Exploring the mechanism and clinical application of intestinal mucosal immunity in the intervention of phlegm-dampness constitution regulation based on the theory of "spleen being in charge of the defensive function"

ZHANG Anqi; WAN Jinyi; YAO Haiqiang

doi:10.3969/j.issn.1006-2157.2023.02.003

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Exploring the mechanism and clinical application of intestinal mucosal immunity in the intervention of phlegm-dampness constitution regulation based on the theory of "spleen being in charge of the defensive function"

TCM Constitution | 更新时间：2023-03-07

- Exploring the mechanism and clinical application of intestinal mucosal immunity in the intervention of phlegm-dampness constitution regulation based on the theory of "spleen being in charge of the defensive function"
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 2, Pages: 159-163(2023)
- 作者机构：
  
  北京中医药大学　北京　100029
- 作者简介：
  
  YAO Haiqiang, Ph.D., Associate Researcher, Beijing University of Chinese Medicine, No.11, Beisanhuan Donglu Road, Chaoyang District, Beijing 100029. E-mail: haiqiangyao@outlook.com
- 基金信息：
  
  National Natural Science Foundation of China(81973714;82274379)
- DOI：10.3969/j.issn.1006-2157.2023.02.003
  CLC： R255.8
- Received：28 July 2022，
  
  Published：28 February 2023
- 稿件说明：
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ZHANG Anqi, WAN Jinyi, YAO Haiqiang. Exploring the mechanism and clinical application of intestinal mucosal immunity in the intervention of phlegm-dampness constitution regulation based on the theory of "spleen being in charge of the defensive function"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(2): 159-163.
DOI：

ZHANG Anqi, WAN Jinyi, YAO Haiqiang. Exploring the mechanism and clinical application of intestinal mucosal immunity in the intervention of phlegm-dampness constitution regulation based on the theory of "spleen being in charge of the defensive function"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(2): 159-163. DOI： 10.3969/j.issn.1006-2157.2023.02.003.

摘要

痰湿体质是由于水液停聚凝而成痰所致，以黏滞重浊为主要特征的体质状态，是多种代谢性疾病的共同“土壤”。“脾主为卫”是对脾脏防病祛邪功能的高度概括。“脾主为卫”的功能失调是痰湿体质者代谢紊乱的重要病理因素，然而其微观机制尚不清晰。“脾主为卫”与肠道黏膜免疫有同质的学术内涵，从肠道黏膜免疫的角度出发，可以为中医“脾主为卫”理论作出新的科学解读。痰湿体质者存在低度慢性炎症状态，可进一步发展为胰岛素抵抗及代谢性疾病，而肠道黏膜免疫功能失调在其中发挥着重要作用。基于“脾主为卫”理论，采用中医益气健脾治法可有效调节肠道黏膜免疫，进而改善代谢紊乱，为痰湿体质的临床调体和相关疾病的治疗提供新的理论依据和治疗策略，有利于进一步指导临床应用。

Abstract

Phlegm-dampness constitution is formed by the stagnation and condensation of water and body fluid. It is a constitution type characterized by viscosity

stagnation

and turbidity

and is the common soil of various metabolic diseases. "Spleen being in charge of the defensive function" is a highly generalizing abstraction of the spleen’s function in preventing disease and removing pathogenic factors. Dysfunction of the spleen is an essential pathological factor in the metabolic disorder of phlegm-dampness constitution. However

its microscopic mechanism is still unclear. "Spleen being in charge of the defensive function" and intestinal mucosal immunity have homogenous academic connotations. From the perspective of intestinal mucosal immunity

a new scientific interpretation can be made for the theory of the "spleen being in charge of the defensive function" in traditional Chinese medicine (TCM). Phlegm-dampness constitution is associated with a low degree of chronic inflammation

which can further develop into insulin resistance and metabolic diseases. Intestinal mucosal immune dysfunction plays a crucial role in this pathogenic process. Based on the theory of "spleen being in charge of the defensive function"

the therapeutic method of replenishing qi and strengthening the spleen can be used to effectively regulate intestinal mucosal immunity and improve metabolic disorders

providing a new scientific basis and therapeutic strategy for the clinical management of phlegm-dampness constitution and the treatment of related diseases

which is beneficial to clinical practice.

关键词

Keywords

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