Objective

2

We aimed to observe the clinical efficacy of treating medium-risk solid pulmonary nodules based on patient’s pathogenesis state.

Methods

2

A prospective randomized controlled study was conducted to select patients with medium-risk solid pulmonary nodules who were admitted to either Dongfang Hospital of Beijing University of Chinese Medicine or Beijing Shijitan Hospital Affiliated to Capital Medical University from September 2020 to July 2022 (128 cases in total). The patients were randomly divided using the random number table method into the experimental group (85 cases) and the blank control group (43 cases) at a 2: 1 ratio. We diagnosed patients with (ⅰ) single state: qi deficiency

yin deficiency

yang deficiency

qi stagnation

and dampness-heat state

(ⅱ) combined state

or (ⅲ) a general state: if the patients did not meet any of the diagnosis criteria. Patients in the experimental group were treated with additional

Sanjie

basic prescription (Processed pinellia

Arisaema with bile

Balloon flower

Tuckahoe

Raw oyster

Radix notoginseng) according to the state at the time of consultation

while patients in the blank control group were not treated. Each course took 3 months

and patients received one or two courses. Lung CT scans were carried out after 3 and 6 months

and treatment efficacy was evaluated based on the reduction rate of the maximum diameter area of pulmonary nodules combined with the density and morphological changes.

Results

2

In total

115 patients completed the study (77 patients in the experimental group and 38 patients in the blank control group). The total clinical effective rates for the experimental group at 3 and 6 months were 51.95% and 49.02%

respectively

which were higher compared to 7.89% and 8.57%

respectively for the blank control group (

P

<

0.01). The maximum diameter of solid pulmonary nodules in the experimental group decreased compared with the baseline value

while it increased in the blank control group.

Conclusion

2

Under the condition of limited traditional syndrome differentiation and treatment

the treatment of medium-risk solid pulmonary nodules based on overall pathogenesis state received certain clinical efficacy.