Objective To observe the blood-enriching effects and mechanism of albiflorin and paeoniflorin on immunosuppressional model mice with blood deficiency pattern induced by cyclophosphamide. Methods The mouse model with blood deficiency pattern induced by intraperitoneal injection of cyclophosphamide was treated with intragastrical administration of albiflorin and paeoniflorin at high dose of 30 mg / kg

low dose of 15 mg / kg. Then the peripheral hemogram

thymus gland index and spleen index

granulocyte-macrophage colony stimulating factor（ GM-CSF）

interleukin-3（ IL-3）

interleukin-6（ IL-6）

tumor necrosis factor α（ TNF-α） and granulocyte colony-stimulating factor were detected.Results High dose albiflorin and high dose paeoniflorin could increase WBC count（ P < 0. 01） and thymus gland index（ P < 0. 01

P < 0. 05）

serum contents of GM-CSF and G-CSF（ P < 0. 001

P <0. 01）

also serum content of IL-3（ P < 0. 01

P < 0. 05）

and decrease the serum content of IL-6（ P <0. 05） and TNF-α（ P < 0. 001

P < 0. 01）. Conclusion The blood-enriching effects against blooddeficiency via regulating the immunological function

suggests that albiflorin and paeoniflorin be the main effective components extracted from White Peony Root（ Radix Paeoniae Alba

Baishao） with the effects of nourishing blood and liver.