Influence of Bushentongluoshugan Formula on expression of TGF-β mRNA of penile tissue in senescent rats

HU Hai-xiang1; LUO Bin2; DONG Jing1

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Influence of Bushentongluoshugan Formula on expression of TGF-β mRNA of penile tissue in senescent rats

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- Influence of Bushentongluoshugan Formula on expression of TGF-β mRNA of penile tissue in senescent rats
- Journal of Beijing University of traditional Chinese Medicine Vol. 0, Issue 10, Pages: 695-697(2007)
- 作者机构：
  
  1. 空军总医院
  2. 北京中医药大学
- 作者简介：
- 基金信息：
- DOI：
  CLC： R285.5
- Published：2007
- 稿件说明：
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HU Hai-xiang1, LUO Bin2, DONG Jing1. Influence of Bushentongluoshugan Formula on expression of TGF-β mRNA of penile tissue in senescent rats[J]. Journal of Beijing University of traditional Chinese Medicine, 2007, 0(10): 695-697.
DOI：

HU Hai-xiang1, LUO Bin2, DONG Jing1. Influence of Bushentongluoshugan Formula on expression of TGF-β mRNA of penile tissue in senescent rats[J]. Journal of Beijing University of traditional Chinese Medicine, 2007, 0(10): 695-697. DOI：

摘要

目的探讨衰老大鼠阴茎组织转化生长因子β(TGF-β)基因表达与补肾通络疏肝方在阴茎勃起中的关系。方法将32只雄性大鼠随机分为衰老组、补肾通络疏肝方组、丙酸睾酮组与对照组(2月龄大鼠)

其中补肾通络疏肝方组和丙酸睾酮组分别给予补肾通络疏肝方及丙酸睾酮治疗

于24 d取阴茎组织

用PCR检测其TGF-βmRNA的表达。结果衰老组TGF-βmRNA的表达较其他3组增强

而表现TGF-βmRNA减弱的组

由少到多依次排定为对照组、丙酸睾酮组及补肾通络疏肝方组;对照组、丙酸睾酮组及补肾通络疏肝方组其TGF-βmRNA内控量较少

与衰老组比较有显著性差异(P<0.01)

丙酸睾酮组及补肾通络疏肝方组之间无显著性差异(P>0.05)。结论补肾通络疏肝方可能通过调节TGF-βmRNA表达而在阴茎勃起中发挥重要作用。

Abstract

Objective To investigate the relationship between the expression of transforming growth factor-β（TGF-β） mRNA and Bushentongluoshugan Formula in penile erection in senescent rats.Method All 32 mature male rats were randomly divided into: the senescent rat group（group 1）

Bushentongluoshugan Formula group（group 2）

testosterone propionate group（group 3） and control group（group 4

the rats were 2 months old）.On the 24th day the penile tissue was taken from the rats and the expression of TGF-β mRNA was detected by PCR technique.Result In group 1 the expression of TGF-β mRNA was increased than those of other three groups.The groups with decreased the expression of TGF-β mRNA were ordered as follow ascent sequence:group4

group 1

group 3

group 2.The controlled amount of TGF-β mRNA in group 4

3 and 2 was lower and had a significant difference respectively compared with that of group 1（P<0.01）.There was no significant difference between group 3 and 2（P>0.05）.Conclusion Bushentongluoshugan Formula may play an important role in the penile erection through regulating the expression of TGF-β mRNA.

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Related Institution

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1 Dongfang Hospital,Beijing University of Chinese Medicine

2 Beijing University of Chinese Medicine

The General Hospital of Chinese Air Force in Beijing

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