Exploration of the role of mitochondrial function in cardiac diseases from the perspective of "heart kidney interaction, heart spleen mutual generation"

XU Ningyang; LI Guoxin; LIANG Lizhe; SONG Nan; LIU Yue; YANG Guanlin

doi:10.3969/j.issn.1006-2157.2023.03.019

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Exploration of the role of mitochondrial function in cardiac diseases from the perspective of "heart kidney interaction, heart spleen mutual generation"

Clinical Studies | 更新时间：2023-04-07

- Exploration of the role of mitochondrial function in cardiac diseases from the perspective of "heart kidney interaction, heart spleen mutual generation"
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 3, Pages: 415-420(2023)
- 作者机构：
  
  1.辽宁中医药大学　沈阳　110847
  2.辽宁省中医药研究院
- 作者简介：
  
  LI Guoxin, Ph.D., Chief Physician, Doctoral Supervisor. Liaoning Academy of Traditional Chinese Medicine, No. 60, Huanghe North Street, Yuhong District, Shenyang 110034. E-mail: syyljdlgx024@126.com
- 基金信息：
  
  Key R&D Program of Science and Technology Department of Liaoning Province(2020JH2/10300090);Famous Traditional Chinese Medicine Inheritance Studio of Liaoning Province(辽中医药函〔2021〕1号)
- DOI：10.3969/j.issn.1006-2157.2023.03.019
  CLC： R228
- Received：09 June 2022，
  
  Online First：05 January 2023，
  
  Published：30 March 2023
- 稿件说明：
移动端阅览
XU Ningyang, LI Guoxin, LIANG Lizhe, et al. Exploration of the role of mitochondrial function in cardiac diseases from the perspective of "heart kidney interaction, heart spleen mutual generation"[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(3): 415-420.
DOI：

XU Ningyang, LI Guoxin, LIANG Lizhe, et al. Exploration of the role of mitochondrial function in cardiac diseases from the perspective of "heart kidney interaction, heart spleen mutual generation"[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(3): 415-420. DOI： 10.3969/j.issn.1006-2157.2023.03.019.

摘要

心系疾病与线粒体功能异常密切相关。中医的心、脾、肾在心系疾病中具有重要作用，其通过线粒体功能发挥效用也有相关证据可循。基于中医理论、临床试验和动物实验发现，“心肾失交、心脾失调”是心系疾病演变中的关键病机，也是线粒体相关功能紊乱的宏观表达。梳理相关文献发现，目前临床通过益肾补气、益气温阳、温补心肾、健脾养心、益气健脾等方药加减治疗由线粒体功能异常导致的心系疾病。“心肾相交”理论是对线粒体动力学(融合、裂解)正常的宏观调控，“心脾相生”理论是对线粒体能量代谢的稳态调节。线粒体的功能繁多且复杂，中医药通过其相关理论在治疗心系疾病中有重要指导作用。因此，从“心肾相交、心脾相生”角度出发，探讨线粒体功能在治疗心系疾病中的作用具有重要意义，可为中医药治疗心系疾病提供更多可能性。

Abstract

Cardiac diseases are closely related to mitochondrial dysfunction. In traditional Chinese medicine (TCM)

the heart

spleen

and kidney play important roles in cardiac diseases. There is evidence indicating that TCM exert its effects through regulating mitochondrial function. Based on the theory of TCM

clinical trials

and animal experiments

it is found that "loss of heart kidney interaction and imbalance of heart and spleen" is not only the key pathogenesis in the evolution of cardiac diseases

but also the macro expression of mitochondrial related functional disorders. A review of relevant literature revealed that cardiac diseases caused by abnormal mitochondrial function are treated through addition and subtraction of prescriptions such as nourishing kidney and benefiting qi

nourishing qi and warming yang

warming and benefiting heart and kidney

strengthening spleen and nourishing heart

or nourishing qi and strengthening spleen. The "heart kidney interaction" theory is the macro-control of mitochondrial dynamics (fusion and lysis); the theory of "heart spleen mutual generation" is a steady-state regulation of mitochondrial energy metabolism. The functions of mitochondria are various and complex

and TCM plays an important guiding role in the treatment of cardiac diseases through its related theories. Therefore

it is of great significance to explore the role of mitochondrial function in the treatment of cardiac diseases from the perspective of "heart kidney interaction

heart spleen mutual generation"

so as to provide more possibilities for TCM-based treatment of cardiac diseases.

关键词

Keywords

references

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