Discussion on pathogenesis characteristics and treatment of colorectal cancer from the perspective of "intertwined blood stasis and toxin syndrome"

ZHAO Zhengqi; LIANG Weiyu; YANG Chuqi; WU Mengting; ZHANG Guangji

doi:10.3969/j.issn.1006-2157.2023.06.020

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Discussion on pathogenesis characteristics and treatment of colorectal cancer from the perspective of "intertwined blood stasis and toxin syndrome"

Hematology and Oncology | 更新时间：2023-07-05

- Discussion on pathogenesis characteristics and treatment of colorectal cancer from the perspective of "intertwined blood stasis and toxin syndrome"
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 6, Pages: 869-873(2023)
- 作者机构：
  
  1.浙江中医药大学基础医学院　杭州　310053
  2.浙江省中医“瘀毒”证重点实验室
  3.中医“治未病”智慧健康浙江省工程研究中心
- 作者简介：
  
  Prof. ZHANG Guangji, Ph.D., Doctoral Supervisor. School of Basic Medical Sciences, Zhejiang Chinese Medical University, No.548, Binwen Road, Binjiang District, Hangzhou 310053. E-mail: zgj@zcmu.edu.cn
- 基金信息：
  
  National Key Research and Development Plan Key Special Project for Modernization of Traditional Chinese Medicine(2019YFC1708700;2019YFC1708701);National Natural Science Foundation of China(82030119)
- DOI：10.3969/j.issn.1006-2157.2023.06.020
  CLC： R273
- Received：14 November 2022，
  
  Published Online：26 May 2023，
  
  Published：30 June 2023
- 稿件说明：
移动端阅览
ZHAO Zhengqi, LIANG Weiyu, YANG Chuqi, et al. Discussion on pathogenesis characteristics and treatment of colorectal cancer from the perspective of "intertwined blood stasis and toxin syndrome"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(6): 869-873.
DOI：

ZHAO Zhengqi, LIANG Weiyu, YANG Chuqi, et al. Discussion on pathogenesis characteristics and treatment of colorectal cancer from the perspective of "intertwined blood stasis and toxin syndrome"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(6): 869-873. DOI： 10.3969/j.issn.1006-2157.2023.06.020.

摘要

以“瘀毒互结”为探讨核心，通过梳理古代文献并结合现代研究进展，提出“瘀毒互结”是结直肠癌的重要病机。在结直肠癌进展过程中，瘀血阻滞肠络而致糟粕不行，日久变生毒邪则蓄积于肠道之中，进而导致肠道菌群紊乱，这一进程与“因瘀致毒，毒复致瘀，瘀毒互结”相契合。因此，排便习惯改变是“瘀”的外在表现，肠道菌群紊乱是“毒”的内在本质。基于“瘀毒互结”在结直肠癌中的重要性，运用活血化瘀法。通畅血脉，选择以毒攻毒法消解蕴结于病灶局部之毒，达到标本兼顾的目的，这就是“瘀毒同治”的内涵。为临床上更加合理地运用“活血化瘀，以毒攻毒”法治疗结直肠癌提供了理论依据。

Abstract

This article focuses on the pathogenesis of "blood stasis and toxic accumulation syndrome"

combining ancient literature with modern research. It is believed that "blood stasis and toxic accumulation syndrome" is an important pathogenesis of colorectal cancer. In the process of colorectal cancer progression

blood stasis blocks the intestinal collaterals and causes astriction. After a long period of time

toxin accumulates in the intestines

which leads to the disorder of intestinal flora. This process is consistent with "toxin caused by blood stasis

toxin resuscitated to cause blood stasis

and blood stasis and toxin intersect". Therefore

a change of defecation habits is the external manifestation of "blood stasis"

and the disorder of intestinal flora is the internal essence of "toxin". Based on the importance of "intertwined blood stasis and toxin syndrome" in colorectal cancer

activating blood circulation and removing blood stasis to unblock blood vessels

and removing toxins locally present in the lesion with poison heals both tip and root. This is the connotation of "treating intertwined blood stasis and toxin with the same treatment". This article provides a theoretical basis for the more rational use of "activating blood circulation to remove blood stasis

and removing toxin with toxins" in the treatment of colorectal cancer.

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references

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