Study on syndrome evolution of re-positive patients infected with SARS-CoV-2 Omicron variant BA.1

WANG Mengmeng; CUI Yinglin; GUAN Dongsheng; DU Xuzhao; ZHANG Zhixin; ZHOU Chaofeng; YANG Ling; QIAO Mingliang; LI Bin; XIE Hongxia; ZHANG Wentao

doi:10.3969/j.issn.1006-2157.2023.05.010

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Study on syndrome evolution of re-positive patients infected with SARS-CoV-2 Omicron variant BA.1

COVID-19 Theme | 更新时间：2023-06-05

- Study on syndrome evolution of re-positive patients infected with SARS-CoV-2 Omicron variant BA.1
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 5, Pages: 651-656(2023)
- 作者机构：
  
  1.河南中医药大学　郑州　450002
  2.河南中医药大学第二附属医院
- 作者简介：
  
  Prof. GUAN Dongsheng, Ph.D., Chief Physician, Doctoral Supervisor. Henan University of Chinese Medicine, No.2 Dongfeng Road, Jinshui District, Zhengzhou 450002. E-mail: gds349@126.com
- 基金信息：
  
  Special Project on Emergency Response in Chinese Medicine for Novel Coronavirus Infection and Pneumonia of State Administration of Chinese Medicine(2022ZYLCYJ01-1);Scientific and Technological Research Project on Epidemic Prevention and Control in Henan Province(211100310600)
- DOI：10.3969/j.issn.1006-2157.2023.05.010
  CLC： R254.3
- Received：13 October 2022，
  
  Online First：10 April 2023，
  
  Published：30 May 2023
- 稿件说明：
移动端阅览
WANG Mengmeng, CUI Yinglin, GUAN Dongsheng, et al. Study on syndrome evolution of re-positive patients infected with SARS-CoV-2 Omicron variant BA.1[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(5): 651-656.
DOI：

WANG Mengmeng, CUI Yinglin, GUAN Dongsheng, et al. Study on syndrome evolution of re-positive patients infected with SARS-CoV-2 Omicron variant BA.1[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(5): 651-656. DOI： 10.3969/j.issn.1006-2157.2023.05.010.

摘要

目的

探讨感染新型冠状病毒奥密克戎变异株BA.1复阳患者的证候演变规律，为中医药治疗新型冠状病毒感染提供参考。

方法

收集2022年1—3月河南省岐伯山医院和港区医院奥密克戎变异株BA.1感染者病历资料，选取感染且复阳患者61例作为复阳组，同期收治的正常转阴患者60例为对照组，分别对患者感染入院后1、4、7、14、21、30 d的中医证候诊断进行判定。

结果

对照组表现为表证—湿热蕴肺证—疫毒闭肺证—虚证(气阴两虚为主)的证候演变过程，复阳组表现为湿热蕴肺证—疫毒闭肺证—虚证(气阴两虚为主)的证候演变过程。复阳组证候由实证转为虚证多发生在(20.00±8.54)d，最终转阴多发生在(31.79±7.93)d之后，复阳多发生在(28.27±8.55)d。对照组患者证候类型由实证转为虚证多发生在(12.89±2.77)d，最终成功转阴多发生在(18.78±6.29)d之后。

结论

复阳患者证候演变规律为：1～14 d以湿热蕴肺为主，后发展至极期疫毒闭肺证，14～30 d疾病后期及恢复期以虚证为主，多为气阴两虚者。复阳患者病程比普通转阴患者病程长。

Abstract

Objective

We aimed to explore the syndrome evolution of re-positive COVID-19 patients who were infected with SARS-CoV-2 Omicron variant BA.1 and to provide a reference for Chinese medicine-based treatment of COVID-19.

Methods

Collecting the medical records of patients infected with Omicron variant BA.1 from January to March 2022 in Qiboshan Hospital and Port Hospital in Henan Province. Selecting 61 patients who have re-positive after infection as the re-positive group

and 60 normal negative patients admitted at the same time as the control group. The TCM syndromes were diagnosed in 1

and 30 days after hospital admission.

Results

Examination of syndrome evolution in the control group revealed: exterior syndrome

dampness-heat encumbering the lung syndrome

epidemic toxins blocking the lungs

and deficiency syndrome(mainly qi and yin deficiency). Similarly

examination of symptomatic evolution in the re-positive group revealed dampness-heat encumbering the lung syndrome

epidemic toxins blocking the lungs

and deficiency syndrome(mainly qi and yin deficiency). In the re-positive group

the syndrome changed from excess to deficiency in (20.00±8.54) days

and the final successful turning negative occurred after (31.79±7.93) days. Re-positive occurred after (28.27±8.55) days. In the control group

the syndrome type changed from excess to deficiency in (12.89±2.77) days

and finally turned negative after (18.78±6.29) days.

Conclusion

Syndrome evolution in re-positive patients is as follows: 1-14 days are dominated by dampness and heat encumbering the lung syndrome

which then develops to the extreme stage of epidemic toxins blocking the lung syndrome. The late stage and recovery period of the disease in 14-30 days mainly involve a deficiency syndrome

mostly deficiency of qi and yin. The course of disease in re-positive patients is longer than that in patients with common turning negative conversion.

关键词

Keywords

references

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