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主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    05 June 2019, Volume 42 Issue 6 Previous Issue    Next Issue
    Qi Forum
    Reflections on interpretation of qi in the context of modern science*
    Xing Yurui
    2019, 42 (6):  445-450.  doi: 10.3969/j.issn.1006-2157.2019.06.001
    Abstract ( 447 )   PDF (1203KB) ( 254 )   Save
    As the cornerstone of TCM theory, the concept of qi always arouses reflection and discussion in the context of modern science. In response to such a situation, this paper firstly explains the reason for the question “What is qi?” to come into existence, i.e. it is difficult for people to comprehend the concept of qi with attributes of natural philosophy in the context of modern science based mainly on atomism. Secondly, the present research points out that contemporary scholars have expounded the concept of qi from the perspectives of biology, physics and even modern systems science and tried to reveal the essence of qi through laboratory research or by analogy with some findings in modern science, but their conclusions are far from the real concept of qi. Thirdly, it elaborates the ways to enunciate the concepts of qi in philosophy and TCM respectively to modern audience. Fourthly, it is noted that when the value of primordial qi theory is evaluated, both its merits and demerits should be analyzed instead of focusing on the former only. Lastly, the author explores future research directions and issues worth attention.
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    Theoretical Studies
    Treatment of shoulder and neck pain based on the connection between liver and large intestine*
    Chen Jingwen, Liu Zhenzhu, Zhang Ning, Li Menglin, Liu Jintao, Wang Weiguang, Huang Xunying, Xi Chongcheng, Zhai Shuangqing
    2019, 42 (6):  451-454.  doi: 10.3969/j.issn.1006-2157.2019.06.002
    Abstract ( 613 )   PDF (1172KB) ( 272 )   Save
    The theory of the connection between liver and large intestine is a part of the theory of the connection of zang-fu organs. The earliest record of this theory is seen in the book Introduction to Medicine by Li Chan published in the Ming Dynasty. We can understand the close relationship between liver and large intestine in terms of the interaction between wood and metal according to the theory of five elements. Also, blood can moisten large intestine and removing stagnancy and obstruction in the intestines can help soothe the liver. In addition, according to the opening, closing and pivoting nature of the six meridians, the foot jueyin liver meridian and the hand taiyang large intestine meridian correspond with each other as both are of closing nature. In addition, liver and large intestine are associated with shoulder and neck based on the correspondence between zang-fu organs and body parts, and on meridian circulations. In the modern society, cellphone has been overused, leading to eyestrain, which in turn impairs blood as long looking at something impairs blood. Furthermore, the night-owl lifestyle negatively impacts liver’s function of storing blood. As a result, the shoulder and neck pain of many patients is caused by liver blood insufficiency and sinew and muscle malnutrition. Liver blood insufficiency gives rise to stagnation of liver qi and constipation, since the large intestine cannot be moistened. Thus, clinical practitioners can nourish liver blood to moisten large intestine and remove stagnancy and obstruction in large intestine to soothe the liver, which will have excellent curative effect on this kind of shoulder and neck pain. As this method is rather different from treatments targeted at cold congealing, qi stagnation and blood stasis, it could provide a new approach to the treatment of shoulder and neck pain.
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    Research on the construction of TCM pattern differentiation and treatment model on the theory of herbal properties*
    Huang Xindi, Ding Changsong, Liang Hao, Deng Le
    2019, 42 (6):  455-459.  doi: 10.3969/j.issn.1006-2157.2019.06.003
    Abstract ( 417 )   PDF (1787KB) ( 165 )   Save
    Pattern is a unique way to identify disease in traditional Chinese medicine. As the basis and essence of TCM theory, it plays a key role in connecting principles, strategies, formulas and medicinal substances of TCM. Clinically, the etiology, pathogenesis, location, status and other characteristics of disease are discovered through pattern differentiation, which serves as a basis for treatment. Based on the principle of suiting the prescription to the pattern to achieve its efficacy, this paper analyzes the interconnection between patterns, prescriptions and Chinese medicinal substances to construct the Chinese Medicinal Substance Attribute and Pattern Differentiation Correlation Model (CMSA-PD CM). The relationship between the properties, flavors and efficacy of medicinal substances, compatibility of medicinal substances and pattern differentiation is explored with the model. Finally, the model is applied to the analysis of the prescription for hidrosis pattern caused by lung-defence insecurity to illustrate its clinical relevance. It will provide reference for analyzing the thinking process behind pattern differentiation and for rational clinical prescription.
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    Relationship between Internet addiction and liver in traditional Chinese medicine*
    Zhang Xiao, Zhang Qinyuan, Zhang Baihua, Wang Chenggang, Guo Gongshe
    2019, 42 (6):  460-464.  doi: 10.3969/j.issn.1006-2157.2019.06.004
    Abstract ( 436 )   PDF (1302KB) ( 177 )   Save
    The pathogenetic mechanisms of Internet addiction, a disease of the modern times, can be analyzed from the perspective of emotions in traditional Chinese medicine, and the symptoms of the disease and those of emotional diseases in Chinese medicine can provide mutual reference to each other. The formation and development of Internet addiction is closely correlated with the liver in TCM.The present paper explored the following four correlations theoretically: the correlation between constitution characteristics of Internet addicts and the physiology and function of the liver in TCM, that between the onset of Internet addiction and the liver governing the free flow of qi, that between the negative emotions of Internet addiction and liver governing emotions, and that between the symptoms of Internet addiction and those of patterns of the liver. The findings of a survey of emotions associated with Internet addiction of college students in Shandong Province were also reported. In “A General Survey of Clinical Medicine” and “A General Survey of Medical Classics” in Chinese Medical Code (electronic version), the bibliometric frequency of the liver governing the free flow of qi was studied. The basic TCM patterns and core clinical manifestations of Internet addiction were also discussed according to literature data mining. In addition, the relation between Internet addiction and liver in TCM was studied from the perspective of clinical practice and medical literature.
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    Mechanism of five notes of ancient China’s pentatonic scale in disease treatment based on meridian and collateral theory*
    Lin Facai
    2019, 42 (6):  465-468.  doi: 10.3969/j.issn.1006-2157.2019.06.005
    Abstract ( 637 )   PDF (1169KB) ( 367 )   Save
    A study of the mechanism of the correspondence between the five notes and the meridians is of great significance for the therapeutic effect of the five-element music. The five notes of ancient China’s pentatonic scale are in close association with the meridians and the acupoints on them. Based on the five-element theory, a corresponding relationship between the five notes and the meridians came into existence. The present research explored the mechanisms of the five notes, the correspondence between the meridians along with acupoints and the five notes, the diagnosis and treatment with the five notes, and the appropriate application time for the music therapy based on midnight-noon ebb-flow theory of meridians and collaterals, aiming to lay a solid foundation for a better understanding of the mechanism of the five-element music and provide new thoughts and methods for the clinical application of the five notes including the administration of music treatment in accordance with time of the day.
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    Textual Research
    A discussion of differences between “Shennong” classics and “Materia Medica” classics based on lost articles of ancient versions of Shen Nong’s Classic of the Materia Medica found in other classics*
    Peng Bisheng
    2019, 42 (6):  469-473.  doi: 10.3969/j.issn.1006-2157.2019.06.006
    Abstract ( 472 )   PDF (1179KB) ( 240 )   Save
    The extant editions of Shen Nong’s Classic of the Materia Medica (Shennong Bencaojing) are taken mostly from Materia Medica Arranged According to Pattern (Zhenglei Bencao) compiled in the Song Dynasty, whose original source is Collective Commentaries on the Classic of Materia Medica (Bencaojing Jizhu) compiled by Tao Hongjing in the Liang Dynasty. These editions, however, are different from the ancient original versions. It is discovered that the lost articles of the ancient versions of Shen Nong’s Classic of the Materia Medica found in other classics fall into two categories: “Shennong” classics and “Materia Medica” classics through an investigation into the Imperial Readings of the Taiping Era (Taiping Yulan), Taoist Canon (Daozang) and other ancient books. The “Shennong” classics are mainly about Chinese herbal medicine theories and Taoist theories of necromancy, astrology, medicine, etc. while “Materia Medica” classics include entries of Chinese medicinal herbs. These two groups of classics roughly correspond with the prologue and main body of the extant Shen Nong’s Classic of the Materia Medica. It is presumed that the extant classic may be a combination of the ancient “Shennong” classics and “Materia Medica” classics.
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    Preliminary interpretion “da ding” as tumour
    Kenny Sze
    2019, 42 (6):  474-476.  doi: 10.3969/j.issn.1006-2157.2019.06.007
    Abstract ( 407 )   PDF (1160KB) ( 196 )   Save
    The meaning of the phrase “zu sheng da ding” in the chapter Discussion on the Interrelationship Between Life and Nature (Shengqi Tongtian Lun) in Huangdi’s Internal Classic (Huangdi Neijing) has aroused much controversy among generations of TCM physicians since Wang Bing republished Plain Questions (Suwen) in Huangdi’s Internal Classic over a thousand years ago. This paper re-investigates the hidden meanings of the characters da (大) and ding (丁) respectively while questioning the previous interpretation of “da ding” as furuncle. It finally concludes that the “da ding” is an ancient term for tumour. Based on this, a possible interpretation of zu (足) and a supplementary interpretation of “shou ru chi xu” (受如持虚) are also suggested,i.e. “be enough to” and “suffer excess with deficiency” respectively.
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    Chinese Medicinal Pharmacology
    Effects of Mimenghua Granule on IL-12 and IL-6 in lacrimal gland cells of castrated male rabbits with induced dry eyes*
    Jiang Pengfei, Peng Jun, Peng Qinghua
    2019, 42 (6):  477-482.  doi: 10.3969/j.issn.1006-2157.2019.06.008
    Abstract ( 366 )   PDF (1772KB) ( 278 )   Save
    Objective To observe the effects of Mimenghua (Flos Buddlejae) Granule (MG) on the expressions of IL-6 and IL-12 in lacrimal gland cells of castrated male rabbits.Methods Thirty New Zealand long-eared white rabbits were randomly and evenly divided into 5 groups: normal group, model group, MG group, saline group and testosterone group. Except rabbits in the normal group, all the others were castrated by bilateral orchiectomy and epididymectomy. SIT and BUT test were performed 1 day before and 30 days after castration. After 30 days of intervention, all rabbits were executed. Lacrimal gland tissues were collected for HE staining to observe the structure of lacrimal gland. Immunohistochemistry was used to detect the expressions of IL-6 and IL-12 in lacrimal gland tissues from rabbits of all groups.Results In the normal group, the lacrimal gland tissue was neatly arranged and the structure was clear. No expression of IL-6 and IL-12 was observed. In the model group and the saline group, the lacrimal gland tissue was not aligned, and the structure was degenerated. IL-6 and IL-12 were expressed in the cell membrane and in the cytoplasm. The lacrimal gland tissue of the MG group and the testosterone group were neatly arranged, and the structure was clear. Only small amounts of IL-6 and IL-12 were expressed in the cell membrane and cytoplasm. Compared with the normal group, the SIT and BUT values in the model group and saline group were decreased (P<0.05), and the differences in SIT and BUT values in the MG group and testosterone group were not statistically significant (P>0.05).Conclusion MG can reduce inflammation of lacrimal gland tissues by inhibiting the expression of IL-6 and IL-12 in lacrimal gland tissues to treat dry eyes.
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    Mechanism of Mahuang Fuzi Xixin Decoction in treating allergic rhinitis based on biomolecular network regulation*
    Xu Tian, Lian Yajun, Song Danping, Zhang Shuang, Fan Shuning, Ma Chongyang, Cheng Fafeng, Wang Xueqian, Wang Qingguo
    2019, 42 (6):  483-489.  doi: 10.3969/j.issn.1006-2157.2019.06.009
    Abstract ( 360 )   PDF (3559KB) ( 147 )   Save
    Objective To study the mechanism of Mahuang Fuzi Xixin Decoction (MFXD) in treating allergic rhinitis.Methods The effective components of Mahuang Fuzi Xixin Decoction were obtained by using TCMSP database(oval bioavailability≥30% and medical similarity≥0.18). UniProt database was used to unify the terms of effective targets of MFXD, and comparative toxicology genetics database (CTD) was used to annotate target-related diseases, and as a result, MFXD anti-allergic rhinitis related targets were obtained. The above targets were input into the String database for protein-protein interaction network prediction. Finally, gene ontology (GO) and Kyoto gene and genome encyclopedia (KEGG) enrichment analysis were carried out using the DAVID database to reveal the potential signal pathway of MFXD in the treatment of allergic rhinitis.Results 35 active ingredients and 112 anti-allergic rhinitis targets of MFXD were selected. Its anti-allergic rhinitis may be related to human tumor protein P53 (TP53), transcription factor AP-1 (JUN), interleukin 6 (IL-6), vascular endothelial growth factor (VEGFA) and tumor necrosis factor (TNF).In addition, anti-allergic rhinitis targets of MFXD significantly enriched in calcium signaling pathways, nucleotide combined with structure of oligomerization domain (NOD) receptor signaling pathways, T cell receptors signaling pathways, mitogen activated protein kinase (MAPK) signaling pathway, toll-like receptors signaling pathways, such as cytokines, cell factor receptor interaction signaling pathways.Conclusion MFXD can regulate biomolecular networks with multiple targets and multiple pathways, and its potential anti-allergic rhinitis, multiple pathways biological mechanism may be related to calcium signaling, nod-like receptor, t-cell receptor, MAPK, toll-like receptor and other signaling pathways.
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    Effects of Wuzi Yanzong Pill on spermatogenesis by modulating expression of cytoskeleton protein in Sertoli cells in rats with kidney essence deficiency pattern*
    Qin Mao, Ke Minghui, Liu Baoxing, Zhang Xiuping, Cui Tianwei, Ma Wenjing, Gao Yunxiao, Ke Zhenghao
    2019, 42 (6):  490-495.  doi: 10.3969/j.issn.1006-2157.2019.06.010
    Abstract ( 428 )   PDF (1916KB) ( 172 )   Save
    Objective To observe the effects of Wuzi Yanzong (Five-ingredient Family Development) Pill (WYP) on expression of cytoskeletal proteins in Sertoli cells and on spermatogenesis in rats with kidney essence deficiency pattern.Methods Normal adult male Sprague-Dawley rats (n=25) were randomly divided into five groups: normal group, model group, low-dose WYP group, mid-dose WYP group and high-dose WYP group (n=5 in each group). The normal group was given 0.5% sodium carboxymethyl cellulose (CMC-Na) (50 mg/kg) by gavage in the morning and afternoon daily; the model group received multiglycosides of Tripterygium wilfordii Hook f (GTW) (20 mg/kg) in the morning and 0.5% CMC-Na (50 mg/kg) in the afternoon; and the WYP groups were given GTW (20 mg/kg) in the morning followed by WYP (0.5, 1.0, or 2.0 g/kg daily) in the afternoon respectively for 30 days. The testis and epididymal tissues were then collected to obtain the total sperm count and the percentage of progressively motile sperm. Immunohistochemistry was employed to detect the expressions of vimentin and α-tubulin in the Sertoli cells. TUNEL assay was used to measure the apoptosis of spermatogenic cells.Results Compared with the normal group, the total sperm count and the percentage of progressive motility (PM) in the model group were decreased. Expressions of vimentin and α-tubulin in the Sertoli cells were decreased. Apoptosis of spermatogenic cells was increased. Compared with the model group, the total sperm count and the PM percentage in the mid-dose WYP group and the high-dose WYP group were increased. Meanwhile, the expressions of vimentin and α-tubulin in Sertoli cells in all three WYP groups were increased with decreased apoptosis of spermatogenic cells.Conclusion WYP seem to improve spermatogenesis, possibly through modulating the expressions of cytoskeletal proteins in Sertoli cells and inhibiting the apoptosis of spermatogenic cells.
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    Effect of “Heart-kidney therapy” on retinal neurotrophic factor in diabetic rats*
    Wu Zhengzheng, Wang Qian, Ge Dongyu, Yan Jing, Gong Ximei, Liu Huixian
    2019, 42 (6):  496-501.  doi: 10.3969/j.issn.1006-2157.2019.06.011
    Abstract ( 345 )   PDF (1840KB) ( 121 )   Save
    Objective To explore the protective mechanism of “Heart-kidney therapy” for retinal nerve dysfunction in diabetic rats.Methods SD rats were randomly divided into normal group, model group and Mimenghua (Flos Buddlejae) compound prescription (MCP) group. Diabetic rat models were created by intraperitoneal injection of streptozotocin (STZ). Intragastric administration of MCP was carried out for 90 days consecutively. Visual electrophysiology was used to detect the visual function of diabetic rats on 30, 60, 90 d respectively. The morphological changes of retina were observed with HE staining on 90 d. Apoptosis of retinal ganglion cells was detected with TUNEL. The mRNA and protein expression of brain-derived neurotrophic factor (BDNF) and ciliary neurotrophic factor (CNTF) in retina were detected with PCR and Western blot.Results Visual electrophysiology examination showed that the OPs wave amplitude and b-wave amplitude in ERG were decreased which indicated decreased optic nerve function in the model group with statistically significant difference, compared with the normal group (P<0.01). HE staining showed that retinal ganglion cells in the model group were swollen, disordered and decreased in number. PCR and Western blot showed that the mRNA and protein expression of BDNF and CNTF were decreased, compared with the normal group. After the intervention with the Chinese prescription (Mimenghua prescription), the OPs wave amplitude and b-wave amplitude in ERG were increased in the MCP group, compared with the model group (P<0.01). The number of apoptotic retinal ganglion cells decreased, and mRNA and protein expression of BDNF and CNTF in retina increased in the MCP group, compared with the model group.Conclusion Mimenghua compound prescription can protect the retinal nerve function in diabetic rats by regulating the expression levels of mRNA and protein of BDNF and CNTF.
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    Clinical Studies
    Clinical analysis of abnormal coagulation parameters and blood stasis symptoms in patients with advanced malignant tumors*
    Chen Meiyun, Tang Decai
    2019, 42 (6):  502-507.  doi: 10.3969/j.issn.1006-2157.2019.06.012
    Abstract ( 397 )   PDF (1197KB) ( 154 )   Save
    Objective To investigate the coagulation parameters in patients with advanced malignant tumors, and their correlation with blood stasis pattern distribution in traditional Chinese medicine.Methods Through retrospective investigation, the clinical data of patients with lung cancer, gastric cancer, colorectal cancer, liver cancer, pancreatic cancer and breast cancer were collected. A comparative analysis was made of the coagulation parameters and blood stasis pattern of patients with different types of tumors, patients that got improved and discharged and those who passed away.Results Abnormal coagulation is common in patients with malignant tumors. Most patients have blood stasis pattern at the same time. Among patients with different types of cancers, those with pancreatic cancer are the most likely to have blood stasis pattern and those with breast cancer the least likely. 87.2% of patients with advanced malignant tumors had abnormal coagulation, and there was significant difference between the improved and discharged group and the deceased group (P<0.05). Patients with abnormal elevation of FIB and D-D account for the largest proportions, and there was significant difference among patients with different types of tumors (P<0.05). 83.8% of patients were diagnosed with blood stasis pattern according to TCM pattern differentiation. The difference between the improved and discharged group and the deceased group was statistically significant (P<0.05), and the difference between patients with different tumors was statistically significant (P<0.05). There was a correlation between abnormal coagulation parameters and blood stasis pattern (P<0.05).Conclusion Disorders of coagulation and blood stasis pattern are related to the prognosis of tumors, and blood stasis pattern is related to coagulation.It indicates that improving the coagulation parametres in patients with malignant tumor and blood stasis pattern may play a positive role in their prognosis.
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    Effects of Jiangtang Tongluo Decoction II and mecobalamin tablets on serum IL-1β,sVCAM-1 and HCY levels in the treatment of diabetic peripheral neuropathy*
    Ma Long, Han Yongli, Chen Song
    2019, 42 (6):  508-513.  doi: 10.3969/j.issn.1006-2157.2019.06.013
    Abstract ( 383 )   PDF (1150KB) ( 227 )   Save
    Objective To observe the clinical efficacy and influence of Jiangtang Tongluo (Anti-diabetic Vessel-dredging) Decoction II and mecobalamin tablets on serum IL-1β,sVCAM-1 and HCY levels in the treatment of diabetic peripheral neuropathy.Methods 96 cases of diabetic peripheral neuropathy diagnosed as yin deficiency with blood stasis pattern in Huangjiahu Infirmary of Hubei University of Chinese Medicine were randomly divided into a control group (n=48) and an observation group (n=48). Both groups received mecobalamin tablets while the patients in the observation group were given Jiangtang Tongluo Decoction II for 4 consecutive weeks (2 weeks as one treatment course). Glucolipid metabolism and nerve conduction velocity were measured for efficacy evaluation, the levels of serum IL-1β,sVCAM-1 and HCY being monitored.Results Effective rate was 91.7% in the observation group, which was higher than that (77.1%) of the control group (P<0.05). The improvement of glucolipid metabolism in patients of the observation group were better than those of the control group, as the levels of FPG, HbA1c, TC ,TG and LDL-C were lower than those of the control group with the higher level of HDL-C(P<0.05), the nerve conduction velocity of median nerve and peroneal nerve was significantly increased(P<0.05), and the levels of serum IL-1β,sVCAM-1 and HCY for patients in the observation group were lower than those of the control group after treatment(P<0.05).Conclusion This formula seems to improve the glycemic metabolism and to increase the rate of nerve conduction. Its mechanism might be related to decreasing the levels of serum IL-1β,sVCAM-1 and HCY to reduce the damage to the endothelial cells.
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    Meta-analysis of the efficacy and safety of Yangxue Qingnao Granule and nimodipine in the treatment of chronic cerebral circulation insufficiency*
    Chang Ze,Han Zhenyun,Tian Danfeng,Gao Qiang,Zhang Dandan,Lin Jingfeng,Wang Yihao, Liu Ganlu, Wang Yuchun,Hu Wenyue,Ma Huaping
    2019, 42 (6):  514-522.  doi: 10.3969/j.issn.1006-2157.2019.06.014
    Abstract ( 450 )   PDF (3678KB) ( 138 )   Save
    Objective To evaluate the efficacy and safety of Yangxue Qingnao Granule and nimodipine in the treatment of chronic cerebral circulation insufficiency.Methods The databases of CNKI, Wanfang, VIP, CMB, PubMed, The Cochrane library and Embase were searched, and the randomized controlled trials (RCT) of Yangxue Qingnao Granule group and nimodipine group for the treatment of chronic cerebral circulation insufficiency were collected.Two researchers conducted literature screening and literature quality evaluation according to the inclusion and exclusion criteria and the “risk of bias assessment tool” of the Cochrane collaboration. Then, the included RCT studies were meta-analyzed using RevMan 5.3 software.Results A total of 1 457 patients were included in 18 RCT studies, including 744 patients in the Yangxue Qingnao Granule group and 713 patients in the nimodipine group. Meta analysis results show that the Yangxue Qingnao Granule group total effective rate is better than that of nimodipine group (OR = 4.88, 95% CI [3.63, 6.55], P<0.000 01), and total effective rates of Yangxue Qingnao Granule group for the treatment of chronic cerebral circulation insufficiency in a month (OR = 4.52, 95% CI [3.30, 6.19], P<0.000 01) and 3 months (OR=8.24, 95% CI [3.45, 19.67], P<0.000 01) were superior to those of nimodipine group. Compared with the nimodipine group, the Yangxue Qingnao Granule group was able to effectively reduce the fibrinogen (MD=1.07, 95%CI [0.84, 1.30], P<0.00001) and the plasma viscosity ratio index (MD=0.34, 95%CI [0.30, 0.37], P<0.000 01).Conclusion Yangxue Qingnao Granule is better than nimodipine in treating patients with chronic cerebral circulation insufficiency. Due to the limitations of the quality and quantity of included studies and the lack of standard experimental design, the above conclusions still need to be verified by high-quality, large-sample and multi-center clinical studies.
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    Acupuncture & Moxibustion
    Effect of preventive treatment of seasonal allergic rhinitis with umbilical therapy based on preventive acupuncture*
    Qian Hua, Lu Zhu, Song Chenyan, Yang Yingying, Fu Hanying, Zhu Shipeng, Dong Qin
    2019, 42 (6):  523-529.  doi: 10.3969/j.issn.1006-2157.2019.06.015
    Abstract ( 409 )   Save
    Objective To observe the clinical preventive effects of umbilical therapy based on preventive acupuncture on seasonal allergic rhinitis.Methods 102 patients with seasonal allergic rhinitis were divided into three groups with random number table: spring-autumn treatment group, autumn treatment group and control group, 34 cases in each group, and 93 cases were included in the final statistical analysis (the autumn treatment group lost 2 cases and the control group lost 7). The spring-autumn treatment group received umbilical therapy consisting prescriptions of Guizhi(Cinnamon Twig) Decoction, Yupingfeng(Jade Screen) Powder and Canger(Xanthium) Powder for four weeks before the Beginning of Spring (the day marking the beginning of the 1st solar term according to Chinese lunar calendar, usually on Feb. 3, 4 or 5) and the Beginning of Autumn (the day marking the beginning of the 13th solar term, usually on Aug. 7, 8, or 9). The autumn treatment group received treatment only for four weeks before the Beginning of Autumn, while the Control Group received no intervention. Patients were scored according to Total Nasal Symptom Score (TNSS) and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) before and after treatment for clinical efficacy evaluation.Result Compared with the the scores before treatment and those of the control group, the total scores of TNSS and RQLQ respectively in the two treatment groups decreased after preventive treatment (P<0.05). There was no significant difference in the curative effect between the spring-autumn treatment group after the spring treatment and the autumn treatment group after the autumn treatment (P>0.05). The total effective rate of the spring-autumn treatment group after the autumn treatment (70.59%) was higher than that of the same group after the spring treatment (58.82%) and that of the autumn treatment group after the autumn treatment (53.13%). The effective rate of patients with a long course of disease (27.78%) was lower than that of those with a short course (75.00%). The total effective rate for different patterns were 69.70% for deficiency-cold of lung-qi, 46.67% for insufficiency of kidney-yang and 38.89% for weakness of spleen-qi respectively.Conclusion The umbilical therapy based on preventive acupuncture can prevent seasonal allergic rhinitis effectively, and improve the clinical symptoms and life quality of patients significantly. Its efficacy is related to the number of treatments, the course of disease and the type of pattern according to Chinese medicine.
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