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主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 December 2018, Volume 41 Issue 12 Previous Issue    Next Issue
    The original thinking in disease diagnosis and syndrome differentiation in Shanghan Lun*
    Liu Min, Wang Xueqian, Wang Qingguo
    2018, 41 (12):  973-977.  doi: 10.3969/j.issn.1006-2157.2018.12.001
    Abstract ( 519 )   PDF (1281KB) ( 247 )   Save
    Original thinking is what makes the book Treatise on Cold Damage (Shang Han Lun) become a TCM classic. There are eight aspects of original thinking about disease diagnosis and syndrome differentiation in the book. The first one is searching for the primary cause of disease in treatment, which is yin and yang. The second one is combining the differentiation of disease and syndrome, differentiating the syndrome and analyzing the pathogenesis, and Treatise on Febrile Disease is the first precedent in this regard. The third one is the combined use of the four diagnostic methods, the dynamic analysis of analyzing the pathogenesis and the choice between the pulse and the symptom, so the clause “observe the pulse and signs, know what mistakes have been made, and treat according to the presenting pattern” is of profound significance. The fourth one is selecting the essential by discarding the dross and retaining the true by eliminating the false, excavating and extracting the pulse and the symptoms which could represent the essence of the pathogenesis. The fifth one is seeking differences within the similarity and seeking difference from commonness. If the pathogenesis is the same in different diseases, we can choose the same treatment, and vice versa. The sixth one is knowing commonness of the diseases for the change, whid is the basic feature of TCM thinking when identifying syndromes. The seventh one is attaching great importance to the primary symptom. Sometimes one symptom is sufficient for diagnosis and not all signs and symptoms need to be present. If the primary symptom seems to contradict the pathogenesis, we should follow the pathogenesis. The eighth one is grasping the rules in the development of the disease from the first small beginnings, and predicting the tendency of disease. Thus, Treatise on Febrile Disease is of precious value with enormous evidence for presenting original thinking of TCM.
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    On the compiling date of Ge Shi Fang in Ishinpo*
    Tian Ruifan,Liang Yongxuan
    2018, 41 (12):  978-982.  doi: 10.3969/j.issn.1006-2157.2018.12.002
    Abstract ( 435 )   PDF (1207KB) ( 208 )   Save
    As the oldest known Japanese medical classic, Geshi Fang (Ge’s Fromulas) in Ishinpo, is an important circulating version of Ge Hong’s medical prescriptions. At present, the research of this book mainly focuses on literature collection, and there was no in-depth discussion on the compiling date. This paper comprehensively analyzed the book from three aspects of content, taboo words, and terms, and compared it with the handed down medical literature. It was noted that the text of Geshi Fang contains supplementary content of Tao Hongjing. The full text did not avoid the taboo words of Sui and Tang dynasties. The qnantifiers“Guo”, ”Mei” and “Wu” were popular in the Northern and Southern Dynasties, and in the handed down version, these qnantifiers were changed into commonly used units in the Sui and Tang Dynasties. According to the above research, the preliminary conclusion was reached. Geshi Fang in Ishinpo is consistent with Buque Zhouhou Baiyi Fang (One Hundred Supplementary Formulas for Emergencies) written by Tao Hongjing. Thus, the book was probably completed between South Liang Dynasty and Sui Dynasties.
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    Effects of Chaihu Dayuan decoction on the TNF-α, IL-10 and PGE2 levels in the serum and peritoneal lavage fluid of rats with Escherichia coli peritonitis*
    Jiang Xin, Xu Jingnan, Gao Fei, Bai Chen, Huang Ling, Mei Chencheng, Li Yini, Liu Tiegang, Gu Xiaohong
    2018, 41 (12):  983-987.  doi: 10.3969/j.issn.1006-2157.2018.12.003
    Abstract ( 393 )   PDF (1154KB) ( 193 )   Save
    Objective To investigate the effect of Chaihu Dayuan decoction (Bupleurum Moyuan-Targeting Decoction, CHDYY) on the proinflammatory and anti-inflammatory factors in the serum and peritoneal lavage fluid of rats with Escherichia coli (E. coli) peritonitis from the perspective of membrane source (mo yuan, pleurodiaphragmatic interspace) theory. Methods 54 SD rats were randomly divided into normal group, model group and CHDYY group (n=18 with the duration of intervention for 10 days in each group). Peritonitis model was established in the model group and the CHDYY group with intraperitoneal injection of E.coli solution at 20 mL/kg. The norrnal group and the model group received no treatment while the CHDYY group was orally administered with concentrated CHDYY decoction. The body temperature and body weight of the rats were recorded every day, and the samples were collected on the 1st day, 3rd day and 10th day respectively after the intervention. Levels of tumor necrosis factor alpha (TNF-α), interleukin 10 (IL-10) and prostaglandin E2 (PGE2) in serum and peritoneal lavage fluid were measured with ELISA assay. Results Compared with the model group, the body temperature of the CHDYY decoction group decreased significantly at 1~3 hour after intervention (P<0.05), and abdominal adhesion improved significantly. On the 1st and 3rd days of the CHDYY group, the serum TNF-α concentration was significantly decreased (P<0.05), and the serum IL-10 concentration in the CHDYY group was significantly increased (P<0.05) on the 1st day, 3rd day and 10thday in the CHDYY group, and the serum PGE2 concentration in the CHDYY group was significantly increased (P<0.05). The concentration of TNF-α in the peritoneal lavage fluid on the 1st, 3rd and 10th day of the CHDYY group increased significantly (P<0.01), and the concentration of IL-10 was significantly increased (P<0.05) on the 3rd day and 10th day of the CHDYY group (P<0.05). The concentration of PGE2 in the peritoneal lavage fluid of the CHDYY group was significantly increased (P<0.05) on the 10th day. Conclusion Chaihu Dayuan decoction seems to increase the level of TNF-αin the abdominal cavity, reduce the level of serum TNF-α, increase the level of anti-inflammatory factors IL-10 and PGE2 in the serum and peritoneal lavage fluid, and restore the balance between proinflammatory and anti-inflammatory factors.
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    Antihypertensive effects of Wuwei Jiangya San on spontaneously hypertensive rats*
    Gong Ming, Wang Wei, Wang Peipei, Wang Zhiyin, Yang Shuangjie, Liu Junjie, Li Shaojing, Li Xueli, Zhao Huihui
    2018, 41 (12):  988-994.  doi: 10.3969/j.issn.1006-2157.2018.12.004
    Abstract ( 327 )   PDF (2699KB) ( 203 )   Save
    Objective To study the effects of Wuwei Jiangya San(five-ingredient antihypertensive formula, WWJY) on spontaneously hypertensive rats and compare the antihypertensive characteristics of WWJY formula, Sancao Jiangya(three-herb antihypertensive, SCJY) decoction and Niuhuang Jiangya(Calculus Bovis antihypertensive, NHJY) pill on spontaneously hypertensive rats (SHR). Methods Forty SHR rats of 14-week-old were randomly divided into four groups: model group, WWJY formula group, SCJY decoction group and NHJY pill group, Wistar-Kyoto (WKY) rats as control group. The blood pressurewas monitored for 10 weeks.Then the changes of the blood pressure, heart rate and rotation tolerance time were observed every week. Samples were taken, to observe the pathological changes of the rats by using HE staining method. Results Compared with control group, the systolic blood pressure (SBP) of model group showed an upward trend (P<0.05), and the rotation tolerance time decreased. Compared with model group, WWJY formula was markedly effective after two weeks (P<0.05), and the SBP was stabled after four-week administration, and the rotation tolerance time were also maintained stable in the later period. SCJY decoction was effective at 0-4 weeks, as the SBP of the group showed inprovement within 4-8 weeks. NHJY pill showed anti-hypertensive effect at week 2. The rotation tolerance duration continuously increased after administration. Compared with model group, the pathological changes in the heart, kidney, and liver tissues were alleviated and improved in all three other interventional groups, especialy in the WWJY group. Conclusion The blood pressure lowering effect of WWJY formula on SHR rats seems to kick in later yet the effect is constant and sustained at the later period, compared to the SCJY decoction and NHJY pill. WWJY formula also has tranquilizing effects,keeping heart rate stable and relieving the pathological damage of liver and kidney.
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    Effects of Dendrobium huoshanense on fatigue and energy metabolism in mice with kidney-yin deficiency*
    Hou Yan, Fei Wenting, Wang Yujie, Zhou Xue, Yue Na, Wang Linyuan, Zhang Jianjun
    2018, 41 (12):  995-1001.  doi: 10.3969/j.issn.1006-2157.2018.12.005
    Abstract ( 364 )   PDF (1234KB) ( 177 )   Save
    Objective To explore the effects of Huoshan Shihu (Dendrobium huoshanense, HSSH) on fatigue and energy metabolism regulation in mice with kidney-yin deficiency.Methods Mice model with kidney-yin deficiency was established by gavage of thyroxine. Effects of Huoshan Shihu on mice with kidney-yin deficiency were observed. The thermotropism behavior and the weight-loaded swimming time of mice were monitored. The levels of T3 and T4 were detected by using Enzyme-linked Immunosorbent Assay (ELISA); cAMP, cGMP, LDH and CK in serum were detected with radioimmunoassay, cAMP/cGMP was thns calculated. and the Na+-K+-ATP-ase and Ca2+-Mg2+-ATP-ase in liver tissue of mice were detected with chromatometry. Results Compared with the normal animals, the time duration in high-temperature zone and the loaded-swimming time of mice in model group were significantly decreased (P<0.01). The levels of T3, T4, cAMP, and cAMP/cGMP were significantly increased(P<0.01,P<0.001). The activities of LDH were decreased(P<0.05), and CK, Na+-K+-ATP-ase and Ca2+-Mg2+-ATP-ase were increased (P<0.001). Compared with the model animals, time duration in high-temperature zone and loaded-swimming time in A (0.33 g/kg), B (1 g/kg), C (2 g/kg), and D (3 g/kg) dose of HSSH group, Tiepi Shihu (Dendrobium candidum, TPSH) group, and Liuwei Dihuang Wan (Six-Ingredient Rehmannia pill, LWDH) group increased significantly; the level of cAMP/cGMP decreased significantly (P<0.05, P<0.01); and the activities of Na+-K+-ATP-ase and Ca2+-Mg2+-ATP-ase decreased significantly (P<0.01,P<0.001). B, C, and D dose of HSSH group, TPSH group and LWDH group appeared to reduce the concentration of T3 and T4 (P<0.05, P<0.01, P<0.001). the activities of LDH were significantly increased in B and C dose of HSSH, TPSH and LWDH groups, and the levels of CK decreased (P<0.05, P<0.01, P<0.001). Conclusion With the effects of nourishing yin and clearing heat, Huoshan Shihu could regulate the energy metabolism rate, improve the loaded-swimming time, and reduce the activity of energy metabolizing enzymes and the thyroxine level of the mice with kidney-yin deficiency induced by thyroxine. Its anti-fatigue mechanism may be related to the regulation of energy metabolism enzymes. This study further proves that the property of Huoshan Shihu is cold.
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    Effects of Buyang Huanwu decoction on myocardial α-MHC, β-MHC, Drp1 mRNA and mitochondrial ultra structure in rats with diastolic heart failure*
    WANG Zhen,LI Jiebai, DONG Xin, SHEN Xiaoxu
    2018, 41 (12):  1002-1006.  doi: 10.3969/j.issn.1006-2157.2018.12.006
    Abstract ( 347 )   PDF (1743KB) ( 156 )   Save
    Objective To study the effect of Buyang Huanwu decoction (Yang-supplementing and Five-returning Decoction, BYHWT) on cardiac myosin heavy chain α, β (myosin heavy chain alpha and beta,α-MHC、β-MHC) mRNA and GTP enzyme dynami-lelated protrin 1(Drp 1) mRNA expressions in rats with diaslic heart foilure(DHF). Methods 48 SD Rats were randomly divided into sham operation group and model group,and the rat model was established by using abdominal aorta constriction method in model group of DHF rats. These rats were then randomly divided into model group, metoprolol group and BYHWT group; and intragastric intervention was administered accordingly, while the sham operation group and model group were given equal amount of deionized water, all once daily. After 8 weeks of continuous drug intervention, real-time fluorescence quantitative RT-PCR was used to determine myocardial α-MHC、β-MHC and Drp1 mRNA. Myocardial ultra structure was observed under Transmission Electron Microscope(TEM) . Result Compared with sham operation group, the expression level of α-MHCmRNA in model group increased (P<0.05); compared with model group, the α-MHCmRNA expression level of metoprolo group increased (P<0.05); compared with sham operation Group, the β-MHCmRNA expression level of model group decreased (P<0.05); compared with model group, the expression level of β-MHCmRNA in BYHWT group and metoprolol group increased (P<0.05); compared with sham operation Group, the Drp1 mRNAexpression level of model group decreased (P<0.05). Compared to the sham operation group, rat mitochondria in the model group seemed to be enlarged with hollow deformity and reduced numbers. Compared to the model group, rat mitochondria in the metoprolol and BYHWT group were improved in architecture and increased in quantity. Conclusion Buyang Huanwu decoction can inhibit α-MHC’s changing into β-MHC, thus delaying myocardial remodeling and protecting myocardium tissue. At the same time, by inhibiting the isolation of Drp1to mitochondria, protecting the structure and function of mitochondria, it can maintain the normal myocardial energy metabolism in diastolic heart failure and slow down the progression of heart failure.
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    Effects of Buzhong Yiqi granule on thyroid function and thyroid antibodies in rats with experirental autoimmune thyroiditis*
    Han Jing, Yuan Quan, Liu Xinyi, Liu Shouyao, Zhou Jun, Xia Zhongyuan
    2018, 41 (12):  1007-1011.  doi: 10.3969/j.issn.1006-2157.2018.12.007
    Abstract ( 296 )   PDF (1906KB) ( 118 )   Save
    Objective To investigate the effects of Buzhong Yiqi Granule (Center-supplementing and Qi-boosting, BZYQG) on thyroid function, thyroid autoantibodies and histopathologic morphology in rats with experimental autoimmune thyroiditis (EAT). Methods Animal models of EAT was established by intravenous injection of thyroglobulin mixed with Freund’s adjuvant immunization, and feeding with high iodine water. All EAT rats were randomly divided into model group, BZYQG group, Euthyrox (Levothyroxin Sodium Tablet or L-T4) group and BZYQG+Euthyrox combination treatment group. After 2 months of treatment, FT3, FT4, T3, T4, TSH, TPOAb, and TGAb in peripheral blood and pathological changes in thyroids were observed by using enzyme-linked immunosorbent assay (ELISA) and HE staining respectively. Results The levels of FT3, FT4, T3, T4, TPOAb and TGAb were significantly increased in the model group compared with blank group (P<0.05), and lymphocyte infiltration in thyroid tissue was more apparent in the model group compared with blank group. Compared with model group, the levels of FT3, FT4, T3, T4 decreased significantly (P<0.05), and the level of TSH had no statistical significance (P>0.05) in BZYQG group. Comparison of thyroid function between BZYQG group and combination treatment group presented differences with no statistical significance (P>0.05). The levels of TPOAb and TGAb were significantly reduced in BZYQG group compared with the model group (P<0.05). Comparison of TPOAb and TGAb among BZYQG group, Euthyrox group and combination treatment group presented with no statistical significance (P>0.05). Compared with model group, the degree of lymphocyte infiltration in thyroid tissue decreased significantly in three intervention groups, and the mixed medicine group was the most obvious one, followed by BZYQG group and L-T4 group. Conclusion BZYQG has the effects of maintaining thyroid functions, reducing thyroid antibody titer, relieving thyroid histopathological damage and improving autoimmunity.
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    Effects of Jiedu Tongluo Tiaogan formula on the endoplasmic reticulum stress and inflammation of adipocytes*
    Jiang Xiaotian, Piao Chunli, Mi Jia, Jin Meiying, Liu Xiangrong, Pan Weiwei
    2018, 41 (12):  1012-1018.  doi: 10.3969/j.issn.1006-2157.2018.12.008
    Abstract ( 289 )   PDF (1611KB) ( 121 )   Save
    Objective To observe the effects of Jiedu Tongluo Tiaogan formula(Detoxifying Collateral-dredging Liver-regulating Formula, JTT) on the expression of IRE1, JNK and NF-κB in 3T3-L1 adipocytes and the secretion of IL-6, TNF-α, CRP and ADPN, to investigate the inflammatory regulation of JTT formula on endoplasmic reticulum stress (ERS) of 3T3-L1 adipocytes. Methods 3T3-L1 preadipocytes were induced into mature adipocytes which were randomly divided into blank control group, model group, low, medium and high dose of JTT formula groups and metformin group. Except for the blank control group, the other groups were induced to ERS adipocytes by using 2 mg/L tunicamycin. After 24h intervention, the secretion ofIL-6, TNF-α, CRP and ADPN in the supernatant of adipocytes was detected by using enzyme-linked immunosorbent assay (ELISA). Protein expression of IRE1, JNK and NF-κB in adipocytes was measured with Western blot assay. Results Western blot assay showed that the expressions of IRE1, JNK and NF-κB in the low, medium and high dose JTT prescription groups were significantly lower than those in the model group, especially in the mid-dose and high-dose JTT groups (P<0.01); the difference was statistically significant. ELISA showed that the expression of ADPN increased in all doses of JTT groups (P<0.01). The expressions of IL-6, TNF-α and CRP were all reduced in the mid-dose and high-dose JTT groups with significant changes in the high-dose JTT group (P<0.01). The expressions of JNK and IL-6 were lower in the high-dose JTT group than that in the metformin group (P<0.01). Conclusion JTT formula may inhibit the secretion of adiponectin by inhibiting inflammation-related factors, thereby reduce the inflammatory response of fat cells and reduce the expression of the key protein IRE1 in the UPR pathway. ERS of 3T3-L1 adipocytes could thus be alleviated in a multi-target manner.
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    The inhibitory effects of cinobufagin on the in vitro proliferation of human castration-resistant prostate cancer PC3 cells*
    Niu Tianli, Qin Guozheng
    2018, 41 (12):  1019-1024.  doi: 10.3969/j.issn.1006-2157.2018.12.009
    Abstract ( 301 )   PDF (1357KB) ( 106 )   Save
    Objective To explore the inhibitory effects of cinobufagin on the in vitro proliferation and apoptosis of human castration-resistant prostate cancer PC3 cells, and to explore its mechanism of action. Methods PC3 cells were divided into 5 groups: control group and 5, 50, 100, 500 nmol/L cinobufagin groups. At 24 and 48 hours, the proliferation of PC3 cells was observed by using MTT assay. At 48 hours, the morphological changes of PC3 cells were observed under microscope; the effect of cinobufagin on the clonal formation ability of PC3 cells was detected by using clone formation assay; the apoptosis of PC3 cells was detected with flow cytometry 48 hours after the action of cinobufagin; and the effect of cinobufagin on the expression of MCL-1 protein was detected by using Western blot assay. Results At 24 hours, the proliferation of PC3 cells was inhibited by cinobufagin (P<0.01). At 48 hours, the proliferation of PC3 cells was also inhibited by cinobufagin (P<0.05). The inhibiting effects of cinobufagin on the proliferation of PC3 cells was in a dose and time dependent manner. Cell clone formation assay showed that 0.5 nmol/L cinobufagin could inhibit cell clone formation (P<0.05), and the inhibition was positively correlated with drug concentration (P<0.05). The results of flow cytometry showed that the apoptosis rate of PC3 cells was significantly increased with the increase of concentration (P<0.01). After the intervention of 50 nmol/L cinobufagin for 48 h, the apoptosis rate of PC3 cells was (39.667+7.636) %; cell proliferation under the light microscope also presented with apparent inhibition and the morphology of apoptosis was changed. Western blot assay showed that the expression of anti-apoptotic protein MCL-1 was down-regulated by different concentrations of cinobufagin (P<0.01), and the expression of MCL-1 was down-regulated by 50 nmol/L cinobufagin at 48 hours (P<0.01). Conclusion Cinobufagin can inhibit the external proliferation of PC3 cells and induce apoptosis of prostate cancer cells. This effect may be related to down-regulating the expression of anti-apoptotic protein McL-1.
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    Effects of electroacupuncture on astrocytes at subventricular zone in rats with hyperlipidemia and cerebral ischemia*
    Mao Junru, Ge Dongyu, Dong Ruijuan, Zhao Liyun, Li Genmao, Ren Xiujun
    2018, 41 (12):  1025-1032.  doi: 10.3969/j.issn.1006-2157.2018.12.010
    Abstract ( 299 )   PDF (2667KB) ( 195 )   Save
    Objective To observe effects of electroacupuncture on astrocyte at subventricular zone (SVZ) of the ipsilateral forebrain in rats with hyperlipidemia and cerebral ischemia. Methods 49 adult male SD rats were randomly divided into normal group, model group, sham operation group, electroacupuncture 1 (EA1) group and electroacupuncture 2 (EA2) group. Rats were fed with high-fat diet for 42 days except those in the normal group. Rats in EA1 group were needled at ST40, once a day for 7 days. Rats in the model and EA groups were induced with hyperlipidemia and cerebral ischemia by 50% FeCl3 at the 50th day. Rats in EA group were needled at ST40 and GV20, once a day for 14 days. Behavioral were assessed with neurological function score. Levels of total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) in serum were tested by biochemical methods. Hematoxylin-eosin (HE) staining assay was used to evaluate histopathology while immunohistochemically assay was used to evaluate GFAP at SVZ. Results TC, TG, LDL rose significantly and HDL reduced significantly in model group after hyperlipidemia rats with cerebral ischemia was established (P<0.05). The level of TC and LDL decreased significantly in EA group (P<0.05). Rats in model group had higher neurological function score; shrinking neurons were present in HE staining, indicating cerebral ischemia. Percentage of GFAP-positive cells area at SVZ increased (P<0.01). Electroacupuncture seemed to improve neurobehavioral score and recover cerebral ischemia injure. Percentage of GFAP area in rats of EA group had increased from day 1 to day 14, and at day 7 percentage of GFAP area in EA1 group was higher than that in EA2 group (P<0.05). Conclusion Stimulating ST40 in hyperlipidemia period, and stimulating ST40 and GV20 after hMCAT occurred can activate astrocytes and repair damaged nervous system by regulating blood lipid metabolism.
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    Analysis of thermal difference, X-ray diffraction and X-ray fluorescence of Arcae Concha and its counterfeit species*
    Yan Yufeng, Xu Shuangmei, Tao Mingbao, Chen Lin, Liu Youping, Chen Hongping
    2018, 41 (12):  1033-1040.  doi: 10.3969/j.issn.1006-2157.2018.12.011
    Abstract ( 250 )   PDF (3293KB) ( 166 )   Save
    Objective To explore the difference between Arcae Concha and its counterfeits by using modern analytical methods. Methods In this study, thermal analysis, X-ray diffraction and X-ray fluorescence analysis were used to analyze Arcae Concha and its counterfeits. Cluster analysis and principal component analysis were used for data analysis. Results Differential thermal analysis graph analysis results disply that the Arcae Concha and mixed falsify samples show the same endothermic peak at 50 ℃ and high temperature; X-ray diffraction spectrum analysis reveals that the Arcae Concha and its counterfeits all belong to aragonite calcium carbonate; X-ray fluorescence analysis demonstrates that elements of Arcae Concha and its counterfeits and their content are nearly same. By cluster analysis and principal component analysis, the inorganic elements of Arcae Concha and its counterfeits can be divided into two categories. The Arca subcrenata Lischke, Arca crebricostata, Arca granosa Linnaeus, Potiarca pilula Reeve, Arca inflata Reeve and Arca navicularis Bruuiere fall into the first category, while the Arca anomala and the Arca nodifera fall into the second one. Conclusion Based on systematic comparative analysis of Arcae Concha and its counterfeits with the thermal analysis, X-ray diffraction and X-ray fluorescence, it is found that there is little difference in composition and structure between Arcae Concha and its counterfeit. The results can provide a foundation for reasonable safe medication.
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    Data mining-based analysis of traditional Chinese medicinals used for myasthenia gravis*
    Xu Peng, Zhang Yibin, Lu Zhiguo, Zhang Dongmei, Cheng Guangyu, Wang Jian
    2018, 41 (12):  1041-1046.  doi: 10.3969/j.issn.1006-2157.2018.12.012
    Abstract ( 447 )   PDF (2051KB) ( 257 )   Save
    Objective Based on data mining, to explore the medication regularity of traditional Chinese medicine in treating myasthenia gravis. Method We searched VIP,Wanfang Data, CNKI and CBM databases to collect theses on traditional Chinese medicine (TCM) treating myasthenia gravis from inception to May, 2018. Two reviewers independently screened literature, extracted data and established database. Frequency count,cluster analysis and association rule were used to analyze regularity of key herbs and a pair (group) of herbs. Results We identified 187 studies that involved a total of 379 prescriptions and 270 herbs about treating Myasthenia Gravis. The cumulative frequency of drug use was 4724 times. The arrangement of top 10 herbs by using frequency were astragalus, atractylodes, liquorice, angelica sinensis, lanceolata, cimicifugafoetida, yam, bupleurum, tangerine peel, poria and among classes of drugs, the tonics, drugs for relieving exterior disorder, heat-clearing herbs, drugs that cleared excess wind and dampness, drugs that regulated flow of qi were mainly used. The clustering analysis of core herbs showed 5 classifications. According to the analysis of association rules that the degree of support was >30%, the rules in pair herbs were 13, in 3 herbs were 24, and in 4 herbs were 16, which were performed by the combination of qi invigorating drugs in the tonics, blood tonics and upraising the middle qi in drugs for relieving exterior disorder. Conclusion The medication regularity of traditional Chinese medicine for treating Myasthenia Gravis is dominated by the method of reinforcing deficiency. The combination of drugs is mainly composed of Buzhong Yiqi decoction as the core, and the complementary law of Spleen and Kidney intervening runs through the whole course of disease, meanwhile, applying clearing heat, eliminating dampness and detoxification are based on the differentiating symptoms and signs.
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    To run outstanding JBUTCM by basing on the foundation, tracking the frontiers as well as keeping pace with the times
    Zhang Chi, Li Yan, You Haiyan, Liang Jichun, Lu Guanglin, Luo Bin, Bai Jin
    2018, 41 (12):  1052-1056.  doi: 10.3969/j.issn.1006-2157.2018.12.014
    Abstract ( 334 )   PDF (1143KB) ( 99 )   Save
    The work and achievements of Journal of Beijing University of Chinese Medicine (JBUTCM) from the Fifth Editorial Committee held in November 2011 to October 2018 were summarized from the aspects of construction of periodicals and editorial department. The work of periodical construction includes: basing on the foundation, focusing on academic depth and training the excellent team of authors; tracking the frontier by speeding and increasing the proportion of papers assisted by different levels of funds, with taking into account the articles of various disciplines; keeping pace with the times by strengthening the digital construction of periodicals and expanding the amount of information in English; running first-class publication and outstanding journal. The construction of editorial department includes standardization procedure and institutionalization operation in system construction, standardization operation, discussion and study, team construction, etc. Finally, the existing problems and the direction of efforts are put forward, that is, deepening the digital construction of JBUTCM, grasping the academic dynamics of TCM in breadth and depth, and contributing to the development of TCM discipline.
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