Tumor immune regulation from the perspective of the physiological function of the spleen and stomach in traditional Chinese medicine

CHEN Jiena; LI Yuan; DING Xia

doi:10.3969/j.issn.1006-2157.2023.01.006

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Tumor immune regulation from the perspective of the physiological function of the spleen and stomach in traditional Chinese medicine

Theoretical Studies | 更新时间：2023-02-03

- Tumor immune regulation from the perspective of the physiological function of the spleen and stomach in traditional Chinese medicine
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 1, Pages: 32-36(2023)
- 作者机构：
  
  1.北京中医药大学中医学院　北京　100029
  2.北京中医药大学国家中医体质与治未病研究院
- 作者简介：
  
  Prof. DING Xia, Ph. D. , Doctoral supervisor. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Beisanhuan Donglu Road, Chaoyang District, Beijing 100029. E-mail: dingx@bucm.edu.cn
- 基金信息：
  
  National Natural Science Foundation of China(92059102)
- DOI：10.3969/j.issn.1006-2157.2023.01.006
  CLC： R273
- Received：30 May 2022，
  
  Published：30 January 2023
- 稿件说明：
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CHEN Jiena, LI Yuan, DING Xia. Tumor immune regulation from the perspective of the physiological function of the spleen and stomach in traditional Chinese medicine[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(1): 32-36.
DOI：

CHEN Jiena, LI Yuan, DING Xia. Tumor immune regulation from the perspective of the physiological function of the spleen and stomach in traditional Chinese medicine[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(1): 32-36. DOI： 10.3969/j.issn.1006-2157.2023.01.006.

摘要

中医学“内伤脾胃，百病由生”与“善治病者，惟在调理脾胃”的学术思想对认识脾胃功能在肿瘤的发生、发展与转归中的作用具有重要指导意义。西医学认为，肿瘤的生物学行为不仅取决于肿瘤细胞本身的特性，更与肿瘤细胞所在的微环境及宏环境的免疫调控失衡密切相关。中医学认为，“脾胃虚弱，癌毒积蕴”为肿瘤发生、发展的主要病机特点。“脾胃虚弱”为肿瘤免疫宏环境形成的内在基础，“癌毒积蕴”为肿瘤免疫微环境形成的重要条件，两者互为因果，促进肿瘤的发生与发展。基于“脾为之卫”与“四季脾旺不受邪”的理论，中医药通过健脾与攻毒兼施的治疗总则在肿瘤的防治中取得了显著的临床疗效，强调了中医脾胃功能在肿瘤免疫调控中的独特优势。从中医脾胃生理功能出发，探讨脾胃功能在肿瘤免疫微环境与机体免疫宏环境中的科学内涵，可以促进中西医结合学科在肿瘤发生、发展与防治理论的融合与发展。

Abstract

In traditional Chinese medicine (TCM)

the academic perspectives that "the occurrence of various diseases may result from internal damage to the spleen and stomach" and that "those who are good at treating diseases

regulate the spleen and stomach well" have been endowed with guiding significance to understand the occurrence

development

and prognosis of tumors. Western medicine has the view that the hallmarks of cancer depend not only on the characteristics of tumor cells themselves

but are also closely related to the microenvironment where tumor cells are located and the imbalanced immune macroenvironment. In TCM

the main pathogenesis of tumors is defined as a "weakness of the spleen and stomach

and accumulation of cancer toxins" . "Weakness of the spleen and stomach" is the internal basis for the formation of the tumor immune macroenvironment

and the "accumulation of cancer toxins" is an important condition for the formation of the tumor immune microenvironment; the two mutually promote the occurrence and development of tumors. Based on the theory that "the spleen acts as the guard of the body" and "the vigorous spleen is able to resist invasion of pathogens

" TCM has achieved remarkable clinical efficacy with the treatment of "invigorating spleen and attacking poison" in the prevention and treatment of tumors. This emphasizes the unique advantages of the "spleen and stomach" in tumor immune regulation. Thus

based on the theory of spleen and stomach in TCM

we explore the scientific connotation of spleen and stomach function in the tumor immune microenvironment and the organism immune macroenvironment

so as to promote the theoretical integration and development of integrated Chinese and Western medicines in tumor occurrence

development

prevention

and treatment.

关键词

Keywords

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