Correlation between functional status and damp-heat obstruction syndrome in patients with rheumatoid arthritis

ZHANG Fuyuan; JIANG Quan; WANG Yao; CHANG Tian; LIU Weixiang; XIA Congmin; LI Kesong; GONG Xun

doi:10.3969/j.issn.1006-2157.2023.06.012

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Correlation between functional status and damp-heat obstruction syndrome in patients with rheumatoid arthritis

Clinical Studies | 更新时间：2023-07-05

- Correlation between functional status and damp-heat obstruction syndrome in patients with rheumatoid arthritis
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 6, Pages: 820-825(2023)
- 作者机构：
  
  1.中国中医科学院广安门医院　北京　100053
  2.中国中医科学院眼科医院
- 作者简介：
  
  JIANG Quan, Ph.D., Chief Physician, Doctoral Supervisor.Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No.5, North Line Pavilion Street, Xicheng District, Beijing 100053.E-mail: doctorjq@126.com
- 基金信息：
  
  National Natural Science Foundation of China(81974568;82230121);National Key R & D Program of China(2018YFC1705202)
- DOI：10.3969/j.issn.1006-2157.2023.06.012
  CLC： R259.322
- Received：13 December 2022，
  
  Online First：26 April 2023，
  
  Published：30 June 2023
- 稿件说明：
移动端阅览
ZHANG Fuyuan, JIANG Quan, WANG Yao, et al. Correlation between functional status and damp-heat obstruction syndrome in patients with rheumatoid arthritis[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(6): 820-825.
DOI：

ZHANG Fuyuan, JIANG Quan, WANG Yao, et al. Correlation between functional status and damp-heat obstruction syndrome in patients with rheumatoid arthritis[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(6): 820-825. DOI： 10.3969/j.issn.1006-2157.2023.06.012.

摘要

目的

探讨类风湿关节炎患者功能状态与湿热痹阻证候的相关性。

方法

回顾性分析来自全国18家研究中心1 008例类风湿关节炎患者的病例资料，将患者分为湿热组和非湿热组，比较两组患者的X线分级、健康评估问卷(HAQ)残疾指数、28处关节疾病活动度评分(DAS28)、疼痛视觉模拟量表(VAS)评分、关节压痛数、关节肿胀数、部分实验室指标及一般资料。

结果

湿热组患者的X线等级、HAQ残疾指数、VAS评分、DAS28－红细胞沉降率(ESR)、关节压痛数、关节肿胀数均高于非湿热组(

0.05)。湿热组患者的血红蛋白、血小板、红细胞沉降率、抗环瓜氨酸肽抗体均高于非湿热组(

0.05)。2组患者的白细胞、类风湿因子、家族史、劳累史、情绪激动史、吸烟史、饮酒史等因素差异无统计学意义(

0.05)。

结论

类风湿关节炎患者功能状态与湿热痹阻证候密切相关，类风湿关节炎湿热痹阻证患者疾病活动度更高，致残程度更重。

Abstract

Objective

We aimed to explore the correlation between the functional status of rheumatoid arthritis (RA) patients and damp-heat obstruction syndrome.

Methods

The case data of 1

008 patients with RA from 18 research centers of China were retrospectively analyzed

and the patients were divided into a damp-heat group and a non-damp-heat group. X-ray grades

a health assessment questionnaire (HAQ) disability index

disease activity score (DAS28)

visual analogue pain scales(VAS) score

joint tenderness number

joint swelling number

laboratory indexes

and general data of the two groups were compared.

Results

The X-ray grade

HAQ

VAS score

DAS28-ESR

joint tenderness number

and joint swelling number of the patients in the damp-heat group were higher than those of the patients in the non-damp-heat group (

0.05). The hemoglobin

platelet

erythrocyte sedimentation

and anti-cyclic citrullinated peptide antibody of patients in the damp-heat group were higher than those of the patients in the non-damp-heat group (

0.05). There were no differences in leukocytes

rheumatoid factor

family history

fatigue history

emotional history

smoking history

drinking history

or other factors between the two groups (

0.05).

Conclusion

The functional status of RA patients was closely related to the syndrome of damp-heat obstruction. The disease activity of RA patients with damp-heat obstruction syndrome was higher and the degree of disability was more severe.

关键词

Keywords

references

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