Discussion on treatment of motor neuron disease by toxins damaging collaterals

CHEN Chen; ZOU Yihuai; NING Yanzhe; YU Xin; LU Mengxin; XU Lingling; CHEN Tianzhu; WU Kang

doi:10.3969/j.issn.1006-2157.2023.08.013

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Discussion on treatment of motor neuron disease by toxins damaging collaterals

Clinical Studies | 更新时间：2023-09-08

- Discussion on treatment of motor neuron disease by toxins damaging collaterals
  增强出版
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 8, Pages: 1150-1155(2023)
- 作者机构：
  
  1.北京中医药大学东直门医院　北京　100700
  2.首都医科大学附属北京安定医院
- 作者简介：
  
  Prof. ZOU Yihuai, Ph.D., Chief Physician, Doctoral Supervisor. Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5, Haiyuncang Street, Dongcheng District, Beijing 100700. E-mail: zouyihuai2004@163.com
- 基金信息：
  
  National Natural Science Foundation of China(81873257)
- DOI：10.3969/j.issn.1006-2157.2023.08.013
  CLC： R259
- Received：23网络出版日期: 2023 November 2022，
  
  Published：30 August 2023
- 稿件说明：
移动端阅览
CHEN Chen, ZOU Yihuai, NING Yanzhe, et al. Discussion on treatment of motor neuron disease by toxins damaging collaterals[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(8): 1150-1155.
DOI：

CHEN Chen, ZOU Yihuai, NING Yanzhe, et al. Discussion on treatment of motor neuron disease by toxins damaging collaterals[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(8): 1150-1155. DOI： 10.3969/j.issn.1006-2157.2023.08.013.

摘要

运动神经元病可归属于中医学“痿痉并病”范畴，属临床难治性疾病，对于该病的辨证治疗诸多学者各有创见，但并无明确的共识。毒损络脉从王永炎院士提出的“毒损脑络”学说发展而来，诸邪蕴积成毒，毒邪损络，扩散蔓延，直接损伤脏腑形质，形质败坏而使病情迅速恶化。结合中医学理论及现代研究，本文认为毒损络脉的病理改变与运动神经元病病变的隐匿性、广泛性、难治性等特点相吻合，提出毒损络脉可能是运动神经元病发生发展的核心病机，即外感、内伤之毒邪胶结壅塞于髓络，毒损髓络，气血失调，代谢失衡，继而脑髓与脊髓损伤则发为运动神经元病。进而由毒损络脉延伸出气虚、内风相关病机，气虚与毒损络脉互为影响导致患者病情日趋加重，运动神经元病筋脉之风象可能由毒损络脉引动，由此提出解毒通络以祛邪、补气育阴以固本的治疗原则，强调益气解毒、育阴熄风，兼以通络的治法，以期拓宽中医药治疗运动神经元病的思路，进一步提高临床疗效。

Abstract

Motor neuron disease (MND)

a clinical refractory disease

can be classified as "a disease of flaccidity and spasticity" in traditional Chinese medicine (TCM). Many doctors have their own ideas regarding the treatment of syndrome differentiation

but there is no clear consensus. The concept of toxins damaging collaterals was developed from the theory of "toxins damaging brain collaterals" put forward by academicia Wang Yongyan

which marks the pathological process of toxicity accumulation and toxicity to collaterals

causing the spread of toxicity

directly damaging the shape and quality of the zang-fu organs and resulting in rapid deterioration of the disease. Combined with the theory of TCM and modern research

the pathological changes of toxins damaging collaterals are consistent with the characteristics of occult

extensive

and intractable lesions of MND. It is suggested that toxins damaging collaterals may be the core pathogenesis of the occurrence and development of MND

namely

the accumulation of toxins from external contraction and internal damage in the medullary collaterals leads to damage to the medullary collaterals

imbalance of qi and blood

metabolic imbalance

and subsequent brain and spinal cord injuries

leading to MND. Moreover

qi deficiency and internal wind-related pathogenesis are extended from toxins damaging collaterals. Qi deficiency and toxins damaging collaterals influence each other

leading to the worsening of disease. Wind images of MND muscles may be induced by toxins damaging collaterals. Therefore

the treatment principle of detoxifying and regulating collaterals to remove evil

replenishing qi

and nourishing yin to solidify the root is put forward

emphasizing supplementing qi and detoxifying

nourishing yin and dispelling wind

and regulating collaterals

in order to expand the options for MND treatment and further improve the clinical effect.

关键词

Keywords

references

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