主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 June 2016, Volume 39 Issue 6 Previous Issue    Next Issue
    Xiang-Shu thinking in Yun-Qi theory in Huangdi’s Canon of Medicine
    HUANG Yuyan, TANG Erqun
    2016, 39 (6):  445-448.  doi: 10.3969/j.issn.1006-2157.2016.06.001
    Abstract ( 437 )   PDF (1258KB) ( 704 )   Save
    The characteristic of Xiang(image)-Shu(number) thinking was reflected in Yun-Qi theory (doctrine of the five circuit phases and six atmospheric influences) in Huangdi’s Canon of Medicine in the following aspects: the pattern of Yun-Qi, understanding of climate and phenophase, understanding of incidence of diseases, and understanding and application of medicines. In this theory, property of Xiang was systematically assigned to Shu, and Xiang and Shu were organized in a unique and complicated way to establish Yun-Qi pattern, by which climate, phenophase and incidence of diseases at a specific time were calculated, on the other hand, the status of Yun-Qi pattern was back-calculated based on metaphorical meaning of climate and phenophase. Xiang-Shu thinking also ran through the understanding and application of medicines of Yun-Qi theory, consequently different with later Chinese materia medica. So, the way of Xiang-Shu thinking would be helpful to master and apply Yun-Qi theory.
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    Using dialectics to discuss the controversial “harmonizing therapy”
    LIU Junjie, XIAO Changjiang,LI Zirong,YANG Xiaoying
    2016, 39 (6):  449-451.  doi: 10.3969/j.issn.1006-2157.2016.06.002
    Abstract ( 416 )   PDF (1171KB) ( 631 )   Save
    The TCM term “harmonizing therapy”, stemming from Huangdi Neijing, includes relieving symptoms of the Shaoyang Meridian, soothing the liver and spleen, and regulating the liver and stomach function. Harmonizing therapy, one of common used TCM clinical therapies,reflects the harmonious thoughts of ancient Chinese philosophy. Physicians of generations couldn't find out any way to convince the others on “harmonizing therapy” due to the various methodologies. Using the scientific dialectics to reason the therapy broadly and narrowly from its abstract therapeutic principle, its concrete treatments and its curative effects, the features of connotation were identified in different levels and points. Furthermore, the contention of “harmonizing therapy” should be treated dialectically, which should not be limited to be a certain therapy despite of degree and premise. Using dialectics to guide TCM basic theory may supply new thinking and ideas for modern TCM clinical practice.
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    Historical origin of small package of Chinese medicine decoction pieces and discussion on the standardized medication dispensing*
    ZHAI Huaqiang, TIAN Weilan, LI Rui, CHEN Yan, JIN Shiyuan, WANG Yongyan
    2016, 39 (6):  452-455.  doi: 10.3969/j.issn.1006-2157.2016.06.003
    Abstract ( 393 )   PDF (1117KB) ( 473 )   Save
    Small package of Chinese medicine decoction pieces (hereinafter “small package of TCM”) has its unique advantage. After searching the literature in CNKI, Wanfang, VIP database, the papers linked to small package of TCM were analyzed from its aspect of history, pros and cons, package selected, dispensing procedure. Then a “ten Chinese characters pithy formula” directed at the process of small package of TCM dispensing was summarized as “examine(Chinese:审), display (Chinese: 摆), watch (Chinese:看), check (Chinese:对), take (Chinese:拿), weigh (Chinese:掂), assign (Chinese:分), verify (Chinese:核), pack (Chinese:包), dispense (Chinese:发)”, which was easy to remember, to understand and to operate, contributing to improving the quality of clinical dispensing and standardizing the skill of TCM dispensing.
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    Effect of polysaccharide in Radix saposhnikovae on absorption, and transformation of comofugin in Caco-2 cells*
    YANG Jingming, JIANG Hua, WANG Ziwei, HU Lili, MENG Xiangcai
    2016, 39 (6):  456-460.  doi: 10.3969/j.issn.1006-2157.2016.06.004
    Abstract ( 388 )   PDF (1453KB) ( 427 )   Save
    Objective To study the influence of polysaccharide in Radix saposhnikovae (Divaricate Saposhnikovia Root, Fangfeng)on the absorption, and transformation of cimifugin in human small intestine. Methods Caco-2 cell monolayer model was applied to stimulate the absorption mechanism of human small intestine. After detection of the contents of polysaccharide at apical side and at baso lateral side, the effect of polysaccharide on cimifugin absorption of small intestine was studied. The contents of total chromones were measured using HPLC after cimifugin co-cultured with Caco-2 cells for 2 h and 4 h. Results Concentration of polysaccharides made no difference on cimifugin permeation through Caco-2 monolayer cell membrane (P>0.05). After Caco-2 cells were cultured with polysaccharide and cimifugin solution for 2 h and 4 h, the content of polysaccharide had no effect on cimifugin content in culture solution and Caco-2 cells (P>0.05). But with the added quality of polysaccharide increasing, prim-O-glucosyl-cimifugin showed an increasing tendency, and 4′-O-β-glucosyl-5-O-methylvisamminol increased significantly(P<0.01), in direct proportion to quantity of polysaccharide. Cimifugin transformation was due to polysaccharide, with the total chromones content of control group of 10.3 nmol/L and that of polysaccharide group of 75.6 nmol/L. Conclusion Polysaccharide of Radix saposhnikovae has no obvious effect on the absorption of cimifugin, but can promote its transformation to prim-O-glucosyl-cimifugin and 4′-O-β-glucosyl-5-O-methylvisamminol, and prevent chromones from degradation.
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    Expression of Notch protein in myocardium of acute myocardial infarction rats and intervention of Yiqi Huoxue Formula*
    YANG Dandan, GUO Shuwen , SUN Qing, ZHANG Lu, ZHAO Haibin
    2016, 39 (6):  461-465.  doi: 10.3969/j.issn.1006-2157.2016.06.005
    Abstract ( 380 )   PDF (1710KB) ( 299 )   Save
    Objective By establishing the acute myocardial infarction (AMI) model, to investigate the expression of Notch signal protein in the myocardium of AMI model rats and the repair ment mechanism of Yiqi Huoxue Formula (supplementing qi and activating blood formula) on cardiac injury. Methods Altogether 64 SD rats, SPF grade, were randomly divided into sham group, model group, Yiqi Huoxue Formula (TCM) group, perindopril group. The AMI model was induced by ligation of left coronary artery. Since the next day, the rats in TCM group and perindopril group were intragastrically (i.g.) administered corresponding drugs, with rats in sham group and model group administered distilled water. On Day 7 and Day 28, left ventricular ejection fraction (LVEF) and left ventricular fractional shortening (LVFS) were measured using visual sonic system designed exclusively for laboratory animals, pathological morphology was examined using HE staining, and the protein expressions of Notch 1, Notch 3 and Notch 4 were detected using Western blot. Results Compared with sham groups, LVEF and LVFS in model group decreased significantly both on Day 7 and Day 28 (P<0.01). The number of myocardial cells in the infarct border area decreased and inflammatory cells were observed. Notch 1 expression increased on both time points (P<0.01), Notch 3 expressed increasingly only on Day 7 (P<0.05). After intervention of TCM, LVEF, LVFS, Notch1, Notch3 decreased significantly compared with model group on Day 7 (P<0.05), LVEF increased significantly and Notch 1 expression decreased significantly on Day 28 (P<0.01). Conclusion Yiqi Huoxue Formula can improve cardiac function in rats with AMI, and longer term application is more efficacy. Its biological mechanism maybe related to the injury related protein Notch 1 and Notch 3.
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    Effect of different components of Coix Seed on related genes in jejunal basolateral membrane of rats with syndrome of spleen deficiency and water dampness*
    HAN Xiaochun , JI Xuming, ZHANG Yanan ,WANG Yanfang ,YIN Ying ,WANG Shijun
    2016, 39 (6):  466-469.  doi: 10.3969/j.issn.1006-2157.2016.06.006
    Abstract ( 394 )   PDF (1996KB) ( 253 )   Save
    Objective To investigate the effects of different components of Coix Seed (Semen Coicis, Yiyiren) on certain genes of transporters and factors in jejuna basolateral membrane of rat with syndrome of spleen deficiency and water dampness. Methods After modeling, the rats with syndrome of spleen deficiency and water dampness were treated by different components extracted from Coix Seed. Then jejunum was tested by gene chip; functional-annotation-gene to basolateral plasma membrane was analyzed by Quick-GO, and the most representative gene was found out by principal component (PC) analysis. Results There were 20 differential genes in seven groups. After dimension reduction by principal component analysis (PCA), 89.7% of variance could be explained when the number of principal component was three. By correlation analysis between loading and score in PC1 and PC2, the expression of genes on basolateral plasma membrane of PC1 was very close to those of PC2, showing the similar function of different components of Coix Seed on jejuna basolateral membrane. However, there was a different situation in PC2 and PC3. Normalization of the weight of PC1, PC2 and PC3 showed that the leading weight genes were Slc22a7, Car9, Agtr1b, S100g, Aqp9, Msn, Aqp3, Slc4a1, and Slc4a10. Conclusion Coix Seed can repair the injury of small intestine due to modeling stimulation, and upregulate SLC expression leading to regain the ability of raising white blood cell, materializing the TCM abstract term “invigorating spleen”. Coix Seed can downregulate AQP3 expression of the model, and reduce liquid absorption from intestinal lumen, materializing the term of “eliminating dampness”
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    Effect of Zuogui Jiangtang Jieyu Formula on amino acid transporter expression in hippocampal astrocytes of diabetes mellitus rats with depression*
    XU Yalan,ZHAO Hongqing,DU Qing, YAN Hui,MENG Pan, WANG Yuhong
    2016, 39 (6):  470-475.  doi: 10.3969/j.issn.1006-2157.2016.06.007
    Abstract ( 353 )   PDF (3140KB) ( 300 )   Save
    Objective To investigate the effects of Zuogui Jiangtang Jieyu Formulation (ZGJTJYF) on the expression of excitatory amino acid transporter 3(EAAT 3) and vesicular glutamate transporter 2(VGLUT 2) in hippocampal astrocytes of diabetes mellitus rats with depression (DD). Methods DD rats were induced by intragastrical administration of high-fat diet, tail intravenous injection of streptozotocin (STZ) with 28 days’ chronic stress and were randomly divided into five groups—model group, positive drug group (metformin with fluoxetine), high-, middle-, and low- dose of ZGJTJYF (high-dose, mid-dose, and low-dose) group. Healthy SD rats were assigned into blank control group. After four consecutive weeks the cognition ability was measured using Morris water maze, and the expression of EAAT3 and VGLUT2 were detected by using immunohistochemical double labeling method. Results Compared with blank control group, escape latency of model group was significantly longer (P<0.01), EAAT 3 expression decreased, VGLUT 2 expression increased remarkably (both P<0.05). Compared with model group, escape latency of positive drug group and in high-dose group decreased significantly(P<0.01),expression of EAAT3 in positive drug group and all ZGJTJYF groups increased(P<0.05), and VGLUT2 expression in positive drug group and high-dose group decreased significantly (P<0.05). Conclusion Zuogui Jiangtang Jieyu Formula can improve the disorder of EAAT3 expression and VGLUT2 expression in hippocampal astrocytes of diabetes mellitus rats with depression.
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    Evaluation criteria of coronary artery disease animal models with pattern of turbid phlegm with blood stasis:a literature study*
    YANG Kailun, ZHOU Haobo, PAN Ye, YIN Jia, GAO Shan, YU Chunquan
    2016, 39 (6):  476-479.  doi: 10.3969/j.issn.1006-2157.2016.06.008
    Abstract ( 396 )   PDF (1119KB) ( 283 )   Save
    Taking pattern of turbid phlegm with blood stasis as the subject, which is the main TCM pattern of coronary artery disease(CAD) according to epidemiological investigation, we used systematic retrieval methods to find all papers linked to CAD animal models with pattern of turbid phlegm with blood stasis (hereinafter: animal models) under strict inclusion and exclusion criteria. We attempted to find out the objective standards and specific standards to evaluate whether the animal models were established successfully, in order to provide a foundation for making scientific evaluation standard of the animal models.
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    Quality representation and correlation analysis of Ligustrum lucidum Ait. based on characteristic spectrum of drug system*
    ZHAO Limin, LU Guangying, YANG Shujuan, XU Shuya, PENG Ping, LI Gang, LI Huanjuan, FENG Duo,YANG Changming, SHI Renbing
    2016, 39 (6):  480-488.  doi: 10.3969/j.issn.1006-2157.2016.06.009
    Abstract ( 430 )   PDF (3483KB) ( 544 )   Save
    Objective To establish quality representation and correlation analysis method of Ligustrum lucidum Ait. (Glossy Privet Fruit, Nüzhenzi)based on characteristic spectrum of drug system, so as to evaluate the quality of Nüzhenzi decoction pieces accurately and comprehensively. Methods Using established HPLC-PDA method to represent the quality of Nüzhenzi characteristic spectrum of drug system. Then the qualitative representation of 14 batches of Nüzhenzi decoction pieces was based on the quantity and type of characteristic peaks of specific chromatograms, the quantitative representation of 14 batches of Nüzhenzi pieces was based on the content of four characteristic index components including salidroside, tyrosol, specnuezhenide and quercetin and the sum of iridoids (using specnuezhenide for representation) and flavonoids (using quercetin for representation), then correlation analysis was based on the representation results of quantity and quality respectively in 14 batches of Nüzhenzi pieces referenced to the benchmark decoction piece. Results Taking Lot. S10 as the benchmark, in Nüzhenzi HPLC specific chromatogram there were 11 characteristic peaks which were common in all batches, including two benzene glycosides peaks ,five iridoids peaks,four flavonoids peaks. The contents of effective index components in batch S14, S12,S5,S8,S9,S6 and S11 were higher, with the highest correlation in S14, S12, S5, S8, S9 and S10, so the quality of S5, S8, S9, S12, and S14 were superior to other batches. Conclusion The evaluation model of quality representation and correlation analysis of Nüzhenzi specific chromatogram concerning on correlation of the overall quality and the effectiveness of the application, can effectively and accurately evaluate the quality of Nüzhenzi.
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    Specific chromatogram of Mongolian medicine compound Sendeng-4 and simultaneous determination of its six index components*
    BAI Pu, SA Chula, DONG Yu
    2016, 39 (6):  489-493.  doi: 10.3969/j.issn.1006-2157.2016.06.010
    Abstract ( 423 )   PDF (1340KB) ( 393 )   Save
    Objective To establish HPLC specific chromatogram of Sendeng-4, a Mongolian medicine compound, and to simultaneously determine six index components—gallic acid,genipin-1-β-D-gentiobioside, geniposide, (2R, 3R)-dihydromyricetin, rutin, and myricetin. Methods HPLC specific chromatogram was obtained under the following system: Extend-C18 column (250 mm × 4.6 mm, 5 μm), mobile phase of acetonitrile (A) and 0.6 % phosphoric acid aqueous solution (B) , gradient elution, flow rate at 1 mL/min, the column temperature at 25 ℃, detection wavelength at 254 nm, and the injection volume 10 μL. HPLC system for determination was listed as the following: Extend-C18 column (250 mm × 4.6 mm, 5 μm), mobile phase of acetonitrile (A) and 0.6% phosphoric acid aqueous solution (B), gradient elution, flow rate at 0.5 mL/min, the column temperature at 27 ℃, the detection wavelengths at 254 nm and 292 nm, and the injection volume 10 μL. Results More than 90 peaks were detected on HPLC specific chromatogram, from which ten were identified by comparing with standard HPLC chromatogram and six were measured. After determination, the content and the peak area of each component had a good linear relationship, with correlation coefficients 0.999 9, average recovery of 98.29%~103.75% and RSD 1.44%~2.97%. Conclusion The method established is accurate, simple and repeatable, and can be used to control the quality of Mongolian medicine compound Sendeng-4.
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    Simultaneous determination of the content of three active components in different parts of Isodon excisoides by HPLC*
    DAI Liping , ZHAO Meng, ZHAO Jiaojiao , MIAO Mingsan, LIU Mengqi,ZHANG Lingxia, CHEN Suiqing
    2016, 39 (6):  494-497.  doi: 10.3969/j.issn.1006-2157.2016.06.011
    Abstract ( 399 )   PDF (1253KB) ( 289 )   Save
    Objective To establish the method of simultaneous determination of blumenol A, kamebanin and henryin in different parts of Isodon excisoides by using HPLC. Methods The parameters of HPLC were listed as the following: YMC C18(4.6×250 mm,5 μm)reversed-phase LC column; acetonitrile-water (32∶68) isocratic elution; flow rate at 1.0 mL/min; temperature of 30 ℃;UV detection wavelength of 230 nm. Results Blumenol A, kamebanin and henryin showed a good linearity in the range of 0.001 11~0.022 2 g/L (r=0.999 7), 0.001 855~0.037 1 g/L (r=0.999 5), 0.013 25~0.265 0 g/L (r=0.999 7) respectively. The average recovery of the three ingredients were 99.58% (blumenol A), 99.51% (kamebanin) and 102.78% (henryin) with RSD 2.29%, 1.49%, 1.57% correspondingly. The content of three index components in different parts of Isodon excisoides varied, with the largest content in leaves. Conclusion The method established is sensitive, accurate and effective, which can be used for determination of the content of three active components in different parts of Isodon excisoides.
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    Chemical components from leaves of Lycium barbarum*
    YAO Yao, SHUI Dong, TIAN Jianying, MIAO Zhenhua, ZHAO Jing, LI Weiqi, LI Juan
    2016, 39 (6):  498-501.  doi: 10.3969/j.issn.1006-2157.2016.06.012
    Abstract ( 396 )   PDF (1144KB) ( 447 )   Save
    Objective To study the chemical components in the leaves of Lycium barbarum (Barbary Wolfberry, Gouqi). Methods After suspension of the crude extract from leaves by 70% alcohol, the extraction was performed with petroleum ether, ethyl acetate and n-butanol successively. Then repeated silica gel column chromatography, Sephadex LH-20 chromatography, preparative HPLC and thin layer chromatography were applied for isolation and purification of the compounds in ethyl acetate and n-butanol extracts. Chemical structures of the compounds were identified by physical properties and spectra analysis including NMR and ESI-MS. Results A total 10 components were identified: 4-methoxybenzoic acid (1), 4-methoxycinnamic acid (2), scopoletin (3), 4-hydroxybenzaldehyde (4), 4′-hydroxyacetophenone (5), (Z)-2-ethylidene-3-methylsuccinic acid (6), quercetin (7), adenosine (8), scopolin (9), rutin (10). Conclusion 1, 2, 4, 6, 8 were isolated for the first time from Lycium L., and 3, 5, 9 were isolated from Lycium barbarum L. for the first time.
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    Optimization of ultrasonic-assisted extraction of total flavonoids from Lomatogonium rotatum by response surface analysis*
    LIU Ting,GAO Youheng,GE Chunjuan,YAN Changhua,LIANG Yaoqiu,LI Xiao
    2016, 39 (6):  502-507.  doi: 10.3969/j.issn.1006-2157.2016.06.013
    Abstract ( 400 )   PDF (2117KB) ( 662 )   Save
    Objective To optimize ultrasonic-assisted extraction process of total flavonoids from Lomatogonium rotatum by using single factor experiment and response surface methodology, so as to provide the theoretical evidence for the exploitable and utilization of flavonoids in Lomatogonium rotatum.Methods Ethanol solution was selected as the extraction solvent. Based on the single factor experiment,three independent variables of ethanol volume fraction(X1),material to liquid ratio(X2) and sonication time(X3)with the response value of the content of total flavonoids(Y) were designed for Box-Behnken central composite experiment, then a quadric regression equation was established to predict the yield of total flavonoids.Results The optimum extraction process was 65% ethanol solution(V/V)with liquid to material ratio of 20 mL/g for 20 minutes.The actual yield of total flavonoids were 21.26 mg/g,very close to the predictive values.The binomial fitting multiple correlation coefficient (r) is 0.956 8.Conclusion Optimizing the extraction process of total flavonoids of Lomatogonium rotatum by response surface methodology was proved to be stable,reasonable and feasible.
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    Professor L Renhe’s experience for diagnosis, staging and treatment of emaciation-thirst disease*
    LONG Hongzhu,TIAN Wenyang,YANG Xiaohui
    2016, 39 (6):  508-510.  doi: 10.3969/j.issn.1006-2157.2016.06.014
    Abstract ( 397 )   PDF (1166KB) ( 309 )   Save
    After linking the theory of Huangdi’s Canon of Medicine with his years’ clinical experiences, Professor L Renhe treats emaciation-thirst according to three stages: Pidan stage, Xiaoke stage, and Xiaodan stage. At Pidan stage, the primary syndrome is yin deficiency, so the therapy is tonifying spleen and stomach and nourishing yin; at Xiaoke stage, internal heat due to yin deficiency should be treated in the way of clearing heat on the basis of tonifying spleen and stomach and nourishing yin; at Xiaodan stage, also the end stage, qi and yin are consuming with blood stasis, so the therapy is recuperating the vitality with invigorating five organs. This article also discuss the origin of L Renhe’s thought by combining the description of emaciation-thirst recorded in Huangdi’s Canon of Medicine.
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    Evaluation of intervention effect of TCM constitution health education*
    CHENG Jiehui, WU Zhixing, ZHU Yanbo, YUAN Liping, HUANG Qingyi, HE Xiaoping, ZENG Yonghong
    2016, 39 (6):  511-515.  doi: 10.3969/j.issn.1006-2157.2016.06.015
    Abstract ( 421 )   PDF (1142KB) ( 448 )   Save
    Objective To explore the intervention effect of TCM constitution health education on constitution and relevant health indicators. Methods The research design was adopted with no control group before and after the test evaluation. A total of 595 subjects were recruited. Interventions of emotion, diet, sleeping and living, exercise, and meridian and acupoint massage were concluded in the TCM constitution health education interventions. Investigated their constitution, health related quality of life(MOSSF-36) and laboratory indexes before and after the intervention of 3 months and 6 months. Results 509 subjects were available. After 3 months intervention, the score of gentleness type was significantly increased by 3.67 points (P<0.05) while scores of pathological constitutions except yang-deficiency type were significantly decreased (P<0.05). All of the absolute values of standardized response mean (SRM) ranged from 0.10 to 0.51. After 6 months intervention, the score of gentleness type was significantly increased by 3.67 points (P<0.05) while scores of all pathological constitutions were significantly decreased (P<0.05). All of the absolute values of SRM ranged from 0.23 to 0.75. Physical component summary (PCS) scores and mental component summary (MCS) scores of MOS SF-36 were significantly increased (P<0.05) after 3 months and 6 months intervention. After 3 months intervention, systolic pressure (SP), diastolic pressure (DP), 2-hour postprandial glucose (2hPG), and total cholesterol (TC) decreased significantly (P<0.05), but high density lipoprotein-cholesterol (HDL-C) was significantly increased (P<0.05). After 6 months intervention, SP, DP, 2hPG, TC, triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) were significantly decreased (P<0.05), but HDL-C was significantly increased (P<0.05). Conclusion TCM constitution Health education intervention can improve the constitutional conditions, clinical abnormal indexes, and the quality of life resulting in the improvement of health. However, the intervention effects were generally low, which indicates that the constitution is relatively stable. Therefore, a long-term of TCM constitution intervention is necessary for health promotion.
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    Contemporary TCM academic teams engaged in research on knee joint osteoarthritis: a study based on literature metrology*
    WU Jiubin, LI Meng, XIE Yanming, WANG Zhifei
    2016, 39 (6):  516-519.  doi: 10.3969/j.issn.1006-2157.2016.06.016
    Abstract ( 391 )   PDF (1345KB) ( 532 )   Save
    Objective To explore the contemporary academic teams engaged in research on knee osteoarthritis (KOA), so as to summarize their main members and primary academic ideas. Methods From the Chinese biomedical literature database (CBM) from 1900 to 2015, the TCM literature linked to KOA was searched out, from which the author information was extracted using regular expressions, prolific authors were screened out using Price Law, academic teams were found using UCInet software. Then, important academic teams screened out according to H index were visualized using Netdraw software to find out their main members from whom the chief members’ academic ideas on KOA were explored and summarized. Results A total of 7 375 authors with 3 932 TCM papers on KOA were included, 86 prolific authors belonging to nine academic teams, and five teams were important— LIU Xianxiang Team, ZHAO Wenhai Team, LIU Deyu Team, WEN Jianmin Team and FAN Yueguang Team. Conclusion The contemporary TCM academic teams which have special features on treatment KOA, inherit and carry forward the TCM theories from different views in clinical research and practice.
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    Clinical observation of Bushen Qianggu Decoction on multiple myeloma*
    HUANG Zhili, YU Tianqi, CHEN Yayong, GUO Shanshan
    2016, 39 (6):  520-523.  doi: 10.3969/j.issn.1006-2157.2016.06.017
    Abstract ( 413 )   PDF (1137KB) ( 343 )   Save
    Objective To observe the effects of Bushen Qianggu Decoction(BQD) on macrophage migration inhibitory factor(MIF) of patients with multiple myeloma(MM)and its clinical efficacy, so as to provide the ground for clinical promotion. Methods 30 patients who accorded with the inclusive criteria were divided into two groups randomly. BQD combined with VAD chemotherapy regimen were used in treatment group; thalidomide combined with VAD chemotherapy regimen were used in control group. The indexes of pre- and post- treatment were observed, including serum MIF, hemoglobin, serum M protein, marrow plasmacyte rate, serum calcium, serum β2 microglobulin (β2-MG) , lactic acid dehydrogenase (LDH), and C-reaction protein (CRP). And the clinical efficacy and adverse reaction were studied. Results There were statistical differences between treatment group and control group in serum MIF,hemoglobin, serum M protein, marrow plasmacyte rate, CRP (P<0.01) and β2-MG (P<0.05). There was no difference in serum calcium and LDH (P>0.05). The total effective rate in treatment group was 86.66% compared to 80% in control group, no significant differences after Ridit analysis (P>0.05). The incidence of constipation, sleepiness, edema, peripheral neuropathy of control group were significantly higher than that of treatment group (P<0.05). Conclusion The clinical efficacy of BQD on MM was close to thalidomide with obviously less adverse reactions. BQD decreased serum MIF, M protein, marrow plasmacyte rate, serum β2-MG, and CRP, increased hemoglobin, and adverse reactions were decreased significantly. This study showed that BQD has certain advantages on MM by the way of inhibiting the high expression of serum MIF and angiogenesis.
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    Data analysis of Journal of Beijing University of Chinese Medicine winning the prise of 100 Outstanding Academic Journals of China for three continous years
    YOU Haiyan, ZHANG Chi, LI Yan, LU Guanglin, LUO bin,BAI Jin, LIANG Jichun
    2016, 39 (6):  524.  doi: 10.3969/j.issn.1006-2157.2016.06.018
    Abstract ( 392 )   PDF (1198KB) ( 284 )   Save
    Objective To analyze the evaluation evidence of Journal of Beijing University of Chinese Medicine winning the prise of 100 Outstanding Academic Journals of China for three consecutive years from 2012 to 2014. To understand objectively the academic influence of the journal and to provide theoretical support for the adjustment of developmental strategy. Methods The evaluation evidence of the prise is based on the statistical data from China Journal Citation Reports(CJCR). This article analyzed and compared the data from CJCR related with Journal of Beijing University of Chinese Medicine, including journal cited indicators (general cited rate and core impact factor), journal source indicators and journal indicators in similar discipline. Results The core general cited rate of Journal of Beijing University of Chinese Medicine from 2012 to 2014 was 0.769, 0.589, 0.722. The journal ranked 24, 111, 72 in the overall evaluation ranking in Chinese Scierue and Technology S&T Core Journals (Nature and Science). Conclusions Journal of Beijing University of Chinese Medicine ranked front in the indicator statistics by Chinese S&T Core Journals (Nature and Science). The academic influence of this journal always took the dominant place among academic journals in the category of TCM university journals.
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