Influence of sex on the therapeutic effect of acupuncture on knee osteoarthritis: a secondary analysis of data from a multi-center randomized controlled study

HAO Xiaowan; TU Jianfeng; WANG Liqiong; YU Fangting; LIN Lulu; LI Hongping; SHI Guangxia; LIU Cunzhi

doi:10.3969/j.issn.1006-2157.2023.01.021

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Influence of sex on the therapeutic effect of acupuncture on knee osteoarthritis: a secondary analysis of data from a multi-center randomized controlled study

Acupuncture Moxibustion and Tuina | 更新时间：2023-02-03

- Influence of sex on the therapeutic effect of acupuncture on knee osteoarthritis: a secondary analysis of data from a multi-center randomized controlled study
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 1, Pages: 125-131(2023)
- 作者机构：
  
  1.北京中医药大学国际针灸创新研究院　北京　100029
  2.北京中医药大学针灸推拿学院
  3.首都医科大学附属北京中医医院
- 作者简介：
  
  A/Prof. SHI Guangxia, Ph.D., Master’s Supervisor. International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, No. 11, Beisanhuan Donglu Road, Chaoyang District, Beijing 100029. E-mail: shiguangxia2008@126.com
- 基金信息：
  
  Beijing Municipal Science & Technology Commission(D171100003217003);The 4th Project of China Association of Science and Technology Youth Talents Enrollment Project(2018QNRC001)
- DOI：10.3969/j.issn.1006-2157.2023.01.021
  CLC： R269.843
- Received：09 January 2022，
  
  Published Online：20 October 2022，
  
  Published：30 January 2023
- 稿件说明：
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HAO Xiaowan, TU Jianfeng, WANG Liqiong, et al. Influence of sex on the therapeutic effect of acupuncture on knee osteoarthritis: a secondary analysis of data from a multi-center randomized controlled study[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(1): 125-131.
DOI：

HAO Xiaowan, TU Jianfeng, WANG Liqiong, et al. Influence of sex on the therapeutic effect of acupuncture on knee osteoarthritis: a secondary analysis of data from a multi-center randomized controlled study[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(1): 125-131. DOI： 10.3969/j.issn.1006-2157.2023.01.021.

摘要

目的

探讨膝骨关节炎针刺治疗疗效在不同性别之间是否存在差异。

方法

对一项多中心、随机对照试验数据进行二次分析。试验将442例膝骨关节炎患者随机分为手针组(145例)、电针组(151例)、假针刺组(146例)。手针组以犊鼻、内膝眼、曲泉、膝阳关、阿是穴为主穴，按照循经配穴法选择3个配穴，电针仪不输出电流；电针组取穴同手针组，电针仪输出2/100 Hz疏密波；假针刺组选择8个非经非穴点浅刺，电针仪不输出电流。每次针刺干预30 min，每周3次，共8周。分别在治疗前后记录西安大略和麦克马斯特大学骨关节炎指数(WOMAC)功能评分、疼痛数字评价量表(NRS)评分。针刺有效应答定义为WOMAC功能评分至少下降6分，且NRS评分至少下降2分。

结果

手针组中男性有效应答率58.8%，女性59.6%，不同性别有效应答率差异无统计学意义(

0.05)；电针组中男性有效应答率62.5%，女性59.7%，不同性别有效应答率差异无统计学意义(

0.05)；假针刺组中男性针刺有效应答率52.5%，女性45.3%，不同性别有效应答率差异无统计学意义(

0.05)。

结论

针刺治疗膝骨关节炎疗效与性别无关，不同性别患者发生不良反应事件的情况都很少，提示针刺作为一种非药物疗法，具有较好的疗效以及安全性。

Abstract

Objective

To investigate whether there is sex difference in the acupuncture treatment of knee osteoarthritis.

Methods

A secondary analysis of data from a multicenter randomized controlled trial was performed. A total of 442 patients with knee osteoarthritis were randomly divided into the acupuncture group (

=145)

electroacupuncture group (

=151)

and sham acupuncture group (

=146). For the acupuncture group

obligatory acupoints were selected

including ST35

EX-LE4

LV8

GB33

and

ashi

points

with three matching acupoints along the channel

and the electroacupuncture instrument was connected without any current. The same acupoints were selected for the electroacupuncture group

but the 2/100 Hz dilatational wave was connected. For the sham acupuncture group

eight shallow points that were unrelated to any channel or acupoint were selected

and the electroacupuncture instrument was not connected to a current. For all groups

the intervention lasted 30 min per session

three times a week

for eight weeks in total. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and the Numerical Rating Scale (NRS) were used for assessment before and after treatment. An effective acupuncture response was defined as a decrease of at least 6 points in the functional index of WOMAC and a decrease of at least 2 points in the NRS.

Results

In the acupuncture group

the effective response rate was 58.8% and 59.6% for males and females

respectively (

0.05). In the electroacupuncture group

the effective response rate was 62.5% and 59.7% for males and females

respectively (

0.05). In the sham acupuncture group

the effective response rate was 52.5% and 45.3% for males and females

respectively (

0.05).

Conclusion

The efficacy of acupuncture in the treatment of knee osteoarthritis is probably unrelated to sex

and the incidence of adverse events seems to be very low regardless of sex

suggesting that acupuncture

as a non-drug therapy

tends is effective and safe.

关键词

Keywords

references

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