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主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 March 2020, Volume 43 Issue 3 Previous Issue    Next Issue
    Theoretical studies
    Inspiration from Huangdi Neijing for “pan-marrow” hypothesis*
    He Chunfeng, Liu Wei
    2020, 43 (3):  181-185.  doi: 10.3969/j.issn.1006-2157.2020.03.001
    Abstract ( 447 )   PDF (849KB) ( 149 )   Save
    According to traditional Chinese medicine (TCM), brain marrow, spinal marrow, bone marrow, and essence, all in the category of “marrow”, are closely related in terms of physiology and pathology. Based on argument from analogy and understanding of marrow in Huangdi Neijing (Huangdi’s Internal Classic), this paper develops the theoretical system of the hypothesis of “pan-marrow”, an umbrella term for different types of marrow, and establishes correspondence between “pan-marrow” in Chinese medicine and multiple systems in Western medicine. As all marrow originates from kidney and gathers in the sea of marrow according to TCM, inspirations for treatment of marrow-related diseases are provided, i.e. besides supplementing kidney and essence, attention should be paid to supplementing both yin and yang and regulating body fluids, to offer new options for the prevention and combined treatment of multi-system disorders.
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    Ttextual Research
    Research on the origin and evolution of medicinal tea formula*
    Lan Yujing, Ma Ran, Zhang Lin
    2020, 43 (3):  186-191.  doi: 10.3969/j.issn.1006-2157.2020.03.002
    Abstract ( 420 )   PDF (873KB) ( 102 )   Save
    With a long history in China, the use of tea as medicinal herb was recorded in medical books of many dynasties. The earliest record of the medicinal value of tea was found in the Newly Revised Materia Medica, the first pharmacopoeia in ancient China. The concept “medicinal tea” owed its formation to the rise of tea culture and the development of dietary therapy culture in the Tang Dynasty. Medicinal formulas with tea as an ingredient were first recorded in the Important Formulas Worth a Thousand Gold Pieces for Emergency published in the Tang Dynasty, and the term “medicinal tea” appeared formally in Formulas from Benevolent Sages Compiled during the Taiping Era published in the Song Dynasty. A review of the origin and evolution of medicinal tea formulas from the Tang Dynasty to the Qing Dynasty revealed that medicinal tea formulas came to prominence in the Song Dynasty when the development of tea culture reached its peak. Altogether 580 medicinal tea formulas were recorded in the three formula books compiled by the imperial government of the Song Dynasty. Medicinal tea formulas recorded in Beneficial Formulas from the Taiping Imperial Pharmacy accounted for 8% of all the formulas in the book, and were indicated for various diseases including mainly wind patterns, head conditions and eye diseases. Among the various uses of medicinal tea formula, to administer herbal medicine with tea was unique. The present research into medicinal tea formulas resolves the contemporary misunderstanding that “drinking tea weakens the curative effect of herbal medicine” and provides reference for the application of medicinal tea in modern Chinese medicine.
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    Challenge to the statement that Wang Haogu was Zhang Yuansu’s disciple*
    Yu Miao, Zhang Huikang, Zhou Jichun
    2020, 43 (3):  192-195.  doi: 10.3969/j.issn.1006-2157.2020.03.003
    Abstract ( 374 )   PDF (544KB) ( 103 )   Save
    When it comes to the Yishui School, named after the founder Zhang Yuansu’s native district in Hebei Province, it is widely believed that both Li Dongyuan and Wang Haogu were once disciples of Zhang Yuansu, and Wang Haogu, younger than Li Dongyuan, later became Li’s disciple. Based on a textual research into relevant information from biographies, prefaces and postscripts of related works and relevant historical materials, we drew the conclusion that: Once a successful candidate well-versed in Confucian classics in the highest imperial examinations when he was young, Wang Haogu developed great interest in traditional Chinese medicine later and learned from Li Dongyuan, but he had never been a disciple of Zhang Yuansu, and Wang Haogu was older than Li Dongyuan. The misunderstanding that “Wang Haogu was Zhang Yuansu’s disciple” originated from the Siku Quanshu Zongmu (Annotated Catalog of the Complete Library in the Four Branches of Literature), and the other misunderstanding that “Wang Haogu learned traditional Chinese medicine in his early years, and Wang Haogu was younger than Li Dongyuan” originated from the postscript of Yinzheng Lueli (Discussions and Cases of Yin Patterns of Cold Damage) by Wang Yuezhen of the Qing Dynasty.
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    Chinese Medicinal Pharmacology
    Effects of Chishao, its total monoterpenes and its total phenols on clearing heat, cooling blood and dissolving stasis in rats with heat toxicity and blood stasis pattern*
    Zhang Jianjun, Li Wei, Yue Na, Wang Yujie, Zhou Xue, Zhang Rui
    2020, 43 (3):  196-202.  doi: 10.3969/j.issn.1006-2157.2020.03.004
    Abstract ( 363 )   PDF (1209KB) ( 62 )   Save
    Objective To investigate the effects of Chishao (Red Peony Root, Radix Paeoniae Rubra), its total monoterpenes and its total phenols on clearing heat, cooling blood and dissolving stasis in rats with heat toxicity and blood stasis pattern to discuss the material basis for such effects. Methods SD rats were randomly divided into the blank group, model group, Qingying Tang (Nutrient Aspect Heat-Clearing Decoction, QYT) group, Chishao group, Chishao total monoterpenes (CTM) group and Chishao total phenols (CTP) group. Models with heat toxicity and blood stasis pattern were established by intraabdominal injection of carrageenan (25 mg/kg) combined with tail vein injection of endotoxin (80 μg/kg). At the same time, corresponding medicinals were administered to the treatment groups by gavage at 20 g/kg for 8 days consecutively. The same amount of deionized water was given by gavage and normal saline was injected to the blank group. The levels of PGE2, cAMP, TNF-α, IFN-γ, IL-1β, IL-6, ET-1, NO, TXB2 and 6-keto-PGF1α were measured with ELISA. The changes in the levels of TT, PT, APTT and FIB were detected with chromogenic substrate method. Results Compared with model group, levels of PGE2, cAMP, TNF-α, IFN-γ, IL-1β and IL-6 were reduced in Chishao group and CTP group(P<0.05), and levels of cAMP, IFN-γ, IL-1β and IL-6 were lowered in CTM group(P<0.05). In Chishao group and CTM group, TT,PT and APTT levels were increased(P<0.05), FIB levels decreased(P<0.05), NO and 6-keto-PGF1α levels and NO/ET-1 ratios increased(P<0.05), and ET-1 and TXB2 levels and TXB2/6-keto-PGF1α ratio lowered(P<0.05). In CTP group, the contents of NO and the NO/ET-1 ratios were increased, and the levels of ET-1 and TXB2 and the TXB2/6-keto-PGF1α ratios decreased(P<0.05). Conclusion Both CTM and CTP have heat-clearing, blood-cooling and stasis-dissolving effects on rats with heat toxicity and blood stasis pattern. However, CTP demonstrates better effect of clearing heat and cooling blood than CTM while the latter has better effect of dissolving stasis than the former.
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    Effects of Baishao on liver yin deficiency pattern in alcoholic liver injury and its mechanism*
    Jia Lan, Wang Leilei, Meng Liang, Hua Ji’an, Fu Lu, Yao Junkai, Gao Xuemin, Wang Jingxia
    2020, 43 (3):  203-211.  doi: 10.3969/j.issn.1006-2157.2020.03.005
    Abstract ( 426 )   PDF (2421KB) ( 73 )   Save
    Objective To study the effects of Baishao (White Peony Root, Radix Paeoniae Alba) on liver yin deficiency pattern in mice with alcoholic liver injury and mechanism. Methods ICR mice were randomly divided into blank group, model group, Yiguan Jian (Effective Integration Decoction, YGJ) group and Baishao group, with 10 mice in each group. Mice models of alcoholic liver injury with liver yin deficiency pattern were established by intragastric administration of Lieber-DeCarli alcohol diet plus thyroid hormone. Meanwhile, the blank group and the model group were given physiological saline by gavage, the YGJ group was given YGJ (9.07 g/kg, 20 mL/kg) by gavage, and the Baishao group baishao exact (4.3 g/kg, 20 mL/kg) by gavage. After 28 days, the state of mice in each group was observed, and their body weight, body temperature and heart rate were measured. Levels of transaminase activities, cytokine, enzyme activities related to ethanol and fat metabolism and antioxidant enzyme activities of the serum and liver tissue were detected. Frozen liver sections were examined with Oil Red O staining and liver biopsies with H&E staining. Results Compared with the blank group, the weight of the mice in the model group was significantly reduced, the body temperature increased, the heart rate increased, accompanied with symptoms like lusterless hair, tiredness, sleepiness and irritability. The levels of serum ALT, AST, TG, TC and cAMP and levels of liver MDA, CYP2E1, TNF-α, IL-1β and IL-6 in the model group were significantly increased. The serum levels of cGMP and liver tissue levels of SOD, CAT, ADH, ALDH2, IL-10 and IL-1Ra were significantly reduced. In addition, lipid deposition and hepatocyte necrosis occurred in the liver. Compared with the model group, serum levels of ALT, AST, TG, TC and cAMP in the Baishao group were significantly lowered (P<0.05), and cGMP levels were significantly increased (P<0.05). The liver levels of CYP2E1, TNF-α, IL-1β and IL-6 were significantly decreased (P<0.05), and the levels of SOD, CAT, ADH, ALDH2, IL-10 and IL-1Ra were significantly increased (P<0.05). Also, the lipid content of the liver tissue was significantly decreased (P<0.01), and hepatocyte necrosis was reduced. Conclusion Baishao has obvious curative effect on liver yin deficiency pattern caused by alcoholic liver injury. Its mechanism is related to the regulation of cAMP/cGMP levels and cytokine levels, the restoration of normal hepatocyte function and metabolism, enhanced activities of key enzymes and antioxidant enzymes of ethanol metabolism in liver tissue, inhibition of lipid peroxidation and reduction in lipid deposition.
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    Effects of Songyu Anshen Fang on cAMP/PKA signaling pathways in hippocampus of insomnia rats*
    Li Jingyi, Huang Junshan, Chen Qin, Wang Xiufeng, Zhang Yu, Zhang Yifan
    2020, 43 (3):  212-217.  doi: 10.3969/j.issn.1006-2157.2020.03.006
    Abstract ( 330 )   PDF (893KB) ( 75 )   Save
    Objective To explore the effects of Songyu Anshen Fang (Radix et Rhizoma Nardostachyos and Radix Curcumae Spirit-calming Formula, SYASF) on 5-hydroxytryptamine 1A receptor (5-HT1AR) and cAMP signaling pathways in hippocampus of insomnia rats and to identify possible targets of such effects. Methods Fifty SD rats were randomly divided into control group, model group, low-dose SYASF group, high-dose SYASF group and buspirone group, with 10 rats in each group. Except the control group, rat models of liver constraint and insomnia were established in the other four groups with long-term tail-clip stimulation and intraperitoneal injection of chlorphenylalanine (PCPA). After the establishment of models, corresponding medicinals were administered to the low-dose SYASF group (8.5 g/kg), high-dose SYASF group (17 g/kg) and buspirone group (2.0 mg/kg) by gavage once a day for 14 consecutive days. Normal saline was given to the model group and the control group with the same frequency and duration. The general state of rats was observed during administration. By the end of administration, changes in body mass and results of open-field tests of the rats were observed and expressions of genes and proteins of 5-HT1AR, cAMP and PKA in all groups were detected. Results Compared with the control group, the time spent in the central area, number of grooming and number of fecal particles of the model group in the open field test were increased (P<0.05), and the expressions of 5-HT1AR, cAMP, PKA mRNA and protein in hippocampus of the model group were all decreased (P<0.05). Compared with the model group, the time spent in the central area, number of grooming and number of fecal particles of the high-dose SYASF group were reduced, while the mRNA and protein expressions of 5-HT1AR, cAMP, PKA increased (P<0.05). In the low-dose SYASF group, the time spent in the central area, number of grooming and number of fecal particles were decreased, while the mRNA and protein expressions of 5-HT1AR, PKA and cAMP were elevated (P<0.05), compared with the model group. There was no statistically significant difference between the high-dose SYASF group and the buspirone group (P>0.05). Conclusion SYASF can improve sleep of rats with liver constraint and insomnia, and its mechanism may be regulation through the cAMP/PKA signaling pathways mediated by 5-HT1AR in the hippocampus.
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    Effects of Xiaoyao Pill on bone morphogenetic protein 6 and membrane receptors in oocytes of mouse preantral follicles cultured in vitro*
    Sun Xiaohuan, Du Huilan
    2020, 43 (3):  218-224.  doi: 10.3969/j.issn.1006-2157.2020.03.007
    Abstract ( 333 )   PDF (1220KB) ( 72 )   Save
    Objective To observe the effects of Xiaoyao (Free Wanderer) Pill (XYP) on bone morphogenetic protein 6 (BMP6) and membrane receptors in oocytes of mouse preantral follicles cultured in vitro and to explore the potential mechanisms of the intervention by XYP in the quality of oocytes. Methods Twelve female SD rats were randomly divided into four groups: high-, middle- and low-dose XYP groups and control group. XYP suspension (2.7, 1.8 and 0.9 g/kg) were administered to the three XYP groups and the same amount of distilled water was given to the control group respectively for four days. By the end of the intervention, blood was drawn from the femoral artery to obtain rat serum containing XYP from the high-, middle- and low-dose XYP groups and normal serum from the control group. Primary preantral follicles of 60 female Kunming mice aged 12 days were micro-isolated mechanically. They were divided into high-, middle-, low-dose XYP groups and control group and incubated with 10% rat serum containing XYP from the high-, middle- and low-dose XYP rat groups and 10% normal serum from the control rat group respectively for six days. The protein and mRNA expressions of BMP6, BMPRⅡ, ALK2 and ALK6 in the oocytes were detected by cellular immunofluorescence and real-time reverse transcription PCR. Results Compared with the control group, the above protein and mRNA expressions in XYP groups were higher (P<0.05), and those in the high-dose XYP group were the highest (P<0.05). Conclusion XYP may improve the quality of oocytes cultured in vitro by increasing the expressions of BMP6, BMPRⅡ, ALK2, and ALK6 in the oocytes.
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    Effects of Bushen Huatan Quyu Fang on follicular dysgenesis in copper-loaded mice models with hepatolenticular degeneration*
    Han Hui, Lyu Danli, Song Chengwei, Zheng Mingcui, Zhan Min, Xu Jinbo, Wu Limin
    2020, 43 (3):  225-233.  doi: 10.3969/j.issn.1006-2157.2020.03.008
    Abstract ( 354 )   PDF (3486KB) ( 63 )   Save
    Objective To investigate the effect of Bushen Huatan Quyu Fang (kidney-tonifying, phlegm-resolving, and blood-stasis-eliminating formula, BSHTQYF) on follicular dysgenesis in copper-loaded mice and elucidate its underlying mechanism. Methods Female C57 mice were randomly divided into 6 groups: 1) normal group, 2) copper-loaded model group, 3) dimercaptosuccinic acid (DMSA) group, 4) Gandouling (Cure for Hepatolenticular Degeneration) (GDL) group, 5) BSHTQYF group and 6) BSHTQYF+DMSA group, with 20 mice in each group. To establish copper-loaded models, mice were administered with copper sulfate (CuSO4·5H2O) solution (100 mg/kg) by gavage once a day for 28 days while normal saline was given to the normal group. Since the 15th day of copper administration, the DMSA group was treated with DMSA (0.16 g/kg), the GDL group with GDL (1.2 g/kg), the BSHTQYF group with BSHTQYF (1.5 g/kg) and the BSHTQYF+DMSA group with DMSA and BSHTQYF by gavage once a day for 14 days while the normal group and the model group were given normal saline. HCG was injected to induce ovulation and the number of eggs released was counted. Follicular development was observed with hematoxylin-eosin staining. Ultrastructure of mouse cumulus complex was observed with electron microscopy. The expression of cumulus complex granulosa cell Ki67 was observed with immunofluorescence. Results Compared with the normal group, the number of eggs released, the number of normal secondary follicles and antral follicles, the number of normal mitochondria and the expression of Ki67 in granulosa cells in the copper-loaded mice of all the other groups were significantly decreased (P<0.05). Meanwhile, the number of abnormal mitochondria increased significantly in the copper-loaded mice, compared with the normal group(P<0.05). The above parameters were significantly improved in the BSHTQYF group, compared with the model group and the GDL group (P<0.05), and those in the BSHTQYF+DMSA group were significantly better than those in the DMSA group (P<0.05). Conclusion BSHTQYF can increase the number of eggs released by copper-loaded mice, promote the development of follicles in copper-loaded mice, improve the ultrastructure of mitochondria, and enhance the proliferation of cumulus complex granulosa cells.
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    Chinese Medicinal Chemistry
    Comparative analysis of fingerprint and chemical model of Danggui before and after wash with wine*
    Liu Caifeng, Liang Jun, Yang Haiju, Liu Leilei, Zhang Yuming, Bai Jie, Du Shouying
    2020, 43 (3):  234-241.  doi: 10.3969/j.issn.1006-2157.2020.03.009
    Abstract ( 354 )   PDF (2601KB) ( 61 )   Save
    Objective To establish the fingerprint of Danggui (Chinese Angelica, Radix Angelicae Sinensis) with HPLC before and after wash with wine, and make comparative analysis of the principal components, quantitative analysis and extraction rate analysis to provide reference for its quality control. Methods Gradient elution was performed with HPLC with InertSustainSwiftTM C18 (250 mm × 4.6 mm, 5 μm) as the column and acetonitrile-0.1% phosphoric acid solution as the mobile phase. The UV detection wavelength was 230 nm, the volume flow rate was 1 mL/min and the sample size was 15 μL. The fingerprints of Danggui before and after wash with wine were established and compared. Principal component analysis, quantitative analysis and extraction rate analysis were carried out. Results HPLC fingerprints of crude Danggui and wine washed Danggui were established, and 16 common peaks were identified among 30 batches of samples. Fingerprints of 15 batches of Danggui before and after wine wash were compared with the reference fingerprints, revealing similarities greater than 0.9. The similarity of fingerprints between Danggui and wine washed Danggui is also greater than 0.9. In the principal component analysis, the samples before and after wash were gathered together. The contents of ferulic acid in 15 batches of Danggui were evaluated before and after wine wash, showing that the ferulic acid contents in the herbs after wash with wine were lower than those in the crude herbs. At the same time, the 15 batches of crude Danggui had a higher extraction rate than the wine washed Danggui. Conclusion The method established in this study is stable and feasible, providing reference for comparison and contrast of the similarities and differences of Danggui before and after wine wash and for its quality control. Incorporating multiple methods, this study is conducive to comprehensive evaluation of Danggui before and after wine wash.
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    Acupuncture & Moxibustion
    Therapeutic effects of internal warm acupuncture on middle- and late-stage ankylosing spondylitis*
    Wang Junwei, Ou Guofeng, Yuan Puwei, Dong Bo, Yao Jie, Wang Guozhu, Xiao Bin
    2020, 43 (3):  242-247.  doi: 10.3969/j.issn.1006-2157.2020.03.010
    Abstract ( 377 )   PDF (877KB) ( 66 )   Save
    Objective To observe the clinical efficacy and safety of internal warm acupuncture in the treatment of middle-stage and advanced ankylosing spondylitis, and to explore its application prospects. Methods 62 patients with middle-stage and advanced ankylosing spondylitis were divided according to the sequence of their consultations into treatment group treated with internal warm acupuncture and control group given conventional acupuncture treatment with 31 cases in each group. After 8 consecutive weeks of treatment, the main signs and symptoms (thoracic mobility, occiput to wall, finger to ground and Schober’s test), laboratory test results (ESR and CRP), spinal pain VAS scores, Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) of patients in the two groups before and after treatment were observed. Results The main signs and the VAS scores of spinal pain of both groups after treatment were significantly improved compared with those before treatment (P<0.05). There were statistically significant differences between the two groups in terms of occiput to wall, finger to ground, Schober’s test and VAS score (P<0.05), but there was no significant difference in thoracic mobility (P>0.05). After treatment, ESR and CRP of both groups were significantly lower than those before treatment (P<0.05). There was, however, no significant difference in ESR and CRP between the two groups after treatment (P>0.05). There were statistically significant differences in BASFI and BASDAI of both groups before and after treatment (P<0.05), and the treatment group demonstrated better outcome than the control group (P<0.05). Conclusion Both internal warm acupuncture therapy and conventional acupuncture therapy have good clinical efficacy and safety in treating middle-stage and advanced ankylosing spondylitis, but the former produced better curative effect in improving spinal mobility, relieving pain, preventing disability, and slowing progression with satisfying safety and feasibility, thus warranting further investigation and popularization.
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    Clinical Studies
    Prevention and treatment of early interstitial lung disease by dissolving mild blood stasis*
    Gong Xuefeng, Cui Hongsheng, Ren Peizhong, Chen Qiuyi
    2020, 43 (3):  248-251.  doi: 10.3969/j.issn.1006-2157.2020.03.011
    Abstract ( 363 )   PDF (646KB) ( 72 )   Save
    Static blood is the pathological product and pathogenic factor of blood stagnation in the body according to traditional Chinese medicine. Based on clinical practice, the concept of “mild blood stasis” was proposed to denote the early pathological state during the formation of blood stasis, which exists in the initial stage of many diseases. To be specific, mild blood stasis refers to the pathological state in which blood flow is slightly stagnant or blood stasis occurs only in a few unnoticeable places. It is characterized by blood stasis that is tangible but not easily noticed, blood that is stagnant but not yet causing blockage, diseases that are chronic and complication with other pathogenic factors. At the early stage of interstitial lung disease (ILD), as the condition is mild and manifestations of blood stasis are not prominant, harmonizing collaterals to remove blood stasis can produce a satisfactory effect. Therefore, early ILD is believed to be closely related to “mild blood stasis” in that its core pathogenesis is that disharmony between meridians and collaterals, qi stagnation and phlegm coagulation cause mild blood stasis. Clinically, it is manifested as symptoms like cough, shortness of breath and chest oppression, signs like clubbing of the fingers or toes, crackles on auscultation and other signs and changes in medical imaging results. Based on the understanding of mild blood stasis, this paper explores the prevention and treatment of early-stage ILD by harmonizing collaterals to remove blood stasis. Therapies to boost qi, nourish and invigorate blood, rectify qi and dissolve phlegm can be used to regulate lung collaterals, dispel pathogen and remove turbidity so that onset and progression ILD can be prevented. In other words, mild blood stasis can be dissolved to reverse pulmonary interstitial fibrosis progression.
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    Preliminary evaluation of clinical efficacy of Zaizao Shengxue Capsule in treating myelodysplastic syndrome*
    Ding Hao, Zeng Qing, Di Haixia, Luo Meihong, Shen Xiaohui, He Chunling, Tian Shaodan
    2020, 43 (3):  252-258.  doi: 10.3969/j.issn.1006-2157.2020.03.012
    Abstract ( 533 )   PDF (866KB) ( 55 )   Save
    Objective To investigate the clinical efficacy of Zaizao Shengxue (Blood-engendering Renewal) Capsule (ZZSXC) in the treatment of myelodysplastic syndrome. Methods A total of 139 patients who met the diagnostic criteria of Chinese and Western medicine for myelodysplastic syndrome were enrolled according to the principles of randomized multicenter controlled trials. The 103 patients in the treatment group were given 5 ZZSXCs each time, thrice daily. The 36 patients in the control group were given 8 Fufang Zaofan (Compound Zaofan) Pills (FFZFP) each time, thrice daily. The two groups were treated for 3 months. Then their hematological improvements in HI-E, HI-P and HI-N and peripheral blood parameters (HGB, RBC, MCV, PLT, WBC and NEUT) as well as subgroup analysis, TCM pattern and physical sign scores, bleeding, infection, clinical efficacy and safety were evaluated. Results In both the treatment group and the control group, the overall percentages of improvement in such hematological parameters as HI-E, HI-P and HI-N were 51.6% and 38.5%, 44.8% and 40.0%, and 51.0% and 68.2% respectively without statistically significant difference between the two groups (P>0.05). The differences in RBC and HGB of all the patients and the subgroup of low-risk patients in the treatment group before and after treatment were statistically significant (P<0.05). The differences in WBC of the subgroup of high-risk patients in the treatment group before and after treatment were statistically significant (P<0.05). The differences in NEUT of all the patients and the subgroup of low-risk patients in the control group before and after treatment were statistically significant (P<0.05). MCV was decreased of the subgroup of low-risk patients in the treatment group after treatment compared with that before treatment with statistical significance (P<0.05). The percentages of patients that enjoyed marked curative effects and curative effects in terms of TCM patterns in the treatment group and the control group were 29.9% and 30.3%, and 62.1% and 57.6%, respectively, with no statistically significant difference between the two groups (P>0.05). There was no statistically significant difference in curative effects for individual symptoms and signs between the two groups (P>0.05). There was no statistically significant difference in hemostasis, incidence of infection and safety parameters between the two groups (P>0.05). Conclusion Both ZZSXC and FFZFP can improve morbid hematopoiesis and hematological parameters in patients with MDS, and remarkably improve their TCM patterns and individual symptoms and signs with good clinical drug safety.
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    Preliminary study of difference in TCM pattern types between patients with Type I and those with Type II endometrial cancer*
    Chen Huifang, Liu Xiaoli, Xie Wei, Liu Jun, Xue Xiaoou
    2020, 43 (3):  259-264.  doi: 10.3969/j.issn.1006-2157.2020.03.013
    Abstract ( 319 )   PDF (729KB) ( 72 )   Save
    Objective To explore the distribution of TCM patterns in patients with type I endometrial cancer (EC) and those with type II EC and patients’differences in age, endometrial thickness and body mass index (BMI), in order to provide a theoretical basis for the prevention and treatment of endometrial cancer with traditional Chinese medicine. Methods Clinical data of 87 EC patients were retrospectively analyzed, and differences in TCM pattern, age, endometrial thickness and BMI between type I and type II EC patients were identified. Results The 67 patients with type I EC were mainly diagnosed as having the pattern of spleen-kidney yang deficiency, and the 20 patients with type II EC liver-kidney yin deficiency. There was statistically significant difference between the two groups (P<0.05). The average age of type I EC patients who were of or after childbearing age was younger than that of type II EC patients who were all after childbearing age. There was statistically significant difference between the groups (P<0.05). Average preoperative endometrial thickness of patients with type I EC was greater than that of patients with type II EC with statistically significant difference (P<0.05). The percentage of overweight patients with type I EC is higher than that of overweight patients with type II EC and there was statistically significant difference between the two (P<0.05). The percentage of type I EC patients with hypertension, diabetes and dyslipidemia was higher than that of type II EC patients but there was no statistically significant difference between them (P>0.05). Conclusion Type I EC patients mainly suffered from spleen-kidney yang deficiency, while Type II EC patients liver-kidney yin deficiency. There were differences in age, endometrial thickness and BMI between the two groups. Treatment should be tailored to the specific conditions of patients based on pattern differentiation to give full play to the advantages of TCM in the prevention and treatment of EC.
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