Exploration of mechanism and strategy to treat spleen disease and adjust defensive qi for delaying the progression of pancreatic cancer based on "spleen acting as the guard for the five zang viscera and six fu viscera"

ZHANG Chuanlong; LI Yi; JIANG Xiaochen; PANG Bo; HUA Baojin

doi:10.3969/j.issn.1006-2157.2023.03.007

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Exploration of mechanism and strategy to treat spleen disease and adjust defensive qi for delaying the progression of pancreatic cancer based on "spleen acting as the guard for the five zang viscera and six fu viscera"

Theoretical Studies | 更新时间：2023-04-07

- Exploration of mechanism and strategy to treat spleen disease and adjust defensive qi for delaying the progression of pancreatic cancer based on "spleen acting as the guard for the five zang viscera and six fu viscera"
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 3, Pages: 326-330(2023)
- 作者机构：
  
  1.中国中医科学院广安门医院　北京　100053
  2.中国中医科学院广安门医院国际医疗部
- 作者简介：
  
  Prof. Pang Bo, M. D., Chief Physician, Doctoral Supervisor. Guang’anmen Hospital, China Academy of Chinese Medical Sciences. No.5 Beixiange Road, Xicheng Districct, Beijing 100053. Email: drpangbo@gmail.com
- 基金信息：
  
  Special Project on Research and demonstration Application of Clinical diagnosis and treatment Technology in Capital of Beijing Municipal Commission of Science and Technology(CI2021A01805;CI2021B009)
- DOI：10.3969/j.issn.1006-2157.2023.03.007
  CLC： R273.59
- Received：04 June 2022，
  
  Published Online：05 January 2023，
  
  Published：30 March 2023
- 稿件说明：
移动端阅览
ZHANG Chuanlong, LI Yi, JIANG Xiaochen, et al. Exploration of mechanism and strategy to treat spleen disease and adjust defensive qi for delaying the progression of pancreatic cancer based on "spleen acting as the guard for the five zang viscera and six fu viscera"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(3): 326-330.
DOI：

ZHANG Chuanlong, LI Yi, JIANG Xiaochen, et al. Exploration of mechanism and strategy to treat spleen disease and adjust defensive qi for delaying the progression of pancreatic cancer based on "spleen acting as the guard for the five zang viscera and six fu viscera"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(3): 326-330. DOI： 10.3969/j.issn.1006-2157.2023.03.007.

摘要

胰腺疾病多责于脾，中医从脾论治胰腺癌可有效延缓其演变进程，但缺少理论支持，值得进一步探讨。基于对“脾为之卫”内涵的阐发，认为“脾为之卫”是机体护卫功能的高度概括，其正常功能的发挥依赖于“脾主运化”。胰腺癌患者分泌功能异常，胆汁、胰液排出受阻而造成“脾失运化”，导致“脾为之卫”向“脾失之卫”的病理转变，或为胰腺癌演进的核心环节。“脾伤卫弱→脾损卫伐→脾衰卫溃”这一病理演变进程与现代研究中胰腺癌的演变进程高度契合，合理解释了治脾以延缓胰腺癌演进效果显著的机理所在，维护和恢复“脾为之卫”的功能，以重塑胰腺癌肿瘤微环境，是延缓胰腺癌演进的关键。结合现代研究，总结出清脾以复卫气、健脾以行卫气、补脾以生卫气三大治脾调卫策略，以期为临床辨治胰腺癌提供有益参考。

Abstract

Pancreatic diseases are mostly caused by disorders of the spleen. Treatment of pancreatic cancer caused by the spleen based on traditional Chinese medicine can effectively delay its evolution

but there is a lack of theoretical support

which is worthy of further discussion. Based on the elucidation of the connotation of "spleen acting as the guard for the five zang viscera and six fu viscera"

this paper states that "spleen acting as the guard for the five zang viscera and six fu viscera" is a summary of the body’s security function

which depends on "spleen dominant digestion" . The secretory functions of pancreatic cancer patients are abnormal

so the obstruction of bile and pancreatic juice excretion leads to "spleen failing to digest"

which leads to the pathological transformation from "spleen acting as the guard for the five zang viscera and six fu viscera" to "spleen lossing of guard"

or it may be the main cause of the evolution of pancreatic cancer. The pathological evolution process of "spleen injury-spleen failure-spleen collapse" is highly consistent with the evolution of pancreatic cancer based on modern research

which reasonably explains the significant curative effect of spleen treatment on the delay of the progression of pancreatic cancer. It is pointed out that the key to delaying the progression of pancreatic cancer is to maintain and restore the function of the "spleen acting as the guard for the five zang viscera and six fu viscera" in order to reshape the tumor microenvironment of pancreatic cancer. Combined with modern research

this paper summarizes the three spleen-regulating strategies of clearing spleen to restore defensive qi

invigorating spleen to run defensive qi

and tonifying spleen to replenish defensive qi

in order to provide a useful reference for clinical diagnosis and treatment of pancreatic cancer.

关键词

Keywords

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