سابِق|تال

Analysis on the differentiation and treatment of premature ovarian insufficiency from "qi" based on granulosa cell autophagy

  • role： First author第一作者
  • Affiliation：

    Heilongjiang University of Chinese Medicine, Harbin 150040, China

  • Introduction：李广慧，女，在读硕士生
LI Guanghui1,  
  • role： Corresponding author通信作者
  • Affiliation：

    The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China

  • Email：doctorfxl@163.com
  • Introduction：Prof. FENG Xiaoling, Ph.D., Chief Physician, Doctoral Supervisor. The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, No. 26, Heping Road, Xiangfang District, Harbin 150040. E-mail: doctorfxl@163.com
FENG Xiaoling2*

ملخص

Premature ovarian insufficiency belongs to the category of early menstrual cessation, blood depletion, and infertility in traditional Chinese medicine, which not only affects women′s fertility and forces them into a premature perimenopausal period, but also increases the risk of long-term complications such as osteoporosis, cognitive impairment, and cardiovascular diseases. Autophagy has a dual regulatory effect on follicular development and atresia, closely related to the onset of premature ovarian insufficiency. In women, blood is the basis and qi is the use. This article argues from the perspective of "qi", positing that the pathogenesis of premature ovarian insufficiency is fundamentally due to the deficiency of qi in the zang-fu organs leading to inadequate nourishment of the uterus, while the obstruction of the uterine vessels by qi depression in the zang-fu organs as manifestation. It also takes the correlation between autophagy and qi in the onset of premature ovarian insufficiency as the starting point, proposing a therapeutic principle centered on replenishing qi as the foundation and activating qi as the key. The internal and external treatment of traditional Chinese medicine can correct the abnormal autophagy of granulosa cells through "regulating qi", thus improving the ovarian microenvironment, protecting the ovarian function, and finally preventing and treating premature ovarian insufficiency.

مفهوم

premature ovarian insufficiency;autophagy;qi deficiency;qi stagnation;regulating qi

References

  1. [1].
    TSILIGIANNIS S, PANAY N, STEVENSON JC. Premature ovarian insufficiency and long-term health consequences[J]. Curr Vasc Pharmacol, 2019, 17(6): 604-609.
  2. [2].
    WU XY, CAI H, KALLIANPUR A, et al. Impact of premature ovarian failure on mortality and morbidity among Chinese wmen[J]. PLoS One, 2014, 9(3): e89597.
  3. [3].
    ZHOU JW, PENG XW, MEI SQ. Autophagy in ovarian follicular development and atresia[J]. Int J Biol Sci, 2019, 15(4): 726-737.
  4. [4].
    DING ZW, SHAO GB, LI MY. Regulatory mechanism of autophagy in premature ovarian failure[J]. Cell Biochem Funct, 2024, 42(7): e4122.
  5. [5].
    朱震亨. 丹溪心法[M]. 王英，竹剑平，江凌圳，整理. 北京：人民卫生出版社，2005: 182.
  6. [6].
    傅山. 傅青主女科[M]. 北京：中国中医药出版社，2019.
  7. [7].
    陈自明. 妇人大全良方[M]. 盛维忠，校注．北京：中国中医药出版社，2007: 10.
  8. [8].
    孙承颐，房繄恭. 房繄恭“调经促孕十三针”治疗卵巢早衰经验[J]. 中国中医基础医学杂志，2020, 26(9): 1403-1405.
  9. [9].
    陈士铎. 辨证录[M]. 北京：中国中医药出版社，2007: 440.
  10. [10].
    尚玉洁，周惠芳. 国医大师夏桂成从心论治卵巢储备功能减退思想探赜[J]. 中华中医药杂志，2021, 36(3): 1426-1429.
  11. [11].
    张丹，蔡竞，崔晓萍，等. 基于线粒体代谢障碍探讨从脾论治卵巢早衰机制[J]. 现代中西医结合杂志，2022, 31(16): 2253-2256.
  12. [12].
    KIM KH, LEE MS. Autophagy：a key player in cellular and body metabolism[J]. Nat Rev Endocrinol, 2014, 10(6): 322-337.
  13. [13].
    SHINTANI T, KLIONSKY DJ. Autophagy in health and disease: a double-edged sword[J]. Science, 2004, 306(5698): 990-995.
  14. [14].
    CHOI JY, JO MW, LEE EY, et al. The role of autophagy in follicular development and atresia in rat granulosa cells[J]. Fertil Steril, 2010, 93(8): 2532-2537.
  15. [15].
    CHOI JY, JO MW, LEE EY, et al. Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells[J]. Fertil Steril, 2011, 95(4): 1482-1486.
  16. [16].
    MIZUSHIMA N, KOMATSU M. Autophagy: renovation of cells and tissues[J]. Cell, 2011, 147(4): 728-741.
  17. [17].
    TU ZH, MU XY, LI QY, et al. Autophagy participates in cyst breakdown and primordial folliculogenesis by reducing reactive oxygen species levels in perinatal mouse ovaries[J]. J Cell Physiol, 2019, 234(5): 6125-6135.
  18. [18].
    黄海，陈丽，李必保，等. 从中医气、血浅议细胞自噬[J]. 中医学报，2021, 36(10): 2035-2040.
  19. [19].
    李琰珉. 褪黑素调控PI3K/AKT/mTOR自噬通路治疗早发性卵巢功能不全的机制研究[D]. 济南：山东大学，2020.
  20. [20].
    代倩兰，刘绍能. 基于中医精气理论探讨细胞自噬与精化气的关联性[J]. 环球中医药，2023, 16(1): 107-110.
  21. [21].
    黄贵华，纪云西，吴大力，等. 细胞自噬与中医气虚痰瘀关系探讨[J]. 中医杂志，2011, 52(20): 1717-1719.
  22. [22].
    王晋平，刘布谷，唐农，等. 从细胞自噬探讨“温阳益气化浊法”的现代微观机制及在老年性痴呆中的作用[J]. 中华中医药杂志，2017, 32(1): 114-116.
  23. [23].
    LIU WW, CHEN M, LIU C, et al. Epg5 deficiency leads to primary ovarian insufficiency due to WT1 accumulation in mouse granulosa cells[J]. Autophagy, 2023, 19(2): 644-659.
  24. [24].
    王蓓蕾，阮越勇，于洋，等. 从中医“气化”角度探讨自噬现象[J]. 中华中医药杂志，2020, 35(11): 5452-5454.
  25. [25].
    金笑天，江涵，吕赟，等. 女性卵巢储备功能下降的危害因素及中医体质类型分布[J]. 中国妇幼保健，2021, 36(21): 4986-4989.
  26. [26].
    林雨乔，刘建，杨洪艳. 特发性早发性卵巢功能不全患者中医体质分析[J]. 广州中医药大学学报，2023, 40(10): 2431-2437.
  27. [27].
    孙一奎. 医旨绪余[M]. 张玉才，许霞，校注. 北京：中国中医药出版社，2009: 42.
  28. [28].
    吴瑭. 温病条辨[M]. 北京：人民卫生出版社，2012: 188.
  29. [29].
    杨宇航. 基于数据挖掘探讨尤昭玲教授调治卵巢低反应的用药规律[D]. 长沙：湖南中医药大学，2018.
  30. [30].
    李杲. 脾胃论[M]. 北京：中国中医药出版社，2019: 2.
  31. [31].
    唐丽，牟珍妮，申思楠，等. 基于PI3K/Akt/mTOR通路探讨助卵汤对大鼠早发性卵巢功能不全的保护作用机制[J]. 中国实验方剂学杂志，2023, 29(4): 52-59.
  32. [32].
    滕秀香，姚海洋，刘丹，等. 柴嵩岩辨证治疗早发性卵巢功能不全经验[J]. 北京中医药，2018, 37(4): 292-294.
  33. [33].
    王凯悦，王宇，常惠，等. 基于数据挖掘技术探讨补益类中药治疗早发性卵巢功能不全的用药规律[J]. 广东药科大学学报，2023, 39(6): 77-84.
  34. [34].
    李善霞，邓丽敏，谭青月，等. 应用毓麟珠“从气论治”肾虚型早发性卵巢功能不全的临床观察[J]. 辽宁中医杂志，2021, 48(8): 116-119.
  35. [35].
    董晓英，冯逊逊，郑秀蕊，等. 毓麟珠对早发性卵巢功能不全模型小鼠卵巢形态、卵泡发育及mTOR信号通路的影响[J]. 中国中医药信息杂志，2018, 25(10): 49-53.
  36. [36].
    周紫琼，凌舒艺，戴雨晴，等. 针灸治疗早发性卵巢功能不全的作用及机制[J]. 针灸临床杂志，2023, 39(11): 97-102.
  37. [37].
    吴林纳，杨霖轩，杨雪，等. 基于数据挖掘探析《针灸大成》论治早发性卵巢功能不全相关症状的诊疗思路[J]. 中国性科学，2024, 33(2): 138-142.
  38. [38].
    孙晓彤. 针药并用对卵巢储备功能下降模型大鼠颗粒细胞自噬相关因子表达的影响[D]. 沈阳：辽宁中医药大学，2021.
  39. [39].
    张彩荣，邓吉立，朱维娜，等. PI3K/Akt/mTOR信号通路介导艾灸改善大鼠卵巢早衰的研究[J]. 针刺研究，2018, 43(2): 75-79.

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