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主 办:北 京 中 医 药 大 学
ISSN 1006-2157 CN 11-3574/R

Table of Content

    30 July 2021, Volume 44 Issue 7 Previous Issue    Next Issue
    Expert Commentary
    Overview of the traditional elements of Chinese scientific and technological civilization on elderly brain health
    Wang Yongyan, Wang Zixu, Wang Lei, Bai Weiguo
    2021, 44 (7):  581-584.  doi: 10.3969/j.issn.1006-2157.2021.07.001
    Abstract ( 157 )   PDF (695KB) ( 90 )   Save
    In this century, the emerging Law of Conservation of Information has a great influence on the evolution of scientific and technological civilization, which enlightens us to view scientific and technological civilization from the historical perspective. By tracing the origin of the research on brain health of the elderly and reviewing the elements of traditional civilization, this paper explains the cognition, understanding and interpretation of brain and brain health in Chinese traditional culture, which embodies the great wisdom of Chinese people. It advocates that the maintenance of brain health relies on to maintaining peaceful mind through sincerity and respect, and conforming to natural laws.The elderly should understand the natural law of birth, ageing, sickness and death and treating disease before its onset, adjust the balance of body and mind, and pursuespiritual thinking. It is clarified that early intervention of cognitive disorders is the key to the prevention and treatment of senile dementia, where traditional Chinese medicine can play a unique advantageous role, and the key to preventing and treating dementia is to delay the plateau period. The elderly with early mild cognitive impairment need to purify their mind through their own awareness of the living state, to respect sincerity and goodness,while cooperating with empathetic treatment by the medical staff and comfort of their families, so as to achieve the purpose of regulating health care, delaying the plateau period and preventing senile dermentia.
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    Theoretical Studies
    Study on eight trigrams-zangfu corresponding system based on image thinking of I-ching*
    Li Honghai, Han Qi, Ma Yuexiang
    2021, 44 (7):  585-590.  doi: 10.3969/j.issn.1006-2157.2021.07.002
    Abstract ( 195 )   PDF (778KB) ( 636 )   Save
    Eight trigrams-zangfu system has been used by many TCM doctors since ancient times. It plays a unique advantageous role in the interpretation of visceral manifestation and pathology. However, there still exist disputes and incompleteness in its specific corresponding relations. For example, Luo Dingchang, a doctor in the Qing Dynasty, thought that lung corresponds to Qian hexagram. Sun Yikui in the Ming Dynasty, however, held that Dui is the corresponding hexagram.Meanwhile, Zheng Qin'an in the Qing Dynasty, mainly discussed the heart and kidney from the two hexagrams of Li and Kan. As a result, the theory of eight trigrams-zangfu has not formed a unified and systematic corresponding system. Therefore, our team combined literature review and theoretical discussion in studying the relevant contents of I-Ching (The Book of Changes in Zhou Dynasty), the TCM-Zhouyi theory, and the basic theory of TCM by using the image-number thinking in I-Ching. Based on the acquired eight trigrams, diction, shape, image and nature related to the physiological and functional characteristics of each viscera, we concluded that the correspondence of eight trigrams-zangfu system is as follows by using the thinking methods of image classification and image-number relation: Zhen corresponds to liver, gallbladder; Xun, liver; Li, heart, small intestine, pericardium; Kun, spleen, small intestine, bladder,triple energizer; Dui, lung, large intestine; Qian, lung; Kan, kidney, bladder,triple energizer; Gen, spleen, stomach, large intestine, gallbladder. And their corresponding relations are refined to the specific functions of zang-fu organs. It is hoped that the analysis and summary of the eight trigrams-zangfu corresponding system will be helpful to the development and research, and inheritance of TCM-Zhouyi theory and visceral manifestation theory, which can provide theoretical reference for clinical practice.
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    A preliminary study on the reduction and reconstruction of the yin-yang mechanism of circadian rhythm*
    Liu Yingchao, Li Yi, Wu Dan, Zhou Liang, Zhang Siqi, He Zixuan, Dong Yiqun, Jiao Zhihua, Bao Chunling, Dong Guirong
    2021, 44 (7):  591-596.  doi: 10.3969/j.issn.1006-2157.2021.07.003
    Abstract ( 121 )   PDF (973KB) ( 59 )   Save
    Circadian rhythm, also known as biological rhythm or biological clock, is the circadian activity of life with a cycle of about 24 hours. Western medicine uses genes and proteins to explain the molecular mechanism of biorhythm, while traditional Chinese medicine, since ancient times, has been elaborating the sleep-wake mechanism with theories such as yin-yang conversion and defense qi entering yin and exiting yang. Through restoring and reconstructing Taiji diagram, extreme yin turning into yang, extreme yang turning into yin, defense qi circadian regulation, to explain the new yin-yang mechanisms of the circadian rhythm, we can find the waning and waxing of yin-yang and genes oscillation, the unity of opposites and negative feedback regulation, defense qi movement and the biological clock positioning are interoperable. Circadian rhythm is of great significance to the in-depth understanding of the principle of life and the solution of health problems, with unknown mysteries and broad prospects. Learning and researching the wisdom of Chinese medicine for thousands of years can provide guidance and inspiration for the present generation.
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    Discussion on the classification of Taiyang disorders*
    Ma Yujie, Cheng Yin, Song Changheng, Zhang Zhiguo
    2021, 44 (7):  597-604.  doi: 10.3969/j.issn.1006-2157.2021.07.004
    Abstract ( 124 )   PDF (845KB) ( 63 )   Save
    The controversies on the classification of Taiyang disorders in Shanghan Lun(Treatise on Cold-Induced Diseases) were reviewed in this paper. Taiyang disorders refer to a series of patterns resulting from pathogenic factors that invade the exterior fighting with healthy qi. The relationships between Taiyang disorders and warm diseases, between warm diseases and wind-warm diseases, as well as between Taiyang disorders and convulsion, dampness and summer-heat diseases were also discussed in this paper. Warm diseases is included in Taiyang disorders and should be treated with Baihu Tang (White Tiger Formula); wind-warm disease is a kind of warm disease caused by improper sweating;convulsion, dampness and summer disease all fall into the category of Taiyang disorders. At the same time, based on the nature of pathogenic factors and the constitution of the patients, Taiyang disorders were reclassified in this article into wind attack, cold damage, convulsion, dampness attack, summer attack, warm disease and wind edema. Besides, the main herbs for different types of Taiyang disorder were explored. Mahuang (ephedra, HerbaEphedrae), Shigao (gypsum, Gypsum Fibrosum) and Huangqi (astragalus root, Radix Astragali) were for exterior pattern, while Guizhi (cassia twig, Ramulus Cinnamomi), Gegen (pueraria root, Radix Puerariae Lobatae), Gualougen (snakegourd root, Radix Trichosanthis), Baizhu (white atractylodes rhizome, Rhizoma Atractylodis Macrocephalae), and Fangji (four stamen stephania root, Radix Stephaniae Tetrandrae) were for treating both the exterior and interior, which can act in the exterior through proper combination.Finally, the causes of the controversies on the classification of Taiyang disorders were analyzed based on the formation of Treatise on Cold-Induced Diseases, and the limitations of general symptoms for Taiyang disorderswere discussed.
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    Chinese Medicinal Pharmacology
    Protective effects of Tanhuo Formula on neuroglial cells and cerebral perfusion in rats with cerebral ischemia*
    Li Mingcong, Zhao Ting, Zhao Hui, Feng Xuefeng, Lu Yun, Yang Le, Zhan Yu, Gao Li
    2021, 44 (7):  605-614.  doi: 10.3969/j.issn.1006-2157.2021.07.005
    Abstract ( 91 )   PDF (1682KB) ( 38 )   Save
    Objective To observe the pharmacological effects and mechanism of Tanhuo Formula(THF) on protecting neuroglial cells and improving cerebral perfusion in rats with cerebral ischemia. Methods Cerebral ischemia model was induced by right middle cerebral artery occlusion. Rats were randomly divided into sham group, model group, three THF groups (high-dose: 3.68 g/kg, mid-dose: 1.84 g/kg, low-dose: 0.92 g/kg), and ginaton group (0.06 g/kg) by using random sequence table. Neurological deficit score was used to evaluate the degree of neurological deficit in cerebral ischemia rats. T2-weighted imaging (T2WI) was used to measure the infarct volume in cerebral ischemia rats. Three-dimensional time-of-flight magnetic resonance angiography (3D-TOF MRA) was used to observe intracranial vascular signals in rats. Arterial spin labeling (ASL) was used to analyze the changes of blood perfusion in injured brain regions. Neuronal specific nuclear protein (NeuN) and 2'3'-cyclic nucleotide 3'-phosphodiesterase(CNPase) immunofluorescence staining were used to observe the damage to neurons and oligodendrocytes. Results Compared with the model group, the neurological deficits scores of rats in the high-dose THF group with cerebral ischemia for 24, 48 and 72 h were reduced (P< 0.05, P< 0.01); the scores of neurological deficits of rats in the mid-dose and low-dose THF groups were also lower than those in the model group with cerebral ischemia for 48 and 72 h (P< 0.05). Compared with the model group, the infarct volume of rats in the THF high-dose group was reduced (P<0.05). Compared with the sham group, the right anterior cerebral artery (ACA) and the right anterior communicating artery (AComA) signals in the model group were lower (P< 0.01). compared with the model group, the relative signal intensity of the right side of the AComA in each treatment group and ginaton group was enhanced (P< 0.01). Compared with the model group, the relative cerebral blood flow (rCBF) in the infarct of the rats increased in the ginaton group (P<0.05) ,while rCBF in the cortext surrounding the infarct increased in the three THF groups and ginaton group (P<0.01). Immunofluorescence staining results showed that the positive expressions of NeuN and CNPase in the cortex surrounding the infarct of the model group were lower than those in the sham group (P<0.05,P<0.01); the positive expressions in the cortex surrounding the infarct of NeuN and CNPase in the high-dose THF group and ginaton group were higher than those in the model group (P<0.05, P<0.01); Mid-dose THF also increased the positive expression of CNPase in the cortex surrounding the infarct (P< 0.05). Conclusion THF can improve the symptom of neurological deficits, reduce the volume of infarction, increase the cerebral perfusion, protect neuron and oligodendrocytes from injury in rats with cerebral ischemia.
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    Effects of Liqi Tongbian Formula on brain-gut peptides in rats with functional constipation of qi stagnation pattern*
    Tang Shuihua, Li Sihan, Lin Xiangying, Ke Xiao, Ke Minhui, Huang Minghan, Yang Chunbo
    2021, 44 (7):  615-624.  doi: 10.3969/j.issn.1006-2157.2021.07.006
    Abstract ( 87 )   PDF (1011KB) ( 32 )   Save
    Objective To explore the mechanism of Liqi Tongbian Formula (Qi-regulating Bowel-opening Decoction, LQTBF) in the treatment of functional constipation (FC). Methods Rat FC models with qi stagnation pattern were established by using intragastric gavage of compound diphenoxylate and tail-clamping irritation. The rat models were randomly divided (Random Number Table) into blank group, model group, mosapride group(2 mg/kg), low-dose LQTBF(5.15 g/kg), mid-dose LQTBF group(10.3 g/kg), and high-dose LQTBF group(20.6 g/kg) (n=8 in each group) and received intervention for 14 continuous days. The general condition, time to first black bowel movement after intragastric gavage of ink, and the dry and wet weight of feces in each group of rats were evaluated. The levels of 5-HT, VIP and NE in the serum were detected by using ELISA. The mRNA expression of SP and CRF in rat colon tissue was measured with real time PCR. The expression of SP and CRF protein in colon tissue was measured with Western blot assay. Results Before treatment, compared with the blank group, time to first black bowel movement in the model group and interventional groups was prolonged (P< 0.01), and the fecal moisture content was lowered (P< 0.01). After 7 days of treatment, compared with the model group, time to the first black bowel movement in each treatment group was shortened (P< 0.05, P< 0.01), and the fecal moisture content in the high-dose LQTBF group was increased (P< 0.05). After 14 days of treatment, compared with the model group, time to first black bowel movement in each treatment group was shortened (P< 0.01); The fecal water content of rats in mosapride group and mid-dose, high-dose LQTBF groups increased (P< 0.05, P< 0.01); Compared with Mosapride group, time to first black bowel movement in the high-dose group was shortened (P< 0.05). After 14 days of treatment, compared with the blank group, the content of 5-HT in the model group, mosapride group and LQTBF groups were decreased (P< 0.05, P< 0.01). The content of NE in model group, mosapride group and low-dose LQTBF group increased (P< 0.01), while the content of NE in high-dose LQTBF group decreased (P< 0.01). The content of VIP in model group, mosapride group and LQTBF groups increased (P< 0.05, P< 0.01). The expression levels of SP, CRF mRNA and SP protein in model group, mosapride group and low-dose LQTBF group were decreased (P< 0.05, P< 0.01), the expression levels of SP protein in mid-dose and high-dose LQTBF groups were increased (P< 0.05, P< 0.01), and the expression levels of CRF protein in model group, mosapride group and LQTBF groups were decreased (P< 0.05, P< 0.01); Compared with the model group, the content of 5-HT in mosapride group and each dose group of LQTBF formula was increased (P< 0.01). the content of NE in mosapride group and middle and high dose groups of LQTBF formula was decreased (P< 0.01), and the content of VIP in mosapride group and LQTBF groups was decreased (P< 0.01). The expression levels of SP mRNA and SP protein were increased in mid-dose and high-dose LQTBF groups (P< 0.05, P< 0.01), and the expression levels of CRF mRNA and CRF protein were increased in all LQTBF groups (P< 0.05, P< 0.01). The expression of SP protein decreased in low-dose LQTBF group (P< 0.01); Compared with mosapride group, the contents of NE and VIP in low-dose LQTBF group were increased (P< 0.01). In the middle dose LQTBF group, the content of NE were decreased (P< 0.01), and the content of VIP were increased (P< 0.05). The contents of NE and VIP in high-dose LQTBF group were decreased (P< 0.05, P< 0.01). the content of 5-HT, the expression levels of SP mRNA and SP protein in middle and high-dose LQTBF groups were increased (P< 0.01). the expression levels of CRF mRNA and protein were increased (P< 0.05, P< 0.01). Conclusion LQTBF could improve gastrointestinal motility and intestinal water metabolism in rats. Its mechanism may be related to regulating the secretion of brain-gut peptides.
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    Clinical Studies
    TCM pathogenesis of early neurological deterioration in acute ischemic stroke based on the theory of toxin and Xuanfu*
    Kang Ligaoge, Kong Lingbo, Gao Ying
    2021, 44 (7):  625-630.  doi: 10.3969/j.issn.1006-2157.2021.07.007
    Abstract ( 90 )   PDF (762KB) ( 31 )   Save
    The high disability and mortality rates of acute ischemic stroke have brought great burden to human beings and society. As an important factor causing adverse prognosis, early neurological deterioration has become one of research hotspots in modern medicine.Traditional Chinese medicine (TCM) has long recognized the deterioration of early neurological function, but there is still a lack of systematic theoretical explanation.As important theories of stroke pathogenesis, the theories of “toxin damaging the brain collateral” and “failure open and close of Xuanfu” can also provide theoretical support for the occurrence and development of early neurological deterioration in acute ischemic stroke. Because of its attachment, fierceness, turbidity, transforming and other characteristics, toxin can derive from wind, fire, phlegm, blood stasis and deficiency, and damage the body, which has a wide impact on the function of Xuanfu. As the smallest portal of the circulation of qi and blood in the human body, Xuanfu is widely distributed. Under the influence of toxin, the opening and closing function of Xuanfu and other viscera's functions will be seriously affected, causing the deterioration of acute ischemic stroke in acute stage. The explanation based on TCM theory of early neurological deterioration is helpful to further improve the treatment of acute ischemic stroke with TCM, and to better play the important role of TCM in disease prevention and rehabilitation.
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    “Pivot movement” theory and treatment of postpartum depression based on pattern differentiation*
    Qu Miao, Sun Wenjun, Tang Qisheng
    2021, 44 (7):  631-634.  doi: 10.3969/j.issn.1006-2157.2021.07.008
    Abstract ( 91 )   PDF (574KB) ( 29 )   Save
    The academic statement of “earth as Pivot of Four Elements” was put forward by Huang Yuanyu in Sisheng Xinyuan (Elaboration of Writings of the Four Medical Sages). Huang raised that the spleen and stomach were the pivot, which governed yin, yang, ascending, descending, floating and sinking. Yin and yang moved around each other, and “pivot movement” theory was thus formed. He emphasized that spleen qi was the pivot of the ascending and descending of qi, which can regulate the five emotions. And the ascending of liver qi could arouse the mind, which became a great inspiration for later practitioners to distinguish and treat mental diseases. Postpartum depression belongs to mental disease in traditional Chinese medicine. This paper discussed the diagnosis and treatment of postpartum depression from the perspective of “pivot movement” theory, stating deficiency of qi and blood and the descending of liver and spleen qi as the basic pathogenesis, Using tonifying qi and blood and ascending liver and spleen qi as the therapeutic principle, and following the idea of “medicine pescribed should target at middle qi” as the apprach to making prescriptions. That may provide another ideas for clinical practice.
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    Clinical Studies
    Analysis on the principle of abdominal vibration massage in the treatment of meridian tendon disease*
    Zhou Kelin, Dong Shuo, Wei Peidong, Guo Sheng
    2021, 44 (7):  635-640.  doi: 10.3969/j.issn.1006-2157.2021.07.009
    Abstract ( 70 )   PDF (694KB) ( 38 )   Save
    In the chapter Jingjin(Muscles of the Channels) of Lingshu(Spiritual Pivot), the disease of tendons is divided into spasm and flaccidity, which are caused by cold and damp heat pathogenic factors, and can be treated by “swift insertion of heated needles”. Modern studies have found that impediment syndrome, diseases of limbs and muscles and tendons-related diseases of multiple systems and viscera all belong to the category of tendon diseases; and it is believed that abdominal vibration massage has a good therapeutic effect. On the basis of pattern identification and treatment in TCM, the abdominal vibration massage is used by supplementation and draining to treat the diseases. Considering the causes and pathogenesis of spasm and flaccidity, the main treating methods are to activate yang qi, dispel dampness and purge heat. Abdominal massage techniques, such as vibrating, rolling, rubbing, pushing and holding, can not only stimulate the abdominal meridians and acupoints centered on the Shenque point,but also adjust the functions of viscera, invigorate yang qi,strengthen spleen and resolve dampness, harmonize qi and blood, dredge meridians and collaterals, and distribute nutrition, to eliminate the cause of tendon diseases, warm and nourish tendons, and restore their physiological state and function. Moreover, the simultaneous treatment of tendons and bones and the local relaxation of tendons help to achieve straightened bones and softened tendons and improve the muscle tension and muscle strength, so as to relieve the symptoms of spasm and flaccidity.
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    Efficacy of Fuzheng Jiedu Formula in children with continuous or chronic immune thrombocytopenia and pattern of qi failing to control blood*
    Hu Miao, Yu Huiping, Xu You, Yang Jianfeng, Zhang Xiaoqian, Li Jing, Chen Na, Xu Xuexue, Wang Yue
    2021, 44 (7):  641-649.  doi: 10.3969/j.issn.1006-2157.2021.07.010
    Abstract ( 83 )   PDF (1007KB) ( 41 )   Save
    Objective To study the clinical efficacy and safety of Fuzheng Jiedu Formula (Reinforcing Healthy Qi and Removing Toxin Granules, FZJDF) in children who suffer fromcontinuous or chronic immune thrombocytopenia with pattern of qi failing to control blood. Methods 120 children who suffer from continuous or chronic immune thrombocytopenia with pattern of qi failing to control blood were selected from the outpatients of Professor Yu Huiping in Dongzhimen Hospital of Beijing University of Chinese Medicine from February 2017 to September 2020. They were randomly divided into experimental group (n=60) and control group (n=60) according to the time sequence. Patients in both groups were given multi-vitamin tablets and compound rutin tablets. The experimental group was additionally given FZJDF, and the control group was given the placebo (the simulant granule of FZJDF). Two groups were daily treated with one prescription divided into two doses, one in the morning and one in the afternoon, and the treatment course was 6 months. The total effective rate, TCM pattern effetiveness, platelet count, TCM pattern scores, haemorrhage grading and adverse reactions of the two groups were compared before and 6 months after treatment. Results The total effective rate was 63.33% in the experimental group and 13.16% in the control group after the treatment for 6 months. The difference was statistically significant (P<0.01). The effective rate of TCM pattern was 96.67% in the experimental group and 50.00% in the control group. The differenceswere statistically significant (P<0.01). Comparing with before treatment, the efficacy of improving platelet count in the experimental group was increased after the treatment for 1,3,6 months, The difference was statistically significant(P<0.01). TCM pattern scores (primary and secondary symptoms) of patients were both reduced after treatment in two groups compared with those before treatment (P<0.05, P<0.01). At six months after treatment, TCM pattern scores (primary and secondary symptoms) of patients in the experiment group were all lower than those in the control group (P<0.01). Comparing the haemorrhage grade scale of two groups, the total improvement rate of the experimental group was 98.33% and it was better than that (55.26%)in the control group. The difference was statistically significant (P<0.01). Conclusion FZJDF demonstrates its benefits for children who suffer from continuous or chronic immune thrombocytopenic purpura with pattern of qi failing to control blood. It can increase the platelet count with high safety profile.
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    Clinical effect of Peiyuan Xiaozheng Formula on bone pain in patients with stage 5 chronic kidney disease on dialysis complicated with mineral and bone disorder*
    Liu Hong, Xiong Weijian, Luo Haoxuan, Long Mei, Ding Weisen, Li Ying, Zhong Jin
    2021, 44 (7):  650-658.  doi: 10.3969/j.issn.1006-2157.2021.07.011
    Abstract ( 67 )   PDF (987KB) ( 24 )   Save
    Objective To study clinical effect of Peiyuan Xiaozheng Formula (Original Qi-Nourishing and Abdominal Mass-Eliminating Formula, PYXZF) on bone pain in patients at chronic kidney disease stage 5 dialysis (CKD 5D) complicated with chronic kidney disease-mineral and bone disorder (CKD-MBD), presenting the patterns of spleen-kidney deficiency and toxin stasis. Methods A total of 76 CKD 5D patients complicated with CKD-MBD bone pain, presenting patterns of spleen kidney deficiency and toxin stasis, were selected from hemodialysis center of Chongqing Hospital of Traditional Chinese Medicine from October 2018 to May 2020.They were randomly divided into control group (CG) (n=30) and experimental group (EG) (n=46). In 12 weeks, CG was given symptomatic treatment, while EG was given an additional PYXZF. The changes of traditional Chinese medical (TCM) pattern scores, visual analogue scale (VAS), serum calcium (Ca), phosphorus (P), parathyroid hormone (iPTH) and serum bone specific alkaline phosphatase (BAP) were observed before treatment, as well as after treatment. Results The total effective rates of CG and EG were 60.71% and 90.9% respectively. The clinical efficacy of EG was better than that of CG (P<0.01). After treatment, the scores of pattern in EG were significantly lower than those before treatment (P< 0.05,P<0.01). The scores of edema, lack of appetite, loose stool, nausea and vomiting, heavy cumbersome limbs, chest pain and wheezing, pruritus in CG were decreased (P<0.05,P<0.01). Compared with those before treatment, VAS scores of EG decreased after 8 weeks and 12 weeks of treatment (P<0.05, P<0.01). The VAS scores of CG decreased after 12 weeks of treatment (P<0.05). Compared with that before treatment, serum Ca in EG was increased (P<0.01), and serum P, BAP and iPTH were decreased (P<0.05,P<0.01) after 8 weeks of treatment. Furthermore, serum Ca still was increased (P<0.01), and serum P, BAP and iPTH were decreased (P<0.01) in EG after 12 weeks of treatment. Serum Ca of CG was increased (P<0.05), serum P, BAP and iPTH were decreased (P<0.05) after 12 weeks of treatment. Conclusion PYXZF can effectively improve CKD-MBD bone pain in CKD 5D patients. The mechanism may be related to the regulation of abnormal mineral and bone metabolism and the improvement of excessive bone turnover caused by secondary hyperparathyroidism.
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    Acupuncture and Moxibustion
    A clinical study of interactive scalp acupuncture on cognition, depression, and anxiety among post cerebral stroke patients*
    Zhang Shaohua, Wang Yulong, Zhang Chunxia, Zhang Chunping, Xiao Peng, Li Qianfeng, Liang Weirong, Pan Xiaohua, Zhou Mingchao
    2021, 44 (7):  659-667.  doi: 10.3969/j.issn.1006-2157.2021.07.012
    Abstract ( 74 )   PDF (935KB) ( 34 )   Save
    Objective To observe the effects of interactive scalp acupuncture on cognitive function, depression, anxiety and sleep quality in patients with post-stroke patients. Methods A total of 445 patients with stroke who had been admitted to the Rehabilitation Department of Nan'ao People's Hospital, Shenzhen Second People's Hospital and Shenzhen Futian District Hospital of Traditional Chinese Medicine from May 2019 to May 2020 were selected and randomly divided into the experimental group (n=223) and the control group (n=222), with 23 cases shed in the experimental group and 22 cases shed in the control group.Two groups of patients were treated with standard care and conventional rehabilitation exercise therapy.The experimental group was given interactive head acupuncture therapy, while the control group was given conventional scalp acupuncture and cognitive training therapy for a course of 8 weeks.Before the initial treatment, at the end of the treatment course, and at the follow-up 2 months later,Montreal Cognitive Assessment Scale (MoCA), Mini-mental State Examination (MMSE), Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Pittsburgh Sleep Quality Index (PSQI), and Modified Barthel Index (MBI) were evaluated. The levels of serum Brain-derived Neurotrophic Factor (BDNF) and Nerve Growth factor (NGF)were measured before and after the first treatment.Results At the end of the treatment course and at the follow-up, the scores of MoCA, MMSE and MBI in the experimental group were increased compared with those before treatment (P< 0.01), and the scores of HAMD, HAMA and PSQI were decreased compared with those before treatment (P< 0.01).MoCA scores increased (P< 0.01) and HAMD scores of the control group decreased (P< 0.01) both at the end of the treatment course and at the follow-up, whereas MMSE and MBI scores of the control group increased only at the end of treatment (P< 0.01). The scores of MoCA, MMSE and MBI in the experimental group were higher than those in the control group at the end of the course and at the follow-up (P< 0.01), and the scores of HAMD, HAMA and PSQI in the experimental group were lower than those in the control group (P< 0.01).In terms of serological indexes, the levels of BDNF and NGF in both groups at the end of the course of treatment were higher than those before treatment (P< 0.01), and those in the experimental group were higher than those in the control group (P< 0.01).Conclusion Interactive scalp acupuncture can significantly improve not only the cognitive function, depression, anxiety but also the sleep quality and self-care ability of patients with stroke, and promote the recovery of cerebral nerve function. Compared with conventional rehabilitation treatment, it has the efficacy advantage which can be maintained after stopping the treatment.
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    Book Review
    Interpretation of WHO Global Report on Traditional and Complementary Medicine 2019*
    Huang Jing, Fang Tingyu, Liu Zining, Liu Ping
    2021, 44 (7):  668-672.  doi: 10.3969/j.issn.1006-2157.2021.07.013
    Abstract ( 75 )   PDF (753KB) ( 29 )   Save
    WHO Global Report on Traditional and Complementary Medicine 2019 reveals the current situation of Traditional and Complementary Medicine (T&CM) worldwide based on data from three global surveys and updated information from WHO member states. It includes five sections: national policy on T&CM; regulatory status of herbal medicine; practice, providers, education and health insurance; challenges and the need for WHO support and an overview of 149 member country. This report addresses the challenges of lacking credible data and information in this field, and provides valuable references for policymakers, health professionals and the public. The Chinese version of this report has just been published in Jan, 2021. This paper offers an interpretation of this report, including its background and the main points in each section. This report covers T&CM laws regulations and regulatory status of herbal medicine, so analysis and reading of this report will provide us with the latest and the most valuable information of T&CM, which enlightens us about how to further carry out international dissemination of traditional Chinese medicine to serve the world people.
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