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主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 January 2018, Volume 41 Issue 1 Previous Issue    Next Issue
    On ascending counterflow and descending slide of middle energizer cold base on item 32 in Shanghan Lun· Pingmai Fa*
    Fan Dongdong, Zheng Fengjie
    2018, 41 (1):  5-8.  doi: 10.3969/j.issn.1006-2157.2018.01.001
    Abstract ( 405 )   PDF (1217KB) ( 227 )   Save
    Item 32 in Shanghanlun (Treatise on Cold Damage Diseases, Edition of Song Dynasty) discussed the characteristics of middle energizer deficiency cold pattern and cold qi affecting lesser yin lower energizer. Due to spleen-stomach yang deficiency and abnormal ascending and descending, middle energizer cold does not always stagnate in middle energizer, but has tendency of ascending counterflow and descending slide. Therefore, the analysis of middle energizer deficiency cold pattern should comprehensively consider the degree of deficiency and debilitation of yang qi, severity of cold pathogen, amount of water-dampness stagnation, and disease tendency besides standing on disease location of spleen and stomach in middle energizer. Deep understanding of pathogenesis characteristics of middle energizer cold and evolvement rule of middle energizer deficiency cold pattern has positive significance in guiding clinical practice.
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    Application of radar map in field of Chinese medicine*
    Zhou Sheng, Hu Jiahui, Meng Qinggang
    2018, 41 (1):  9-13.  doi: 10.3969/j.issn.1006-2157.2018.01.002
    Abstract ( 378 )   PDF (1652KB) ( 276 )   Save
    Radar map is one of visual processing tools for multi-dimensional data and is currently used in many fields. Based on the analysis of radar maps’ current applications, it is discovered that the applications of radar maps mainly focus on two aspects, the multi-dimensional data visualization and artificial intelligence analysis, which may be used as entry points to introduce radar maps into the research area of Traditional Chinese Medicine (TCM). When using radar maps for TCM data visual expression, the data needs to be processed according to its condition, including the ratio adjustment and weighted conversion processing. According to the modeling method of radar maps, this paper took a group of TCM clinical research data as an example to conduct the data visualization of radar maps and case analysis. In the aspect of artificial intelligence analysis of multi-dimensional data, radar map can be used for conducting qualitative and quantitative charts of data, and combining the image information feature recognition technology radar map can be used for data classification. Based on the characteristics of radar map, the prospect of using radar map for artificial intelligence analysis on TCM multi-dimensional data was discussed and expected.
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    On “jiji (几几)” in Suwen, Shanghanlun and Jingui Yaolue*
    Ning Jing, Wang Yulin
    2018, 41 (1):  14-19.  doi: 10.3969/j.issn.1006-2157.2018.01.003
    Abstract ( 397 )   PDF (1185KB) ( 338 )   Save
    There are examples of “jiji (几几)” used in ancient medical books and other ancient books. The explanations on it are different. On the basis of combing the textual researches in ancient and modern times, the writing, pronunciation, meaning and usage of “jiji (几几)” were given a textual research comprehensively and systematically. The study gets the conclusions as follows: “jiji (几几)” in Suwen (Plain Questions), Shanghanlun (Treatise on Cold Damage Diseases) and Jingui Yaolue (Synopsis of Prescriptions of the Golden Chamber) is different from “shushu (几几)” in Shuowen Jiezi (Analytical Dictionary of Characters). The meaning of “jiji (几几)” in ancient medical books and Shijing (the Book of Songs) is “tight”, and its pronunciation is jǐjǐ. “Jin (巹)” “jin (谨)” “qian (掔)” that contact through “duruo” of Shuowen Jiezi (Analytical Dictionary of Characters), and “jian (坚)” “jin (紧)” “ji (懻)” are the cognate words of “jiji (几几, 肌肌)”. “Jiji (几几)” is a compound word, and its overlapping indicates a succession of “tight” status, and “jiangjiji (强几几)” is a phrase of parataxis. The different texts about “chenchen (沈沈)” in Lingshu (Miraculous Pivot) and Taisu (Grand Simplicity) are substitutive synonyms of “jiji (几几)”.
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    Confused medication files of Empress Dowager Cixi in the 6th year of Guangxu’s reign (1880)*
    Zhuang Wenyuan, Yang Dongfang
    2018, 41 (1):  20-24.  doi: 10.3969/j.issn.1006-2157.2018.01.004
    Abstract ( 338 )   PDF (1134KB) ( 291 )   Save
    Medication files in royal court of Qing Dynasty were the original treatment records for emperors, queens and concubines. The medication files of Empress Dowager Cixi in the 6th year of Guangxu’s reign (1880) are complete, but seemingly reliable royal records had some mistakes. Beside the royal files in royal court of Qing Dynasty, there were also other materials recorded related information about the illness of Empress Dowager Cixi. Through comparing contradictions between medication files in royal court of Qing Dynasty and other materials, the problems were explored in medication files of Empress Dowager Cixi for returning to original and authentic medication records of Empress Dowager Cixi.
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    Mechanism of Yixin Jiedu Fang in inhibiting apoptosis of H9C2 cells*
    Chang Hong, Wang Yong, Li Chun, Huo Kuiyuan, Wang Wei
    2018, 41 (1):  25-30.  doi: 10.3969/j.issn.1006-2157.2018.01.005
    Abstract ( 342 )   PDF (2291KB) ( 195 )   Save
    Objective To study the effect and possible mechanism of Yixin Jiedu Fang Supplementing Heart and kemoving Toticity Decoction in inhibiting apoptosis of H9C2 myocardial cells. Methods H9C2 cells were divided into normal group, model group, Yixin Jiedu Fang group and quercetin group. The apoptosis of H9C2 myocardial cells was induced by using hypoxia-hypoglycemia/reoxygenation-reglycemia method, and protective effect of Yixin Jiedu Fang was studied. The survival rate of H9C2 cells was detected by using CCK-8 assay. The morphological changes of H9C2 cells were observed with microscope. Intracellular calcium overload was detected by using Fluo-3AM method and apoptosis of H9C2 cells was detected by using Hoechst 33342 method. The genetic expressions of Fas and FasL were detected by using real-time fluorescence quantitative polymerase chain reaction (RT-PCR), and expressions of p-Akt protein and caspase-8 protein were detected by using Western blotting method. Results Compared with normal group, the survival rate of H9C2 cells decreased, cell shrinkage and deformation, intracellular calcium overload and more apoptosis cells were observed, expressions of Fas mRNA and FasL mRNA increased, expression of caspase-8 protein increased, and expression of p-Akt protein decreased in model group (all P<0.05). Compared with model group, the survival rate of H9C2 cells increased, cellular morphology were improved, intracellular calcium overload was relieved, expression of p-Akt protein was up-regulated, and expressions of FasL mRNA and caspase-8 protein were down-regulated in Yixin Jiedu Fang group (all P<0.05). Conclusion Yixin Jiedu Fang can inhibit the apoptosis of H9C2 cells, and the mechanism maybe related to the relief of intracellular calcium overload and control of exogenous apoptotic pathway.
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    Influence of total flavonoids in Shayuanzi on blood fat level and synthesis pathway of triglyceride in rats with hyperlipidemia (kidney yang deficiency pattern)*
    Fu Lu, Wang Jingxia, Yao Junkai, Tang Xiaoran, Jia Lan, Zhang Jian Jun, Gao Xuemin
    2018, 41 (1):  31-38.  doi: 10.3969/j.issn.1006-2157.2018.01.006
    Abstract ( 293 )   PDF (2768KB) ( 285 )   Save
    Objective To investigate the therapeutic effect of total flavonoids in Shayuanzi (Semen Astragali Complanati, flatstem milkvetch seed, TFS) on hyperlipidemia (kidney yang deficiency pattern) and their influence on liver synthesis pathway of triglyceride (TG). Methods SD rats (10 weeks old) were divided, according to weight randomized block method, into 6 groups: sham-operation group, model group, estrogen group, high-dose TFS group, mid-dose TFS group) and low-dose TFS group (each n=10). The rat model of hyperlipidemia (kidney yang deficiency pattern) was copied by bilateral ovariectomization and high fat diet for 6 weeks. The sham-operation group and model group were intragastrically given normal saline (10 mL/kg), estrogen group, estradiol (0.2 mg/kg), and TFS groups, total flavonoids in Shayuanzi (28.5 mg/kg, 57 mg/kg and 114 mg/kg respectively) for 8 weeks. The levels of triglyceride (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) were detected. The activities of liver fatty acid synthase (FAS) and acctyl-CoA carboxylase (ACC), and levels of GPAT, CPT-1α and acy-CoA oxidase (ACO) were detected by using enzyme immunoassay (EIA). The protein expressions of sterol regulatory element-binding protein-1c (SREBP-1c) and peroxisome proliferator-activiated receptor-α (PPAR-α) were detected by using immunohistochemistry technique. ResultsCompared with model group, the levels of serum TG, TC and LDL-C decreased significantly (P<0.05, P<0.01), level of serum HDL-C increased significantly (P<0.05), activities of liver ACC and GPAT level decreased significantly (P<0.01, P<0.01), levels of ACO and CPT-1α increased significantly (P<0.01, P<0.05), protein expression of SREBP-1c was significantly down-regulated, and protein expression of PPAR-α was significantly up-regulated in high-dose TFS group. Conclusion TFS has a good effect of regulating blood lipid metabolism, which is its major material base of regulating blood fat. The mechanism may be related to that TFS can inhibit the expression of liver SREBP-1c, reduce the activities and levels of FAS, ACC and GPAT in TG synthesis pathway, and up-regulate protein expression of PPAR-α, ACO and CPT-1α for inhibiting liver TG synthesis and controlling blood fat level.
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    Effect of ethanol extract from Machixian on colon cancer cells and their stem cell proliferation in vitro: a mechanism study*
    Xiong Yihong, Deng Chao, Bai Wen, Liu Yu, Yao Xiaoqin, Jin Heiying
    2018, 41 (1):  39-44.  doi: 10.3969/j.issn.1006-2157.2018.01.007
    Abstract ( 319 )   PDF (1767KB) ( 187 )   Save
    Objective To discuss the influence of ethanol extract from Machixian (Herba Portulacae, Portulaca) on colon cancer cells and their stem cell proliferation in vitro and effective mechanism. Methods The stem cells of colon cancer were cultivated with serum free medium. The inhibitory effects of ethanol extract from Machixian in difference doses on growth of HT-29 cells and HT-29 stem cells were detected by using CCK-8 assay. The influence of ethanol extract from Machixian on apoptosis and cell cycle of HT-29 cells and HT-29 stem cells was detected by using flow cytometer. The influence of ethanol extract from Machixian on genetic and protein expressions of Notch1, Notch2 and β-catenin in Notch signal pathway and Wnt signal pathway of HT-29 cells and HT-29 stem cells was analyzed by using reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting method. Results The ethanol extract from Machixian had inhibitory effect on proliferation of HT-29 cells and HT-29 stem cells, its effective time and dose were positively correlated to cellular proliferation inhibition rate, and its inhibitory effect on proliferation and improve effect on apoptosis rate were more significant on HT-29 cells than those on HT-29 stem cells (P<0.05). The ethanol extract from Machixian could down-regulate genetic expressions of Notch1 and β-catenin and protein expressions of Notch1, Notch2 and β-catenin of HT-29 cells and HT-29 stem cells (P<0.05). Conclusion The ethanol extract from Machixian can inhibit in vitro the proliferation of colon cancer cells and their stem cells through down-regulating protein expressions of Notch1, Notch2 and β-catenin.
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    Mechanism of Jiawei Maxing Shigan Tang in treatment of acute exacerbated chronic obstructive pulmonary disease*
    Meng Yufeng, Du Jianchao, Feng Cuiling, Li Genmao, Ge Dongyu
    2018, 41 (1):  45-52.  doi: 10.3969/j.issn.1006-2157.2018.01.008
    Abstract ( 392 )   PDF (3624KB) ( 176 )   Save
    Objective To investigate the effective mechanism of Jiawei Maxing Shigan Tang (JMST, Modified Decoction of Ephedra, Apricot Kernel, Gypsum and Licorice) in treatment of acute exacerbated chronic obstructive pulmonary disease (AECOPD). Methods Wistar rats (n=40) were randomly divided into blank control group, model group, JMST group and clarithromycin group. The blank control group was given normal feeding, and model group, JMST group and clarithromycin group were given airway instillation of lipopolysaccharide (LPS) and smudging for establishing AECOPD model. The model group was given normal saline, JMST group, JMST (8.7 g/kg) and clarithromycin group, clarithromycin suspension (50 mg/kg) continuously for 30 d. The lung function was measured on the 31st d. The lung tissue was collected to making pathological sections for observing goblet cells after AB-PAS staining. The expressions of mucoprotein 5AC (MUC5AC) and neutrophil elastase (NE) were detected by using immunohistochemistry technique. Results Compared with blank control group, the ratio of 0.3-second forced expiratory volume to forced vital capacity (FEV0.3/FVC) decreased significantly, and number of goblet cells and expressions of MUC5AC and NE increased significantly in model group, JMST group and clarithromycin group. Compared with model group, FEV0.3/FVC increased significantly, and number of goblet cells and expressions of MUC5AC and NE decreased significantly in JMST group. The comparison in FEV0.3/FVC, number of goblet cells and expressions of MUC5AC and NE had no statistical difference between JMST group and clarithromycin group. Conclusion Jiawei Maxing Shigan Tang can significantly promote FEV0.3/FVC, inhibit proliferation of goblet cells, down-regulate expressions of MUC5AC and NE and relieve airway mucus hypersecretion in AECOPD rats, which may be its one of therapeutic mechanisms in treatment of AECOPD.
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    Melanosis of colon induced by different laxatives in guinea pigs: an experimental study*
    Yu Qiang, Liu Wei, Jiang Jing, Liu Renhai
    2018, 41 (1):  53-59.  doi: 10.3969/j.issn.1006-2157.2018.01.009
    Abstract ( 374 )   PDF (3135KB) ( 212 )   Save
    Objective To discuss the pathogenesis of melanosis of colon (MC). Methods SPF guinea pigs were randomly divided into 4 groups: normal group (given water,2 mL n=8), group of Dahuang (Radix et Rhizoma Rhei, Rhubarb; Dahuang group, 1.16 g/kg n=16), group of Fanxieye (Folium Sennae, Senna Leaf, Fanxieye group, 0.46 g/kg n=16) and Phenolphthalein Tablets group (15.43 mg/kg n=16), and all groups were intragastrically given corresponding medicinal. The half numbor of guinea pigs was executed on the 4th week and other half were executed on the 8th week. The status of colonic pigmentation of guinea pigs in each group was observed by direct visual observation and melanin staining. The colonic histopathology of guinea pigs in each group was observed by the method of HE staining. The apoptosis of colon tissue was detected by using terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL), and level of tumor necrosis factor-α (TNF-α) was detected by using enzyme-linked immunosorbent assay (ELISA) in all groups. Results There was MC occurred in varying degrees in Dahuang group, Fanxieye group and Phenolphthalein Tablets group after 4 weeks and 8 weeks (P<0.01). MC aggravated along with time increased, however, there was statistical difference in MC severity only between Fanxieye group and normal group after 4 weeks and 8 weeks (P<0.05). The value of optical density (OD) was significantly higher in Dahuang group, Fanxieye group and Phenolphthalein Tablets group than that in normal group after 4 weeks and 8 weeks (P<0.01), and along with time increased, OD value also increased but had no statistical difference (P>0.05). The level of TNF-α was higher in Dahuang group than that in normal group after 4 weeks and 8 weeks (P<0.05), and increased significantly along with time increased (P<0.01). The level of TNF-α had no statistical difference between Fanxieye group and normal group after 4 weeks (P>0.05), was higher in Fanxieye group than that in normal group after 8 weeks (P<0.05), and increased significantly along with time increased (P<0.01). The level of TNF-α had no statistical difference between Phenolphthalein Tablets group and normal group after 4 weeks and 8 weeks (P>0.05), and along with time increased, level of TNF-α also increased but had no statistical difference (P>0.05). Conclusion Dahuang, Fanxieye and Phenolphthalein Tablets all can induce MC in guinea pigs, and the pathogenesis may be related to apoptosis of colonic epithelial cells. But the relationship between MC and level of TNF-α needs further research.
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    Influence of medicated serum of Liuwei Dihuang Tang on PHD2/HIF-1α signal pathway in HK-2 cells*
    Tang Qun, Wu Hua, Liu Chunyan, Luo Lin, Yi Chun, Xu Wenfeng, Zhuang Gaojian
    2018, 41 (1):  60-64.  doi: 10.3969/j.issn.1006-2157.2018.01.010
    Abstract ( 353 )   PDF (1237KB) ( 211 )   Save
    Objective To investigate the effect of PHD2/HIF-1 signaling pathway on the renal interstitial fibrosis, and the intervention effect of medicated serum of Liuwei Dihuang Tang on HK-2 cells induced by hypoxia. Methods A total of 40 SPF male SD rats were divided into blank group and medicated group (each n=20). The blank group was orally given normal saline 〔10 mL/(kg·d)〕 and medicated group was orally given Liuwei Dihuang Tang for 1 week continuously, and then blood samples were collected from rat abdominal aorta for separating serum after centrifugation. HK-2 cells were cultured in vitro. HK-2 cells were divided into blank control group (10% of fetal bovine serum), normal group (10% of normal serum), CoCl2 group (150 μmol/L of CoCl2+10% of normal serum) and medicated serum group (150 μmol/L of CoCl2+10% of medicated serum of Liuwei Dihuang Tang). HK-2 cells were cultivated in vitro and treated in all groups for 24 h, and then the influence of medicated serum of Liuwei Dihuang Tang on protein levels and mRNA expressions of PHD2, HIF-1α and connective tissue growth factor (CTGF) in HK-2 cells were detected, respectively, by using Western blotting method and reverse transcription polymerase chain reaction (RT-PCR). Results Compared with normal group, the protein level and mRNA expression of PHD2 in HK-2 cells all decreased (P<0.05), while protein levels of HIF-1α and CTGF and mRNA expressions of HIF-1α and CTGF increased (P<0.05) in CoCl2 group. Compared with CoCl2 group, the protein level and mRNA expression of PHD2 increased (P<0.05), and those of HIF-1α and CTGF decreased (P<0.05) in medicated serum group. Conclusion PHD2/HIF-1α signal pathway takes part in RIF, and Liuwei Dihuang Tang can inhibit RIF through up-regulating PHD2 expression, improving HIF-1α degradation and down-regulating CTGF expression.
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    Influence of metformin combined with Gexia Zhuyu Tang on inflammatory factors and sex hormone level in rats with polycystic ovarian syndrome*
    Jiang Xiaolin, Zhang Bing, Hou Haiyan, Teng Fei, Ma Xiande, Lyu Meijun, WangYing, Chu Chunli, Dong Xiaoqian, Zhang Lide
    2018, 41 (1):  65-70.  doi: 10.3969/j.issn.1006-2157.2018.01.011
    Abstract ( 326 )   PDF (1445KB) ( 236 )   Save
    Objective To study the influence of metformin combined with Gexia Zhuyu Tang (Decoction for Dissipating Blood Stasis under Diaphragm) on serum inflammatory factors, sex hormone level and glycolipid metabolism in rat model of polycystic ovarian syndrome (PCOS) induced by dehydroepiandrosterone. Methods PCOS rats (n=69) were randomly divided into control group (n=34) and intervention group (n=35). The control group was intragastrically given metformin (270 mg/kg) and intervention group, metformin (270 mg/kg) and Gexia Zhuyu Tang (34.5 mg/kg) for continuous 28 d. The changes of serum inflammatory factors [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and C-reactive protein (CRP)], blood fat [triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) and total cholesterol (TC)], blood sugar [fasting plasma glucose (FPG) and 2-h postprandial blood glucose (2-hPBG)], and sex hormone level [follicle-stimulating hormone (FSH), luteinizing hormone (LH), estrogen (E2) and testosterone (T) were detected by using enzyme-linked immunosorbent assay (ELISA). The protein expressions of IL-6 and TNF-α were detected by using immunohistochemistry technique. Results After intervention, the levels of IL-6, TNF-α, CRP, LH, LH/FSH, E2, T, TG, LDL-C, TC, FPG and 2 hPG all decreased in 2 groups (P<0.05), and they were all lower in intervention group than those in control group (P<0.05). The levels of HDL-C and FSH increased in 2 groups after intervention (P<0.05), and they were higher in intervention group than those in control group (P<0.05). The protein expressions of IL-6 and TNF-α were lower in intervention group than those in control group (P<0.05). Conclusion Metformin combined with Gexia Zhuyu Tang can reduce the levels of peripheral serum inflammatory factors and meliorate levels of blood fat, blood sugar and hormones in PCOS rats, and the effect of which is better than that ot sinle metformin.
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    Screening of active components from phloroglucinols in Mianma Guanzhong for anti-neuraminidase of H1N1 influenza virus*
    Yan Yantao, Wang Juan, Geng Donghao, Fu Shenzhen, Hu Jinghong, Gao Zengping
    2018, 41 (1):  71-75.  doi: 10.3969/j.issn.1006-2157.2018.01.012
    Abstract ( 329 )   PDF (1097KB) ( 246 )   Save
    Objective To study the inhibitory effect of phloroglucinols in Mianma Guanzhong (Dryopteris crassirhizoma Nakai, Basket Fern Nakai) on neuraminidase ( NA ) of H1N1 influenza virus. Methods
    A library of 34 phloroglucinols ligands was established through retrieving, and X-ray three-dimensional crystal structure file of NA (H1N1) was downloaded from Protein Data Bank. The phloroglucinols possessing lower binding energy and stronger hydrogen bond interaction with NA were screened by using AutoDock Vina software and LigPlot+software, and the inhibitory effect of candidate phloroglucinols on NA was verified by using fluorometric assay. Results There were 4 phloroglucinols (filixic acids ABA, ABB, ABP and ABBA) with better combination with NA screened through molecular docking. The Results of fluorometric assay showed that dryocrassin ABBA had the strongest inhibitory effect on NA [(IC50) =(26.73±0.57) μmol/L]. Conclusion Dryocrassin ABBA in Mianma Guanzhong has higher effect of anti-NA of H1N1 influenza virus, which lays a foundation for further study on new anti-influenza drugs.
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    Expression of miR-122-related factors of liver fibrosis regulated by Fuzheng Huayu Tablet*
    Zhang Wei, Shao Mingliang, Zhang Haicong, Wu Zongyao, Miao Tongguo, Zheng Huanwei,Xie Xingtong, Wang Rui
    2018, 41 (1):  76-82.  doi: 10.3969/j.issn.1006-2157.2018.01.013
    Abstract ( 360 )   PDF (1529KB) ( 242 )   Save
    Objective To investigate softening-hardness dissipating-binds effects of Fuzheng Huayu (reinforcing-healthy qi resolving-stasis) Tablet combined with anti-virus therapy on liver fibrosis, and relationship between these effects and regulation of pathway of miR-122-interleukin-10-reactive oxygen species (miR-122/IL-10/ROS). Methods The patients with chronic hepatitis and liver fibrosis (n=85) were chosen from Aug. 2015 to Aug. 2016, and then divided randomly into test group (n=45) and control group (n=40). The control group was treated with entecavir (0.5 mg/d) and monoammonium glycyrrhizinate (0.1 g/d), and test group, additionally with Fuzheng Huayu Tablet (4.5 g/d) for 48 weeks. After treatment, ISHAK fibrosis score was reviewed through routine pathology, and activities of serum superoxide dismutase (SOD) and ROS were detected by using ELISA. The expressions of miR-122 mRNA and IL-10 mRNA were detected by using RT-PCR, and content of serum inflammatory factors of liver fibrosis, including procollagen III N-terminal peptide (PCIIINP), type IV collagen (IV-C), hyaluronidase (HA) and laminin (LN), were detected by using immunoturbidimetry. Results ISHAK fibrosis score had no significant difference between 2 groups before treatment, and decreased in 2 groups after treatment, which was superior in test group to that in control group (P<0.05). The content of serum inflammatory factors of liver fibrosis all decreased in 2 groups after treatment, and the decreases of PCIIINP and HA were more significant in test group compared with control group (P<0.05). The activities of ROS and SOD had no difference in 2 groups before treatment, and ROS decreased in 2 groups after treatment. The inhibitory effect on ROS was better in test group than that in control group after treatment (P<0.05), and SOD increase was effectively relieved in test group after treatment (P<0.05). The expressions of miR-122 mRNA and IL-10 mRNA all decreased in 2 groups after treatment, which was more significant in test group compared with control group (P<0.05). Conclusion Fuzheng Huayu Tablet reduces directly the levels of collagen and HA, degrades abnormal deposition of extracellular matrix, and regulates dynamic balance of collagen, and it antagonizes effectively the genetic expressions of IL-10 and miR-122, relieves inflammatory disorders and controls progress of histology.
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    Comparative study on clinical characteristics of pattern of phlegm heat and bowel excess in acute stage of stroke involving meridians-collaterals or involving zang-fu organs*
    Chen Tingting, Ren Jinting, Ren Lina, He Zhongyan, Sun Chang, Wang Donghui, Sun Mingguang, Wang Fang, Xie Yingzhen
    2018, 41 (1):  83-88.  doi: 10.3969/j.issn.1006-2157.2018.01.014
    Abstract ( 310 )   PDF (1099KB) ( 338 )   Save
    Objective To explore the clinical characteristics of pattern of phlegm heat and bowel excess in acute stage of stroke involving meridian-collateral or involving zang-fu organs from the aspects of severity of neurological impairment, pattern distribution at different time points and duration of bowel excess. Methods The basic information, scores of National Institute of Health Stroke Scale (NIHSS), whether bowel qi being unobstructed or not, duration of bowel excess, and pattern distribution at different time points (onset for 1 d to 3 d, onset for 4 d to 7 d and onset for 8 d to 14 d) were inputted based on structured data by using retrospective analysis of medical records in 204 cases of pattern of phlegm heat and bowel excess of stroke involving meridian-collateral (meridian-collateral group) and 217 cases of pattern of phlegm heat and bowel excess of stroke involving zang-fu organs (zang-fu organ group). The clinical characteristics from the data were compared, analyzed and studied. Results The severity of neurological impairment except of conscious state was significantly higher in zang-fu organ group than that in meridian-collateral group (P<0.01). The average duration of unobstructed bowel qi was significantly longer in zang-fu organ group than that in meridian-collateral group (P<0.01), and the percentage of patients with throughout obstructed bowel qi was significantly higher in zang-fu organ group than that in meridian-collateral group in acute stage of stroke. The pattern of phlegm heat and bowel excess showed a decline trend after stroke onset for 1 d to 14 d in meridian-collateral group, and showed an ascending trend after stroke onset for 1 d to 7 d and a decling trend after stroke onset for 8 d to 14 d in zang-fu organ group. The cases of pattern of qi deficiency with blood stasis or pattern of collaterals blocked by wind-phlegm and static blood were significantly higher in meridian-collateral group at 4-14 d than those at 1-3 d, and cases of pattern of wind stirring due to yin deficiency, pattern of phlegm heat and blood stasis or pattern of wind phlegm and blood stasis were significantly higher in zang-fu organ group at 8-14 d than those at time point 1. Conclusion The duration of pattern of phlegm heat and bowel excess is positively correlated to the severity of stroke, that is, neurological impairment is more serious and duration is longer in patients with pattern of phlegm heat and bowel excess of stroke involving zang-fu organs.
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