Exploring the effect of phlegm and blood stasis on olfactory disorder in nasosinusitis based on the theory of "chronic diseases affecting collaterals"

SUN Weijia; ZHANG Lu; QIN Lingli; ZHU Xueying; CAI Lizhen; GAO Yue; CHEN Dian; CAI Yajie

doi:10.3969/j.issn.1006-2157.2023.08.007

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Exploring the effect of phlegm and blood stasis on olfactory disorder in nasosinusitis based on the theory of "chronic diseases affecting collaterals"

Theoretical Studies | 更新时间：2023-09-08

- Exploring the effect of phlegm and blood stasis on olfactory disorder in nasosinusitis based on the theory of "chronic diseases affecting collaterals"
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 8, Pages: 1100-1105(2023)
- 作者机构：
  
  中国中医科学院西苑医院　北京　100091
- 作者简介：
  
  ZHANG Lu, Ph.D., Chief Physician, Doctoral Supervisor. Xiyuan Hospital, China Academy of Chinese Medical Sciences, No.1, Xiyuan Playground, Haidian District, Beijing 100091. E-mail: m18611142837@163.com
- 基金信息：
  
  National Natural Science Foundation of China(82174216)
- DOI：10.3969/j.issn.1006-2157.2023.08.007
  CLC： R276.1
- Received：07 January 2023，
  
  Published Online：08 June 2023，
  
  Published：30 August 2023
- 稿件说明：
移动端阅览
SUN Weijia, ZHANG Lu, QIN Lingli, et al. Exploring the effect of phlegm and blood stasis on olfactory disorder in nasosinusitis based on the theory of "chronic diseases affecting collaterals"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(8): 1100-1105.
DOI：

SUN Weijia, ZHANG Lu, QIN Lingli, et al. Exploring the effect of phlegm and blood stasis on olfactory disorder in nasosinusitis based on the theory of "chronic diseases affecting collaterals"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(8): 1100-1105. DOI： 10.3969/j.issn.1006-2157.2023.08.007.

摘要

鼻鼻窦炎是造成嗅觉障碍的主要病因，且此类嗅觉障碍缠绵难愈，符合“久病入络”理论中慢性迁延性疾病“久”而“顽”的发病规律。中医学认为，络脉病变多凝痰聚瘀，按邪气入络的3个阶段以中西医互参的方法分析其病机演变规律，认为鼻鼻窦炎嗅觉障碍初期多因外邪袭络，痰浊内生；中期多因痰结肺络，凝涩血运；末期多由痰瘀互结，浊毒伤络所致。治疗分别以清浊化痰、活血化瘀、祛邪解毒为原则。此外，鼻鼻窦炎嗅觉障碍存在微循环障碍、炎症因子增多、脂质代谢紊乱、诱导细胞凋亡等现代生物学机制，为从痰瘀认识和诊疗该病提供了科学依据。从痰瘀探讨“久病入络”所致的鼻鼻窦炎嗅觉障碍旨在为临床提供新的中医诊疗思路，为无法满足西医治疗的患者提供更加完善的中医诊疗方案。

Abstract

Nasosinusitis is the main cause of the olfactory disorder

and this kind of olfactory disorder is persistent and difficult to cure

which is in line with the pathogenesis of chronic and prolonged diseases "long" and "persistent" in the theory of "chronic diseases affecting collaterals" . Traditional Chinese medicine(TCM) believes that collateral diseases are caused by the coagulation of phlegm and accumulation of blood stasis. This paper analyzes the evolution of the pathogenesis according to the three stages of pathogenic factors invasion the collateral by the method of cross-referencing between TCM and western medicine

and conclude that in the initial stage of nasosinusitis-related olfactory disorder

external pathogen attacks the collateral and phlegm and turbidity are internally produced; in the middle stage

phlegm retention occurs in the lung collateral and blood flow is blocked due to coagulation; and in the final stage

the binding of phlegm and stasis occurs

and the collateral is injured by turbidity and toxicity. Treatment is based on clearing turbidity and phlegm

promoting blood circulation and removing blood stasis

and eliminating pathogenic factors and resolving toxins. In addition

there are modern studies of biological mechanisms underlying nasosinusitis-related olfactory disorder

such as microcirculation disturbance

increased levels of inflammatory factors

disturbances in lipid metabolism

and induction of apoptosis

which provide a scientific basis for understanding and treating the disease from the viewpoint of phlegm and stasis. In this paper

the purpose of exploring nasosinusitis-related olfactory disorder caused by phlegm and stasis is to provide patients with new ideas of TCM treatment

and to provide a better TCM treatment solution for patients with limited access to western medicine.

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references

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