Rheumatic immune diseases in children are difficult to treat, frequently recur, and can seriously affect children’s physical and mental health. At present, treatment of rheumatic immune diseases mainly depends on hormones, biologicals and immunosuppressants. However, these drugs have nonnegligible side effects. Traditional Chinese medicine deems that the side effects of drugs belong to the category of drug "toxicity". Drugs that are toxic are called "toxicity" drugs, with regard to "toxicity" drugs, the theory of "You Gu Wu Yun" in Inner canon of Huangdi considers that although drugs are "toxic, " drugs are used for an explicit "reason, " so the disease itself receives the drug first, which are not harmful to the human body. Based on this theory, we propose "toxicity" drugs’ use principles that "toxicity" drugs are severe; therefore, drugs should not be used until the plight is urgent. "Toxicity" drugs should be stopped when the disease is mostly cured. The "effectiveness" and "toxicity" must be weighed to find a balance between the body and the drugs. Treatment ought to be adapted according to personal condition, because tolerance to "toxicity" drugs varies. Drugs must be used based on disease differentiation and syndrome differentiation, and toxicity must be reduced by compatibility. We also put forward the "toxicity" drugs’ use strategies of precising drugs’ use, taking measures to attenuate toxicity, improving the benefit/risk ratio, which are of great guiding significance to the safe use of drug in pediatric clinics.

You Gu Wu Yun;drug toxicity;toxicity drug;children;rheumatic immune disease