Exploration of the relationship between gut microbial dysbiosis and cholesterol stones based on the theory of "earth stagnation wood depression"

FENG Binbin; HAN Junquan; YANG Chaoshuai; GAO Tianying; RAN Jiawen; WANG Hong

doi:10.3969/j.issn.1006-2157.2023.07.015

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Exploration of the relationship between gut microbial dysbiosis and cholesterol stones based on the theory of "earth stagnation wood depression"

Clinical Studies | 更新时间：2023-08-07

- Exploration of the relationship between gut microbial dysbiosis and cholesterol stones based on the theory of "earth stagnation wood depression"
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 7, Pages: 980-984(2023)
- 作者机构：
  
  1.天津中医药大学　天津　301617
  2.天津中医药大学第二附属医院
- 作者简介：
  
  Prof.WANG Hong, Chief Physician, Doctoral Supervisor. The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, No.69, Zengchandao Road, Tianjin 300250. E-mail: ctwanghong@sina.com
- 基金信息：
  
  National Natural Science Foundation of China(82274522)
- DOI：10.3969/j.issn.1006-2157.2023.07.015
  CLC： R256
- Received：02 March 2023，
  
  Published：30 July 2023
- 稿件说明：
移动端阅览
FENG Binbin, HAN Junquan, YANG Chaoshuai, et al. Exploration of the relationship between gut microbial dysbiosis and cholesterol stones based on the theory of "earth stagnation wood depression"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(7): 980-984.
DOI：

FENG Binbin, HAN Junquan, YANG Chaoshuai, et al. Exploration of the relationship between gut microbial dysbiosis and cholesterol stones based on the theory of "earth stagnation wood depression"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(7): 980-984. DOI： 10.3969/j.issn.1006-2157.2023.07.015.

摘要

胆固醇结石是世界范围内的常见病和多发病，手术是治疗胆固醇结石的有效方法，但术后部分患者可能出现结石再生，对此尚缺乏有效的防治策略。胆汁中胆固醇过饱和是胆固醇结石形成的前提，但具体发病机制尚未完全明确。近年来研究发现，肠道菌群失调是脂质代谢异常的重要病理基础，与胆固醇结石的形成关系密切，以肠道菌群为切入点，维持肠道菌群稳态可有效防治胆固醇结石。“土壅木郁”是脾土壅滞，反侮肝木，致使肝木郁滞的病理过程，在胆固醇结石的发病过程中起着重要作用。本文通过探讨“土壅”与肠道菌群的关系，提出脾土在胆固醇结石中的重要作用，为“土壅木郁”理论在胆固醇结石发病过程中的作用进行新的解读。同时，提出治胆当以疏肝为达，以治脾为要，可通过改善肠道菌群失调，调节脂质代谢以防治胆固醇结石形成，为胆固醇结石提供新的防治思路。

Abstract

Cholesterol stones are a common occurrence worldwide. Surgery is an effective way to treat cholesterol stones

but some patients may experience stone regeneration after surgery

and there is still no effective prevention and treatment strategy. Cholesterol supersaturation in bile is a prerequisite for the formation of cholesterol stones

but the specific pathogenesis remains poorly understood. In recent years

studies have found that intestinal dysbacteriosis is an important pathological basis for abnormal lipid metabolism closely related to the formation of cholesterol stones

and maintaining intestinal flora homeostasis can effectively prevent and treat cholesterol stones by taking intestinal flora as the starting point. "Earth stagnation and wood depression" is the pathological process of spleen and soil stagnation

and anti-insult liver wood result in liver wood stagnation

which plays an important role in the pathogenesis of cholesterol stones. By discussing the relationship between "earth stagnation" and intestinal flora

this paper proposes the important role of traditional Chinese medicine spleen soil in cholesterol stones and provides a new interpretation of the role of the "earth stagnation and wood depression" theory in the pathogenesis of cholesterol stones. At the same time

it is proposed that gallbladder treatment should be achieved by thinning the liver and treating the spleen

which can improve the imbalance of intestinal flora and regulate lipid metabolism to prevent and control the formation of cholesterol stones and may provide new prevention and treatment ideas for cholesterol stones.

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Keywords

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