume of each lung lobe, and proportion of emphysema volume increased in all three COPD groups. Furthermore, the more serious the symptoms were, the larger volumes of lung lobes and the more proportion of emphysema volume were. The proportion of emphysema volume in upper lobes or in right middle lobe were larger. Conclusion The correlation between the volume of lung lobes and emphysema and the degrees of integral of TCM symptoms were proved. And the introduction of the quantitative indicators could increase the objectivity and reliability of TCM treatment on COPD.
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    A meta-analysis of Chinese medicines on treatment of recurrent spontaneous abortion*
    LIANG Chengcheng ,LEI Lei
    2016, 39 (5):  429-436.  doi: 10.3969/j.issn.1006-2157.2016.05.015
    Abstract ( 370 )   Save
    Objective To systematic review on Chinese medicines for recurrent spontaneous abortion (RSA) by meta-analysis. Methods The literature was collected by computer retrieval on domestic database, manual retrieval on conference proceedings and information of pharmaceutical factories. According to the inclusive and exclusive criteria, tests were selected, data were extracted and evaluated and the systematic review was carried out by description analysis, the meta-analysis was conducted using RevMan 5.3 software from Cochrane Collaboration. Results 15 studies with 1 051 cases were included. The following indicators in Chinese medicine group (experiment group) were superior to those of control group (P=0.00)—clinical efficiency[OR=3.92,95%CI(2.11,7.28)],improvement of symptom score[WMD=1.83,95%CI(1.77,1.89)],successful tocolysis rate[OR=5.55,95%CI(2.29,13.41)], HCG levels[WMD=10 791.66,95%CI(8 644.24,12 939.08)],negative rate of ACA[OR=4.13,95%CI(2.05,8.33)], negative rate of EmAb[OR=3.13,95%CI(1.53,6.39)], CD3 antibody[WMD=-2.48,95%CI(-4.73,-0.23)], CD8 antibody[WMD=0.98,95%CI(0.16,1.79)].However, there was no significant difference in CD4 antibody[WMD=1.04,95%CI(-0.13,2.22)](P=0.08).Conclusion Current evidence proves that Chinese medicine has advantages in treating RSA.Due to the bias from selection and detection,the argumentation intensity was loosen inevitably. So much more high quality randomized double-blind controlled trials are needed to provide more high quality evidence.
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    TCM syndrome elements of 124 elderly patients with multi-system disease*
    ZHAO Zhanrong, XIAO Juncai, HUANG Fei, WANG XiuZhi, WANG Bao, ZHANG Jian, LI Yi
    2016, 39 (5):  437-441.  doi: 10.3969/j.issn.1006-2157.2016.05.016
    Abstract ( 469 )   Save
    Objective To make a preliminary exploration on TCM syndrome elements of elderly patients with multi-system diseases. Methods A total 124 medical records of elderly patients with multi-system diseases were analyzed using SPSS software, of which count data were represented by the raw data and analyzed using Student’s test and the measurement data were represented by figure “0”or “1”and analyzed using Chi-square test .And TCM syndrome were input separately according to disease nature or disease location- “0”for none, otherwise “1”.Results The frequency of disease nature elements from high to low was listed as the following: yin deficiency syndrome(65.3%), qi deficiency syndrome (58.1%), heat syndrome (41.1%), blood stasis syndrome (37.9%), qi stagnation syndrome (36.3%); that of disease location elements was listed as: spleen(54.8%), kidney (49.2%), liver (24.2%) and lung (23.4%). 75% patients over 80 years suffered form qi deficiency, higher than 50% patients less than 80 years old. The mean age of patients with qi deficiency syndrome was 77.65±9.98, while that of heat syndrome patients was 73.14±8.44. The patients with qi deficiency syndrome were older than those without qi deficiency syndrome, and the patients with heat syndrome were younger than those without heat syndrome. The quantity of the disease in phlegm syndrome group was the most (6.00±1.83), and there was a significant difference compared with other groups. The elderly patients suffered from diabetes, coronary heart disease or chronic lung disease had more TCM syndrome elements and more complicated syndromes, and the patients with chronic gastritis had less TCM syndrome elements and less complicated syndromes. Conclusion The rule of TCM syndrome elements of elderly patients with multi-system disease is characterized by complexity, uncertainty and particularity.
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