Application of radiomics histogram analysis in efficacy evaluation of TCM treatment of pulmonary ground glass nodules

ZHAO Qing; WANG Wenjie; WANG Lei

doi:10.3969/j.issn.1006-2157.2023.10.002

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Application of radiomics histogram analysis in efficacy evaluation of TCM treatment of pulmonary ground glass nodules

Special Theme: TCM Prevention and Treatment of Pulmonary Nodules | 更新时间：2023-11-06

- Application of radiomics histogram analysis in efficacy evaluation of TCM treatment of pulmonary ground glass nodules
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 10, Pages: 1338-1344(2023)
- 作者机构：
  
  中国中医科学院广安门医院　北京　100053
- 作者简介：
  
  WANG Lei, Ph.D., Chief Physician, Master’s Supervisor. Guang’anmen Hospital, China Academy of Chinese Medical Sciences, No.5, Beixian’ge Street, Xicheng District, Beijing 100053. E-mail: wanglei1@gamyy.cn
- 基金信息：
  
  Key Innovation Program of Guang’anmen Hospital, Chinese Academy of Chinese Medical Sciences(2022S467)
- DOI：10.3969/j.issn.1006-2157.2023.10.002
  CLC： R256.1
- Received：28 May 2023，
  
  Published Online：27 September 2023，
  
  Published：30 October 2023
- 稿件说明：
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ZHAO Qing, WANG Wenjie, WANG Lei. Application of radiomics histogram analysis in efficacy evaluation of TCM treatment of pulmonary ground glass nodules[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(10): 1338-1344.
DOI：

ZHAO Qing, WANG Wenjie, WANG Lei. Application of radiomics histogram analysis in efficacy evaluation of TCM treatment of pulmonary ground glass nodules[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(10): 1338-1344. DOI： 10.3969/j.issn.1006-2157.2023.10.002.

摘要

临床报道中医药成功治疗了多例肺结节患者，但由于这些缩小或消失的肺结节缺少病理资料，关于中医药治疗有效的到底是炎性结节还是早癌结节一直存在争论。目前，中医药治疗肺结节的疗效多采用通过计算机断层扫描技术(CT)得到的影像直径、CT衰减值、肿瘤模型积分等方法评价，不能全面反映肺结节进展情况。放射组学技术的发展为肺磨玻璃结节的定性诊断提供更全面的数据信息，其中，通过观察直方图的图形(层数及是否形成波形)、熵值、体积、质量及偏度的变化，既有助于判定肺磨玻璃结节良恶性，又可用于反映其进展情况，具有动态、直观和无创的优势，希望为客观评估中医药治疗肺结节疗效提供新方法。

Abstract

In clinical reports

patients with pulmonary nodules have been treated successfully with traditional Chinese medicine (TCM). However

due to the lack of pathological data on the reduction or disappearance of pulmonary nodules

whether TCM is effective in treating inflammatory nodules or early-stage cancer nodules remains controversial. The evaluation of the efficacy of TCM intervention in pulmonary nodules is often based on metrics obtaining through computed tomography(CT) such as nodule diameter

CT value

and tumor model integration

which do not comprehensively represent the current status of pulmonary nodule progression. CT radiomics technology provides more comprehensive data for the qualitative diagnosis of ground glass pulmonary nodules. By analyzing the CT histogram parameters using artificial intelligence technology

such as graphics (layers and wave shape)

entropy

volume

mass

and skewness

benign and malignant nodules can be identified. It can also be used for evaluating the progress of the nodules

as it is dynamic

intuitive

and non-invasive

which maybe provide a new method for objectively evaluating the efficacy of TCM in treating pulmonary nodules.

关键词

Keywords

references

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