The mechanism of tonifying the kidney and essence in treating retinal degeneration based on the relation between kidney essence and stem cells

LI Jiaxian; LIANG Lina; XU Kai; JIN Yu

doi:10.3969/j.issn.1006-2157.2023.09.016

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The mechanism of tonifying the kidney and essence in treating retinal degeneration based on the relation between kidney essence and stem cells

Clinical Studies | 更新时间：2023-10-09

- The mechanism of tonifying the kidney and essence in treating retinal degeneration based on the relation between kidney essence and stem cells
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 9, Pages: 1301-1306(2023)
- 作者机构：
  
  中国中医科学院眼科医院眼功能实验室　北京　100040
- 作者简介：
  
  LIANG Lina, Ph.D., Researcher, Chief Physician, Doctoral Supervisor. Department of Eye Function Laboratory, Eye Hospital, China Academy of Chinese Medical Sciences, No.33, Lugu Road, Shijingshan District, Beijing 100040. E-mail: lianglina163@163.com
- 基金信息：
  
  National Natural Science Foundation of China(82274589;81973912)
- DOI：10.3969/j.issn.1006-2157.2023.09.016
  CLC： R774.1
- Received：19 March 2023，
  
  Published Online：04 August 2023，
  
  Published：30 September 2023
- 稿件说明：
移动端阅览
LI Jiaxian, LIANG Lina, XU Kai, et al. The mechanism of tonifying the kidney and essence in treating retinal degeneration based on the relation between kidney essence and stem cells[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(9): 1301-1306.
DOI：

LI Jiaxian, LIANG Lina, XU Kai, et al. The mechanism of tonifying the kidney and essence in treating retinal degeneration based on the relation between kidney essence and stem cells[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(9): 1301-1306. DOI： 10.3969/j.issn.1006-2157.2023.09.016.

摘要

干细胞作为一类具有自我更新、高度增殖和多向分化潜能的细胞群体，在视网膜变性治疗领域展现出广阔的前景。中医学肾精与干细胞在繁衍生殖、生长发育、生髓化血、濡养脏腑等生理功能及先天与后天来源等方面存在诸多相似性，尤其是先天之精与干细胞之间可能存在着理论同一性的关系。视网膜变性的中医病机归结于肾虚精亏，目窍失养，治宜补肾益精为法。间充质干细胞属于干细胞的一类，补肾益精法对骨髓来源间充质干细胞的迁移、归巢、分化及旁分泌有明显的促进作用。本文以此为切入点，探讨补肾益精法在视网膜变性治疗中的潜在机理，为今后开展相关研究提供新的思路及理论依据。

Abstract

Stem cells

which have a high self-renewal capacity

high proliferation

and multi-directional differentiation potential

have shown broad prospects in the treatment of retinal degeneration. There are many similarities between the kidney essence and stem cells in the aspects of reproduction

growth and development

marrow and blood generation

nourishing zang-fu organs

and origin. In particular

there may be a relationship of theoretical identity between the congenital essence and stem cells. The traditional Chinese medicine pathogenesis of retinal degeneration is attributed to deficiency of the kidney essence and the loss of nourishment of the eyes. The treatment method is tonifying the kidney and essence. Mesenchymal stem cells belong to a class of stem cells. The method of tonifying the kidney and essence can significantly promote the migration

homing

differentiation

and paracrine of bone marrow mesenchymal stem cells. This article takes this as a starting point to explore the potential mechanism of the method of tonifying the kidney and essence in the treatment of retinal degeneration and provides new ideas and a theoretical basis for future research.

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references

IEJIMA D , ITABASHI T , KAWAMURA Y , et al . HTRA1 (high temperature requirement A serine peptidase 1) gene is transcriptionally regulated by insertion/ deletion nucleotides located at the 3’ end of the ARMS2 (age-related maculopathy susceptibility 2) gene in patients with age-related macular degeneration [J]. J Biol Chem ， 2015 , 290 ( 5 )： 2784 － 2797 .

Age-Related Eye Disease Study Research Group . A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no.8 [J]. Arch Ophthalmol ， 2001 , 119 ( 10 )： 1417 － 1436 .

PARDUE MT , Allen RS . Neuroprotective strategies for retinal disease [J]. Prog Retin Eye Res ， 2018 ， 65 ： 50 － 76 .

傅仁宇．审视瑶函 [M]. 郭君双，赵艳，整理．北京：人民卫生出版社， 2006 ： 175 － 176 .

王肯堂．杂病证治准绳 [M]. 喻正科，整理．太原：山西科学技术出版社， 2013 ： 587 .

温昊天，隋华，李琦，等．干细胞与中医理论关系的思考 [J]. 中华中医药杂志， 2017 ， 32 ( 4 )： 1422 － 1424 .

STERN JH , TIAN YZ , FUNDERBURGH J , et al . Regenerating Eye Tissues to Preserve and Restore Vision [J]. Cell Stem Cell ， 2018 ， 22 ( 6 )： 834 － 849 .

高英茂，李和，李继承，等．组织学与胚胎学 [M]. 北京：人民卫生出版社， 2011 ： 318 － 324 .

杨恬，左伋，刘艳平，等．细胞生物学 [M]. 北京：人民卫生出版社， 2015 ： 414 － 424 .

明溪，虞坚尔，李刚，等．基于中医“肾精”学说与间充质干细胞的内在相关性探讨补肾药在哮喘治疗中的作用机理 [J]. 中医杂志， 2016 ， 57 ( 16 )： 1358 － 1362 .

张进，徐志伟，史亚飞，等．基于干细胞的“脏腑之精”理论内涵研究 [J]. 中医杂志， 2012 ， 53 ( 5 )： 364 .

张爱娟，王汉裕，邝卫红．间充质干细胞的中医理论归属探讨 [J]. 广州中医药大学学报， 2016 ， 33 ( 2 )： 258 － 261 .

HORWITZ EM , PROCKOP DJ , FITZPATRICK LA , et al . Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta [J]. Nat Med ， 1999 ， 5 ( 3 )： 309 － 313 .

裴雪涛 . 简明干细胞生物学 [M]. 北京：科学出版社， 2003 ： 75 .

沈自尹，黄建华．从淫羊藿激活内源性干细胞探讨“肾藏精”的科学涵义 [J]. 中医杂志， 2010 ， 51 ( 1 )： 8 － 10 .

徐德成，马迎民，范吉平．中医“肾精”的现代医学内涵 [J]. 中医杂志， 2017 ， 58 ( 22 )： 1891 － 1897 .

UCCELLI A , MORETTA L , PISTOIA V . Mesenchymal stem cells in health and disease [J]. Nat Rev Immunol ， 2008 ， 8 ( 9 )： 726 － 736 .

HOLAN V , PALACKA K , HERMANKOVA B . Mesenchymal Stem Cell-Based Therapy for Retinal Degenerative Diseases: Experimental Models and Clinical Trials [J/OL]. Cells ， 2021 , 10 ( 3 )： 588 [ 2023－02－03 ]. https：//www.mdpi.com/2073－4409/10/3/588 https：//www.mdpi.com/2073－4409/10/3/588 .

MAO XY , PAN T , SHEN H ， et al . The rescue effect of mesenchymal stem cell on sodium iodate-induced retinal pigment epithelial cell death through deactivation of NF－κB-mediated NLRP3 inflammasome [J]. Biomed Pharmacother ， 2018 ， 103 ： 517 － 523 .

LIU Y , LI Y , WANG CG , et al . Morphologic and histopathologic change of sodium iodate-induced retinal degeneration in adult rats [J]. Int J Clin Exp Pathol ， 2019 ， 12 ( 2 )： 443 － 454 .

BARZELAY A , ALGOR SW , NIZTAN A , et al . Adipose-Derived Mesenchymal Stem Cells Migrate and Rescue RPE in the Setting of Oxidative Stress [J/OL]. Stem Cells Int ， 2018 ， 2018 ： 9682856 [ 2023－02－05 ]. https：//www.hindawi.com/journals/sci/2018/9682856/ https：//www.hindawi.com/journals/sci/2018/9682856/ .

GONG LH , WU Q , SONG BW , et al . Differentiation of rat mesenchymal stem cells transplanted into the subretinal space of sodium iodate-injected rats [J]. Clin Exp Ophthalmol ， 2008 ， 36 ( 7 )： 666 － 671 .

OTANI A , DORRELL MI , KINDER K , et al . Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells [J]. J Clin Invest ， 2004 ， 114 ( 6 )： 765 － 774 .

LEJKOWSKA R , KAWA MP , PIUS-SADOWSKA E , et al . Preclinical Evaluation of Long-Term Neuroprotective Effects of BDNF-Engineered Mesenchymal Stromal Cells as Intravitreal Therapy for Chronic Retinal Degeneration in Rd6 Mutant Mice [J/OL]. Int J Mol Sci , 2019 , 20 ( 3 )： 777 [ 2023－02－05 ]. https：//www.mdpi.com/1422－0067/20/3/777 https：//www.mdpi.com/1422－0067/20/3/777 .

QU LH , GAO LX , XU HW , et al . Combined transplantation of human mesenchymal stem cells and human retinal progenitor cells into the subretinal space of RCS rats [J/OL]. Sci Rep ， 2017 ， 7 ( 1 )： 199 [ 2023－02－05 ]. https：//www.nature.com/articles/s41598－017－00241－5 https：//www.nature.com/articles/s41598－017－00241－5 .

葛坚，王宁利．眼科学 [M]. 3版．北京：人民卫生出版社， 2015 ： 597 .

江伟，唐由之，梁丽娜，等．二至明目汤治疗非渗出性年龄相关性黄斑变性临床分析 [J]. 中国中医眼科杂志， 2013 ， 23 ( 3 )： 201 － 203 .

侯乐，唐由之，梁丽娜．补肾益精方对干性年龄相关性黄斑变性动物模型骨髓来源干细胞动员的影响 [J]. 中国中医眼科杂志， 2017 ， 27 ( 1 )： 3 － 7 .

侯乐．补肾益精方促进自身骨髓干细胞修复干性年龄相关性黄斑变性的作用研究 [D]. 北京：中国中医科学院， 2017 .

许凯，唐由之，梁丽娜，等．补肾益精方对外周血BMSCs在干性ARMD小鼠中视网膜分化及CNTF表达的影响 [J]. 国际眼科杂志， 2021 ， 21 ( 4 )： 597 － 603 .

梁丽娜，李雪丽，许凯，等．补肾益精方对先天性视网膜色素变性RCS大鼠感光细胞凋亡的抑制作用 [J]. 眼科新进展， 2018 ， 38 ( 7 )： 611 － 615 .

李雪丽，唐由之，范吉平，等．补肾益精方对RCS大鼠视网膜变性损伤的保护作用研究 [J]. 中国中医眼科杂志， 2016 ， 26 ( 3 )： 144 － 149 .

李雪丽，范吉平，唐由之，等．补肾益精方对RCS大鼠骨髓来源干细胞动员作用的研究 [J]. 中华中医药杂志， 2017 ， 32 ( 2 )： 533 － 536 .

李雪丽，唐由之，许凯，等．补肾益精方对外周血干细胞在RCS大鼠视网膜上的募集及睫状神经营养因子表达的影响 [J]. 中华眼视光学与视觉科学杂志， 2018 ， 20 ( 8 )： 475 － 483 .

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