Correlation study of unstable angina pectoris with depression and objective indicators and specific TCM syndromes after coronary revascularization

LI Qiuye; JIANG Haiyang; CHEN Wei; WANG Shuai; HE Fanyu; WANG Fengrong

doi:10.3969/j.issn.1006-2157.2023.02.019

您当前的位置：

首页 >

文章列表页 >

Correlation study of unstable angina pectoris with depression and objective indicators and specific TCM syndromes after coronary revascularization

Clinical Studies | 更新时间：2023-03-07

- Correlation study of unstable angina pectoris with depression and objective indicators and specific TCM syndromes after coronary revascularization
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 2, Pages: 263-268(2023)
- 作者机构：
  
  1.辽宁中医药大学　沈阳　110032
  2.辽宁中医药大学附属医院
- 作者简介：
  
  Prof. WANG Fengrong, Ph.D., Chief Physician, Doctoral Supervisor. Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No.33 Beiling Street, Huanggu District, Shenyang 110032. E-mail: wfr925@126.com
- 基金信息：
  
  State Administration of Traditional Chinese Medicine Clinical Collaboration Pilot Project of TCM and Western Medicine for Major and Intractable Diseases;National Traditional Chinese Medicine Inheritance and Innovation Platform Project;Liaoning Province Traditional Chinese Medicine Clinical Key (Special) Service Capacity Building Project(LNZYXZK201908)
- DOI：10.3969/j.issn.1006-2157.2023.02.019
  CLC： R259.414
- Received：16 January 2022，
  
  Published：28 February 2023
- 稿件说明：
移动端阅览
LI Qiuye, JIANG Haiyang, CHEN Wei, et al. Correlation study of unstable angina pectoris with depression and objective indicators and specific TCM syndromes after coronary revascularization[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(2): 263-268.
DOI：

LI Qiuye, JIANG Haiyang, CHEN Wei, et al. Correlation study of unstable angina pectoris with depression and objective indicators and specific TCM syndromes after coronary revascularization[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(2): 263-268. DOI： 10.3969/j.issn.1006-2157.2023.02.019.

摘要

目的

探讨冠脉血运重建后不稳定型心绞痛患者发生抑郁与血小板水平(PLT)、淋巴细胞计数(TLC)、血小板淋巴细胞比率(PLR)、胆红素(TBIL)及特定证候的相关性。

方法

2020年11月—2021年7月，纳入冠脉血运重建后不稳定型心绞痛患者87例。入院后检测PLT、TLC及TBIL，计算PLR。同日对患者进行汉密尔顿抑郁量表(HAMD)评分，8～24分者纳入抑郁组(42例)，低于8分者纳入对照组(45例)。将PLT、TLC、TBIL、PLR与是否抑郁进行双变量Spearman相关性分析。然后将是否抑郁作为因变量，PLT、TLC、TBIL、PLR作为自变量，进行二元Logistic回归分析，确定影响因素。对气滞血瘀证、气滞痰郁证、气郁化火证以1、0赋值进行数字化处理，并进行Spearman相关性分析，然后将研究对象依不同中医证候分为符合与不符合，对Spearman相关性分析中有统计学意义的实验室检查指标进行独立样本

检验。

结果

PLT(

＝0.312，

＝0.003)、PLR(

＝0.486，

0.001)与抑郁的发生正相关，TLC(

＝－0.296，

＝0.005)、TBIL(

＝－0.424，

0.001)与抑郁情绪的发生负相关。PLT与气滞血瘀证正相关(

＝0.354，

＝0.001)，PLR与气郁化火证正相关(

＝0.293，

＝0.006)，TLC(

＝－0.229，

＝ 0.033)与气郁化火证负相关。

结论

PLR为冠脉血运重建后不稳定型心绞痛患者发生抑郁的独立危险因素，TBIL为其保护因素。高水平的PLT与气滞血瘀证的发生密切相关，高水平的TLC、PLR与气郁化火证的发生相关。

Abstract

Objective

We aimed to explore the correlation between depression in patients with unstable angina pectoris after coronary revascularization and the levels of platelet (PLT)

total lymphocyte count (TLC)

platelet-lmphocyte ratio (PLR)

and total bilirubin (TBIL) and specific TCM syndromes.

Methods

Altogether 87 patients with unstable angina pectoris after coronary revascularization from November 2020 to July 2021 were selected. Laboratory examination was conducted after admission

including PLT

TLC

and TBIL values. The PLR was obtained by calculating the ratio of PLT and TLC. On the same day

the patient's Hamilton Depression Scale (HAMD) score was collected. Patients with a score between 8 and 24 were included in the depression group (42 cases); patients with a score below 8 were included in the control group (45 cases). Bivariate Spearman correlation analysis was conducted to investigate the relationship between each laboratory examination indices (PLT

TLC

TBIL

and PLR) and depression. Then

depression was taken as a dependent variable and each above laboratory examination index was taken as an independent variable to conduct binary Logistic regression analysis to determine the influencing factors. TCM syndromes (qi stagnation and blood stasis syndrome

qi stagnation and phlegm stagnation syndrome

and syndrome of qi depression transforming into fire) were classified by assigning values of 1 and 0

and Spearman correlation analysis was conducted. Then

the subjects were divided into compliance and non-compliance subgroups according to different TCM syndromes

and the independent sample t-test was conducted for laboratory examination indices with statistical significance in Spearman correlation analysis.

Results

PLT (

=0.312

=0.003) and PLR (

=0.486

0.001) were positively correlated with the occurrence of depression

while TLC (

=-0.296

=0.005) and TBIL (

=-0.424

0.001) were negatively correlated with the occurrence of depression. PLT was positively correlated with the occurrence of qi stagnation and blood stasis syndrome (

=0.354

=0.001)

and TLC (

=-0.229

=0.033) and PLR (

=0.293

= 0.006) were negatively or positively correlated with the occurrence of syndrome of qi depression transforming into fire

respectively.

Conclusion

PLR is an independent risk factor for depression in patients with unstable angina pectoris after coronary revascularization

and TBIL is a protective factor. High levels of PLT are closely related to the occurrence of qi stagnation and blood stasis syndrome

and high levels of TLC and PLR are related to the occurrence of syndrome of qi depression transforming into fire.

关键词

Keywords

references

王宇杰，杨振刚，蒋文潇，等．温阳化饮方对不稳定型心绞痛阳虚饮停证患者冠状动脉血运重建后反复心绞痛发作的影响 [J]. 中医杂志， 2020 ， 61 ( 3 )： 226 － 228 .

陈鹏，王磊，张俭，等 . 冠脉血运重建术后再发心绞痛的中西医干预策略 [J]. 中国中西医结合杂志， 2010 ， 30 ( 12 )： 1237 － 1240 .

宋博凡，努热曼古丽·阿布都克热木，高彦琳，等 . 血小板与淋巴细胞比值与冠心病患者冠脉斑块稳定性的关系 [J]. 中国医药导报， 2020 ， 17 ( 20 )： 54 － 57 .

WILLIAMS MS ， ZIEGELSTEIN RC ， MCCANN UD ， et al . Platelet Serotonin Signaling in Patients With Cardiovascular Disease and Comorbid Depression [J]. Psychosom Med , 2019 , 81 ( 4 ) : 352 － 362 .

HUANG GQ , CHEN HJ , WANG QZ , et al . High platelet-to-lymphocyte ratio are associated with post-stroke depression [J]. J Affect Disord , 2019 , 246 ： 105 － 111 .

胡佳，周伟，周志明，等．炎症指标对缺血性脑卒中卒中后抑郁的预测价值 [J]. 南方医科大学学报， 2019 ， 39 ( 6 )： 665 － 671 .

刘真成，边云飞．不稳定型心绞痛伴高血压病人血清尿酸及总胆红素水平的关系研究 [J]. 中西医结合心脑血管病杂志， 2019 ， 17 ( 15 )： 2329 － 2331 .

金庞，周波，王国民，等．阿米替林联合喹硫平对双向情感障碍患者的疗效及对TBIL和脑源性神经营养因子水平的影响 [J]. 广东医学， 2021 ， 42 ( 6 )： 723 － 726 .

中华医学会心血管病学分会，中华心血管病杂志编辑委员会．不稳定性心绞痛和非ST段抬高心肌梗死诊断与治疗指南 [J]. 中华心血管病杂志， 2007 ， 35 ( 4 )： 295 － 304 .

黄榕翀，郭宏洲．《2019欧洲心脏病学会慢性冠脉综合征的诊断和管理指南》解读 [J]. 实用心脑肺血管病杂志， 2019 ， 27 ( 10 )： 1 － 5 .

中华中医药学会．中医内科常见病诊疗指南　中医病证部分 [M]. 北京：中国中医药出版社， 2008 ： 39 － 42 .

世界中医药联合会心血管病专业委员会，中国中西医结合学会心血管病专业委员会，中华中医药学会介入心脏病学会，等．冠状动脉血运重建术后心绞痛中西医结合诊疗指南 [J]. 中国中西医结合杂志， 2020 ， 40 ( 11 )： 1298 － 1307 .

中华中医药学会介入心脏病学专家委员会．经皮冠状动脉介入治疗(PCI)手术前后抑郁和(或)焦虑中医诊疗专家共识 [J]. 中医杂志， 2015 ， 56 ( 4 )： 357 － 360 .

曲淼，孙文军，唐启盛 . “枢轴运动”理论与产后抑郁症辨治 [J]. 北京中医药大学学报， 2021 , 44 ( 7 )： 631 － 634 .

瞿秋霜，李晶晶，梅刚，等 . 老年抑郁障碍患者细胞因子及免疫相关性研究 [J]. 南京医科大学学报(自然科学版) ， 2017 ， 37 ( 10 )： 1278 － 1282 .

AJITH Y , DIMRI U , GOPALAKRISHNAN A , et al . Th1 / Th2 immune responses and oxidative stress in caprine flea allergy dermatitis [J]. Parasite Immunol ， 2017 ， 39 ( 12 )： 1 － 12 .

刘子铭，李凯勇，张诗琴等．血清胆红素及炎症指标与冠心病关系的探讨 [J]. 中国循证心血管医学杂志， 2018 ， 10 ( 7 )： 805 － 809 .

耿学斌，李莉，马燚，等．血清胆红素与心绞痛患者冠状动脉病变程度和预后的关系 [J]. 中国动脉硬化杂志， 2019 ， 27 ( 3 )： 236 － 240 .

王昀，王超，丁婉丽，等 . 双心疾病之冠心病伴焦虑抑郁“瘀热虚滞”病机探析 [J]. 北京中医药大学学报， 2022 ， 45 ( 4 )： 347 － 352 .

薛丹，张裕惠，揭晓，等．从“瘀毒郁互结”探讨急性心脑血管事件伴抑郁的病因病机 [J]. 北京中医药大学学报， 2022 ， 45 ( 3 )： 313 － 319 .

史珍珍，王留伟，汤继海，等．振源胶囊联合黛力新治疗冠心病合并焦虑抑郁患者相关临床研究 [J]. 世界中西医结合杂志， 2021 ， 16 ( 1 )： 153 － 156 .

Views

394

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Pathogenesis and treatment of coronary heart disease with anxiety and depression in older adults

Research on the mechanism of Sini Powder regulating the HPA axis and inflammatory levels to ameliorate depression-like behaviors and inhibiting tumor proliferation in liver cancer

Effects of electroacupuncture on mitophagy in hippocampal neurons of mouse depression model

Relationship between qi stagnation constitution and anxiety/depression in 10, 325 junior high school students, and in which the mediating effect of sleep duration

Discussion of the pathogenesis and treatment of pulmonary nodules complicated by extrapulmonary nodules based on "holism of physique and spirit"

Related Author

CAI Yongyuan

YAN Zhaoqi

WANG Qiuming

GENG Jinzhu

REN Tiantian

CHEN Jiamei

LIU Zhiming

LIU Ruxiu

Related Institution

Guang′anmen Hospital, China Academy of Chinese Medical Sciences

First Affiliated Hospital of Guangzhou University of Chinese Medicine

Graduate School, Hunan University of Chinese Medicine

The First Hospital of Hunan University of Chinese Medicine

暨南大学中医学院广州市中医方证重点实验室Guangzhou Key Laboratory of Formula-Pattern of Traditional Chinese Medicine, School of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, China

AI问答

Postal code：100029
Tel：(010)53911857 Email：jbutcm@bucm.edu.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰