The key of traditional Chinese medicine syndrome differentiation of cytokine storm

ZHEN Jianhua; YU He; GU Xiaohong

doi:10.3969/j.issn.1006-2157.2023.06.005

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The key of traditional Chinese medicine syndrome differentiation of cytokine storm

Theoretical Studies | 更新时间：2023-07-05

- The key of traditional Chinese medicine syndrome differentiation of cytokine storm
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 6, Pages: 763-769(2023)
- 作者机构：
  
  1.北京中医药大学生命科学学院　北京　100029
  2.北京中医药大学中医学院
- 作者简介：
  
  Prof. GU Xiaohong, Chief Physician, Doctoral Supervisor. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Beisanhuan Donglu Road, Chaoyang District, Beijing 100029. E-mail: guxh@bucm.edu.cn
- 基金信息：
  
  National Natural Science Foundation of China(82004249);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202203)
- DOI：10.3969/j.issn.1006-2157.2023.06.005
  CLC： R228
- Received：16 October 2022，
  
  Online First：06 February 2023，
  
  Published：30 June 2023
- 稿件说明：
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ZHEN Jianhua, YU He, GU Xiaohong. The key of traditional Chinese medicine syndrome differentiation of cytokine storm[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(6): 763-769.
DOI：

ZHEN Jianhua, YU He, GU Xiaohong. The key of traditional Chinese medicine syndrome differentiation of cytokine storm[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(6): 763-769. DOI： 10.3969/j.issn.1006-2157.2023.06.005.

摘要

细胞因子风暴是机体对外界刺激产生的免疫过激反应，主要表现为细胞因子－白细胞正反馈环路的风暴式增高，并由此导致高炎性状态下的组织损伤与器官功能障碍。通过分析细胞因子风暴相关疾病的生物学病因、组织病理、病程进展及临床表现等信息，对细胞因子风暴进行辨证解析，认为其由外因、不内外因等多元病因启动，伴发毒、痰、瘀、虚等病理因素，涉及温热、湿热两类温病，临床传变符合卫气营血辨证，正邪交争可有顺证、逆证之分，病位多责肺、心、脾、胃。临证辨治细胞因子风暴相关疾病时，应注重辨识上述信息，判别细胞因子风暴发生的风险，并采用适当治法截断其进程、扭转其态势、预防其发生、改善其预后。

Abstract

Cytokine storm

which is an overreaction of the immune system to external stimulation

is characterized by a rapid increase in cytokine levels and leucocyte counts due to a positive feedback loop

and results in tissue damage and organ dysfunction with a highly inflammatory state. By analyzing the pathogeny

histopathology

disease progression

and clinical manifestation of diseases related to cytokine storm

this article summarizes key information from traditional Chinese medicine for syndrome differentiation. The etiologies of cytokine storm include external causes and causes that are neither internal nor external

and pathologies such as toxin

phlegm

blood stasis

and deficiency are also observed during cytokine storm. The spectrum of diseases covers warm-heat and damp-heat diseases

which could be differentiated using Weifen-Qifen-Yingfen-Xuefen theory; in addition

the fight between vital qi and pathogenic qi can be divided into syndromes with good prognosis and syndromes with unfavorable prognosis. The most commonly injured organs are the lung

heart

spleen

and stomach. However

during the treatment of diseases related to cytokine storm

attention should be paid to the above information to estimate the risk of a cytokine storm occurring

and to adopt appropriate treatment method to prevent its occurrence and improve prognosis.

关键词

Keywords

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