Immunosuppressants are widely used in the treatment of rheumatic immune diseases

but most of them have toxic side effects

causing damage to the immune

digestive

reproductive and other systems

not only reducing patient compliance

but also seriously affecting disease prognosis. At present

Western medicine has no clear solution for the toxic side effects of immunosuppressants. The theory of traditional Chinese medicine(TCM) states that immunosuppressants such as glucocorticoids and cytotoxic drugs are mainly aggressive products. Long-term use of immunosuppressants can damage the lung

spleen and kidney

damage the vital qi of the body

and lead to deficiency symptoms occur. "Treating deficiency with three sources and two systems" is the great method developed by Wang Qishi

a doctor in the late Ming Dynasty

to treat deficiency and fatigue. After continuous enrichment and development in later generations

this has become a classic theory for treating consumption diseases. We studied the toxic side effects of immunosuppressants from the perspective of "treating deficiency with three sources and two systems". We believe that the symptom of consumption caused by immunosuppressants should be treated from the "three sources" of lung

spleen and kidney

and the two types of syndromes of kidney yin deficiency and kidney yang deficiency should be treated from the "two systems" of lung and spleen. In clinical practice

we can determine the corresponding treatment principles according to different system’s injury syndromes

so as to provide a TCM scheme for safe clinical drug use and expand the theoretical system of toxicity reduction based on TCM.