Objective To study the effects of matrix metalloproteinase-2（MMP-2） and tissue inhibitor of metalloproteinase-2（TIMP-2） in chronic heart failure（CHF）

and investigate the influences and mechanism of different compound formulas of Chinese medicine in the ventricular remodeling of CHF at molecular biological level.Methods The rat model of CHF was established by using coronary ligation

forced swimming and underfeed.The rats were divided into mode group

Western medicinal group

supplementing qi group（Yiqi group）

activating blood group（Huoxue group）

supplementing qi and activating blood group（Yiqihuoxue group）

supplementing qi

activating blood and inducing diuresis group（Yiqihuoxuelishui group） and normal group.The changes of expressions of MMP-2 and TIMP-2 were detected by applying real-time fluorescence quantitative polymerase chain reaction（RT-PCR） and SABC immunohistochemistry technique.Results The expression of MMP-2 increased significantly and expression of TIMP-2 decreased in model group compared with normal group（P<0.01）.After treatment

the expression of MMP-2 decreased significantly and expression of TIMP-2 increased in all medication groups.The difference was insignificant between Yiqihuoxue group or Yiqihuoxuelishui group compared with Western medicinal group（P>0.05）

and curative effect was much better in Yiqihuoxuelishui group than that in Yiqihuoxue group（P<0.01）.Conclusion The Chinese medicinal with the actions of supplementing qi

activating blood and inducing diuresis have effect on myocardial tissue

and can inhibit or reverse ventricular remodeling to treat CHF through influencing the expressions of MMP-2 and TIMP-2.