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Exploring the pathogenesis and differential treatment of postmenopausal osteoporosis based on the theory of " kidney qi heat"

  • role： First author第一作者
  • Affiliation：

    Liaoning University of Traditional Chinese Medicine, Shenyang 110847, China

  • Introduction：顾海立，男，在读硕士生
GU Haili1,  
  • role： Corresponding author通信作者
  • Affiliation：

    Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032, China

  • Email：dongdongyu10256@163.com
  • Introduction：Prof. YU Dongdong, Ph.D., Chief Physician, Master′s Supervisor. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33, Beiling Street, Huanggu District, Shenyang 110032. E-mail: dongdongyu10256@163.com
YU Dongdong2*

Resümee

Postmenopausal osteoporosis (PMO) is a clinically refractory bone metabolic disease that often occurs in women after menopause. According to its clinical manifestations, it is classified as " bone flaccidity" and " bone withering" in traditional Chinese medicine (TCM). Based on the theory of " kidney qi heat", this paper explains the etiology and pathogenesis of PMO. It is proposed that yin deficiency, depletion of liquid, and yin not containing yang form the basis of its pathogenesis. Furthermore, the internal heat of yang hyperactivity and crippled backbones are the central links that lead to the mutual loss of yin and yang and the withering of bones. Based on the above pathogenesis, the early treatment of the disease is based on nourishing yin and promoting liquid, supplementing qi and nourishing blood production using Yiyin Zengye Decoction with modification. In the medium term, the treatment is based on nourishing yin, clearing heat, invigorating the kidney, and supplementing essence using Ziyin Qingre Decoction with modification. In the final terminal stage, the treatment is based on nourishing yin, tonifying yang, and strengthening the foundation using Yinyang Shuangbu Decoction with modification. At the same time, the correlation between " kidney qi heat" and inflammatory and immune reaction is explored to provide new concepts for clinical research and improve the clinical application value of TCM in the prevention and treatment of PMO.

Schlüsselwort

postmenopausal osteoporosis;kidney qi heat;inflammatory reaction;immune reaction;nourishing yin and clearing heat

References

  1. [1].
    LANE JM, RUSSELL L, KHAN SN. Osteoporosis[J].Clin Orthop Relat Res，2000，372:139-150.
  2. [2].
    GARTLEHNER G, PATEL SV, FELTNER C, et al. Hormone therapy for the primary prevention of chronic conditions in postmenopausal women: evidence report and systematic review for the US preventive services task force[J]. JAMA, 2017, 318(22): 2234-2249.
  3. [3].
    辛小玲，李兆弟，于峥，等．骨痿的病因病机[J].中国中医基础医学杂志，2012，18(5):470.
  4. [4].
    马涵琳，张霞，张帅，等．“肾气热则骨枯髓减”探讨儿童糖皮质激素性骨质疏松的发病机制[J].中国骨质疏松杂志，2023，29(10):1528-1532.
  5. [5].
    叶天士．叶选医衡[M].张明锐，刘连续，德学慧，等，校注．北京：人民军医出版社，2012：18.
  6. [6].
    BIJELIC R, MILICEVIC S, BALABAN J. Risk factors for osteoporosis in postmenopausal women[J]. Med Arch，2017，71(1):25-28.
  7. [7].
    张志聪．黄帝内经素问集注[M].王宏利，吕凌，校注．北京：中国医药科技出版社，2014：10.
  8. [8].
    WU D, CLINE-SMITH A, SHASHKOVA E, et al. T-cell mediated inflammation in postmenopausal osteoporosis[J]. Front Immunol, 2021, 12: 687551.
  9. [9].
    ROSS FP. Interleukin 7 and estrogen-induced bone loss[J]. Trends Endocrinol Metab，2003，14(4):147-149.
  10. [10].
    吕杰，王耀献，刘玉宁．从炎症发病机制探讨糖尿病肾病从热论治[J].中国中西医结合肾病杂志，2014，15(1):60-61.
  11. [11].
    赵佶敕．圣济总录校注[M].王振国，杨金萍，校注．上海：上海科学技术出版社，2016：568.
  12. [12].
    常志芳，冯成龙，史晓霞，等．免疫与骨质疏松的研究进展[J].中国骨质疏松杂志，2015，21(4):508-513.
  13. [13].
    王凌，李大金．绝经后骨质疏松症发病的骨免疫学机制[J].中华内分泌代谢杂志，2009，25(1):124-126.
  14. [14].
    ISLANDER U, JOCHEMS C, LAGERQUIST MK, et al. Estrogens in rheumatoid arthritis；the immune system and bone[J].Mol Cell Endocrinol，2011，335(1):14-29.
  15. [15].
    邹世恩，张绍芬．细胞因子在绝经后骨质疏松症发病机制中的作用[J].中国骨质疏松杂志，2012，18(4):375-380.
  16. [16].
    罗成燕，王凌，孙婵，等．调节性T细胞源性IL-10与TGF－β1对破骨细胞分化及骨吸收的抑制作用[J].中华内分泌代谢杂志，2009，25(4):434-437.
  17. [17].
    何姣姣，陈以发，陈玉林，等．绝经后骨质疏松的骨免疫学机制[J].中国骨质疏松杂志，2023，29(7):1032-1036.
  18. [18].
    张倩，王花欣，王媛，等．中药防治绝经后骨质疏松症的研究进展[J].中国骨质疏松杂志，2020，26(7):1083-1088.
  19. [19].
    于冬冬，李昊然，李泽，等．香砂六君子汤激活Wnt/β-catenin信号通路促进成骨分化防治PMOP的机制研究[J].中国骨质疏松杂志，2023，29(6):786-791.
  20. [20].
    吴谦．医宗金鉴[M].鲁兆鳞，校注．沈阳：辽宁科学技术出版社，1997：278.
  21. [21].
    于冬冬，赵丹阳，杨芳，等．中药复方鹿角胶丸防治绝经后骨质疏松症的机制研究[J].中国骨质疏松杂志，2020，26(11):1668-1673.
  22. [22].
    齐鹏坤，于冬冬，韩煜．龟鹿二仙汤治疗绝经后骨质疏松症临床观察[J].辽宁中医药大学学报，2018，20(4):154-156.
  23. [23].
    齐鹏坤，于冬冬，韩煜．龟鹿二仙汤合阿仑膦酸钠治疗绝经后骨质疏松症[J].中华中医药杂志，2018，33(11):5270-5272.

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