Effects of Sanqi Gel on expressions of cyclooxygenase-2 and transforming growth factor-β<sub>1</sub> during epidural adhesion

WANG Rong-guo~1; ZHOU Wei~

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Effects of Sanqi Gel on expressions of cyclooxygenase-2 and transforming growth factor-β₁ during epidural adhesion

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- Effects of Sanqi Gel on expressions of cyclooxygenase-2 and transforming growth factor-β₁ during epidural adhesion
- Journal of Beijing University of traditional Chinese Medicine Vol. 33, Issue 1, Pages: 54-56(2010)
- 作者机构：
  
  1. 北京中医药大学针灸推拿学院
  2. 中国中医科学院望京医院
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：01 January 2010
- 稿件说明：
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[1]王荣国,周卫,章永东,孔焕宇,李莉,林新晓,张万强.三七凝胶对硬膜外粘连中COX-2、TGF-β_1的影响[J].北京中医药大学学报,2010,33(01):54-56+78.

WANG Rong-guo~1, ZHOU Wei~. Effects of Sanqi Gel on expressions of cyclooxygenase-2 and transforming growth factor-β₁ during epidural adhesion[J]. Journal of Beijing University of traditional Chinese Medicine, 2010, 33(1): 54-56.
[1]王荣国,周卫,章永东,孔焕宇,李莉,林新晓,张万强.三七凝胶对硬膜外粘连中COX-2、TGF-β_1的影响[J].北京中医药大学学报,2010,33(01):54-56+78. DOI：

WANG Rong-guo~1, ZHOU Wei~. Effects of Sanqi Gel on expressions of cyclooxygenase-2 and transforming growth factor-β₁ during epidural adhesion[J]. Journal of Beijing University of traditional Chinese Medicine, 2010, 33(1): 54-56. DOI：

摘要

目的探讨三七凝胶预防硬膜外粘连（Epidural adhesion）的相关机制。方法将72只雄性SD大鼠随机分为生理盐水组、粘连平组、凝胶组和三七凝胶组

每组18只

建立椎板切除术模型

分别在术后第7、14、21天采用免疫组化进行动态观察

分析愈合过程中TGF-β

和COX-2的表达情况。结果不同处理方法对TGF-β

和COX-2的影响作用不同

作用强度存在差异。其中术后14 d生理盐水组、凝胶组和粘连平组COX-2的表达显著高于三七凝胶组（P

0.05）;术后7、14、21 d 3个时间点中生理盐水组、凝胶组和粘连平组TGF-β

的表达均显著高于三七凝胶组（P

0.05）。结论三七凝胶可能通过抑制COX-2和TGF-β

的表达预防硬膜外瘢痕粘连。

Abstract

Objective To discuss the relevant mechanism of Sanqi Gel in the prevention of epidural adhesion.Method All male SD rats（n=72） were randomly divided into the normal saline water group

Zhanlianping group

carbopol gel group and Sanqi Gel group（each n=18）.The model of laminectomy was established and observed at different time points after the laminectomy for 7

14 and 21 days respectively by applying immunohistochemistry method.The expressions of transforming growth factor-β

（TGF-β

） and cyclooxygenase-2（COX-2） were analysed during the healing period.Result The different treating methods had different effects on the expressions of TGF-β

and COX-2 with different effective strength.The expression of COX-2 was higher significantly in the normal saline water group

carbopol gel group and Zhanlianping group than that in the Sanqi Gel group（P

0.05） 14 days after the operation.The expression of TGF-β

was higher significantly in the normal saline water group

carbopol gel group and Zhanlianping group than that in the Sanqi Gel group（P

0.05） at 3 time points（7

14 and 21 days after the operation）.Conclusion Sanqi Gel can prevent epidural adhesion through inhibiting the expressions of COX-2 and TGF-β

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Effects of Sanqi Gel on expressions of cyclooxygenase-2 and transforming growth factor-β1 during epidural adhesion

DOI：

摘要

Abstract

关键词

Keywords

references

Effects of Sanqi Gel on expressions of cyclooxygenase-2 and transforming growth factor-β₁ during epidural adhesion