主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 August 2018, Volume 41 Issue 8 Previous Issue    Next Issue
    Impact of Huipai Puxue on Guben Peiyuan school of Xin’an medicine*
    Hong Jing, Tan Hui, Wang Yongpei, Wang Jian
    2018, 41 (8):  621-625.  doi: 10.3969/j.issn.1006-2157.2018.08.001
    Abstract ( 487 )   PDF (1302KB) ( 333 )   Save
    Huipai Puxue (HPPX, Hui School of Ancient Textual Research) was a regional school of sinology developed in ancient Huizhou while Guben Peiyuan (GBPY, consolidating vital base and supplementing primordial qi) was a medical branch of Xin’an branch with distinct feature, long history and powerful academic impact. The two schools orignated from the same geographic location. The development of HPPX coincided with the emergence of “five basic theories” in GBPY. The two schools also shared the same vision of transforming academic theories into clinical practices. This paper proposed it was HPPX that influenced the development of GBPY School. TCM practitioners of GBPY school were inspired by HPPX to persist in pursuing truth, and developing theories to enrich TCM theories and enlighten TCM practitioners in the later generations.
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    Jingyue Quanshu’s contribution to critical disease management in TCM emergency discipline*
    Wang Xiaopeng, Chen Tengfei, Zhang Naifang, Ha Yanxiang, Zhang Rui, Liu Qingquan
    2018, 41 (8):  626-629.  doi: 10.3969/j.issn.1006-2157.2018.08.002
    Abstract ( 452 )   PDF (1217KB) ( 362 )   Save
    Jingyue Quanshu(Jingyue's Complete Works) presented a comprehensive understanding of emergencies and other life-threatening conditions. Most of all, Zhang categorized the causes and mechanisms of these disorders according to his own understanding with reference to opinions of former experts. He also offered detailed and Objective descriptions of their clinical manifestations. All of these have been valued references for later generations. In addition, Zhang emphasized the importance of prognostic care in the treatment of critically ill patients.This paper attempts to summarize the contribution of Jingyue Quanshu to the critically ill subjects of TCM emergency treatment, and provide ideas and methods for clinical diagnosis and treatment of acute and severe diseases
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    Effects of Danggui Buxue Tang on endothelial cells exposed to flow shear stress*
    Qin Zhen, Zhang Yanyan, Wei Zhengxin, Huang Shuiqing
    2018, 41 (8):  630-635.  doi: 10.3969/j.issn.1006-2157.2018.08.003
    Abstract ( 428 )   PDF (1395KB) ( 161 )   Save
    Objective To investigate the effects of Danggui Buxue Tang (DGBX, angelica sinensis blood-tonifying decoction) on human endothelial cells in a steady flow shear stress (FSS). Methods Cells were incubated on a parallel plate flow chamber at a steady FSS of 0, 0.12, 1.2, and 2.4 Pa for 6 hours. Cells exposed to different FSS were randomly divided into 5 groups: control group perfused with M199 culture medium, simvastatin group (0.1 μmol/L simvastatin), and DGBX groups {3 g/L DGBX decoction: Chinese angelica (Danggui, Radix Angelica Sinensis,AS) and astragalus root (Huangqi, Radix Astragali,RA) at the dose ratios of 1∶1, 1∶3, and 1∶5}. After 12 hours, the cellular proliferation, levels of nitric oxide (NO), expressions of endothelial nitric oxide synthase (eNOS), vascular endothelial growth factor receptor 2 (VEGFR2) mRNAs and proteins were measured. Results In control group, eNOS and VEGFR2 levels in the endothelial cells exposed to FSS at 1.2 and 2.4 Pa were significantly higher than those of cells exposed to FSS at 0 and 0.12 Pa(P<0.05). Compared with the control group, DGBX decoction up-regulated the cellular proliferation and expression of eNOS and VEGFR2, and NO levels at FSS of 0 and 0.12 Pa (P<0.05). And DGBX decoction (AS∶RA at 1∶3, 1∶5) up-regulated the expressions of eNOS and VEGFR2, cellular proliferation and NO level at FSS of 1.2, 2.4 Pa (P<0.05). Conclusion FSS seems to play an important role in the effects of DGBX decoction on endothelial cells.
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    Protective effects of hydroxysafflor yellow A on oxidative damage in H9c2 cells through inhibiting microRNA-1*
    Wu Hong, Lei Zhen, Gao Shuibo, Zhang Lingxia, Dai Liping
    2018, 41 (8):  636-641.  doi: 10.3969/j.issn.1006-2157.2018.08.004
    Abstract ( 423 )   PDF (1693KB) ( 210 )   Save
    Objective To investigate the protective effect of hydroxysafflor yellow A (HSYA) on oxidative damage in cardiomyocytes, and to further observe the relationship between this effect and microRNA-1 (miR-1). Methods The optimal concentration of HSYA was firstly screened by cell viability. The cells were divided into blank group, model group and HSYA group. The level of reactive oxygen species (ROS) was detected by using fluorescence microscope; the rate of apoptosis was measured with flow cytometry and the expression of miR-1 was determined by real-time q-PCR, on which the protective effect of HSYA on myocardial cells injured by H2O2 was clarified. Furthermore, the level of miR-1 and ROS in miR-1 mimic-transfecting myocardial cells injured by H2O2 was explored, as well as the effect of HSYA on the injuries. Results Compared with the blank group, the level of ROS, apoptosis rate, and miR-1 expression all increased in model group, and the differences were statistically significant. Compared with model group, the level of ROS, apoptosis rate and miR-1 expression all decreased in HSYA group, and the differences were also statistically significant. After the transfection of H9c2 cells with miR-1 mimics, the level of miR-1 and ROS increased, which was superimposed on the level of miR-1 and ROS induced by H2O2, while HSYA downregulated the level of miR-1 and ROS. Conclusion HSYA can reduce the level of ROS generation and apoptosis induced by H2O2 in H9c2 cells and defend against oxidative damage in cardiomyocytes. The mechanism may be related to down-regulation of miR-1.
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    Mechanisms of Baoyuan Jiedu decoction in the intervention of carcinogenic muscular atrophy through inhibiting cytokins-ubiquitin-proteasome pathway*
    Zhang Honghua, Zong Xin, Deng Tiantian, Zhao Ruohan, Ji Xuming
    2018, 41 (8):  642-647.  doi: 10.3969/j.issn.1006-2157.2018.08.005
    Abstract ( 394 )   PDF (1853KB) ( 201 )   Save
    Objective To investigate the effect of Baoyuan Jiedu (BYJD) decoction on C2C12 cells differentiation in cancer-induced myotube atrophia model and explore its mechanism. Methods Lewis lung carcinoma cell supernatant at different concentrations (1∶2,1∶4, and 1∶8) were injected into C2C12 cells to induce cancer-induced myotube atrophy and identify the optimal concentration and culture duration. Four groups was divided after the model was built: normal group, high-dose BYJD group (125 g/L), mid-dose BYJD group (62.5 g/L), and low-dose BYJD group (31.25 g/L). The condition of myotube was observed under electro-microscope; levels of TNF-α and IL-6 were measured with ELISA; muscle fiber transverse diameter of C2C12 cells were observed by using inverted microscopy at every 24 h; the expressions of Atrogin-1 and MuRF-1 were detected by using Real-time PCR and Western blot assay. Results TNF-α and IL-6 in C2C12 indicated that the optimal condition to induce cancer-induced myotube atrophy was Lewis lung carcinoma cell supernatant at concentration of 1∶2 for 96 hours. TNF-α and IL-6 in BYJD groups decreased significantly (P<0.05); transverse diameter of myotubes in BYJD groups were prolonged after intervention of BYJD decoction at high-dose, mid-dose and low-dose (P<0.05); the expression of Atrogin-1, MuRF-1 protein and mRNA was down-regulated (P<0.05). Conclusion BYJD decoction could effectively reduce cancer-induced myotube atrophy by inhibiting UPP through lowering cytokine levels.
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    Effects and mechanisms of Bushen Tiaojing Fang on the embryo implantation via STAT3 signaling pathway during implantation window in superovulated mouse*
    Duan Yancang, Li Zhili, Liu Wei, Fu Tian, Yang Jiangxia, Wang Yahui, Zhang Yayao, Hao Renjuan, Yu Huiwen, Du Huilan, Xu Huazhou, Ma Huirong, Song Cuimiao
    2018, 41 (8):  648-654.  doi: 10.3969/j.issn.1006-2157.2018.08.006
    Abstract ( 404 )   PDF (1903KB) ( 252 )   Save
    Objective To observe the effects of Bushen Tiaojing Fang (BSTJF, kidney-tonifying menstruation-regulating formula) on endometrium of controlled ovarian hyperstimulated (COH) mice through signal transducer and activator of transcription 3(STAT3), and to explore mechanisms of BSTJF for improving embryo implantation. Methods Sixty Kunming mice were randomly divided into the model group, BSTJF group and normal group (n=20 in each group). On the fourth day of pregnancy, 10 mice from each group were sacrificed. The levels of serum estradiol (E2) and progesterone (P) were measured by using radioimmunoassay. The expressions of endometrial leukemia inhibitory factor (LIF), phosphorylated STAT3(P-STAT3) protein were evaluated with Western blot assay; Leptin and leptin receptor (OB-R) were detected with immunohistochemistry. At eighth day when all mice were then sacrificed, the average number of blastocysts was counted. Results Compared with the normal group, serum E2 level in the model group was decreased (P<0.05), and P was increased (P<0.01); the contents of LIF and P-STAT3 protein in the endometrium decreased (P<0.01); the expressions of Leptin and OB-R in epithelial cells decreased (P<0.01); the average number of implanted embryos was also decreased (P<0.01). Compared with the model group, serum P decreased in the BSTJF group(P<0.05); the contents of LIF and P-STAT3 protein in endometrium increased (P<0.01), the expression of Leptin protein in endometrial epithelial cells increased (P<0.05). The average number of blastocysts was increased (P<0.01). Conclusion BSTJF can improve the embryo implantation of COH mice. Its mechanism might be related to regulation of relative proteins in STAT3 signal pathway in the endometrium during implantation window.
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    Metabonomic study of compound gouteng antihypertensive tablet's effects on left ventricular hypertrophy in hypertensive rats*
    Jian Weixiong, Xiao Suixi, Liu Pei, Luo Ying, Chen Ouying, Tan Yuansheng
    2018, 41 (8):  655-662.  doi: 10.3969/j.issn.1006-2157.2018.08.007
    Abstract ( 366 )   PDF (3600KB) ( 284 )   Save
    Objective To study the metabolite changes and mechanism of compound gouteng (uncaria) anti-hypertensive tablet in the treatment of left ventricular hypertrophy. Methods 24 rats with spontaneously hypertension were randomly divided into the model group, compound gouteng antihypertensive tablet(CGTA) group and telmisartan(TMST) group. WKY (Wistar-Kyoto) rats were chosen as the control group. Metabolites were detected and analyzed by using gas chromatography-mass spectrometry (GC-MS), and the differential metabolite profiles of left ventricular myocardium were analyzed with partial least squares (PLS). Based on the importance of independent variables (VIP) and the coefficient of independent variable, the left ventricular metabolites of the four groups were investigated. Results The variable mapping of SHR group and CGTA group showed positive correlations with CGTA group were shown in cytosine nucleotide, putrescine, succinic acid, D-acid, glycerol fructose, inosine, dihydrolanosterol, ascorbic acid, glutamic acid, and 1,5-ag; and that negative correlations were found in lactic acid, 3-phosphoglycerate, ribose, xylitol, and proline. The variable maps of CGTA group and TMST group showed positive correlation with CGTA group were identified in putrescine, cytosine nucleotide acid, glycerol, lyxonic acid, twenty-four acid, inositol, and inosine; negative correlation were present in xylitol, sorbitol, ribose, and lactic acid. Conclusion The compound gouteng antihypertensive tablet may have specific effects on cell structure, energy optimization and oxidative stress reaction.
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    Effects of Cyclocarya Paliurus leaves aqueous extract on pancreatic β cell’s apoptosis in type 2 diabetic rats*
    Yao Junkai, Wang Jingxia, Gao Xuemin, Fu Lu, Gao Fei, Wang Yujie, Jia Lan, Wang Leilei
    2018, 41 (8):  663-669.  doi: 10.3969/j.issn.1006-2157.2018.08.008
    Abstract ( 363 )   PDF (1773KB) ( 207 )   Save
    Objective To investigate the effects of Cyclocarya Paliurus aqueous extract (CPAE) on pancreatic β cell apoptosis in type 2 diabetic (T2D) rats. Methods T2D ract model was established by high-fat diet feeding for 8 weeks and single intraperitoneal injection of streptozotocin. From the ninth week, the rats in the model group (sodium chloride solution), metformin group (0.3 g/kg), low, medium and high dose CPAE groups (0.18, 0.36, 1.08 g/kg) were treated for 4 consecutive weeks. Glucose tolerance was measured at the last administration. After sacrifing the rats and removing the pancreas, the contents of superoxide dismutase (SOD), peroxidase (CAT), glutathione peroxidase (GSH-PX), malondialdehyde (MDA) and free fatty acid (FFA) were detected with colorimetric method. Tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) were measured with radioimmunoassay. The levels of apoptosis factor (Fas) and its ligand (Fasl), activated cysteine protease (Caspase8) were detected by using ELISA. Western blot assay was used to detect total c-Jun N-terminal kinase 1 (T-JNK1), phosphorylated c-Jun N-terminal kinase 1 (P-JNK1), pancreatic duodenal homeobox 1 (PDX-1) protein expression; TUNEL staining was used to observe pancreatic cell’s apoptosis. Results CPAE treated groups presented with increased contents of SOD, CAT, GSH-PX and increased expression of PDX-1 in the pancreas of the CPE groups; fasting blood glucose, area under the curve, MDA, FFA, TNFα, IL6, Fas, Fasl, Caspase8 content, T-JNK1, p-JNK1 expression, and pancreatic cell apoptosis rate were all reduced in the model group. Conclusion CPAE can improve the pancreas antioxidant, alleviate oxidative stress, and inhibit pancreatic β cell’s apoptosis. The mechanism may be related to inhibiting the expression of T-JNK1 and P-JNK1 protein, increasing the expression of PDX-1 protein and decreasing the content of Fas, Fasl and Caspase8.
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    Detection of the content of heavy metal elements in tortoise shells and tortoise shell glue by using inductively coupled plasma mass spectrometry*
    Xu Qing, Li Meng, Zhang Fan, Meng Jieqin, Luo Xuemei, Liu Chunsheng, Yang Yaojun
    2018, 41 (8):  670-674.  doi: 10.3969/j.issn.1006-2157.2018.08.009
    Abstract ( 368 )   PDF (1231KB) ( 272 )   Save
    Objective To detect the content of heavy metals in medical materials of Guijia (Tortoise Carapace and Plastron, Testudinis Carapax et Plastrum) and Guijiajiao (Tortoise Shell Glue, Testudinis Carapacis et Plastri Colla), and investigate and study the heavy metal pollution of medical materials of Guijia and Guijiajiao. Methods In this study, inductively coupled plasma-mass spectrometry (ICP-MS) was applied to detect the content of 6 heavy metals [chromium (Cr), arsenic (As), cadmiu (Cd), mercury (Hg), lead (Pb) and copper (Cu)] in multiple batches of Guijia and Guijiajiao on sale in the market and their adulterants. Results The results showed that heavy metals in Guijia and Guijiajiao were identified in the following descending order: Cu (21.96 μg/g), Cr (1.70 μg/g), Pb (1.28 μg/g), As (0.29 μg/g), Hg (0.15 μg/g), Cd (0.09 μg/g). Among them, the content of Cr and Pb exceeded national limit standard significantly. Conclusion There are certain patterns in the distribution of heavy metals in medical materials of Guijia and Guijiajiao. Heavy metals were significantly less in Guijiajiao than that in Guijia. This study can be a reference for controlling and reviewing the quality of Guijia and Guijiajiao.
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    Effects of acupotomy on surface electromyogram of tibialis anterior and biomechanical parameters of tendons in rabbits with knee osteoarthritis*
    Zhou Shuai, Zhang Wei, Wang Tong, Wang Lijuan, Guo Changqing
    2018, 41 (8):  675-680.  doi: 10.3969/j.issn.1006-2157.2018.08.010
    Abstract ( 381 )   PDF (2028KB) ( 206 )   Save
    Objective To observe the effects of acupotomy on surface electromyogram (EMG) of tibialis anterior and biomechanical parameters (tendon stretching, creep and stress relaxation) of tendons in rabbits with knee osteoarthritis (KOA). Methods 48 New Zealand rabbits were randomly divided into normal group, model group, acupotomy group and electroacupuncture (EA) group. The inserts points of the vastus medialis and vastus lateralis muscles, EX-LE4 and EX-LE5, were treated with needling and acupotomy manipulation in the acupotomy group. Rabbits in the EA group received acupuncture on SP10, ST34, EX-LE4 and EX-LE5. Treatment offered in the two groups were three sessions per week for three consecutive weeks. Surface EMG was performed in viable rabbits to collect data when load weight was set at 0, 500, and 1 000 g; Biomechanical tests were performed on the tendons of the tibialis anterior in each group by using fatigue testing machine after the rabbits were sacrificed by using fatigue testing machine. Results In the model group, the EMG value was significantly decreased compared with that in the normal group (P<0.05) when the load weight was zero. Compared with the model group, surface EMG was significantly increased (P<0.01) in the acupotomy group at the load weight of 500 g; this difference, however, was not significant when the load weight reached 1000 g. The creep rate of the model group was significantly higher than that of the normal group (P<0.01). Compared with the model group, the creep rate of acupotomy group was significantly lower (P<0.05) but not different from the normal group (P>0.05). The stress relaxation rate and maximum strain index of tensile mechanics in the model group were significantly different from those in the normal group (P<0.05). Both the acupotomy and EA treatment could reduce the maximum strain index(P<0.05). Conclusion Acupotomy could relieve the fatigue of tibialis anterior in rabbits with osteoarthritis adjust creep stress relaxation, and restore knee mechanical balance of the knee joint.
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    Senior prestigious TCM practitioners’ experience in the treatment of chronic bronchitis: analysis of medicinals based on latent structure*
    Chen Liping, Li Jiansheng,Cai Yongmin, Bian Hua
    2018, 41 (8):  681-688.  doi: 10.3969/j.issn.1006-2157.2018.08.011
    Abstract ( 410 )   PDF (2134KB) ( 225 )   Save
    Objective To explore causes, mechanisms, symptoms, and commonly-used medicinals for chronic bronchitis from the viewpoint of senior prestigious traditional Chinese medicine practitioner in Beijing-Tianjin-Hebei Region. Methods 346 chronic bronchitis cases in Beijing-Tianjin-Hebei region were obtained from the database of lung disease cases treated by modern senior TCM practitioners. The Lantern software 3.1.2 was used to construct the latent model of chronic bronchitis symptoms and commonly-used medicinals. The association of medicinal-symptom, and medicinal combination was explored by using SAS software 9.1. Results 110 observable variables (pattern, tongue and pulse) in first contact of the 346 cases were collected and constructed as a latent model, and 17 latent variables, 35 hidden classes and 6 comprehensive clustering models were obtained. 27 latent variables, 55 hidden classes and 7 comprehensive cluster models were obtained from 137 medicinal models. Associations between medication and disease were identified at 5% minimum support degree and 60% confidence level, and 74 groups of 2 medicinals, 273 groups of 3 medicinals, and 411 groups of 4 medicinals were obtained. Constitutions of chronic bronchitis patients from the Beijing-Tianjin-Hebei region were featured by“upper dryness, middle dampness and lower deficiency”. Common patterns of chronic bronchitis include phlegm-heat pattern, lung yin deficiency pattern, and wind-heat invading the lung pattern; Core symptoms of chronic bronchitis involved cough, panting, phlegm, and white sputum; Core medicinals includes pinellis rhizome, bitter apricot kernel (Kuzingren, Semen Armeniacae Amarum) and ephedra (Mahuang, Herba Ephedrae); Core formula includes Sanzi Yangqi Tang (Three-Seed Filial Devotion Decoction), Er Chen Tang (Two Matured Substancess Decoction), and Xiao Qing Long Tang (Minor Green Dragon Decoction). Conclusion Implicit structure model integrated application of multidimensional clustering and Bayesi network It can solve the lack of Objective and quantitative preblems in TCM syndrome differentiation, and it conforms to the nonlinear thinking of TCM. therefore, it can be used to explore the academic experience of famous old Chinese medicine.
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    The inflammatory microenvironment of patients with polycystic ovary syndrome and pattern of “dampness heat in the liver meridian” and effects of kidney-tonifying liver-clearing method*
    Yu Jin, Liu Luxi, Zhai Dongxia, Zhang Danying, Cheng Wen, Bai Lingling, Yao Ruipin, Sun Shuai, Yu Chaoqin
    2018, 41 (8):  689-695.  doi: 10.3969/j.issn.1006-2157.2018.08.012
    Abstract ( 387 )   PDF (1531KB) ( 274 )   Save
    Objective To study the inflammatory microenvironment of polycystic ovary syndrome (PCOS) with dampness heat in the liver meridian and effects of Bushen Qinggan (BQ, kidney-tonifying liver-clearing)method. Methods PCOS patients with the pattern of dampness heat in the liver meridian were recruited as the subjects while healthy women of reproductive at childbearing age as controls. PCOS patients were treated with BQ medication for three consecutive months and followed for another three months Serum characteristic inflammatory cytokines were measured with protein microarray technology and ELISA. Pregnancy and ovulation in patients were evaluated. Clinical symptoms, hormones and inflammatory cytokines of PCOS patients were compared before and after the treatment. Besides, the correlation between parameters was also explored. Results Compared with healthy reproductive women, the serum levels of inflammatory factor CXCL1/GROα, IL-1ra/IL-1F3, IL-16, IL-8, IL-18/IL-1F4 in PCOS patients with dampness heat in the liver meridian were significantly increased (P<0.05). BQF could promote ovulation and pregnancy of the patients. Besides, BQF could significantly relieve symptoms of menstrual irregularities, acne, premenstrual breast tenderness, mood swings, dry mouth or bitter sensation in the mouth(P<0.05); In addition, BQF reduce the serum level of luteinizing hormone (LH), testosterone (T), free testosterone (FT), insulin (INS) at 60min and 120min, Homeostasis model assessment of insulin resistance (HOMA-IR) and IL-1ra/IL-1F3, IL-18/IL-1F4 (P<0.05). IL-1ra/IL-1F3 and IL-18/IL-1F4 had positive correlations with FT (P<0.01, P<0.05). Conclusion An inflammatory microenvironment was present in PCOS patients with dampness heat in liver meridian; the therapeutic effects of BQF might be related to downregulating of androgen and inflammatory cytokines.
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    Effects of qi-boosting lung-dredging water-draining formula on chronic heart failure combined with premature ventricular contraction: clinical observation*
    Zhang Wei, Xiao Min, Zhang Lijing, Zhao Yong, Li Yufeng, Guo Shi, Chang Peifen, Huang Hong
    2018, 41 (8):  696-701.  doi: 10.3969/j.issn.1006-2157.2018.08.013
    Abstract ( 389 )   PDF (1243KB) ( 304 )   Save
    Objective To evaluate the efficacy and safety of qi-boosting lung-dredging water-draining formula (Yiqi Xiefei Lishui Fang, YXLF) in the treatment of chronic heart failure with premature ventricular contraction (PVC). Methods Randomized doubled blinded placbo-controlled design was used. 60 patients with chronic heart failure combined with PVC, whose TCM diagnosesn were water diffusion due to deficiency of yang, were randomly divided into experimental group and control group(n=30 in each group). The experimental group received YXLF on the basis of standard treatment for chronic heart failure. Patients in the control group were given standard treatment of chronic heart failure and placebo. The course of treatment was 8 weeks. Outcome measures included the prematurity index, PVC frequency, the Tp-e interval, the Tp-e/QT Electrocardiogram and LVEF, NT-pro BNP, 6-minute walking test, Minnesota Heart Failure Quality of Life Scale (MLHF-Q), TCM Syndrome score and others were compared between the two groups. Results Tp-e / QT value, PVC frequency, and prematurity index were improved compared with those before treatment (P<0.05). But there was no significant difference between the two groups (P>0.05). The Tp-e / QT value of the test group was significantly better than that of the control group (P<0.05). Compared with the control group, the NT-pro BNP, 6MWT, MLHF-Q and TCM Syndrome score of experimental group were all improved (P <0.05), but there was no significant difference in LVEF between the two groups (P> 0.05). In terms of efficacy evaluation with cardiac function classification and PVC frequency, there was no difference of statistical significance between the two groups. But TCM treatment effectiveness of experimental group was superior to that of the control group (P<0.05). Conclusion Qi-boosting lung-dredging water-draining formula can improve the heart function and quality of life in patients with chronic heart failure and ventricular premature beats on the basis of conventional treatment. And it can improve the prematurity index, Tp-e interval, and reduce the risk of malignant arrhythmia.
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