Objective To investigate the safety of Majie Pingchuan cataplasm on skin. Methods 1Acute toxicity test. Twelve rabbits were randomly divided into three groups with hair removed and skin damaged

systemic poisoning situation was observed after patching blank matrix cataplasm and Majie Pingchuan cataplasm. 2Skin irritation test. Sixteen rabbits were randomly divided into four groups with hair removed and skin damaged

one twelfth of one sheet of blank matrix cataplasm and Majie Pingchuan cataplasm were separately patched on left or right side skin

erythema and edema were observed in single and repeated stimulation tests. 3Skin allegy test. Thirty guinea pigs were randomly divided into three groups

one twelfth of one sheet of blank matrix cataplasm

Majie Pingchuan cataplasm

0. 2 m L of 2

4-dinitrochlorobenzene were patched on the left side skin. On 28 thday allergic reaction was observed after patching the same excitants six hours continuously on the right skin. Results In the acute toxicity test

there was no death and abnormal physiological conditions in rabbits. In the single stimulus test

erythema and edema did not appear. In the repeated stimulation tset

there was slight erythema disappearing in 48 h

and no edema. In allergy test

Majie Pingchuan cataplasm group did not appear erythema and edema

the sensitization rate was 0. Conclusion Majie Pingchuan Cataplasm had no acute toxicity and irritation on intacted or injured skin of rabbits. There was no allergic reaction in guinea pig skin. Majie Pingchuan cataplasm is safe and non-toxic.