Discussion on the application of <italic style="font-style: italic">Sunluo</italic>’s theory of "eliminate peculiar pathogen and circulate <italic style="font-style: italic">Yingwei</italic>" in myocardial fibrosis

QU Yiwei; MA Dufang; WU Tao; WANG Yong

doi:10.3969/j.issn.1006-2157.2023.02.016

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Discussion on the application of Sunluo’s theory of "eliminate peculiar pathogen and circulate Yingwei" in myocardial fibrosis

Clinical Studies | 更新时间：2023-03-07

- Discussion on the application of Sunluo’s theory of "eliminate peculiar pathogen and circulate Yingwei" in myocardial fibrosis
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 2, Pages: 247-251(2023)
- 作者机构：
  
  1.山东中医药大学中医学院　济南　250013
  2.山东中医药大学附属医院
- 作者简介：
  
  WANG Yong, Ph.D., Attending Physician. The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No.16369, Jingshi Road, Lixia District, Jinan 250014. E-mail: wangyong20070501@126.com
- 基金信息：
  
  National Natural Science Foundation of China(82104797;82004280);Natural Science Foundation of Shandong Province(ZR2020QH333);Shandong Province Integrated Traditional Chinese and Western Medicine Special Disease Prevention Project(鲁卫医字〔2020〕22号)
- DOI：10.3969/j.issn.1006-2157.2023.02.016
  CLC： R256.2
- Received：31 August 2022，
  
  Online First：01 November 2022，
  
  Published：28 February 2023
- 稿件说明：
移动端阅览
QU Yiwei, MA Dufang, WU Tao, et al. Discussion on the application of Sunluo’s theory of "eliminate peculiar pathogen and circulate Yingwei" in myocardial fibrosis[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(2): 247-251. DOI: 10.3969/j.issn.1006-2157.2023.02.016.
DOI：

QU Yiwei, MA Dufang, WU Tao, et al. Discussion on the application of Sunluo’s theory of "eliminate peculiar pathogen and circulate Yingwei" in myocardial fibrosis[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(2): 247-251. DOI: 10.3969/j.issn.1006-2157.2023.02.016. DOI：

摘要

孙络是经络系统最末端的结构分支，相当于西医学之微血管，其与心脏关系密切。“溢奇邪、通营卫”是《黄帝内经》中关于孙络的经典理论，对中医药防治心肌纤维化具有重要指导意义。本文从孙络“溢奇邪、通营卫”的生理功能探讨，认为心肌纤维化是由于奇邪侵袭孙络、营卫不通导致瘀血内阻，进一步影响营卫交会生化功能，导致津血失调，津液聚于孙络之外而不能回流导致水液停聚，瘀、水凝聚蕴结，久聚脉络，稽留不去，终致络阻积成。西医学认为，肾素－血管紧张素－醛固酮系统可以干预心脏微血管，不仅会损伤血管内皮细胞导致血液瘀积、水液外渗，还会导致血管内皮细胞、免疫细胞异常作用于成纤维细胞，促进成纤维细胞合成胶原蛋白，引起细胞外基质过度沉积，最终造成心肌纤维化。治疗上以活血利水为主，辅以补益孙络、调和营卫以治其本，旨在使营卫汇通，血脉流畅，阴阳相贯，以恢复冠状动脉微循环稳态平衡，从而达到防治心肌纤维化的目的。

Abstract

Sunluo

refers to the terminal structural branches of the meridian system

which is equivalent to the microvessels in Western medicine and are closely related to the heart. "Eliminate peculiar pathogen and circulate

Yingwei

" is a classical theory about

Sunluo

Huangdi Neijing

which has important guiding significance for the prevention and treatment of myocardial fibrosis (MF) with traditional Chinese medicine. Referring to the physiological function of

Sunluo

’s "eliminate peculiar pathogen and circulate

Yingwei

" this paper is based on the belief that MF is caused by a peculiar pathogen invading

Sunluo

and blocking

Yingwei

which leads to internal resistance of blood stasis

which further affects the biochemical function of

Yingwei

leads to the imbalance of body fluid and blood

and finally leads to water stagnation. With the mutual formation of stasis and water

the collaterals accumulate for a long time

which eventually leads to collaterals block. According to Western medicine

the renin-angiotensin-aldosterone system can interfere with cardiac microvessels

which not only damages vascular endothelial cells and leads to blood stasis and extravasation of water

but also causes vascular endothelial cells and immune cells to act abnormally on fibroblasts and promote fibroblasts to synthesize collagen protein

leading to excessive deposition of extracellular matrix and eventually leading to MF. Treatment is mainly based on promoting blood circulation and diuresis

as well as nourishing

Sunluo

reconciling

Yingwei

and treating the root

aiming at making

Yingwei

flow

blood vessels smooth

yin and yang interlinked to restore coronary microcirculation homeostasis

so as to prevent and treat MF.

关键词

Keywords

references

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⁰

Discussion on the application of Sunluo’s theory of "eliminate peculiar pathogen and circulate Yingwei" in myocardial fibrosis

DOI：10.3969/j.issn.1006-2157.2023.02.016

摘要

Abstract

关键词

Keywords

references