Discussion on the etiology, pathogenesis and treatment of nasopharyngeal carcinoma based on the theory of "turbid evils invading the clear orifice"

DU Yanyuan; ZHU Xiaoyu; GAO Jin; YU Huibo; XIONG Hongtai; CHEN Xin; MA Susu; ZHENG Honggang

doi:10.3969/j.issn.1006-2157.2023.09.019

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Discussion on the etiology, pathogenesis and treatment of nasopharyngeal carcinoma based on the theory of "turbid evils invading the clear orifice"

Hematology and Oncology | 更新时间：2023-10-09

- Discussion on the etiology, pathogenesis and treatment of nasopharyngeal carcinoma based on the theory of "turbid evils invading the clear orifice"
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 9, Pages: 1319-1324(2023)
- 作者机构：
  
  1.中国中医科学院广安门医院　北京　100053
  2.北京中医药大学研究生院
- 作者简介：
  
  ZHENG Honggang, Ph.D., Chief Physician, Doctoral Supervisor. Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No.5, Beixiange street, Xicheng District, Beijing 100053. E-mail: honggangzheng@126.com
- 基金信息：
  
  Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-C-202205)
- DOI：10.3969/j.issn.1006-2157.2023.09.019
  CLC： R273
- Received：29 March 2023，
  
  Published Online：20 July 2023，
  
  Published：30 September 2023
- 稿件说明：
移动端阅览
DU Yanyuan, ZHU Xiaoyu, GAO Jin, et al. Discussion on the etiology, pathogenesis and treatment of nasopharyngeal carcinoma based on the theory of "turbid evils invading the clear orifice"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(9): 1319-1324.
DOI：

DU Yanyuan, ZHU Xiaoyu, GAO Jin, et al. Discussion on the etiology, pathogenesis and treatment of nasopharyngeal carcinoma based on the theory of "turbid evils invading the clear orifice"[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(9): 1319-1324. DOI： 10.3969/j.issn.1006-2157.2023.09.019.

摘要

“浊邪害清”是清代医家叶天士在《温热论》中提出的有关上焦湿温病证的理论思想，其对阐释鼻咽癌的发生、发展、转归及治疗具有重要指导意义。“浊邪”涵盖了湿热浊邪及瘀毒等病理因素，“清”即清窍，包括鼻、咽等与外界相通的头面孔窍和司神明之心窍。本文基于“浊邪害清”理论，结合西医学研究，认为EB病毒、酒、腌制类食物等湿热浊邪为鼻咽癌的发病诱因。湿热浊邪侵袭机体，流注脉道，日久化生瘀毒，湿热瘀毒外闭鼻窍、内阻心窍、流注周身为鼻咽癌的发病机制。本文从微环境视角探讨“浊邪害清”在鼻咽癌中的微观表现，并立足于“浊邪害清”理论和本团队的临床实践制定鼻咽癌各期的辨证论治方案，以期为中医药治疗鼻咽癌提供借鉴。

Abstract

The theory of "turbid evils invading the clear orifice" is a theoretical thought about damp-heat syndrome of upper jiao put forward by Ye Tianshi

a physician in Qing Dynasty

Wenre lun

which has important guiding significance for explaining the occurrence

development

prognosis and treatment of nasopharyngeal carcinoma. "Turbid evils" covers pathological factors such as damp-heat turbid evils and static blood toxin. "Clear orifice" includes the nose and pharynx and other head-face orifices that connect with the outside world

and the heart that governs the bright spirit. Based on the theory of "turbid evils invading the clear orifice" and the research of western medicine

this paper summarizes that damp-heat turbid evils such as EB virus

alcoholic drink and preserved food are the causative factors of nasopharyngeal carcinoma. The pathogenesis of nasopharyngeal carcinoma is that damp-heat turbid evils invade the body

flow into blood vessels

and form static blood toxin for a long time

which blocks the nasal orifice outward and the heart inward and flows all over the body. At the same time

this paper discusses the microscopic of "turbid evils invading the clear orifice" in nasopharyngeal carcinoma from the perspective of microenvironment

and based on the theory of "turbid evils invading the clear orifice" and our team’s clinical practice

formulates the differential treatment scheme for nasopharyngeal carcinoma in different stages

in order to provide reference for the clinical application of traditional Chinese medicine in nasopharyngeal carcinoma.

关键词

Keywords

references

BRAY F , FERLAY J , SOERJOMATARAM I , et al . Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. CA Cancer J Clin ， 2018 ， 68 ( 6 )： 394 － 424 .

叶桂．温热论 [M]// 叶桂，薛雪，王士雄．温热湿热集论．张志斌，刘悦，校注．福州：福建科学技术出版社， 2010 .

虞抟．医学正传 [M]. 郭瑞华，校注．北京：中医古籍出版社， 2002 ： 162 .

朱震亨．格致余论 [M]. 鲁兆麟，点校．沈阳：辽宁科学技术出版社， 1997 ： 5 .

叶天士．临证指南医案 [M]. 华岫云，编订．北京：华夏出版社， 1995 .

莫明华．清开灵治疗小儿传染性单核细胞增多症疗效观察 [J]. 中国医药导报， 2007 ， 14 ( 2 )： 87 － 88 .

李东垣．兰室秘藏 [M]. 张年顺，校注．北京：中国中医药出版社， 2007 ： 96 .

吴正伦．养生类要 [M]. 腾鹰，点校．北京：中医古籍出版社， 1994 ： 10 .

演山省翁．活幼口议 [M]. 陈玉鹏，点校．北京：中国中医药出版社， 2015 ： 33 .

MARRON M , BOFFETTA P , ZHANG ZF , et al . Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk [J]. Int J Epidemiol , 2010 ， 39 ( 1 )： 182 － 196 .

BRYAN NS , ALEXANDER DD , COUGHLIN JR , et al . Ingested nitrate and nitrite and stomach cancer risk: an updated review [J]. Food Chem Toxicol ， 2012 ， 50 ( 10 )： 3646 － 3665 .

TSANG CM , TSAO SW . The role of Epstein-Barr virus infection in the pathogenesis of nasopharyngeal carcinoma [J]. Virol Sin ， 2015 ， 30 ( 2 )： 107 － 121 .

HUANG SF , CHIEN TH , FANG WL , et al . The 8th edition American Joint Committee on gastric cancer pathological staging classification performs well in a population with high proportion of locally advanced disease [J]. Eur J Surg Oncol ， 2018 ， 44 ( 10 )： 1634 － 1639 .

陈实功．外科正宗 [M]. 张印生，点校．北京：中医古籍出版社， 1999 ： 278 .

LI Z , DUAN YM , CHENG SY , et al . EBV-encoded RNA via TLR3 induces inflammation in nasopharyngeal carcinoma [J]. Oncotarget ， 2015 ， 6 ( 27 )： 24291 － 24303 .

SHAN Y , YOU B , SHI S , et al . Hypoxia-Induced matrix metalloproteinase－13 expression in exosomes from nasopharyngeal carcinoma enhances metastases [J/OL]. Cell Death Dis ， 2018 ， 9 ( 3 )： 382 [ 2023－01－17 ]. https：//www.nature.com/articles/s41419－018－0425－0 https：//www.nature.com/articles/s41419－018－0425－0 .

王孟英．温热经纬 [M]. 鲁兆麟，点校．沈阳：辽宁科学技术出版社， 1997 ： 43 .

王靖思，孙桂芝，吴洁．孙桂芝诊治鼻咽癌经验介绍 [J]. 辽宁中医杂志， 2015 ， 42 ( 2 )： 262 － 264 .

丁虹，吴紫陆，蔡纪堂，等．半枝莲提取物通过抑制STAT3/SKP2信号通路促进鼻咽癌细胞周期阻滞 [J]. 中国实验方剂学杂志， 2022 ， 28 ( 19 )： 81 － 88 .

吴霞，李药兰，张冬梅，等 . 25种中草药体外抑制鼻咽癌细胞增殖活性研究 [J]. 中成药， 2010 ， 32 ( 12 )： 2161 － 2163 .

李桂玲，归绥琪，夏晴，等．掌叶半夏提取物的有效部位对CaSki的促凋亡作用机制研究 [J]. 中华中医药杂志， 2010 ， 25 ( 3 )： 449 － 452 .

CHEN WX , CHENG L , PAN M , et al . D Rhamnose β－Hederin against human breast cancer by reducing tumor-derived exosomes [J]. Oncol Lett ， 2018 ， 16 ( 4 )： 5172 － 5178 .

LI W , HU X , WANG S , et al . Characterization and anti-tumor bioactivity of astragalus polysaccharides by immunomodulation [J]. Int J Biol Macromol ， 2020 ， 15 ( 145 )： 985 － 997 .

张小平，孙润广，王小梅，等．化学修饰水提麦冬多糖WPOJ的抗肿瘤活性研究 [J]. 食品与生物技术学报， 2014 ， 33 ( 4 )： 368 － 373 .

BOCHU W , LIANCAI Z , QI C . Primary study on the application of Serum Pharmacology in Chinese traditional medicine [J]. Colloids Surf B Biointerfaces ， 2005 ， 43 ( 3/4 )： 194 － 197 .

赵国华，李志孝，陈宗道．百合多糖的化学结构及抗肿瘤活性 [J]. 食品与生物技术， 2002 ， 21 ( 1 )： 62 － 66 .

庞皓玥，胡凯文，周天．活血药调控肿瘤代谢的研究 [J]. 肿瘤代谢与营养电子杂志， 2021 ， 8 ( 1 )： 87 － 92 .

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