Discussion on rheumatic immune diseases based on theory of healthy qi and pathogenic factors

LI Da; JIANG Quan; LIU Weixiang; GONG Xun; WANG Jian; XIA Congmin; TANG Xiaopo

doi:10.3969/j.issn.1006-2157.2023.05.001

您当前的位置：

首页 >

文章列表页 >

Discussion on rheumatic immune diseases based on theory of healthy qi and pathogenic factors

Special Theme: TCM Prevention and Treatment of Rheumatism | 更新时间：2023-06-05

- Discussion on rheumatic immune diseases based on theory of healthy qi and pathogenic factors
  增强出版
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 5, Pages: 593-598(2023)
- 作者机构：
  
  中国中医科学院广安门医院　北京　100053
- 作者简介：
  
  Prof. JIANG Quan, Ph.D., Chief Physician, Doctoral Supervisor. Guang’anmen Hospital, China Academy of Chinese Medical Sciences. No.5, Beixiange Street, Xicheng District, Beijing 100053. E-mail: doctorjq@126.com
- 基金信息：
  
  National Key R & D Program of China(2018YFC1705202);National Natural Science Foundation of China(82230121);Scientific and Technological Innovation Project of China Academy of Chinese Medical Sciences(CI2021A01501)
- DOI：10.3969/j.issn.1006-2157.2023.05.001
  CLC： R259.93
- Received：11 January 2023，
  
  Online First：07 April 2023，
  
  Published：30 May 2023
- 稿件说明：
移动端阅览
LI Da, JIANG Quan, LIU Weixiang, et al. Discussion on rheumatic immune diseases based on theory of healthy qi and pathogenic factors[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(5): 593-598.
DOI：

LI Da, JIANG Quan, LIU Weixiang, et al. Discussion on rheumatic immune diseases based on theory of healthy qi and pathogenic factors[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(5): 593-598. DOI： 10.3969/j.issn.1006-2157.2023.05.001.

摘要

将中医“正邪理论”与西医的免疫学理论结合研究风湿免疫病，认识到其核心病机是邪盛正衰。“正”代表维持机体正常生理功能、促进人体生命最佳状态的影响因素；“邪”代表导致免疫异常的病理因素，或因免疫异常产生的损害机体脏腑组织的病理产物。结合西医免疫学理论，分析风、寒、湿等致病因素的生物学内涵，使风湿免疫病中医病因认识客观化、现代化。风湿免疫病的中医药论治当先明确病情，抓住主要矛盾，明确先后次第，兼取中西医所长，以祛邪安正作为风湿免疫病的基本治则。

Abstract

We combine the theory of healthy qi and pathogenic factors in traditional Chinese medicine (TCM) with the theory of immunology in western medicine

and we realized that rheumatic immune disease is predominantly caused by excessive pathogenic factors and declined healthy qi. "Healthy qi" refers to the influencing factors that maintain the normal physiological function of the human body and the optimal state of life

and "pathogenic factors" refers to all pathological factors that cause immune abnormalities

or pathological products that damage the body tissues and viscera due to immune abnormalities. We clarified the biological connotation of pathogenic factors such as wind

cold

and dampness

so as to objectify and modernize the etiology of TCM. In TCM treatment of rheumatic immune disease

the disease condition should first be clarified

and the focus should then be placed on the main contradictions

clearing the order of priority

making use of the respective advantages of both TCM and western medicine. Eliminating pathogenic factors and reinforcing healthy qi is considered as the basic treatment principle of rheumatic immune diseases.

关键词

Keywords

references

王妍华，罗静，何岚．医学伦理学视角下风湿免疫病慢病管理问题及对策探讨 [J]. 中国医学伦理学， 2021 ， 34 ( 9 )： 1214 － 1217 .

王承德，沈丕安，胡荫奇．实用中医风湿免疫病学 [M]. 北京：人民卫生出版社， 2009 ： 1 － 21 .

PODDUBNYY D . Precision medicine in rheumatology: are we getting closer ? [J] Lancet , 2021 ， 397 ( 10271 )： 258 － 259 .

李德新，刘燕池．中医基础理论 [M]. 2版．北京：人民卫生出版社， 2011 ： 593 .

郝钰，万红娇，邝枣园．医学免疫学与病原生物学 [M]. 4版．北京：科学出版社， 2017 ： 2 － 4 .

张茂，吴小玫，李永柏．试论扶正祛邪与免疫的关系 [J]. 重庆医科大学学报， 2002 ， 27 ( 3 )： 357 － 358 .

任保印 . 浅述脾肾与正气及免疫调节的关系 [J]. 陕西中医， 2008 ， 29 ( 7 )： 847 － 849 .

LUDWIG N , HILGER A , ZARBOCK A , et al . Platelets at the Crossroads of Pro-Inflammatory and Resolution Pathways during Inflammation [J/OL]. Cells ， 2022 ， 11 ： 1957 [ 2022－11－28 ]. https：//doi.org/10.3390/cells11121957 https：//doi.org/10.3390/cells11121957 .

ROJAS M , RESTREPO-JIMENEZ P , MONSALVE DM , et al . Molecular mimicry and autoimmunity [J]. J Autoimmun , 2018 ， 95 ： 100 － 123 .

吴洪福．炎症细胞因子网络与疾病 [J]. 青海医学院学报， 2003 ， 29 ( 4 )： 267 － 270 .

金善善，许文成，王小琴．从炎症细胞因子探讨从风论治肾小球疾病的物质基础 [J]. 辽宁中医杂志， 2019 ， 46 ( 8 )： 1591 － 1594 .

姜泉，蒋红，曹炜，等 . 475例类风湿关节炎患者中医临床证候分析 [J]. 中医杂志， 2007 ， 48 ( 3 )： 253 － 255 .

陈海霞，陈祥胜，孙雄杰，等．苍术炒焦前后正丁醇部位对湿阻中焦证大鼠水盐代谢影响 [J]. 辽宁中医杂志， 2018 ， 45 ( 11 )： 2390 － 2392 .

吴霞．化痰通肺汤治疗慢性阻塞性肺疾病急性加重期痰浊阻肺证的临床疗效观察 [J]. 药品评价， 2019 ， 16 ( 20 )： 34 － 35 .

梁灿璨，吴诗华，魏羽，等．补骨脂盐炙前后对肾阳虚大鼠肝肾功能及水通道蛋白表达的影响 [J]. 中草药， 2017 ， 48 ( 22 )： 4713 － 4718 .

王银山，苏雅丽，丰哲，等．类风湿关节炎辨证分型与各种炎性指标相关性研究 [J]. 山东中医药大学学报， 2009 ， 33 ( 4 )： 296 － 297 .

田婷．急性脑出血瘀热病机的生物标志物研究 [D]. 南京：南京中医药大学， 2016 .

FIRESTEIN GS , BUDD RC , GABRIEL SE , et al . 凯利风湿病学 [M]. 10版．栗占国，译．北京：北京大学医学出版社， 2020 ： 442 － 457 .

赵凤鸣，黄艳，吴铭杰，等．出血性中风瘀热证患者炎症、凝血相关基因的表达特征 [J]. 中医杂志， 2018 ， 59 ( 20 )： 1753 － 1757 .

LU C , XIAO C , CHEN G , et al . Gold and heat pattern of rheumatoid arthritis in traditional Chinese medicine：distinct molecular signatures in dentified by microarry expression profiles in CD4－positive T cell [J]. Rheumatol Int , 2012 , 32 ( 1 ), 61 － 68 .

孙志岭，王玲，王富强，等．类风湿关节炎寒湿痹阻证患者血清蛋白组学分析 [J]. 中国中西医结合杂志， 2013 ， 33 ( 7 )： 901 － 905 .

SARRAND J , BAGLIONE L , PARISIS D , et al . The Involvement of Alarmins in the Pathogenesis of Sjögren’s Syndrome [J/OL]. Int J Mol Sci , 2022 , 23 ( 10 )： 5671 [ 2022－11－ 28 ]. https：//doi.org/10.3390/ijms23105671 https：//doi.org/10.3390/ijms23105671 .

倪圣 . 细胞因子网络失衡与外燥伤肺病机的实验研究 [D]. 荆州：长江大学， 2015 .

孙刚，李晓玲．痰浊证型患者糖、脂等代谢指标检测及其临床意义 [J]. 贵阳中医学院学报， 1997 ， 19 ( 3 )： 59 － 60 .

李小兵，林昌松，骆怡然，等．心脑血管病痰证患者免疫功能特点初探 [J]. 中国中医基础医学杂志， 1997 ， 3 ( 6 )： 50 － 52 .

朱良春．朱良春医集 [M]. 长沙：中南大学出版社， 2006 ： 108 － 111 .

叶锦夏，陈进春，邱明山．类风湿性关节炎痰瘀积分与炎症因子相关性研究 [J]. 中医药通报， 2015 ， 14 ( 6 )： 51 － 54 .

SHE Z , LI CF , WU FF , et al . The Role of B1 Cells in Systemic Lupus Erythematosus [J/OL]. Front Immunol , 2022 ， 13 ： 814857 [ 2022－11 －30 ]. https：//doi.org//10.3389/fimmu.2022.814857 https：//doi.org//10.3389/fimmu.2022.814857 .

RUIZ-ESUQIDE V , GOMARA MJ , PEINADO VI , et al . Anti-citrullinated peptide antibodies in the serum of heavy smokers without rheumatoid arthritis. A differential effect of chronic obstructive pulmonary disease ? [J]. Clin Rheumatol , 2012 ， 31 ( 7 )： 1047 － 1050 .

LUNDBERG K , KINLOCH A , FISHER BA , et al . Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase [J]. Arthritis Rheum ， 2008 ， 58 ( 10 )： 3009 － 3019 .

董玢，娄利霞，韦翊，等．益气活血解毒中药对胶原诱导性关节炎大鼠NF－κB信号通路相关因子表达的影响 [J]. 北京中医药大学学报， 2015 ， 38 ( 10 )： 686 － 689 .

Views

511

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Establishment and clinical application of the "three-stage and threedimension" diagnosis and treatment system for metabolic-associated fatty liver disease

Exploring the pathogenesis and treatment methods of irritable bowel syndrome from the "sanjiao composed by membrane-striae" theory

Pathogenesis of " wind-toxin damaging collaterals " and stage-differentiation treatment in pediatric IgA vasculitis

Characteristics of traditional Chinese medicine syndromes in patients with Chikungunya hemorrhagic fever: a cross-sectional study

Pathogenesis and diagnosis and treatment strategies of multimorbidity of allergic diseases based on traditional Chinese medicine constitution theory

Related Author

HU Jiayan

LI Junxiang

MAO Tangyou

WANG Yuxi

LIN Zhengdao

YU Yitong

YANG Anqi

XU Yan

Related Institution

Dongfang Hospital, Beijing University of Chinese Medicine

Graduate School of Beijing University of Chinese Medicine

Nantong Hospital Affiliated to Nanjing University of Chinese Medicine

Nanjing University of Chinese Medicine

Pediatric Hospital, the First Affiliated Hospital of Henan University of Chinese Medicine

AI问答

Postal code：100029
Tel：(010)53911857 Email：jbutcm@bucm.edu.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰