Clinical study on the treatment of patients with post-COVID-19 syndrome by integration of traditional and western medicine rehabilitation program

WANG Bohan; WANG Xiaoxiao; JIN Hui; JU Wenzheng; TANG Lingling; SUN Xianhong; YU Keyao; WANG Funing; SUN Qinglan; WU Shanheng; SHI Suofang; SHI Xiaolu

doi:10.3969/j.issn.1006-2157.2023.09.009

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Clinical study on the treatment of patients with post-COVID-19 syndrome by integration of traditional and western medicine rehabilitation program

COVID-19 Theme | 更新时间：2023-10-09

- Clinical study on the treatment of patients with post-COVID-19 syndrome by integration of traditional and western medicine rehabilitation program
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 9, Pages: 1242-1249(2023)
- 作者机构：
  
  1.江苏省中医院/南京中医药大学附属医院　南京　210029
  2.东南大学公共卫生学院
- 作者简介：
  
  Prof. SHI Suofang, Ph.D., Chief Physician, Doctoral Supervisor.
  SHI Xiaolu, Ph.D., Associate Chief Physician. Jiangsu Provincial Hospital of Chinese Medicine/Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155, Hanzhong Road, Qinhuai District, Nanjing 210029. E-mail: njshxl8899@126.com
- 基金信息：
  
  Natural Science Foundation of Jiangsu Province(BK20211391);Science and Technology Project of State Administration of Traditional Chinese Medicine(2021ZYLCYJ05-3)
- DOI：10.3969/j.issn.1006-2157.2023.09.009
  CLC： R254.3
- Received：30 March 2023，
  
  Online First：11 July 2023，
  
  Published：30 September 2023
- 稿件说明：
移动端阅览
WANG Bohan, WANG Xiaoxiao, JIN Hui, et al. Clinical study on the treatment of patients with post-COVID-19 syndrome by integration of traditional and western medicine rehabilitation program[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(9): 1242-1249.
DOI：

WANG Bohan, WANG Xiaoxiao, JIN Hui, et al. Clinical study on the treatment of patients with post-COVID-19 syndrome by integration of traditional and western medicine rehabilitation program[J]. Journal of Beijing University of Traditional Chinese Medicine, 2023, 46(9): 1242-1249. DOI： 10.3969/j.issn.1006-2157.2023.09.009.

摘要

目的

评价中西医结合康复方案治疗新型冠状病毒感染后综合征患者的临床疗效。

方法

将南京市溧水区中医院和扬州市第二人民医院收治的115例新型冠状病毒感染恢复期患者任意分为治疗组(57例)和对照组(58例)。治疗组采用中西医结合康复方案，给予中药口服(肺脾气虚证给予健脾养肺方、气阴两虚证给予益气养阴方)、中医传统康复疗法(呼吸疗愈法、经络锻炼法、八段锦)和现代呼吸康复治疗(呼吸训练、有氧训练、抗阻肌力训练)，对照组给予安慰剂茶饮联合现代呼吸康复治疗，疗程均为14 d。对比治疗前后2组患者6 min步行试验、呼吸肌力、改良英国医学研究会呼吸困难分级(mMRC)评级、四肢躯干肌力等指标，以评估患者心肺功能及身体机能的恢复情况。治疗前后观察患者不良反应的发生情况。

结果

(1)在心肺功能方面，与治疗前比较，治疗组患者血氧饱和度、6 min步行距离、距离占预计值增加(

0.05，

0.01)，6 min距离等级、Borg评分改善(

0.01)。治疗后，治疗组患者血氧饱和度升高(

0.05)，6 min距离等级分布较对照组改善(

0.05)，心率、血压、6 min步行距离、距离占预计值、Borg评分组间差异无统计学意义。与治疗前比较，治疗组患者呼气峰流速值增加(

0.01)，mMRC评级改善(

0.01)。与对照组比较，治疗组患者治疗后膈肌活动度增加(

0.05)，膈肌厚度、呼气峰流速值、mMRC评级差异无统计学意义。(2)在身体机能方面，与对照组比较，治疗后治疗组患者上肢前夹肌、躯干屈肌、左髋内收肌肌力变化率增加(

0.05，

0.01)。2组患者未见明显不良反应。

结论

中西医结合康复方案对新型冠状病毒感染后综合征患者的心肺功能、身体机能康复有益。

Abstract

Objective

To evaluate the clinical efficacy of an integration of traditional and western medicine rehabilitation program in the treatment of patients with post-COVID-19 syndrome.

Methods

A total of 115 patients recovering from COVID-19 admitted to Nanjing Lishui District Hospital of Traditional Chinese Medicine and Yangzhou Second People’s Hospital were randomly divided into the treatment group(57 patients) and the control group(58 patients). The treatment group was treated with an integration of traditional and western medicine rehabilitation program

including Chinese medicine(

Jiangpi Yangfei

Formula for syndrome of qi deficiency of lung and spleen

and

Yiqi Yangyin

Formula for syndrome of deficiency of both qi and yin)

traditional Chinese medicine rehabilitation therapies(breathing therapy

meridian exercise method

baduanjin)

and modern respiratory rehabilitation(breathing exercises

aerobic exercise

and resistance training)

while the control group was treated with tea placebo combined with modern respiratory rehabilitation. The course of treatment was 14 days. Before and after treatment

patients in both groups completed a 6-min walking test

respiratory muscle strength

mMRC grade and muscle strength of extremities and trunk to assess the recovery of cardiopulmonary function and physical function. The incidence of adverse effects was observed before and after treatment.

Results

(1)In terms of cardiopulmonary function

when compared with those before treatment in the treatment group

the blood oxygen saturation

6-min walking distance

and distance as a percentage of predicted value were increased(

0.05

0.01); the 6-min distance class and Borg score were improved(

0.01). After treatment

compared with the control group

the blood oxygen saturation in the treatment group was increased(

0.05)

and the 6-min distance class was improved(

0.05). There were no significant differences in heart rate

blood pressure

6-min walk distance

distance as a percentage of predicted value

and Borg score between the two groups. Compared with the condition before treatment

the peak expiratory flow rate value was increased in the treatment group(

0.01)

and the mMRC grade was improved(

0.01). Compared with the control group

the diaphragmatic activity was increased in the treatment group after treatment(

0.05). There were no significant differences in diaphragm thickness

peak expiratory flow rate and mMRC grades between the two groups. (2)In terms of physical function

after treatment

the change rates of muscle strength of anterior clamp muscle of the upper limb

trunk flexor

left hip adductor muscle in the treatment group were increased than the control group(

0.05

0.01). No significant adverse effects were observed in either group.

Conclusion

The integration of traditional and western medicine rehabilitation program is beneficial for the rehabilitation of cardiopulmonary function and physical function in patients with post-COVID-19 syndrome.

关键词

Keywords

references

DONG MZ , ZHANG J , MA XF , et al . ACE2, TMPRSS2 distribution and extrapulmonary organ injury in patients with COVID－19 [J/OL]. Biomed Pharmacother , 2020 , 131 : 110678 [ 2023－03－01 ]. https：//www.sciencedirect.com/science/article/pii/S0753332220308714？via%3Dihub https：//www.sciencedirect.com/science/article/pii/S0753332220308714？via%3Dihub .

AHMAD M , KIM K , INDORATO D , et al . Post-COVID Care Center to Address Rehabilitation Needs in COVID－19 Survivors: A Model of Care [J]. Am J Med Qual , 2022 , 37 ( 3 ): 266 － 271 .

BAEKER-DAVIES RM , O’SULLIVAN O , SENARATNE KPP , et al . The Stanford Hall consensus statement for post-COVID－19 rehabilitation [J]. Brit J Sport Med , 2020 , 54 ( 16 ): 949 － 959 .

谷晓红 . 中西医协同模式下的疫病康复策略：以新型冠状病毒肺炎后综合征为例 [J]. 北京中医药大学学报， 2022 ， 45 ( 8 )： 757 － 763 .

ORONSKY B , LARSON C , HAMMOND TC , et al . A Review of Persistent Post-COVID Syndrome(PPCS) [J]. Clin Rev Allergy Immunol , 2023 , 64 ( 1 ): 66 － 74 .

史锁芳，方祝元，熊侃，等 . 中医综合疗法治疗新型冠状病毒肺炎恢复期气阴两虚证30例临床研究 [J]. 江苏中医药， 2021 ， 53 ( 1 )： 25 － 28 .

史锁芳，方祝元，熊侃，等 . 扶土生金康复方治疗COVID-19恢复期肺脾不足证患者临床观察 [J]. 南京中医药大学学报， 2020 ， 36 ( 3 )： 281 － 285 .

中华人民共和国国家卫生健康委员会办公厅，国家中医药管理局办公室 . 新型冠状病毒肺炎诊疗方案(试行第八版) [J]. 中国医药， 2020 ， 15 ( 10 )： 1494 － 1499 .

CHEN YQ , LIU CL , WANG TP , et al . Efficacy and safety of Bufei Huoxue capsules in the management of convalescent patients with COVID－19 infection: A multicentre, double-blind, and randomised controlled trial [J/OL]. J Ethnopharmacol , 2022 , 284 : 114830 [ 2023－03－01 ]. https：//www.sciencedirect.com/science/article/pii/S037-8874121010606？via%3Dihub https：//www.sciencedirect.com/science/article/pii/S037-8874121010606？via%3Dihub .

杨九芳，王力霞，杨唐柱，等．中西医结合优化康复方案在新型冠状病毒肺炎患者恢复期的应用价值研究 [J]. 川北医学院学报， 2021 ， 36 ( 3 )： 405 － 408 .

周晶，张阳普，罗昱君，等 . 新型冠状病毒肺炎出院患者中西医结合康复指导 [J]. 康复学报， 2020 ， 30 ( 4 )： 249 － 254 .

中国中西医结合学会 . 新型冠状病毒肺炎中西医结合防治专家共识 [J]. 中国中西医结合杂志， 2020 ， 40 ( 12 )： 1413 － 1423 .

李晓东，刘保延，王宜，等 . 关于《新型冠状病毒肺炎恢复期中医康复指导建议(试行)》的解读 [J]. 中医杂志， 2020 ， 61 ( 11 )： 928 － 934 .

国家体育总局健身气功管理中心．健身气功·八段锦 [M]. 北京：人民体育出版社， 2003 ： 9 .

HAMILTON DM , HAENNEL RG . Validity and reliability of the 6－minute walk test in a cardiac rehabilitation population [J]. J Cardiopulm Rehabil , 2000 , 20 ( 3 )： 156 － 164 .

KENDRICK KR , BAXI SC , SMITH RM . Usefulness of the modified 0－10 Borg scale in assessing the degree of dyspnea in patients with COPD and asthma [J]. J Emerg Nurs , 2000 , 26 ( 3 ): 216 － 222 .

MAHLER DA , WELLS CK . Evaluation of clinical methods for rating dyspnea [J]. Chest , 1988 , 93 ( 3 ): 580 － 586 .

WILLI S , LÜTHOLD R , HUNT A , et al . COVID－19 sequelae in adults aged less than 50 years: A systematic review [J/OL]. Travel Med Infect Di , 2021 , 40 : 101995 [ 2023－03－01 ]. https：//www.sciencedirect.com/science/article/pii/S1477893921000363？via%3Dihub https：//www.sciencedirect.com/science/article/pii/S1477893921000363？via%3Dihub .

JIANG LL , AN XD , DUAN YY , et al . The pathological mechanism of the COVID－19 convalescence and its treatment with traditional Chinese medicine [J/OL]. Front Pharmacol , 2023 , 13 : 1054312 [ 2023－03－01 ]. https：//www.frontiersin.org/articles/10.3389/fphar.2022.1054312/full https：//www.frontiersin.org/articles/10.3389/fphar.2022.1054312/full .

孙宪泓，史锁芳，王博寒，等 . 中医药综合康复方案治疗新型冠状病毒肺炎恢复期不同证型患者的临床研究 [J]. 中华中医药杂志， 2022 ， 37 ( 7 )： 4181 － 4185 .

耿茜，郑劲平，梁晓林，等．新型冠状病毒肺炎患者康复初期肺功能及心肺运动功能评价 [J]. 中国呼吸与危重监护杂志， 2021 ， 20 ( 5 ): 320 － 324 .

VAN ZELLER C , ANWAR A , RAMOS-BASCON N , et al . Pulmonary function, computerized tomography features and six-minute walk test at three months in severe COVID－19 patients treated with intravenous pulsed methylprednisolone: a preliminary report [J/OL]. Monaldi Arch Chest Dis , 2021 , 91 ( 4 ): 1811 [ 2023－03－01 ]. https：//monaldi-archives.org/index.php/macd/article/view/1811 https：//monaldi-archives.org/index.php/macd/article/view/1811 .

赵本南，刘大凤，刘亚玲，等．普通型新型冠状病毒肺炎患者出院后复诊结果分析 [J]. 成都医学院学报， 2021 ， 16 ( 1 ): 24 － 29 .

ABDULLAHI A . Safety and Efficacy of Chest Physiotherapy in Patients With COVID－19: A Critical Review [J/OL]. Front Med(Lausanne) , 2020 ， 7 : 454 [ 2023－03－01 ]. https：//www.frontiersin.org/articles/10.3389/fmed.2020.00454/full https：//www.frontiersin.org/articles/10.3389/fmed.2020.00454/full .

KOLODZIEJ M , WYSZYNSKA J , BAL-BOCHEN＇SKA M . COVID－19: A New Challenge for Pulmonary Rehabilitation? [J/OL]. J Clin Med , 2021 , 10 ( 15 ): 3361 [ 2023－03－01 ]. https：//www.mdpi.com/2077－0383/10/15/3361 https：//www.mdpi.com/2077－0383/10/15/3361 .

DOURADO VZ , NISHIAKA RK , SIMOES MSMP , et al . Classification of cardiorespiratory fitness using the six-minute walk test in adults: Comparison with cardiopulmonary exercise testing [J]. Pulmonology , 2021 , 27 ( 6 )： 500 － 508 .

LAKSMIDEWI AAAP , GABUR MO , INDAH CTL . Skeletal Muscles Injury Related to SARS-CoV－2 Infection: A Case Report [J]. Open Access Maced J Med Sci , 2021 , 9 ( C ): 34 － 39 .

CURE E , CURE MC . Comment on “organ-protective effect of angiotensin-converting enzyme 2 and its effect on the prognosis of COVID－19” [J]. J Med Virol , 2020 , 92 ( 9 ): 1423 － 1424 .

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