Ancient TCM doctors’ views on treatment of vertigo since Han Dynasty:a data mining research
2016, 39 (11):
Objective To study 15 famous ancient TCM docotors’ prescribing herbal medicines for treatment of vertigo from Han Dynasty and the following periods, so as to provide basis for clinical treatment on vertigo as well as for researching and developing new medicines for treating vertigo. Methods A total of 128 traditional Chinese medicine prescriptions were collected and input into TCM Inheritance Auxiliary Platform Version 2.5. Using the method of improved mutual information entropy clustering, association rules, complex systems entropy clustering and unsupervised entropy hierarchical clustering, the pattern types, pairs of drugs ( two Chinese medicines used together), triangle drugs (three Chinese medicines used together) , association rules of drugs, evolution and extraction of combination of the core drugs, and prescriptions newfound were analyzed. Results The leading pattern of vertigo was hyperactivity of liver yang (frequency:30; rate:23.4%. Same below). The most commonly used herbal medicine was Fuling (49, 38.3%), and the most common pair of drugs was Zhigancao-Baizhu (29,22.7%), the most common triangle drugs was Zhigancao-Baizhu-Fuling (17,13.3%). The drugs combination with high correlation was Baizhu-Danggui→Zhigancao, with support of 10% and confidence of 0.937 5. Altogether 22 sets of triangle drugs were extracted, in which the core drugs were Renshen, Baizhu, Zhigancao, Chenpi, Fuling, Danggui. And 11 new prescriptions were available. Conclusion For research and development of new drugs on vertigo, we should focus on the pattern of hyperactivity of liver yang; prior compatibility rules are Baizhu, Danggui with Zhigancao and Chenpi, Baizhu with Renshen and Zhigancao, Renshen with Baizhu; when formulate a new prescrption, Fuling, Fushen, Zhigancao, Chenpi, Sangye, Juhua, Baizhu and Renshen deserve the priority.
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