Objectives To explore the preventive and therapeutic effects of Jianpi Yiqi Shexue Keli（ Spleen-fortifying Qi-tonifying Hemostatic Granule

JPYQSXKL） and its disassembled prescriptions（ Jianpi Granules） in the treatment of zebrafish cerebral hemorrhage induced by simvastatin. Methods 660 melanin alleles mutant Albino zebrafishes were randomly divided into normal control group

model group

Jianpi groups（ A

B

C

D） and subgroups of their different concentration（ 100 μg/m L

250 μg/m L

500 μg/m L

750 μg/m L

and 1 000 μg/m L）（ n = 30 in each group）. Blinding measures were strictly followed throughout the process. The model of intracranial hemorrhage was established by adding 0. 5 μM simvastatin while administering granules of different concentration at the same time. 24 hours later

20 fishes out of each group were observed under the microscope to count the number of hemorrhagic fishes（ S） and thus calculate hemorrhage percentage and its decrease rate. Results（1）The incidence rate of hemorrhage in Jianpi groups（ 100 μg/m L

250 μg/m L

500 μg/m L and 750 μg/m L） was 75%

70%

60% and 70%;（2）The incidence rate of hemorrhage in Jianpi Yiqi groups（ 100 μg/m L

250 μg/m L and500 μg/m L） were 60%

40% and 85%;（3）The incidence rate of hemorrhage in Jianpi Yiqi Shengxue（ Spleen-fortifying Qi-tonifying Blood-nourishing） groups（ 100 μg/m L and 250 μg/m L） were 50% and45%;（4）The incidence rate of hemorrhage in Jianpi Yiqi Shexue groups（ 100 μg/m L

250 μg/m L and500 μg/m L） were 35%

25% and 45%. Conclusions No protective effects of Jianpi granule and Jianpi Yiqi granule on intracranial hemorrhage induced by simvastatin in zebrafish were observed. Jianpi Yiqi Shengxue granule and Jianpi Yiqi Shexue granule appeared to have a good effect yet high dose was toxic.