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主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 April 2017, Volume 40 Issue 4 Previous Issue    Next Issue
    Functional symptoms of the lung system in Traditional Chinese Medicine*
    WANG Yachao, ZHANG Qiming, WANG Yiguo, WANG Feng, WANG Huanli
    2017, 40 (4):  269-271.  doi: 10.3969/j.issn.1006-2157.2017.04.001
    Abstract ( 395 )   PDF (1198KB) ( 411 )   Save
    Objective To explore and identify functional symptoms of the lung system in traditional Chinese Medicine. Methods Based on the Symptom-mechanism Database of Traditional Chinese Medicine, the authors screened all the symptoms that can be explained only by the abnormal functions of the lung system with reference to the specific functions and anatomical location of the lung system. Results Specific symptoms of the lung system include sneezing, more expiration and less inspiration, more inspiration and less expiration, tachypnea, dyspnea, rough breath, weak breath, faint voice, loud voice, muffled voice, cough, faint cough, muffled cough, hoarseness, shortness of breath, hidrosis, hypohidrosis, adiaphoresis, spontaneous perspiration, and night sweating. Conclusion Specific functions of the lung system with mechanism that can be explained only by the abnormal functions of the lung system are the most significant evidence for identifying functional symptoms of the lung system. All symptoms above indicate abnormality of the lung system. Functions of the lung system in Tradinonal Chinese Medicine correspond to the interactive functions of the respiratory system, sweat glands and neuroendocrine system.
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    Selection of core medicinals and formulas for damp-heat constitution based on constitution and pattern differentiation*
    SUN Xueda, NI Cheng
    2017, 40 (4):  272-275.  doi: 10.3969/j.issn.1006-2157.2017.04.002
    Abstract ( 404 )   PDF (1136KB) ( 396 )   Save
    Since the publication of the Standard for Classification and Determination of TCM Constitution by China Association of Chinese Medicine, differentiation between damp-heat constitution and damp-heat pattern has been obscure and thus caused confusion over the medicinal prescriptions selection for some practitioners in clinical practice.This paper, therefore, tries to distinguish damp-heat constitution and damp-heat pattern diagnosis from three aspects:essentials for identification, therapeutic purpose, core medicinal and their combination. Moreover, the differentiation and relationship of those two are further elaborated by describing the case of damp-heat constitution combined with damp-heat pattern in clinical practice. The method of selecting core medicinals and chief formula is then introduced as the major topic of this paper. Characteristics of medicinal combination on damp-heat body constitution are analyzed through analyzing the properties of core medicinals including Radix Scutellariae (Scutellaria Root, Huangqin), Rhizoma Coptidis (Coptis Rhizome, Huanglian), Herba Artemisiae Scopariae (Virgate Wormwood Herb, Yinchen), and Talcum (Talcum,Huashi), and the chief formula Ganlu Xiaodu Dan (Sweet Dew Toxin-Removing Elixir). This paper could be of clinical guidance in the standardizatm and implementation of treatment protocol for damp-heat constitution.
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    Self-isomorphic ideology of human body in Huangdi Neijing*
    LIAN Yi, HE Juan
    2017, 40 (4):  276-280.  doi: 10.3969/j.issn.1006-2157.2017.04.003
    Abstract ( 453 )   PDF (1145KB) ( 464 )   Save
    Isomorphic thinking is widely represented in Traditional Chinese Medical theory, which is primarily exemplified by Huangdi Neijing(Huangdi’s Internal Classic). The abstract theory that supports this type of idea interprets the correlation among categories with similarity instead of certainty, and tends to describe a similar logic of structure. This article selects theories about human body’s similar structure among physiological systems in Huangdi Neijing as examples to introduce the features and applications of this thinking. It shows a self-isomorphic conception in the anatomy of Traditional Chinese Medicine. There exists some logical similarity among categories as Zang and Fu organs, five Zang organs and body, meridians as well as five sensory organs. This association can be sorted by using Five-Element theory. Each element shares typical features of its own classification. Association among the various parts of human body can be identified and used in diagnosis and treatment. It enables the use of multi-modes in isomorphic comparison among categories as multi-dimension reference. Untypical elements also needs to be analyzed and rectified independently, which is the premise of this thinking.
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    Discussion of kidney excess pattern based on kidney-qi pill*
    SUN Jinghui, HU Xiaoying, WANG Chenglong
    2017, 40 (4):  281-283.  doi: 10.3969/j.issn.1006-2157.2017.04.004
    Abstract ( 496 )   PDF (1133KB) ( 566 )   Save
    Since Qian Yi stated that kidney tends to be deficient rather than excessive, a general consensus about absence of kidney excess pattern has been reached among traditional Chinese practitioners in the ancient time. However, Huangdi’s Internal Classic (Huangdi Neijing) has specifically recorded the pulses, symptoms, manifestations, and treatments of kidney excess pattern. Shenqi Wan (Kidney-qi pill) for complex pattern of deficiency and excess, which was created by Zhang Zhongjing, demonstrated morbid dampness was the main cause of kidney excess pattern. Dampness-heat and phlegm-heat is now considered as the dominant cause. In clinical practice, the principle of “treating an excess pattern by purgation” should be followed.
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    Effects of Xingpi Jieyu Fang on behavior and mitochondria ultrastructure of hippocampus and skeletal muscle in depressed rats*
    SHI Huawei, GUO Rongjuan, ZHAO Zhenwu, WANG Hui, DENG Xiaofei, YUAN Qingjie, GUO Xiao, GUO Jianyou, WANG Hui
    2017, 40 (4):  284-289.  doi: 10.3969/j.issn.1006-2157.2017.04.005
    Abstract ( 368 )   PDF (1280KB) ( 295 )   Save
    Objective To explore the effects of Xingpi Jieyu Fang (XPJYF, Spleen-invigorating Depression-relieving Formula) on behaviors and mitochondria ultrastructure of hippocampus neurons and skeletal muscle in depressed rats. Methods Wister rats were randomly divided into five groups: blank control group, model group, sertraline group, XPJYF high-dose and low-dose groups. Chronic unpredictable stress (CUS)was applied to establish depression models in rats for 28 days. Intragastric gavage was used to offer corresponding medication in treatment groups or distilled water in model and blank control groups. Weight change, sugar/water preference test and open-field test were used to evaluate depressive behavior in rats.Changes in ultrastructure of mitochondria in hippocampus neurons and skeletal muscles of depressive rats were measured by using transmission-electron microscope.Results Compared with the blank control group, weight gain in model group rats was significantly slowed while the sugar/water preference rate and total moving distance of open-field test decreased significantly (P<0.01). The number of mitochondria in hippocampal neurons and skeletal muscle in the model group was also reduced with irregular swelling, fractured and fuzzy cristae as well as vacuolar degeneration. under the transmission-electron microscope Compared with the model group, body weight, total sugar/water preference rate, and total moving distance of open-field test in XPJYF high-dose, low-dose group and sertraline group were significantly increased (P<0.01). No swelling or vacuolar degeneration were observed in mitochondria of hippocampal neurons and skeletal muscle in XPJYF high-dose group, which were close to the normal level.Hippocampal neuron and skeletal muscle mitochondria of XPJYF low-dose group and sertraline group were slightly swollen with partly fractured and fuzzy cristae. Conclusion The mitochondria structure of hippocampal neurons and skeletal muscle were damaged in depression induced by chronic stress, which may be a key factor in severe fatigue and symptoms involving multiple systems.Xingpi Jieyu formula could improve depressive behavior and mitochondria structure damage in depressed rats. To some extent, the effects of high-dose Xingpi Jieyu formula were better than sertraline in improving depression of rats.
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    Effects of Liuwei Dihua Tang on the expression of PHD2 and HIF-1α in rats with chronic renal failure*
    TANG Qun, WU Hua, ZHANG Xi, LEI Jiushi, LAN Wenqu, LIU Chunyan
    2017, 40 (4):  290-296.  doi: 10.3969/j.issn.1006-2157.2017.04.006
    Abstract ( 377 )   PDF (1330KB) ( 275 )   Save
    Objective To investigate the effects of Liuwei Dihuang Tang (LWDHT, Six-Ingredient Rehmannia Decoction) on the expression of proline Hydroxylase2 (PHD2) and hypoxia inducible factor alpha-1 (HIF-1α) in renal tissue of rats with chronic renal failure, and to investigate the pathogenesis and molecular mechanism of LWDHT in preventing and treating chronic kidney disease. Methods 60 SD rats were randomly divided into sham-operation group, model group, LWDHT low-dose, medium-dose and high-dose groups, and chronic renal failure model group (5/6 nephrectomy). The LWDHT low-, medium and high-dose groups were treated with 3.38 g/(kg·D), 6.75 g/(kg·D) and 13.5 g/(kg·D) Liuwei Dihua Decoction respectively. Sham-operation group and model group were given 10 mL/(kg·D) saline once per day for 12 weeks. At 12 weeks, 24 h urinary protein, blood urea nitrogen, and serum creatinine were measured and morphological changes of renal tissues in rats of all groups were observed with H&E staining method; protein level and gene expression of PHD2, HIF-1α in rat renal tissue were evaluated by using immunohistochemical method and RT-PCR. Results 24 h urine protein, blood urea nitrogen and serum creatinine of rats in the model group were significantly higher than those in the sham-operation group (P<0.05). These values in LWDHT low-, medium-, and high-dose groups were significantly lower than those of model group (P<0.05). HE staining results showed that renal interstitial fibrosis was not detected in sham-operation group but significant in model group; renal interstitial fibrosis was significantly reduced in the LWDHT low-, medium-, and high-dose groups. Compared with sham-operation group, levels of PHD2 protein and mRNA expression in renal tissue of model group were significantly lower (P<0.05); levels of HIF-1α protein and mRNA expression were markedly increased (P<0.05). Compared with the model group, levels of PHD2 protein and mRNA expression in rats’ kidney tissue in LWDHT low-, medium-, and high-dose groups were significantly increased (P<0.05), and expressions of HIF-1α protein and mRNA were significantly decreased (P<0.05). There was a negative correlation between the expression of PHD2 and HIF-1α mRNA (r=-0.653, P=0.00). Conclusion PHD2/HIF-1α signaling pathway seems to be involved in renal interstitial fibrosis, and Liuwei Dihuang Decoction could effectively prevent and act against chronic kidney disease. Its mechanism may be related to the up-regulation of PHD2, and down-regulation of HIF-1α.
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    In vitro effects of Pixu Sihao Fang dosed serum on colonic smooth muscle cells in rats with spleen-deficiency functional diarrhea*
    CHEN Mindan, HU Jinghong, MA Jie, WU Fengzhi, LIU Yan, TANG Xudong, WANG Fengyun, HAN Chenxia, DAI Ning, LIN Bingqi, CHEN Dou, LI Feng
    2017, 40 (4):  297-301.  doi: 10.3969/j.issn.1006-2157.2017.04.007
    Abstract ( 340 )   PDF (1161KB) ( 269 )   Save
    Objective To study the cellular changes of colonic smooth muscle cells in rats with spleen-deficiency functional diarrhea treated with Pixu Sihao Fang (PXSHF, No.4 Formula for Spleen Deficiency) dosed serum. Methods Colonic smooth muscle cells from functional diarrhea spleen-deficiency rats were extracted for primary culture and then divided into the following six groups: normal control group, model group, PXSHF low-dose, medium-dose, and high-dose groups, and montmorillonite powder (Mnt) group. All the dosed serum groups were treated with 5% drug serum for 48 h. CCK-8 test for detecting the cell proliferation activity and QRT-PCR test for checking the expression of brain-gut petide mRNA were performed. Results OD value of the model group was significantly lower than that of the control group (P<0.01) in CCK-8 test while the OD value of the drug serum groups were significantly higher than that of the model group (P<0.01). QRT-PCR test showed that the CCK/VIP/SS mRNA expression of the model group was significant lower than that of the control group (P<0.05). Compared with the model group, the CCK/VIP/SS mRNA expression in each drug serum group presented with an increase tendency. CCK mRNA expression of the group treated with low-dose PXSHF dosed serum was higher than of the model group (P<0.05). VIP mRNA expression of the groups treated with PXSHF dosed serum were significantly higher than that of the model group (P<0.01). Conclusion PXSHF dosed serum can effectively promote the proliferation activity of the colonic smooth muscle cells. Changes in the expression of CCK, VIP and SS mRNA might be indicative of the role of brain-gut peptide in the development of functional diarrhea with spleen deficiency pattern.
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    Effects of Xiaosheng San on goblet cells of dry eyes in mice: a laboratory study*
    QI Yixin, XIE Like, HAO Xiaofeng, ZHANG Zhifang, HOU Le, XIAO Wenzheng, SUN Huilan, MING Jing
    2017, 40 (4):  302-307.  doi: 10.3969/j.issn.1006-2157.2017.04.008
    Abstract ( 369 )   PDF (1284KB) ( 301 )   Save
    Objective To study the effects of Xiaosheng San(XSS, Xiaosheng Granules) on goblet cells of dry eyes in mice and evaluate its mechanism.Methods 180 male C57BL/6 mice were divided into six groups: normal control (group A), model (group B), saline (group C), XSS low-dose (group D), XSS medium-dose (group E) and high-dose (group F) groups. Dry eye model was established by injecting scopolamine subcutaneously at the base of rear legs in all groups except normal control group. Schirmer I test (SIT), tear break-up time (BUT),corneal fluorescent (FL) staining, and the number of conjunctival goblet cells before and after modeling, and at four weeks after intervention were measured.Results BUT, SIT,and number of goblet cells in group B, C, D, E,and F were significantly decreased after scopolamine treatment(P<0.05), while no significant difference (P>0.05) was found in group A.FL were significantly increased after model establishment (P<0.05).Medium- and high-dose XSS significantly improved SIT, BUT and the number of goblet cells in group E and F (P<0.05). No such changes were observed in group A, B and C (P>0.05). Conclusion Subcutaneous injecfion of scopolamine could effectively establish dry eye model in mice. Xiaosheng Granules could increase tear secretion, prolong tear break-up time, improve stability, inhibit apoptosis of goblet cells and reduce injury to eye surface.
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    Effects of Yupingfeng San containing Radix Hedysari or Radix Astragali on the splenic lymphocyte activation in SAMP8 mice*
    SUN Meihua, LI Wei, ZHANG Wenjun, ZHOU Qianxiang, CHENG Weidong
    2017, 40 (4):  308-313.  doi: 10.3969/j.issn.1006-2157.2017.04.009
    Abstract ( 384 )   PDF (1192KB) ( 257 )   Save
    Objective To compare the effects of Yupingfeng San (YPFS, Jade Wind-Barrier Powder) containing Radix Hedysari (sweetvetch root, hongqi) or Radix Astragali (astragalus root, huangqi) on the splenic lymphocyte activation in SAMP8 mice. Methods In vitro experiment: Yupingfeng San containing Radix Hedysari or Radix Astragali and saline of the same volume were given to young mice respectively via intragastric administration for 14 days to prepare dosed serum for co-culture with SAMP8 mice spleen lymphocytes; In vivo experiment: Yupingfeng San containing Radix Hedysari or Radix Astragali, thymus peptide solution and saline of the same volume were given to SAMP8 mice respectively for 14 days before their blood and spleen samples were taken for preparing dosed serum and splenic lymphocyte suspension. Levels of TNF-α in vitro and in vivo were measured with ELISA; expression of CD28 mRNA and p38MAPK mRNA in vitro and in vivo were measured by using real-time PCR and the expression of CD28 and p38MAPK by using Western blot. Results Compared with blank serum group and normal saline group, in vitro and in vivo levels of TNF-α were increased in dosed serum groups. So were the expression of splenic lymphocyte CD28, p38MAPK mRNA and protein expression. In vitro levels of TNF-α and CD28, p38MAPK mRNA expression in the hedysari group were higher than those in the astragali group (P<0.01); in vivo levels of TNF-α and CD28, p38MAPK mRNA expression in the astragali group were higher than those in the hedysari group (P<0.05). CD28 and p38MAPK mRNA expression in the hedysari group were higher than that in the astragali group (P<0.05). Changes of TCM groups were inferior to that of the thymosin group (P<0.05). Conclusion Yupingfeng San containing Radix Hedysari or Radix Astragali both played a potential role in the splenic lymphocyte activation of SAMP8 mice, which serve as a certain resistance to immunosenescence.
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    Effects of Yifei Huoxue Fang on the inflammatory response in macrophages induced by cigarette smoke extract*
    JIAN Fuping, OU Min
    2017, 40 (4):  314-321.  doi: 10.3969/j.issn.1006-2157.2017.04.010
    Abstract ( 413 )   PDF (1277KB) ( 296 )   Save
    Objective To explore the effects of Yifei Huoxue Fang (YFHXF, lung-invigorating blood-activating formula) on the inflammatory response in macrophages induced by cigarette smoke extract. Methods U937 monocytic cells were differentiated into macrophages using phorbol 12-myristate 13-acetate (PMA). These PMA-induced macrophages were then treated with YFHXF at various concentrations (1.2,2.4,4.8,9.6 g/L) or exposed to cigarette smoke extract (CSE)(5,10,20,50,100 mL/L). At 12, 24, and 48 h, viability of the cells was assessed by using the cell counting kit-8 (CCK-8). Macrophages were divided into 5 groups: normal group, CSE group, CSE+ YFHXF low-dose (1.2 g/L) group, CSE+ YFHXF medium-dose (2.4 g/L) group, and CSE+ YFHXF high-dose (4.8 g/L) group. Levels of IL-8 and TNF-α in cell culture supernatant were detected by using enzyme-linked immunosorbent assay (ELISA), and gene expression of IL-8 and TNF-α were also measured with real-time polymerase chain reaction (RT-PCR). For the study of mechanism, macrophages were divided into 4 groups: normal group, CSE group, CSE+ YFHXF (2.4 g/L) group, and CSE+NF-κB inhibifant(parthenolide) group. The expression of nuclear factor-κB (NF-κB) p50/p65 and p-IκB was examined by using Western blot method. Meanwhile, the expression of nucleus p65 and plasma p-IκB in macrophages was also measured by using the immunofluorescent assay. Results Cytotoxicity was present in macrophages at all timing points induced by CSE (100 ml/L) and at 24, and 48 hours after treated with YFHXF (9.6 g/L). Compared with normal cell group, IL-8 and TNF-α of CSE group, and NF-κB p50/p65 and p-IκB expression were all upregulated (P<0.05). NF-κB nuclear translocation was increased (P<0.05). Yifei Huoxue Fang could inhibit the expression of IL-8 and TNF-α induced by CSE, and viability of NF-κB (P<0.05). Conclusion Yifei Huoxue Fang could inhibit the expression of IL-8 and TNF-α induced by CSE, possibly by inhibiting NF-κB activation.
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    Quality representation characteristics of flavonoids in pharmaceutical preparation of Yinhe Fang under different physiological conditions*
    ZHANG Fang, QUAN Jianye, CHEN Mengjie, LIU Lu, LI Qian, LV Shan, ZHANG Yuanyuan, CHEN Wei, YANG Yuan, SHI Renbing
    2017, 40 (4):  322-327.  doi: 10.3969/j.issn.1006-2157.2017.04.011
    Abstract ( 359 )   PDF (1194KB) ( 245 )   Save
    Objective To investigate the quality representation characteristics of flavonoids in pharmaceutical preparations of Yinhe Fang through developing Yinhe Fang preparation and determining quercetin, kaempferol and isorhamnetin in rat’s blood plasma. Methods Preparation and plasma samples were hydrolyzed with acid, and plasma samples were treated with ether acetone (14:1) extraction. HPLC was used to analyze the concentration of flavonoid aglycones quercetin, kaempferol and isorhamnetin. C18 was used as stationary phase and acetonitrile-0.2% phosphoric acid solution as mobile phase in gradient elution at 270 nm detection wavelength. Results The linear concentration ranges of quercetin, kaempferol and isorhamnetin were 1.49~29.70 mg/L (r=0.999 3), 0.65~12.90 mg/L (r=0.999 5), and 0.47~9.40 mg/L (r=0.999 0) respectively. RSD values were all less than 5.85%. Plasma samples showed good stability after placed at room temperature for 10 h and then frozen at -80℃ for one month, which were consistent with the requirement of biological sample analysis. The serum concentration of quercetin, kaempferol and isorhamnetin were 7.25, 1.71, and 3.73 mg/L respectively in the normal group; 8.53, 2.64, and 5.69 mg/L in the thrombus model group; 8.32, 2.76, and 4.56 mg/L in the anticoagulant model group. Conclusion This method was developed for detecting flavonoids quercetin, kaempferol and isorhamnetin in pharmaceutical preparations of Yinhe Fang in vivo, and can be used to analyze the quality representation characteristics of flavonoids. It provides a scientific evidence for accurate quality control of Yinhe Fang based on flavonoids.
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    Specific analysis of Aconiti Kusnezoffii Radix processed with Fructus Chebulae with HPLC and quantification of its quality control ingredients*
    LIU Shuai, LI Fei, LI Weifei, LI Yan, XU Jinkai, DU Hong
    2017, 40 (4):  328-333.  doi: 10.3969/j.issn.1006-2157.2017.04.012
    Abstract ( 406 )   PDF (1289KB) ( 645 )   Save
    Objective To develop a high-performance liquid chromatography(HPLC), and conduct an qualitative analysis of quality control ingredients of Radix Aconiti Kusnezoffii (Kusnezoff Monkshood Root, Caowu) processed with Fructus Chebulae (Medicine Terminalia Fruit, Hezi), and analyzed the effects of auxiliary materials and processing on the material basis of Aconiti Kusnezoffii Radix (Zhicaowu). Methods HPLC specific chromatogram was performed using Waters SunFire C18 column (250 mm×4.6 mm, 5 μm), gradient elution using formic acid in acetonitrile (A) and 10 mmol/L ammonium acetate solution (B) with flow rate at 1 mL/min, column temperature at 35℃ and injection volume of 10 μL; detection wave length with a UV detector at 254 nm for fingerprint analysis, 271 nm and 235 nm for the determination. Results HPLC specific diagram of caowu processed with hezi was established, and 28 communal peaks were confirmed including 17 from caowu and 11 from hezi. Two new peaks (peak 6 and peak 16) were identified as gallic acid and chebulagic acid based on reference. This HPLC specific analysis method also quantified gallic acid, chebulagic acid, benzoylmesaconine and mesaconitine. Conclusion This specific HPLC method is easy to perform and also reliable. It could quickly identify raw, processed, and hezi-processed caowu, and distinguish different ingredients of caowu and its processed products.
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    Multi-level optimal extraction technique of licorice using R language application*
    YU Li, JIN Weifeng, LI Min, FAN Hongjing, LI Xiaohong, ZHANG Yuyan
    2017, 40 (4):  334-338.  doi: 10.3969/j.issn.1006-2157.2017.04.013
    Abstract ( 413 )   PDF (1151KB) ( 410 )   Save
    Objective To optimize the simultaneous extracting technique of saponins and total flavonoids from licorice (gancao).Methods Ammonia concentration (A), ethanol concentration (B), reflux time(C), and liquid/solid ratio(D) were set as the independent variables in this single factor experiment. Four factors and five levels of central composite design (CCD) in response surface methods were used to determine the content of saponins and total flavonoids in licorice. This study used ultraviolet spectrophotometric method to measure saponins and total flavonoids in licorice at the wave length of 252 nm and 510 nm respectively. The entropy weight method in the R language application was used to assign weight to the above two parameters. The three-layered model of BP neural network was established to test the effect of the number of hidden neurons (size). Finally, genetic algorithm was established to optimize the extraction techniques with real-coded program of R language. Results This method achieved the objective of testing requirements.There was a good linear relationship between saponins at 0.008~0.056 g/L, total flavonoids at 0.024~0.08 g/L, and light absorbance. This method set the neural network model with five hidden layer neurons. After optimizing the parameters of genetic algorithm, the extraction process of saponins and total flavonoids from licorice was optimized. The final optimal parameters were 0.62% ammonia, 64% ethanol, 1.8 h reflux time, and 12:1 of liquid-solid ratio. In this optimal extraction condition, predictive value of this model was 191.65, and experimental average value was 188.90. The relative error was 1.43%, which demonstrated a good predictability of the neural network model and genetic algorithm. Conclusion This mathematical model to optimize the extraction techniques of saponins and total flavonoids from licorice is scientific and feasible. It also provids an innovative reference and approach to the multi-objective extraction techniques for identifying chemical compound and active ingredients of traditional Chinese medicine.
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    Association between pattern changes and cognitive outcome in Alzheimer’s disease*
    SHI Jing, NI Jingnian, WEI Mingqing, ZHANG Xuekai, LI Ting, KANG Shenghua, MA Fuyun, LI Yumeng, LIU Jianping, WANG Yongyan, TIAN Jinzhou
    2017, 40 (4):  339-343.  doi: 10.3969/j.issn.1006-2157.2017.04.014
    Abstract ( 402 )   PDF (1160KB) ( 307 )   Save
    Objective To explore the association between pattern changes and cognitive outcome in patients with Alzheimer’s disease (AD).Methods The study consisted of two parts: a cross-sectional survey and a follow-up. Adults with memory complaints aged 40 to 85 years were recruited. Participants were grouped into normal cognition (NC), mild cognitive impairment(MCI)and dementia. AD Patients were followed up over 24 weeks. The mini-mental state examination (MMSE) and Alzheimer's disease assessment scale-cognitive subscale (ADAS-cog) were used for cognitive tests. Pattern diagnosis was made by using clinical global impression of change in syndrome(CGIC-S). Results 383 participants (100 NC, 120 MCI, 125 AD, and 38 other dementia) were recruited. 73 AD patients were followed up; 46 (63%) were retained at 24 weeks. The new scale had a Cronbach’s alpha of 0.836 and interclass correlation coefficient of 0.652 (P<0.001). 50 cases were selected for a test-retest analyses with 2 weeks’ interval, Pearson r was 0.561 (P=0.004). Kidney deficiency and marrow deficiency were the only two pattern elements changed over time;the pre-post change was related to ADAS-cog change (r=0.401, P=0.003). Conclusion Kidney deficiency subscale should be a fairish test for pattern change in AD clinical trials.
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    Data mining of medicinal combination from Chinese medicine formula for coronary heart disease*
    ZHONG Xiaoxue, HE Qingyong, YIN Xiangjun, ZHAO Guifang
    2017, 40 (4):  344-349.  doi: 10.3969/j.issn.1006-2157.2017.04.015
    Abstract ( 424 )   PDF (1258KB) ( 368 )   Save
    Objective To explore the law of medicinal combinationin traditional Chinese medicine for coronary heart disease using data mining method in order to provide reference for research and development of new drug.Methods This study built a new database based on 263 compound Chinese medicine formulas for coronary heart disease, which were selected from the National Patent Database from September 1985 to July 2015. Association rules, complex network analysis and entropy method were applied to explore the combination law of traditional Chinese compound formula using the traditional Chinese medicine inheritance system software (V2.5). Results Among the selected 263 compound formulas, the most complex one consisted of 30 herbs; the simplest,only one herb; with an average of 6.20±6.10 herbs in one formula.Activating blood and resolving stasis was the most common therapeutic principle(87 cases, 33.08%).Radix et Rhizoma Salviae Miltiorrhizae (Danshen root, Danshen) was the most frequently used herb(143 cases,54.40%); the combination of Danshen and Rhizoma Chuanxiong (Chuanxiong Rhizome, Chuanxiong), and Danshen,Chuanxiong, and Flos Carthami(Safflower, Honghua), were the most frequent couple and triple combination respectively (62, 23.57% and 33, 12.55%); Based on the association rules, frequent medicinal combination were Semen Persicae(Peach Kernel, Taoren)→Honghua(CC=0.844); Lignum Dalbergiae Odoriferae(Rosewood,Jiangxiang)→Danshen(CC=0.84); Honghua, Radix Paeoniae Rubra (red peony root,Chishao) →Chuanxiong(CC=1);Chuanxiong, Taoren→Honghua(CC=0.952). Based on complex network analysis,the core medicinals identified were Radix et Rhizoma Notoginseng(Pseudoginseng Root, Sanqi), Danshen, Honghua, Radix Angelicae Sinensis(Chinese Angelica,Danggui), Chuanxiong, Radix Astragali(Astragalus Root,Huangqi), Radix et Rhizoma Glycyrrhizae(Licorice Root, Gancao), and Radix Ophiopogonis(Dwarf Lilyturf Tube, Maidong). The new compound extracted by entropy method involved Radix Aucklandiae(Common Aucklandia Root,Muxiang), Styrax(Storax, Suhexiang) Benzoinum (Benzoin, Anxixiang), Camphora (Camphor, Zhangnao), Herba Menthae(Field Mint,Bohe), Rhizoma Alpiniae Officinarum (Galangal,Gaoliangjiang), Radix Paeoniae Alba (Galangal White Peony Root,Baishao), Pericarpium Citri Reticulatae (Citrus,Chenpi)Endothelium Corneum Gigeriae Galli (Chicken Gizzard Lining,Jineijin), and Radix Glehniae (Straight Ladybell Root,Beishashen).Conclusion This study sheds light on the combination law of Chinese medicine for coronary heart disease, and provides reference for clinical practice.
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    Understanding of idiopathic pulmonary fibrosis from the perspective of lung toxin*
    LU Xuxiang, JIA Xinhua, ZHU Xue, SHAO Yumeng, ZHANG Yang, ZHANG Wei
    2017, 40 (4):  350-352.  doi: 10.3969/j.issn.1006-2157.2017.04.016
    Abstract ( 381 )   PDF (1130KB) ( 258 )   Save
    Lung toxin refers to the external or internal toxic substances accumulated in the lung, resulting in physiological disorder of Zang-fu organs, and abnormal circulation of qi, blood, and body fluids. Lung toxin mainly includes phlegm and stasis toxin, obstructs lung collaterals and leads to the occult development of idiopathic pulmonary fibrosis, which falls into the category of lung bi-syndrome in Traditional chinese medicine. This disease tends to linger, damage healthy qi, affect physique, and often presents with unfavorable prognosis.
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