主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 September 2016, Volume 39 Issue 9 Previous Issue    Next Issue
    On the origin, development and evolution of five-phase theory*
    YAN Long, HE Juan
    2016, 39 (9):  709-713.  doi: 10.3969/j.issn.1006-2157.2016.09.001
    Abstract ( 545 )   PDF (1301KB) ( 870 )   Save
    The theory of five phases is an essential component of philosophic theories in ancient China. However, the contemporary scholars have different views on the origin and the essence of this theory. Based on analysis of ancient literature,the following points of view are proposed. The ancient’s worship of the digit "five" was the basis of formation of five-phase. Formed in the Shang Dynasty late and early Zhou Dynasty,the concept of five phases came from the characteristics of five basic materials in life. Formed in the Western Zhou Dynasty, the viewpoint of restriction in the five phases was derived from the observations of the relationship between the five materials. In the Spring and Autumn Period, the restriction in the five phases was applied to political, military and other fields, and the uncertain restriction in the five phases was discovered.The concept of generation in the five phases which originated in the alternation of seasons was formed in the Warring States Period. It was the production of combination of four-season doctrine and five-material doctrine. Five-phase theory matured during the Warring States Period. The combination of generation and restriction in the five phases completed five-phase theory. Five-phase theory reached its peak in the Han Dynasty. The over-restriction and counter-restriction of five phases were proposed as the improvement of five-phase theory.
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    Literature review of hermeneutics and Chinese medicine*
    XING Yurui
    2016, 39 (9):  714-719.  doi: 10.3969/j.issn.1006-2157.2016.09.002
    Abstract ( 447 )   PDF (1170KB) ( 321 )   Save
    Since hermeneutics was introduced into the research on Chinese medicine in 2000, there were some highlighted problems, involving weak and decentralized management, low-level due to poor knowledge reserve, excessive interpretation. This paper summarized the current status of the application of hermeneutics in Chinese medicine from five aspects: hermeneutics in TCM classic, hermeneutics in TCM basic theory, hermeneutics methods in TCM, establishment of TCM hermeneutics and hermeneutics applied in other TCM fields. Then the hermeneutics study should proceed by studying the latest global achievements and training the professionals, by establishing TCM self-confidence and a new theoretical system with discourse power under the current context. While the emphasis of expanding the hermeneutics in TCM is to carry out the modern annotation and innovation of TCM classic and core theories of TCM systematically.
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    Relationship between depression and “liver yang qi deficiency”*
    SONG Ming, CHEN Jiaxu, HOU Yajing, WANG Fangfang
    2016, 39 (9):  720-723.  doi: 10.3969/j.issn.1006-2157.2016.09.003
    Abstract ( 569 )   PDF (1212KB) ( 368 )   Save
    Through the analysis of depression in Western medicine and depression syndrome in Chinese medicine, to summarize and discuss the pathogenesis problems related depression. This paper pointed out that modern concept of depression was not exactly as the same as the concept of TCM depression syndrome. And the background of ignorance of liver yang qi deficiency - the core pathogenesis of moderate to severe depression was revealed. At the same time, the general pathogenesis combined with the core pathogenesis of moderate to severe depression was interpreted and applied to diagnose and treat.
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    Perspective on intestinal microecology using basic theory of TCM*
    LIU Leilei, MENG Jingyan
    2016, 39 (9):  724-727.  doi: 10.3969/j.issn.1006-2157.2016.09.004
    Abstract ( 543 )   PDF (1150KB) ( 359 )   Save
    Three elements of material, energy and information, in which human being survive and reproduce, not only exist in external environment of human-nature and human-society, but also in internal environment of human body. Intestinal microecology, an important part of human internal environment, has the correlation with human physiology, pathology and psychology. The balance of intestinal microecology and human body is an interdependence, mutual coordination and restriction system under the interaction of the three elements.Various diseases will occur due to microecological imbalance. With the introduction of TCM, the holism concept, theory of yin-yang, doctrine of viscera state, body constitution theory, healthy qi and pathogen theory, to a certain extent, can be used to interpret the relationship of intestinal microecology and host; furthermore, some digestive system diseases can be treated by the way of improving the intestinal microecology using Chinese medicine. This paper discussed the intestinal microecological balance guided by the basic theory of TCM.
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    New explanation of house of intelligence*
    MENG Qingyan,YAN Peizheng,XIANG Guangxin,ZHANG Qingxiang
    2016, 39 (9):  728-730.  doi: 10.3969/j.issn.1006-2157.2016.09.005
    Abstract ( 420 )   PDF (1144KB) ( 289 )   Save
    House of intelligence(Chinese:精明之府), a TCM term, whose denotative meaning and connotative meaning are discussed and analyzed in this paper, based on xiang (image) thinking methods combinaed with the concept of correspondence between nature and universe. After interpretation of "The head is house of intelligence" in Inner Canon of Huangdi, this paper points out that house of intelligence should be an exact head and facial sensation which is an image of function not a specific anatomical structure. In a word, house of intelligence is an image of human body correspondence to the images of nature and universe. The paper analyzed a classical issue from a new perspective, which is important for better understanding of TCM theories.
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    Therapeutic effect of Five Notes of ancient China’s pentatonic scale based on acoustic resonance
    PAN Liang, FAN Di,HU Hui
    2016, 39 (9):  731-733.  doi: 10.3969/j.issn.1006-2157.2016.09.006
    Abstract ( 412 )   PDF (1201KB) ( 692 )   Save
    Five Notes of the ancient China’s pentatonic scale (hereinafter “Five Notes”)is associated with the five zang-organs theory of Traditional Chinese Medicine by five phases theory . The therapeutic effects of Five Notes had been recorded in ancient Chinese medical books. After observation of environment and human body and their interaction, our ancestors had classified various things or different parts of the same thing into wood, fire, earth, metal and water, based on qi movement style. The same kinds of things have energy in common, which arise from their natural frequency. Human zang-organs undoubtedly are substances, and their energy which present in the form of physiological function, come from zang-organs’vibration of natural frequency. Theory of the manifestations of organs was the combination of zang-organs’matter and energy. Therapeutic effect of music is by the way of resonation between human body and qi via sound waves.
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    Correlation of TA repeat polymorphisms of estrogen receptor-α gene and TCM patterns of hypomenorrhea*
    LIN Xiaohua, JIN Zhe, LIU Jing, TAN Zhanwang
    2016, 39 (9):  734-738.  doi: 10.3969/j.issn.1006-2157.2016.09.007
    Abstract ( 354 )   PDF (1341KB) ( 246 )   Save
    Objective To find out the distribution of TA (thymine-adenine) repeat polymorphisms of estrogen receptor-α (ERα) gene in patients with unexplained hypomenorrhea as well as its correlation with TCM patterns of hypomenorrhea. Methods The present case-control study was carried out by using the sequencing methods to find out the TA repeat polymorphisms distribution differences in patients and controls, and in TCM patterns of patients. Results The frequency of TA19 allele in experimental group was 22.73%, significantly higher than 4.55% in control group (P=0.007) . The rank of distribution of TA19 allele in patterns listed as kidney deficiency, blood stasis and blood deficiency, showed no significant difference (X2=5.137, P=0.077). But the distribution of TA19 in pattern of kidney deficiency and blood deficiency showed significant difference(X2=4.574,P=0.032,OR=0.283). Conclusion The correlation of TA repeat polymorphisms of estrogen receptor-α gene and TCM patterns of unexplained hypomenorrhea was proved. The TA19 allele was more susceptibility to hypomenorrhea, whose association with the different TCM patterns showed no statistical significance.
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    Comparison of reinforcing spleen formulas on skeletal muscle in rats with spleen deficiency pattern*
    ZHANG Guangxia, LIU Biyuan, ZHANG Yuanfeng, XIE Ming
    2016, 39 (9):  739-743.  doi: 10.3969/j.issn.1006-2157.2016.09.008
    Abstract ( 376 )   PDF (1580KB) ( 328 )   Save
    Objective To observe and compare the effects of three reinforcing spleen formulas (Buzhong Yiqi Decoction, Sijunzi Decoction, Shenling Baizhu Powder) on the changes of skeletal muscle power in rats model with spleen deficiency pattern. Methods Male Wistar rats were randomly divided into normal group, model group, Buzhong Yiqi Decoction (BZYQD) group, Sijunzi Decoction (SJZD) group and Shenling Baizhu Powder (SLBZP) group. Except the normal group, the rats of the four groups were modeled after over fatigue and improper diet for consecutive four weeks. On Day 15 after modeling, three medication groups were intragastrically administered (i.g.) corresponding Chinese medicines at dose of 4.05 g/(kg·d), while model group and normal group were i.g. administered distilled water at the same dose, for consecutive 14 days. Then grip strength was measured, biochemical indexes of blood and skeletal muscle were detected, and the pathological changes of skeletal muscle were observed. Results Compared with normal group, the indexes of rats of normal group, involving grip strength, succinate dehydrogenase (SDH) in skeletal muscle, creatine kinase isoenzyme (CK-MM), Ca2+-ATPase, M-AChRM2 and Musclin decreased significantly, while serum AchE increased significantly (P<0.01 or P<0.05). Inflammatory cell infiltration was observed in skeletal muscle, and muscle fiber was scattered in disorder with uneven thickness, loose arrangement and vacuole degeneration in model group. Compared with model group, the biochemical indexes and pathological changes of the three medication groups were ameliorated, among which the grip strength, SDH, CK-MM, M-AChRM2 of skeletal muscle in BZYQD group were higher significantly than those of SJZD group and SLBZP group (P<0.01 or P<0.05). Conclusion Skeletal muscle injuries were found in rats with spleen deficiency pattern. In TCM, Sijunzi Decoction has been used for reinforcing spleen, Shenling Baizhu Powder been used for reinforcing spleen and eliminating dampness, and Buzhong Yiqi Decoction been for reinforcing spleen and rising yang. The three formulas could improve the skeletal muscle of rat model with spleen deficiency pattern, in which Buzhong Yiqi Decoction showed the best efficacy.
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    Multi-target neuroprotective effect of Buyang Huanwu Decoction against cerebral ischemia injury*
    LU Fang, JIANG Ludi, CHEN Yankun, LUO Ganggang, LIU Fang, LI Gongyu, ZHANG Yanling
    2016, 39 (9):  744-749.  doi: 10.3969/j.issn.1006-2157.2016.09.009
    Abstract ( 363 )   PDF (1642KB) ( 241 )   Save
    Objective To explore the multi-target mechanism of neuroprotective effect of Buyang Huanwu Decoction (BYHWD) against cerebral ischemia injury by using molecular docking. Methods 230 ingredients and metabolites of herbal Chinese medicines of BYHWD were collected and docked with seven active binding sites of five glutamate receptors.The potential anti-cerebral ischemia injury active compounds were screened and the molecular mechanism of the active ingredients was analyzed using molecular docking. Results Calycosin, formononetin, perlolyrine and lactiflorin, main compounds of BYHWD, interacted with two or more binding sites of glutamate receptors, which showed that BYHWD’s neuroprotective effect against cerebral ischemia in the way of multiple compounds working on multiply targets and multiply sites. Majority of components from the chief drug Radix Astragali (Huangqi) and minority of components from deputy drug Radix Angelicae Sinensis (Danggui) and assistant herbs Rhizoma Chuanxiong, Radix Paepmoae Rubra (Chishao), and Flos Carthami (Honghua), consistent with the combination principles of BYHWD. Conclusion The multi-target neuroprotective effect of BYHWD against cerebral ischemia injury was studied at the molecular level, which can guide the application of BYHWD in clinic. Meanwhile, this study also can provide reference for discovering novel traditional Chinese medicines to treat cerebral ischemia injury.
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    Xintong Changluo Shuli Quzhuo therapy against focal segmental glomerular sclerosis rats*
    ZHAO Xi, YANG Hongtao,LI Man,LI Jie,XU Bing
    2016, 39 (9):  750-754.  doi: 10.3969/j.issn.1006-2157.2016.09.010
    Abstract ( 322 )   PDF (2255KB) ( 183 )   Save
    Objective To study the therapeutic effect and mechanism of Xintong Changluo Shuli Quzhuo therapy (hereinafter called “TCM”) against rats with focal segmental glomerular sclerosis in rats. Methods The rat model of focal segmental glomerular sclerosis was induced by tail intravenous injection of azithromycin twice. According to their weight, all rats were divided into normal group, model group, benazepril group and TCM group (n=15 each). At the end of 9th week after modeling, the corresponding drugs were administered orally. Then at the 4th week and at the 8th week after treatment, 24 h urine protein, serum albumin, creatinine and urea nitrogen levels were measured and morphological changes were observed under light microscope and electron microscope. Results Compared with model group, each index of TCM group had significant differences, and pathological observation showed that the glomerular injury in TCM group was slighter than that in the model group. Conclusion Xintong Changluo Shuli Quzhuo therapy can obviously protect the renal function of rats, significantly reduce extracellular matrix deposition and glomerular sclerosis, delay the progress of chronic kidney disease.
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    Chemical component analysis of Mongolian medicine compound Xieri GA-4*
    GAO Jianhua, LI Binxin, BAI Feng, DONG Yu, XIN Shasha
    2016, 39 (9):  755-758.  doi: 10.3969/j.issn.1006-2157.2016.09.011
    Abstract ( 391 )   PDF (1236KB) ( 375 )   Save
    Objective To study the chemical components of Xieri GA-4, a Mongolian medicine compound. Methods After isolation by using solvent method, silica gel column chromatography, thin layer chromatography, Sephadex LH-20 column chromatography, the structure of the components were determined by using modern spectrum analysis, including mass spectrometry (MS), hydrogen nuclear magnetic resonance spectrum (1H-NMR), 13C nuclear magnetic resonance spectrum (13C-NMR) . Results Altogether eleven components were isolated and identified as veratric acid (1), isocurcumenol (2), crocin-3 (3), D-mannitol (4), ursolic acid (5), baicalin (6), crocin-1 (7), magnoflorine (8), 4-amino-4-methyl-2-pentanone (9), geniposide (10), chlorogenic acid (11) from the effective parts. Conclusion The eleven components were first obtained from Xieri GA-4.
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    Determination of thermal physical parameters and model establishment for Ganmao Tuire Granule extract
    MENG Qingqing, WANG Baohua, YANG Beibei, JI Wenqin, LI Ping, WANG Fang, DING Lei
    2016, 39 (9):  759-763.  doi: 10.3969/j.issn.1006-2157.2016.09.012
    Abstract ( 432 )   PDF (1585KB) ( 325 )   Save
    Objective To determine the thermal conductivity coefficient (λ)under different temperatures (T) and different concentrations (C) and specific heat capacity (cp), so as to establish the mathematical models of λ-T, λ-C, λ-T-C and cp-C of Ganmao Tuire Granules extract. Methods λ and cp were determined by using instantaneous double line method and equivalent specific heat capacity meter respectively. Then the experimental data were analyzed using software Excel, 1stOpt and MATLAB. Results There was a negative linear correlation between λ and T, λ and C(λ= a-bT, λ=a-bC), furthermore, T and C had certain interactions on influence of λ . λ =a-bC-cT-dCT can be used as a combination model of temperature and concentration on the coefficient of thermal conductivity. In addition, cp had linear negative correlation with C (cp = a-bC). Conclusion Taking Ganmao Tuire granules extract as subject, this study proved the great difference of λ and cp of Chinese medicine extract under different temperature and concentration. This study provided data support and theoretical guidance of thermal-physical parameters, of selection and design the medicine production equipment, of production process control, and of the key technology of production.
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    Five evolutive phases and six climatic factors in correlation with Heavenly Stems and Earthly Branches: a study on birth date and onset date of patients with spleen-stomach diseases*
    ZHANG Xuan, LIU Zhongdi, HE Juan
    2016, 39 (9):  764-768.  doi: 10.3969/j.issn.1006-2157.2016.09.013
    Abstract ( 440 )   PDF (1167KB) ( 272 )   Save
    Objective To study the distribution of five evolutive phases and six climatic factors at birth date and onset date of patients with spleen-stomach diseases. Methods Descriptive statistics was used to analyze the factors of five circuits and six qi of birth date of 1 347 spleen-stomach diseases patients and attack date, then Chi-square test was adopted to determine the differences. Results Distribution of celestial manager qi at birth date showed significant difference (P<0.05). The leading two years of rate of suffering from spleen-stomach diseases was Taiyang cold water controlling the heaven and Taiyin damp earth terrestrial effect. Additionally, distribution of Heavenly Stems, circuits of years and controlling the heaven of the onset year showed significant differences (P<0.05). The incidence of the diseases in years of water circuits, especially in the years of Bing which were characterized by water circuits sufficiency, and in years of Taiyang cold water controlling the heaven and Taiyin damp earth terrestrial effect, showed the highest. Conclusion Cold (water) and damp (earth) were the common mode of the risk of spleen stomach diseases. It suggested that we should pay more attention on the attack of spleen-stomach diseases in cold-damp circuits years, such as Bing Year, Chen-Xu Year. And the persons who were born in Chen-Xu Year should put more emphasis on protecting their spleen and stomach.
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    Comparison of application rules of Chinese herbal medicines on wasting-thirst disease in ancient and present China*
    ZHAO Lei, MU Yangna, LIANG Maoxin(1 The Second Hospital Affiliated to Liaoning University of Traditional Chinese Medicine, Liaoning 110034; 2 Liaoning University of Traditional Chinese Medicine)   Abstract: Objective To explore Chinese herbal medicines
    2016, 39 (9):  769-773.  doi: 10.3969/j.issn.1006-2157.2016.09.014
    Abstract ( 373 )   PDF (1163KB) ( 394 )   Save
    Objective To explore Chinese herbal medicines (hereinafter: drugs) of first choice and common drugs, drug pairs of first choice and common drug pairs on treating wasting-thirst (diabetes mellitus), so as to provide information for clinical practice and new drug research and development. Methods The ancient and present drugs were obtained after searching the website http://www.99zyzx.com/. Then the data were analyzed via logical and statistical analysis to find out drugs and drug pairs of first choice and common used. Results Drugs of first choice in modern treatment were astragali radix (Huangqi), schisandra chinensis (Wuweizi), root of Chinese trichosanthes (Tianhuafen), rehmannia (Dihuang), radix ophiopogonis (Maidong) and radix puerariae (Gegen); common used drugs were ginseng, Chinese yam (Shanyao), rhizome anemarrhenae (Zhimu), the fruit of Chinese wolfberry (Gouqizi), poria cocos (Fuling), coptis chinensis (Huanglian); drug pairs of first choice were astragali radix+ schisandra chinensis, astragali radix+ rehmannia; first choice drugs of ancient treatment were root of Chinese trichosanthes, radix ophiopogonis; first choice medicine pairs were root of Chinese trichosanthes+radix ophiopogonis, root of Chinese trichosanthes+ coptis chinensis. Conclusion By the way of comparison of drugs and drug pairs in ancient and present treatment on wasting-thirst disease, we can found the optimum drugs and drug pairs, from which the potential effective drugs could be found out in order to provide important reference for clinical practice and new drugs research and development.
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    Qingre Huashi Quyu therapy on chronic renal failure patients with damp-heat pattern: a multicenter randomized-controlled clinical trial*
    WANG Yiping,WANG Dong,LI Chuanping,LIU Shifu,JIN Hua,Lü Yong,HU Shunjin,REN Kejun,WEI Ling,MAO Yanping
    2016, 39 (9):  774-778.  doi: 10.3969/j.issn.1006-2157.2016.09.015
    Abstract ( 314 )   PDF (1241KB) ( 452 )   Save
    Objective This multicenter, randomized-controlled clinical trial was designed to study the clinical efficacy of Qingshen Granule, formulated by TCM therapy principle of clearing heat (qingre), eliminating dampness (huashi) and removing blood stasis (quyu), on chronic renal failure patients with damp-heat pattern. Methods A total of 282 patients eligible were divided into treatment group (n=136) and control group (n=146). All patients were treated with conventional therapy, in addition, patients of treatment group took orally Qingshen Granule at a dose of 10 g, three times daily for consecutive 12 weeks. Results The total clinical curative effective rate of the treatment group (79.41%) was significantly higher than that of the control group(67.12%),and there were significant differences between the two groups(P<0.05). The clinical effect of TCM pattern in the treated group(86.76%) was significantly higher than that in the control group (59.59%),and there were significant differences between the two groups (P<0.01). After treatment, the levels of U-pro/24h and Scr were obviously lower (P<0.01), while eGFR was obviously higher (P<0.01), superior to the control group (P<0.05). Conclusion On the basis of conventional therapy, the satisfactory clinical efficacy of Qingshen Granule on chronic renal failure patients with damp-heat pattern was proved by ameliorating clinical symptoms, decreasing TCM pattern scores, reducing urinary protein and protecting renal function.
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    Clinical efficacy of Yiqi Yangyin xiaozheng Tongluo Fang on patients with stage IV diabetic nephropathy*
    GUO Qian, CHEN Zhiqiang, FANG Jing, BAI Lu,WANG Yuehua, GUO Dengzhou, WANG Yuansong, ZHOU Chao, ZHANG Jianghua
    2016, 39 (9):  779-782.  doi: 10.3969/j.issn.1006-2157.2016.09.016
    Abstract ( 393 )   PDF (1320KB) ( 268 )   Save
    Objective To investigate the clinical efficacy of Yiqi Yangyin xiaozheng Tongluo Fang (YYXTF), a Chinese medicine compounds formulated by the principle of replenishing qi, nourishing yin, eliminating abdominal masses, and freeing the collateral vessels, on patients with stage IV diabetic nephropathy (DN). Methods A total of 160 patients with stage IV diabetic nephropathy according to inclusion criteria were randomly divided into traditional Chinese medicine group (TCM group, n=81) and control group (n=79). In addition to general treatment, patients in TCM group took orally YYHXF and those in control group took irbesartan for consecutive six months. The incidence of end point events, improvement of clinical symptoms and urine micro-albumin excretion rate (mAlb), 24 hours urine total protein (U-pro/24 h), serum creatinine (Scr), blood urea nitrogen (BUN), fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), total cholesterol (TC) and triglycerides (TG) were recorded before and after treatment. Results During the follow-up period, compared with control group whose two patients with Scr >133 μmol/L, TCM group without patients progressing to stage V showed no statistical significance (P>0.05). Efficacy rate of relieving symptoms of hypodynamia, mouth dryness, back pain, edema in TCM group were significantly higher than that of control group (P<0.01). Intragroup comparison showed that mAlb and U-pro/24 h decreased after treatment (P<0.01). After treatment, mAlb and U-pro/24 h of TCM group were significantly lower than that of control group (P<0.05), and the level of TG of TCM group also decreased(P<0.05) . Conclusion Yiqi Yangyin Huayu Tongluo Fang showed definite therapeutic effect on stage IV diabetic nephropathy proteinuria. It could reduce TG levels and protected against dyslipidemia. In addition, it relieved the symptoms and improved the quality of patients’ life.
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    Effect of acupuncture on protein expression of 5-HTT, 5-HT1AR, NEα2R of post-stroke depression rats*
    ZHANG Xianbao,WANG Yan,WANG Zhen,LIANG Fajun, GUO Xiaoli,XIAO Wei
    2016, 39 (9):  783-788.  doi: 10.3969/j.issn.1006-2157.2016.09.017
    Abstract ( 348 )   PDF (1405KB) ( 202 )   Save
    Objective To observe the effect of acupuncture intervention on neurotransmitters and their receptors of post-stroke depression (PSD) rats, so as to explore the mechanism from molecular biological level. Methods Altogether 120 SD male rats randomly divide into blank group (n=10), model group(n=30), acupuncture group (n=40) and medication group (n=40). PSD rat model was induced by middle cerebral artery occlusion(MCAO) and chronic unpredictable mild stress (CUMS). After modeling, rats of medication group were intragastrically administered fluoxetine at the dose of 2 mg /kg once daily, those of acupuncture group were needled at bilateral acupoints of Baihui (GV 20), Fengfu (GV 16), Shenmen (TF 4),Taichong (LR 3) for 20 min once daily with manipulating needles once. The treatment (medication or acupuncture) were underwent three courses for 21 days . Then protein expression of norepinephrine receptor 2R(NEα2R), 5-hydroxytryptamine receptor1A (5-HT1AR) and 5-hydroxytryptamine transporter(5-HTT) in PSD rat hippocampus, raphe nucleus, locus coeruleus were detected by Western blot. Results Compared with blank group, 5-HTT protein expression in hippocampus, raphe nucleus and locus coeruleus in model group decreased significantly(P<0.01);NEα2 R protein expression in hippocampus, raphe nucleus, locus coeruleus of model group increased significantly(P<0.01); 5-HT1A R protein expression in hippocampus, raphe nucleus of model group increased significantly(P<0.01), that in locus coeruleus of model group increased(P<0.05). Compared with model group, 5-HTT protein expression in hippocampus, raphe nucleus, locus coeruleus of acupuncture group and medication group significantly increased(P<0.01);NEα 2R protein expression in hippocampus, raphe nucleus, locus coeruleus of acupuncture group and medication group significantly decreased(P<0.01). 5-HT1A R protein expression in hippocampus of acupuncture group and medication group significantly decreased(P<0.01),in raphe nucleus, locus coeruleus of acupuncture group and medication group decreased(P<0.05). Compared with medication group, there were no differences of 5-HTT protein expression, NEα2 R protein expression, 5-HT1AR protein expression in hippocampus, raphe nucleus, locus coeruleus of acupuncture group(P﹥0.05).Conclusion Acupuncture can reduce the expression of 5-HT1AR and NEα2 R in post-stroke depression model rats, increase the expression of 5-HTT. This suggests that the effect of acupuncture against depression due to stroke via increasing the content or transportation rate of 5-HT and NE.
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    Clinical and basic research on medicinal vesiculation: a study based on evidence-based medicine *
    QING Peng, DING Hongmei, HU Jing
    2016, 39 (9):  789-792.  doi: 10.3969/j.issn.1006-2157.2016.09.018
    Abstract ( 359 )   PDF (1150KB) ( 290 )   Save
    By searching literature related to medicinal vesiculation (MV), we consider that MV therapy dated back to Song Dynasty, with the history of about 1 000 years of clinical practice. Although MV has been widely adopted in China with satisfactory efficacy, its clinical efficacy lacks the Objective support from evidence-based medicine (EBM) due to the less study cases, poor study quality and foundation, leading to serious restriction of development and spread of MV therapy. This paper strives to push MV academic study based on EBM combined with current status. We try to discuss the following problems: syndrome differentiation and treatment of MV, establishment of treatment scheme of MV, comparison of clinical practice of dog-days acupuncture and dog-days MV, comparison of clinical efficacy of MV and acupoint application, disease spectrum of MV, correlation of dog-days MV and Sanjiu MV.
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