The minimum clinically important difference in three different versions of the Constitution in Chinese Medicine Questionnaire

ZHU Yanbo; CONG Jianni; SHI Huimei

doi:10.3969/j.issn.1006-2157.2023.05.014

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The minimum clinically important difference in three different versions of the Constitution in Chinese Medicine Questionnaire

TCM Constitutions | 更新时间：2023-06-05

- The minimum clinically important difference in three different versions of the Constitution in Chinese Medicine Questionnaire
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 5, Pages: 681-688(2023)
- 作者机构：
  
  1.北京中医药大学管理学院　北京　102488
  2.北京中医药大学管理学院生命质量测评与健康管理研究中心
  3.北京中医药大学中医学院
- 作者简介：
  
  Prof. ZHU Yanbo, Ph.D., Doctoral Supervisor. School of Management, Beijing University of Chinese Medicine, Intersection of Yangguang South Street and Baiyang East Road, Fangshan District, Beijing 102488.E-mail: yanbo0722@sina.com
- 基金信息：
  
  General Program of Beijing Municipal Natural Science Foundation(7222282);National Key Basic Research and Development Program(2011CB505403)
- DOI：10.3969/j.issn.1006-2157.2023.05.014
  CLC： R2-03
- Received：19 September 2022，
  
  Published Online：10 April 2023，
  
  Published：30 May 2023
- 稿件说明：
移动端阅览
ZHU Yanbo, CONG Jianni, SHI Huimei. The minimum clinically important difference in three different versions of the Constitution in Chinese Medicine Questionnaire[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(5): 681-688.
DOI：

ZHU Yanbo, CONG Jianni, SHI Huimei. The minimum clinically important difference in three different versions of the Constitution in Chinese Medicine Questionnaire[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(5): 681-688. DOI： 10.3969/j.issn.1006-2157.2023.05.014.

摘要

目的

估算3个不同条目版本中医体质量表的最小临床重要差值(MCID)，以利于中医体质量表在临床的应用。

方法

纳入研究对象537例，均自愿完成中医体质综合干预(情志、饮食、起居、运动和穴位干预)，干预前和干预3个月后均完成60条目中医体质量表和简明健康状况调查问卷(SF－36量表)的填写，41条目和30条目中医体质量表的结果根据60条目中医体质量表的调查结果纳入相应条目后计分得到。采用校标法结合分布法估算3个不同条目版本中医体质量表的MCID。校标法的校标为SF－36量表条目1，计算方法为均值变化法和多元线性回归；分布法采用标准化反应平均数。

结果

均值变化法和多元线性回归法计算结果的平均值，四舍五入取整数后估算中医体质量表平和质、气虚质、阳虚质、阴虚质、痰湿质、湿热质、血瘀质、气郁质和特禀质各亚量表的MCID，60条目分别为5、－5、－3、－3、－4、－4、－4、－4和－2，41条目分别为4、－6、－4、－2、－4、－4、－4、－4和－2，30条目分别为5、－5、－4、－3、－4、－5、－4、－5和－2。校标法估算的3个不同条目版本的MCID，除特禀质外均高于标准化反应平均数为0.2时估算的结果。

结论

本研究估算的3个不同条目版本中医体质量表MCID反映了患者认为重要且有意义的中医体质量表的最小评分变化，有助于医生更好地解释中医体质干预的效果或设定干预目标。

Abstract

Objective

We aimed to determine the minimum clinically important difference (MCID) of three different item versions of the Constitution in Chinese Medicine Questionnaire (CCMQ)

to facilitate the clinical application of CCMQ.

Methods

In total

537 subjects were included in the analysis. All subjects voluntarily completed a comprehensive of traditional Chinese medicine (TCM) constitution intervention (mood

diet

daily living

exercise

and acupoints). The subjects filled out the 60-item CCMQ and the Short Form Health Questionnaire (SF-36) at baseline and 3 months after the intervention. The result of the 41-item and the 30-item CCMQ were scored according to the result of the 60-item CCMQ. An anchor-based approach and a distribution-based approach were used to estimate the MCID of the three versions of the CCMQ. The anchor of the anchor-based approach was SF-36 item 1

and the analysis method were the mean change method and multiple linear regression. The standardized response mean (SRM) was used for the distribution-based approach.

Results

The mean change method and multiple linear regression estimation result were averaged and rounded to whole numbers. The MCID values of the 60-item CCMQ of balanced type

qi-deficiency type

yang-deficiency type

yin-deficiency type

phlegm-dampness type

dampness-heat type

blood-stasis type

qi-depression type

and special diathesis type were 5

-5

-3

-4

and -2

respectively. The MCID values of the 41-item CCMQ were 4

-6

-4

-2

-4

and -2

respectively. The MCID values of the 30-item CCMQ were 5

-5

-4

-3

-4

-5

-4

-5

and -2

respectively. The MCID values estimated by the anchor-based approach were higher than those estimated when SRM was 0.2

except for the special diathesis type.

Conclusion

The MCID values of three different versions of the CCMQ estimated in this study can reflect the minimum score change of the CCMQ considered important and meaningful by patients

which is helpful for doctors in explaining the effect of TCM constitution intervention or setting intervention targets.

关键词

Keywords

references

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