Systematic review and network Meta-analysis on effectiveness of acupuncture-moxibustion in treatment of optic atrophy*
2017, 40 (5):
Objective To analyze the curative effect of acupuncture-moxibustion on optic atrophy by applying network Meta-analysis model based on frequency-statistic data filling strategy. Methods The databases of Cochrane Library, PubMed, EMbase, AMED, Nature, Science Online, WorldSciNet, CBM, CNKI and WanFang Database were retrieved with computer for collecting RCT/CCT literature from database establishing time to Jun. 2016. The review on quality and bias risk of every included study were conducted by 2 researchers according to 5.1.0 standard in Cochrane Handbook. Results There were totally 16 studies involving 1 369 samples included. The results of network Meta-analysis showed that the possibility of the best curative effect of each therapy was respectively as follows: Western drug (10.5%), acupuncture (5.9%), acupuncture+moxibustion (4.4%), ear acupoints+ Chinese medications (4.7%), electro-acupuncture (8.0%), acupuncture+Chinese and Western medications (4.9%), moxibustion+Western medications (3.2%), electro-acupuncture+ Chinese and Western medications (4.3%), Chinese and Western medications (10.1%), Chinese medications (6.7%) and acupuncture+Western medications (3.4%). The results indicated that the curative effect of Western medications was the best. Acupuncture+Western medications had advantages compared with only Western medications, and difference in odds ratio had statistical significance. In terms of safety, the safety evaluation could not be confirmed because none of the included literature described the occurrence of adverse events. The modern medical studies on the mechanism of acupuncture in treatment of optic atrophy were relatively less, so it was unable to judge the modern medical mechanism. Conclusion Western medications, Chinese and Western medications and electro-acupuncture may be the best therapies for optic atrophy, but the exact conclusion still needs to be verified further by high-quality clinical researches.
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