Loading...
主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    28 February 2021, Volume 44 Issue 2 Previous Issue    Next Issue
    Voices of Guidance
    Expert Review
    Practical aesthetics of psychosomatic medicine in cultivating both the body and mind
    Wang Yongyan, Wang Hao, Wang Zixu
    2021, 44 (2):  104-107.  doi: 10.3969/j.issn.1006-2157.2021.02.002
    Abstract ( 123 )   PDF (642KB) ( 32 )   Save
    As the original advantages of TCM, “the harmony between the body and mind” and “cultivating both body and mind” embody the holistic view of the principles of Chinese traditional culture. Psychosomatic medicine embodies its practical aesthetics with the idea of cultivating both body and mind and the medical practice, which advocates the beliefs of respecting benevolence and morality, upholding harmony and emphasizing education in traditional Chinese culture. This paper expounds the practical aesthetics of psychosomatic medicine advocating the cultivation of both the body and mind. Firstly, the accumulation of qi forms the body; following the body, shen (mind) generates. The relationship between the body and mind is maintained by “benevolence”, which is the general rule to do a deed. The medical practice of psychosomatic medicine, advocating “the harmony between the body and mind” and “cultivating both body and mind”, embodies the relevance between the body and mind. Secondly, Nourishing shen (mind) requires “keeping a tranquilized mind”, which should be sought in “respect” and cultivating both body and mind. Thirdly, gezhi (studying the nature of phenomena), as one of the carriers of the principles of traditional Chinese culture, guides the understanding of all procedures in TCM diagnosis and treatment by emphasizing “the harmony between the body and mind” and “cultivating both body and mind”. The TCM medical practice, under the guidance of gezhi, reflects the natural beauty of human beings, and the beauty of human nature with physical and mental health, which advocates human relations, respects benevolence and morality, advocates harmony and emphasizes education.
    References | Related Articles | Metrics
    Theoretical Studies
    Relationship between the essence of male reproduction and conception based on “kidney governing reproduction”*
    Shi Zhongyu, Chen Xiaoying, He Changhao, Zhang Xiaomeng, Wang An, Wang Lei, Hu Sumin
    2021, 44 (2):  108-113.  doi: 10.3969/j.issn.1006-2157.2021.02.003
    Abstract ( 135 )   PDF (821KB) ( 46 )   Save
    After thoroughly studying the TCM literature related to the theory of “kidney governing reproduction”, in this paper, the difference between male reproductive essence and kidney essence are analyzed; and based on that, the relationship between male reproductive essence and conception are discussed. The basis of “kidney governing reproduction” is the theory of “kidney storing essence” in visceral manifestation theory, which mainly refers to the kidney’s nature of housing both the innate and acquired essence and essence of zang-fu organs. While the theory of “kidney governing reproduction” is mainly reflected in two aspects. One is the close relationship between the kidney and male reproductive organs; the other is that the kidney can regulate reproductive function of the body by adjusting the essence and qi in the kidney. The differences between the male reproductive essence and kidney essence lie in both their functions and location of storage. Kidney essence, which is stored in the kidney, works to not only nourish and maintain the physiological function of the kidney, but also serves as the material basis for the transformation and generation of male reproductive essence. On the other hand, the male reproductive essence, which of reproductive function and stored in the essence chamber, is to be excreted from the body to join with the female reproductive essence for conception. In a word, the conception and forming of fetus is based on the combination of the male reproductive essence and the female reproductive essence. Therefore, the health of male reproductive essence is a necessary factor for the formation of a fetus, and its abnormality will lead to the deficiency of fetal endowment.
    References | Related Articles | Metrics
    Analysis of “spleen disliking dampness and disgusting dryness”*
    Yuan Yali, Li Xuan, Liu Yong, Niu Xin, Ju Wenxue, Yao Wei
    2021, 44 (2):  114-118.  doi: 10.3969/j.issn.1006-2157.2021.02.004
    Abstract ( 131 )   PDF (731KB) ( 119 )   Save
    “Spleen liking dryness and disliking dampness” is a common understanding among TCM doctors in all dynasties. Despite that, based on an analysis of the physiological functions and pathological characteristics of spleen in TCM, Professor Bai Changchuan, a nationally famous TCM doctor, puts forward the distinct view of “spleen disliking dampness and disgusting dryness”. In this paper, based on a detailed review of the concepts of “spleen yin”, “spleen dampness”, “spleen disliking dampness” and “spleen disliking dryness” and their dialectical relationships, the connotation of “spleen disliking dampness and disgusting dryness” is elaborated. Specifically, it is pointed out that spleen yin can be damaged due to excessive usage of dry medicinals to eliminate dampness, or bitter dry or bitter cold medicinals, or excessive consumption of spicy food, or excessive thinking, together with root-branch middle qi theory. It is suggested that the treatment of spleen disorders should be aimed at smoothing and moistening. This theory will provide reference for improving the visceral manifestation theory of spleen in TCM and guiding clinical practice.
    References | Related Articles | Metrics
    Transformation of modern Chinese medical discourse and its implications: research based on two medical discourse practices of “Integrated Chinese and Western Medicine” and “New Chinese Medicine”
    Xu Yufan
    2021, 44 (2):  119-123.  doi: 10.3969/j.issn.1006-2157.2021.02.005
    Abstract ( 89 )   PDF (812KB) ( 31 )   Save
    In different periods of the integration of Chinese and Western medicine in modern times, Zhang Xichun advocated “Integrated Chinese and Western Medicine” by incorporating Western medicine into the system of traditional Chinese medicine, while Yun Tieqiao suggested the “New Chinese Medicine” based on physiological and pathological standards. This paper selects the theory of exogenous fever in the two medical works for discourse analysis, and identifies three implications behind the difference in medical discourse. Firstly, it represents different emphasis on the absorption and reference of western medicine knowledge. Secondly, it highlights the differences in social structure of different periods and the changes in the strength of the two medical discourses. Thirdly, in different periods of the integration of medicine, modern Chinese medical scientists has changed their attitude from trust to escape about the thinking of traditional Chinese values aided with modern Western ideology, which reveals that medicine has gradually moved from being “traditional” to “modern”.
    References | Related Articles | Metrics
    Textual Research
    A Brief Discussion on Tamba Yuan Jane's YiSheng*
    Shi Shuangwen, Zhang Wenfeng
    2021, 44 (2):  124-127.  doi: 10.3969/j.issn.1006-2157.2021.02.006
    Abstract ( 70 )   PDF (768KB) ( 22 )   Save
    Written by Tamba Yuan Jane, a famous Japanese expert in textual criticism, the book YiSheng gathers his reading experience of over ten years. This paper discusses the background, naming, publication, main contents, textual criticism methods, and academic value of YiSheng, so as to explore and evaluate the academic value of the book, and provide some inspiration and reference for the compilation of ancient books.
    References | Related Articles | Metrics
    Chinese Medicinal Pharmacology
    Effects of astragalus and puerarin on the expression of GRP78, CHOP and PUMA in heart tissues of KKAy mice*
    Che Yu’e, Gao Yushan, Wang Yanfei, Zhang Xiaofeng, Fu Liang, Li Shuyu, Feng Jing, Wu Dan, Shi Changhua, Li Xia, Wang Qian
    2021, 44 (2):  128-133.  doi: 10.3969/j.issn.1006-2157.2021.02.007
    Abstract ( 79 )   PDF (1256KB) ( 120 )   Save
    Objective To investigate the mechanism of astragalus injection combined with puerarin injection in improving the cardiac function of type 2 diabetic(T2DM) KKAy mice by alleviating endoplasmic reticulum stress(ERS) and inhibiting cardiomyocyte apoptosis. Methods 11-week-old KKAy diabetes model male mice were randomly divided into model group and astragalas and puerarin group (astragalus injection 3 mL/kg combined with puerarin injection 1.3 mL/kg) according to their blood sugar. Male C57BL/6J mice of the same age were used as the normal control group. After one week of adaptive feeding, experimental intervention was started at 12 weeks of age, and mice were processed in batches at 20, 24 and 28 weeks of age. The morphological changes of myocardium were observed under electron microscope. RT PCR and Western Blot were used to detect the gene and protein expressions of glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), and p53 up-regulate modulator of apoptosis (PUMA) in heart tissue. Results Transmission electron microscopy showed that the nuclei, endoplasmic reticulum and mitochondria of the model group were swollen; compared with that, those in the astragalus and puerarin group were significantly better. The results of Real-time PCR and Western Blot showed that compared with the normal group, the GRP78 gene and protein expression levels of the 20-, 24-and 28-week-old mice in the model group were significantly higher, and the gene and protein expression of GRP78 in the astragalus and puerarin group were significantly lower than that of the model group (P<0.05). The gene and protein expressions of CHOP and PUMA were increased in the 20-, 24-and 28-week-old mice in the model group, compared with the normal group (P<0.05), and they were both lower in the 24-week-old and 28-week-old astragalus and puerarin groups compared with the model group (P<0.05). Conclusion Astragalus injection combined with puerarin injection seems to have a protective effect on the ultrastructure of diabetic cardiomyocytes. The way it works may be related to alleviating endoplasmic reticulum stress and inhibiting cardiomyocyte apoptosis.
    References | Related Articles | Metrics
    Effects of Rhizoma Coptidis and Cortex Cinnamomi on the intestinal flora, inflammatory factors and short-chain fatty acids in db/db mice*
    Mu Guohua, Zhao Zongjiang, Zhou Jingya, Zhao Jinxi
    2021, 44 (2):  134-142.  doi: 10.3969/j.issn.1006-2157.2021.02.008
    Abstract ( 74 )   PDF (2760KB) ( 35 )   Save
    Objective To study the hypoglycemic effect of Huanglian (coptis, Rhizoma Coptidis) and Rougui (cinnamon bark, Cortex Cinnamomi) on db/db mice, and to explore the mechanism of its effect on the intestinal flora, inflammatory factors and short-chain fatty acids (SCFAs) in db/db mice. Methods Six db/m mice were included in the blank group, and 30 db/db mice were randomly divided into the model group, metformin group, coptis group, cinnamon bark group and coptis and cinnamon bark group (n=6). In the four treatment groups, metformin (0.23g/kg), coptis (18.2g/kg), cinnamon bark (1.82g/kg) and coptis and cinnamon bark were gavaged with the corresponding drugs respectively, and the control group was gavaged with the same amount of normal saline solution. The body weight of each group of mice was measured at week 0 and 8, and the blood glucose was measured at week 0, 4, and 8. The feces of each group of mice were taken at the 8th week for analysis of phylum flora species and species diversity analysis with Illunina MiSeq benchtop sequencer. The content of acetic acid, propionic acid, and n-butyric acid in feces were detected by gas chromatography. The expression of TNF-α and IL-6 in the liver of mice was detected by Western blot. Results The weight gain trend of the mice slowed down and the hyperglycemia state improved in the coptis and cinnamon group, compared with the model group (P<0.01). The abundance of Firmicutes was increased, while that of the Bacteroidetes was decreased in the control group and three treatment groups with Chinese medicinals, compared with the blank group. The abundance of Firmicutes was decreased in the three treatment groups with Chinese medicinals, while the abundance of the Bacteroidetes was increased in the coptis group and cinnamon bark group, compared with the control group and metformin group. Regarding species diversity, there was significant difference between the blank group and control group, similarity between the control group and metformin group, similarity among the coptis group, cinnamon bark group, and blank group, while differences between the coptis and cinnamon bark group and any other group. The abundance curve showed that the abundance and uniformity of the intestinal flora of the three treatment groups were lower than those of the other groups. The content of TNFα in the liver of mice in the control group was significantly higher than that in the blank group (P<0.05), but it was significantly lower in the coptis and cinnamon bark group than that of the control group (P<0.05). The content of IL-6 in the liver of mice in the control group was significantly increased compared with the blank group (P<0.05), but it was significantly lower in all the three treatment groups with Chinese medicinals compared with that of the control group (P<0.05, P<0.01). The contents of acetic acid, propionic acid and butyric acid in SCFAs were significantly increased in the coptis and cinnamon bark group, compared with the control group (P<0.05). The coptis and cinnamon bark group showed a higher mean score compared with the other three treatment groups. Conclusion Huanglian (coptis, Rhizoma Coptidis) and Rougui (cinnamon bark, Cortex Cinnamomi) may help in the prevention and treatment of type 2 diabetes by regulating the intestinal flora, improving the inflammatory response, and increasing the content of SCFAs.
    References | Related Articles | Metrics
    Effect of spleen-fortifying, fire-clearing and collateral-unblocking medicinals on Sonic Hedgehog signaling pathway in rats with chronic atrophic gastritis*
    Li Sihan, Lin Xiuming, Tian Lin, Li Mingzhu, Huang Minghan
    2021, 44 (2):  143-151.  doi: 10.3969/j.issn.1006-2157.2021.02.009
    Abstract ( 64 )   PDF (2322KB) ( 26 )   Save
    Objective To explore the effect of spleen-fortifying, fire-clearing and collateral-unblocking (SFC) medicinals on Sonic Hedgehog signal pathway in rats with chronic atrophic gastritis (CAG). Methods 59 male wistar rats were randomly divided into the control group (n = 16) and model group (n = 43). The CAG model was established by comprehensive modeling method. After that, 3 rats in the model group were randomly selected for gastric pathological examination. After the model was successfully established, the compound gastritis mixture (under the guidance of the SFC method) was given as a representative drug for relevant intervention. Specifically, the control group was randomly divided into blank group, blank + high dose SFC group, while the model group was randomly divided into CAG group, Vitacoenzyme group, low dose, medium dose and high dose SFC groups (n=8). The corresponding drugs were given continuously for 4 weeks. At last, the protein expression levels of Shh, Ptch1, Smo, Gli1, Gli2, Gli3 and Sufu in gastric tissue and the concentration of IL-1 β and GAS in serum were measured. Results In the model group, the expression of Shh, Ptch1, Smo, Gli1 protein and the level of serum GAS decreased, while the expression of Gli2, Gli3, Sufu protein and the level of serum IL-1β increased (P<0.05, P<0.01). Compared with the CAG group, the pathological changes of gastric mucosa in the low, middle and high dose SFC groups were significantly improved, the expression of Shh, Ptch1, Smo and Gli1 protein increased, and the expression of Gli2, Gli3, Sufu protein and the level of serum IL-1β decreased (P<0.05, P<0.01). The level of serum GAS in middle and high dose SFC groups increased significantly (P<0.05). Conclusion SFC method could possibly improve the pathological changes of CAG in rats, and its mechanism may be related to improving the contents of serum IL-1β and GAS and reactivating the expression of Sonic Hedgehog signal pathway.
    References | Related Articles | Metrics
    Mechanism of dampness-resolving kidney-tonifying method in cartilage repair in rats with knee osteoarthritis*
    Ge Haiya, Zhang Yingsheng, Lu Wenya, Geng Qiudong, Qin Juanyu, Liu Dongbo, Wang Heming, Li Nan
    2021, 44 (2):  152-158.  doi: 10.3969/j.issn.1006-2157.2021.02.010
    Abstract ( 51 )   PDF (1693KB) ( 17 )   Save
    Objective To preliminarily explore the mechanism of treating knee osteoarthritis (KOA) by dampness-resolving kidney-tonifying method. Methods 40 SPF SD rats were randomly divided into blank group, model group, dampness-resolving pain-relieving decoction (DP) group, Guilu Erxian (GE) group, and dampness-resolving kidney-tonifying (DK) group (n=8). The model of osteoarthritis was established by injecting papain into the articular dise. After successfully establishing the model, rats in the DP group, GE group and DK group were gavaged with DP decoction 4.68 g/(kg·d), GE decoction 2.7 g/(kg·d) and DK decoction 7.38 g/(kg·d) respectively for 28 days in succession, and the blank group and model group were gavaged with an equal amount of normal saline solution. After 28 days, the cartilage of right femur was taken for morphologic observation with HE staining. The expression of PGE, COX2, IL-1β and TNF-α in synovium and synovial fluid of right tibial plateau were observed with ELISA. The expression of p38, p53 and type Ⅱ collagen of right tibial plateau were detected with PCR. Results The pathological morphologic changes of articular cartilage observed with HE staining showed better results in the DK group, GE group and DP group compared with the model group. The expression of PGE-2, COX-2 and IL-1beta were decreased in various degrees in the DK group compared with the GE group (P<0.05). In the DK group, the expression of p38 and p53 in the cartilage was decreased, while the expression of type II collagen was increased compared with the GE group (P<0.05). Conclusion Dampness-resolving kidney-tonifying method seems to effectively reduce the expression of inflammatory factors in synovium and synovial fluid, promote the anabolism of chondrocytes, and inhibit the apoptosis of chondrocytes, thus promoting the repair of articular cartilage, and delaying the process of KOA.
    References | Related Articles | Metrics
    Science & Technology Theme
    Study on factors affecting the quality of life in patients with chronic heart failure*
    Tan Nannan, Zhang Yili, Du Kangjia, Yang Shuangjie, Wang Juan, Zhao Huihui, Wang Wei
    2021, 44 (2):  159-164.  doi: 10.3969/j.issn.1006-2157.2021.02.011
    Abstract ( 83 )   PDF (747KB) ( 28 )   Save
    Objective To explore the influencing factors related to the quality of life in patients with chronic heart failure (CHF), and provide a reference basis for the prevention and care of such patients. Methods The information of 182 patients who visited Guang'anmen Hospital of China Academy of Chinese Medical Sciences, Dongfang Hospital of Beijing University of Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine and other hospitals during 2010-2012 were selected to construct a database, and statistical analysis such as frequency, difference analysis and multiple regression were performed with SPSS 23.0 software. Results The effect of different factors on the scores in different dimensions of the SF-36 scale showed that gender had a significant effect on physical functioning (P=0.015), vitality (P=0.007), mental health (P=0.017), and social functioning (P=0.020); age had an effect on physical functioning (P=0.013), role-physical (P=0.02), and role-emotional (P=0.007); education level had an influence on physical functioning (P<0.001), vitality (P=0.019), role-emotional (P<0.001) and social functioning (P<0.001); spicy diet had an impact on physical functioning (P=0.01) and general health (P=0.01); exercise frequency had an impact on physical function (P=0.004), role-physical (P=0.039), role-emotional (P=0.006), mental health (P=0.001) and social functioning (P=0.005); whether taking TCM decoction had an impact on general health (P=0.048). The univariate analysis of the total score of the SF-36 scale by different factors showed gender (P=0.007), age (P=0.006), education level (P<0.001), salty diet (P=0.036) and exercise frequency (P=0.006) affected the total score; the results of multivariate analysis showed that education level was positively correlated with the total score (P=0.003, coefficient=7.368). Conclusion Gender, age, different dietary habits, education, and comorbidities could possibly affect the quality of life in patients with chronic heart failure.
    References | Related Articles | Metrics
    Distribution of six-qi endowment in patients with depressive disorder*
    Wang Mengqi, Wang Ranran, Zheng Ruoyun, He Juan
    2021, 44 (2):  165-170.  doi: 10.3969/j.issn.1006-2157.2021.02.012
    Abstract ( 67 )   PDF (726KB) ( 14 )   Save
    Objective To study the characteristics of six-qi distribution in patients with depressive disorder in terms of birth and conception time. Methods A total of 6,818 patients with depressive disorder in 3 hospitals of mental diseases in Henan, Shandong and Beijing were selected as the study group, and 38,867 non-depressed patients at Dongzhimen Hospital in Beijing were used as the control group. Statistical description, chi-square test and binary logistic regression were used to compare the differences in the distribution of six-qi endowment judging from birth and conception time. Results Patients with depressive disorder were more likely to be conceived in the second half year, especially in the year of Chou and Wei (Years of the Ox and Goat), with a statistical difference compared with the control group (P<0.05). Conclusion There is probably a correlation between the susceptibility to depressive disorder and the characteristics of six-qi endowment at conception time.
    References | Related Articles | Metrics
    Clinical Studies
    Analysis of correct and incorrect diagnosis and treatment of epidemic diseases in ancient medical records*
    Dong Fei, Liu Hongliang, Li Feng, Zhao Yansong, Liu Tiegang, Gu Xiaohong
    2021, 44 (2):  171-176.  doi: 10.3969/j.issn.1006-2157.2021.02.013
    Abstract ( 76 )   PDF (1046KB) ( 23 )   Save
    Based on the medical records of epidemic diseases in ancient books, this paper discusses the correct and incorrect diagnosis and treatment of epidemic diseases. Specifically, relevant aspects are discussed including judgment of the nature of the epidemic disease, differentiation of the true and false cold and heat of the pattern, the misuse of cold medicinals, or pungent-warm medicinals to induce sweating, or tonifying medicinals in the treatment of warm-damp epidemic diseases as well as how to avoid treating a serious condition with mild medicinals, how to clearly identify the true and false nature of the disease, and how to reasonable understand “bold and moderate use of drastic medicinals to save life”, etc. Combined with analysis of relevant modern researches, this article aims to provide reference for the diagnosis and treatment of COVID-19.
    References | Related Articles | Metrics
    Inspection of facial shape and motility in Huangdi Neijing and its further application*
    Han Pengpeng, Wang Tianfang, Lyu Hongpeng, Xie Haotian, Xue Peiwen, Zhang Jing, Li Ning
    2021, 44 (2):  177-182.  doi: 10.3969/j.issn.1006-2157.2021.02.014
    Abstract ( 71 )   PDF (915KB) ( 31 )   Save
    This article includes a systematical review of the correspondence between facial area distribution and zang-fu organs and tissues of the human body, and an outline of the inspection of facial shape and motility in Huangdi Neijing (The Yellow Emperor’s Inner Classic). Based on that, it’s further analyzed its application in diagnosing disease, predicting prognosis, differentiating constitution and judging lifespan. Besides, the study also combines with related modern researches to investigate the application of such theories of facial shape and motility, thus providing references for further research and clinical application in the future.
    References | Related Articles | Metrics
    Pathogenesis and treatment of tumors from the perspective of “transformation between healthy qi and pathogenic qi”*
    Liu Yan, Wu Yaosong, Liu Jun, Jiang Shihong, Yang Tiezhu, Ren Shanshan, Chen Yulong
    2021, 44 (2):  183-187.  doi: 10.3969/j.issn.1006-2157.2021.02.015
    Abstract ( 67 )   PDF (696KB) ( 26 )   Save
    Based on an analysis of “transformation between healthy qi and pathogenic qi” discussed in literatures, this paper points out that “e qi” (evil qi) seems to be the key factor of tumor occurrence. “E qi” is transformed from “pathogenic qi” lurked within the body, which is transformed from disharmonious healthy qi. “E qi” diffuses, fumigates, and fills the body, providing a ‘hotbed’ for tumor formation, which is similar to the concept of “tumor microenvironment” in modern medicine. In treatment of tumors, harmonize the discordant and promote qi movement, thus turning the pathogenic qi back to healthy qi to dissipate the ‘e qi’. Through interpreting the mechanism of ‘e qi’ based on the transformation of healthy qi and pathogenic qi, we can better explain the etiology and pathogenesis of tumors in TCM and guide clinical treatment. By correlating the theory of ‘e qi’ with the tumor microenvironment, we hope to reveal the connotation of ‘e qi’ in the cellular and molecular level, and provide references for the modernization of TCM theories.
    References | Related Articles | Metrics
    Application of “treating disease in the upper part of the body by managing the lower” in treatment of esophageal cancer*
    Duan Hairui, Liu Peimin
    2021, 44 (2):  188-192.  doi: 10.3969/j.issn.1006-2157.2021.02.016
    Abstract ( 64 )   PDF (839KB) ( 96 )   Save
    Due to its high morbidity rate and mortality, esophageal cancer remains a common disease in China with heavy burden on society. Although the name of “esophageal cancer” is not clearly recorded in traditional Chinese medicine, its main symptom of progressive dysphagia coincides with the disease of Yege (dysphagia) in TCM, therefore corresponding treatment methods can be referred to. The method of “treating disease in the upper part of the body by managing the lower” was firstly recorded in Huangdi Neijing (Huangdi’s Internal Classic). Under the guidance of the holism concept, this method is built based on the relationship between the viscera, channels and the movement of qi and blood. Although esophageal cancer mainly involves the esophagus in the upper part of the body, its pathogenesis is closely related to dysfunction of the liver, spleen and kidney in the lower part of the body. This theory has also been elaborated on and supported with evidence in related literature and modern researches, so it has the potential to provide new ideas for TCM treatment of esophageal cancer.
    References | Related Articles | Metrics