Study on the mechanism of calming the heart and tranquilizing the mind in treating premature ejaculation from the perspective of gut microbiota

HUANG Nianwen; BI Huanzhou; WANG Bin; WANG Jisheng; FENG Juanlong; SUN Longji; LI Haisong

doi:10.3969/j.issn.1006-2157.2023.10.016

您当前的位置：

首页 >

文章列表页 >

Study on the mechanism of calming the heart and tranquilizing the mind in treating premature ejaculation from the perspective of gut microbiota

Clinical Studies | 更新时间：2023-11-06

- Study on the mechanism of calming the heart and tranquilizing the mind in treating premature ejaculation from the perspective of gut microbiota
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 10, Pages: 1443-1448(2023)
- 作者机构：
  
  1.北京中医药大学东直门医院　北京　100700
  2.北京中医药大学深圳医院
- 作者简介：
  
  Prof. LI Haisong, Ph.D., Chief Physician, Doctoral Supervisor. Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5, Haiyuncang Street, Dongcheng District, Beijing 100700. E-mail: lihs396@sina.com
- 基金信息：
  
  China Postdoctoral Innovation Talent Support Program(BX20220047);National Famous Traditional Chinese Medicine Inheritance Studio Construction Project of National Administration of Traditional Chinese Medicine
- DOI：10.3969/j.issn.1006-2157.2023.10.016
  CLC： R256.55
- Received：10 April 2023，
  
  Published Online：29 August 2023，
  
  Published：30 October 2023
- 稿件说明：
移动端阅览
HUANG Nianwen, BI Huanzhou, WANG Bin, et al. Study on the mechanism of calming the heart and tranquilizing the mind in treating premature ejaculation from the perspective of gut microbiota[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(10): 1443-1448.
DOI：

HUANG Nianwen, BI Huanzhou, WANG Bin, et al. Study on the mechanism of calming the heart and tranquilizing the mind in treating premature ejaculation from the perspective of gut microbiota[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(10): 1443-1448. DOI： 10.3969/j.issn.1006-2157.2023.10.016.

摘要

早泄是以性交之始即行排精，甚至性交前即泄精，不能进行正常性生活为主要表现的疾病。心神不宁是早泄的基本病机，宁心安神法是本病的重要治法，临床上运用宁心安神类中药治疗早泄，效果得到认可，但其具体作用机制尚未完全明确。结合中医理论及分子生物学研究，发现中枢神经系统5－羟色胺代谢紊乱与中医心神不宁证的关系密切。中枢神经系统5－羟色胺在早泄发生发展中发挥重要作用。随着高通量测序技术的发展，研究发现，肠道菌群可参与中枢神经系统5－羟色胺的合成，肠道菌群紊乱很可能是早泄发病的一个促进因素。宁心安神类中药可通过调节肠道菌群，间接或直接影响大脑5－羟色胺水平，这是宁心安神法治疗早泄的可能机制之一。本文从肠道菌群角度出发，探讨宁心安神法治疗早泄的作用机制，以期为中医药治疗早泄提供新的切入点。

Abstract

Premature ejaculation is characterized by ejaculation at the beginning of sexual intercourse

or even before sexual intercourse

and an inability to engage in normal sexual activity. The basic pathogenesis of premature ejaculation is a disquieted heart spirit

and calming the heart and tranquilizing the mind is an important treatment method for this condition. The efficacy of traditional Chinese medicine(TCM) in calming the heart and tranquilizing the mind to treat premature ejaculation has been recognized in clinical practice

but the specific mechanism of action is not yet fully understood. Based on the theory of TCM and molecular biology research

it has been found that abnormal 5-hydroxytryptamine (5-HT

also known as serotonin) metabolism in the central nervous system is closely related to the disquieted heart spirit syndrome of TCM. In the central nervous system

5-HT plays an important role in the occurrence and development of premature ejaculation. With the development of high-throughput sequencing technology

it has been found that the gut microbiota can participate in the synthesis of 5-HT in the central nervous system. Gut microbiota disorder is likely to be a promoting factor in the pathogenesis of premature ejaculation

and herbs that calm the heart and tranquilize the mind can indirectly or directly affect the level of 5-HT in the brain by regulating the gut microbiota

which may be one of the mechanisms by which they prevent premature ejaculation. Therefore

this paper discusses the mechanism by which herbs that calm the heart and tranquilize the mind can treat premature ejaculation from the perspective of gut microbiota. Our study supports the application of TCM in the treatment of premature ejaculation.

关键词

Keywords

references

VERZE P , ARCANIOLO D , PALMIERI A , et al . Premature ejaculation among Italian men: prevalence and Clinical Correlates from an observational, non-interventional, cross-sectional, epidemiological study (IPER) [J]. Sex Med , 2018 , 6 ( 3 ): 193 － 202 .

黄燕平，刘炜，张明，等 . 男科门诊早泄患者的临床特征及影响因素 [J]. 中山大学学报(医学科学版) , 2022 , 43 ( 6 ): 892 － 897 .

罗德凡 . 5-HT调控系统相关基因多态性与原发性早泄发病关联性研究 [D]. 衡阳：南华大学， 2021 .

DENG YY , ZHOU MF , WANG JF , et al . Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain [J/OL]. Gut Microbes , 2021 , 13 ( 1 ): 1 － 16 .[ 2023－03－06 ]. https://www.tandfonline.com/doi/full/10.1080/19490976.2020.1869501 https://www.tandfonline.com/doi/full/10.1080/19490976.2020.1869501 .

ALTHOF SE , MCMAHON CG , WALDINGER MD , et al . An update of the international society of sexual medicine’s guidelines for the diagnosis and treatment of premature ejaculation (PE) [J]. Sex Med , 2014 , 2 ( 2 ): 60 － 90 .

中华医学会男科学分会早泄诊断与治疗指南编写组 . 早泄诊断与治疗指南 [J]. 中华男科学杂志， 2022 , 28 ( 7 ): 656 － 665 .

蔡东洋，杨永平，武娇，等 . 达泊西汀联合行为、心理咨询疗法治疗原发性早泄的临床分析 [J]. 中华男科学杂志， 2020 , 26 ( 7 ): 611 － 615 .

刘奔，陈琳双，余正杰，等 . 生命早期肠道菌群的形成及影响因素 [J]. 中国病原生物学杂志， 2023 , 18 ( 3 ): 358 － 363 .

LIU J , TAN YZ , CHENG H , et al . Functions of gut microbiota metabolites, current status and future perspectives [J]. Aging Dis , 2022 , 13 ( 4 ): 1106 － 1126 .

俞蕾敏，吴婵妮，叶蔚，等 . 基于肠道菌群及色氨酸代谢探讨脐针对腹泻型肠易激综合征患者的治疗机制 [J]. 中国中西医结合消化杂志， 2022 , 30 ( 3 ): 211 － 216 .

ISRAELYAN N , DEL COLLE A , LI ZS , et al . Effects of serotonin and slow-release 5－hydroxytryptophan on gastrointestinal motility in a mouse model of depression [J]. Gastroenterology , 2019 , 157 ( 2 ): 507 － 521 .

FU X , ZHANG XS , JIANG T , et al . Association between lifelong premature ejaculation and polymorphism of tryptophan hydroxylase 2 gene in the Han population [J]. Sex Med , 2020 , 8 ( 2 ): 223 － 229 .

崇洁，马继登，张进威，等 . SCFAs对肠道免疫调控的研究进展 [J]. 生命科学， 2023 , 35 ( 5 ): 663 － 670 .

杨敬泽 . 盲肠和降结肠菌群与肠嗜铬细胞在腹泻型肠易激综合征中的特点研究 [D]. 济南：山东大学， 2020 .

REIGSTAD CS , SALMONSON CE , RAINEY JF 3rd , et al . Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells [J]. FASEB J , 2015 , 29 ( 4 ): 1395 － 1403 .

早泄与勃起功能障碍共病诊疗中国专家共识编写组 . 早泄与勃起功能障碍共病诊疗中国专家共识 [J]. 中华男科学杂志， 2021 , 27 ( 5 ): 461 － 466 .

杜冠潮 . 复方金戟颗粒治疗原发性早泄(肝郁肾虚型)临床观察及机制研究 [D]. 北京：中国中医科学院， 2022 .

SATHIANATHEN NJ , HWANG EC , MIAN R , et al . Selective serotonin re-uptake inhibitors for premature ejaculation in adult men: a cochrane systematic review [J]. World J Mens Health , 2022 , 40 ( 2 ): 257 － 263 .

刘冬梅，陈小勇，何国宝，等 . 盐酸达泊西汀联合行为训练治疗无规律性生活早泄患者的研究 [J]. 中国性科学， 2022 , 31 ( 10 ): 39 － 42 .

RUIGROK RAA ， WEERSMA RK ， VICH VILA A ． The emerging role of the small intestinal microbiota in human health and disease [J/OL]. Gut Microbes , 2023 , 15 ( 1 )： 2201155 [ 2023－03－06 ]. https://www.tandfonline.com/doi/full/10.1080/19490976.2023.2201155 https://www.tandfonline.com/doi/full/10.1080/19490976.2023.2201155 .

唐佳婕，郑佳雪，宋倩，等 . 肠道菌群及5-HT在大气PM 2.5 暴露致小鼠抑郁焦虑样行为中的作用 [J]. 环境与职业医学， 2022 , 39 ( 12 ): 1343 － 1349 .

LI NN , WANG Q , WANG Y , et al . Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis [J]. Stress , 2019 , 22 ( 5 ): 592 － 602 .

林志亮，路聚保，陈启仪，等 . 肠道菌群移植联合营养支持治疗和心理干预对“同济四联征”的临床疗效分析 [J]. 中华胃肠外科杂志， 2022 , 25 ( 9 ): 784 － 791 .

DUERLER P , VOLLENWEIDER FX , PRELLER KH . A neurobiological perspective on social influence: Serotonin and social adaptation [J]. J Neurochem , 2022 , 162 ( 1 ): 60 － 79 .

庞瑾 . 5-HT与原发性头痛合并睡眠障碍、焦虑及抑郁的相关性研究 [D]. 太原：山西医科大学， 2022 .

洑寒莹，戈鑫霞，李雅琦，等 . 从心神失调论治情志病的思路与方法 [J]. 湖北中医药大学学报， 2022 , 24 ( 5 ): 61 － 64 .

李文静，王庆海 . 自噬与5－羟色胺信号系统调控中枢及外周疾病的研究进展 [J]. 中国医药科学， 2022 , 12 ( 24 ): 42 － 45 .

周云丰 . 远志提取物抗抑郁作用及机制研究 [D]. 北京：北京协和医学院， 2020 .

HUA Y ， GUO S ， XIE H , et al . Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou Seed Ameliorates Insomnia in Rats by Regulating Metabolomics and Intestinal Flora Composition [J/OL]. Front Pharmacol ， 2021 ， 12 ： 653767 [ 2023－03－06 ]. https://www.frontiersin.org/articles/10.3389/fphar.2021.653767/full https://www.frontiersin.org/articles/10.3389/fphar.2021.653767/full .

邓省，王继升，代恒恒，等 . 基于数据挖掘分析李曰庆教授治疗早泄的用药特点与规律 [J]. 世界中西医结合杂志， 2021 , 16 ( 9 ): 1589 － 1592 .

陈启军，于岚，赵文文，等 . 远志提取物对抑郁大鼠肠道菌群的作用研究 [J]. 中草药， 2021 , 52 ( 8 ): 2313 － 2323 .

张丹丹，叶晓川 . 基于肠道菌群和代谢组学探讨茯苓酸性多糖宁心的作用机制 [J]. 中华中医药杂志， 2022 , 37 ( 5 ): 2575 － 2583 .

王月儿，李珠，冯曼，等 . 交泰丸对慢性温和不可预知性应激抑郁大鼠肠道菌群的影响 [J]. 天津中医药大学学报， 2022 , 41 ( 2 ): 204 － 211 .

扈琨，陈婧，赵瑞珍，等 . 加味酸枣仁汤联合五行音乐治疗原发性失眠临床观察 [J]. 北京中医药大学学报， 2022 , 45 ( 3 ): 284 － 290 .

杜鹤，刘佳星，闫艳，等 . 整合代谢组学与肠道菌群分析酸枣仁汤改善失眠大鼠的作用机制 [J]. 中国中药杂志， 2022 , 47 ( 24 ): 6741 － 6752 .

郑劼，许一凡，陈艳燕，等 . 甘麦大枣汤联合氟西汀通过调控肠道菌群改善慢性应激小鼠抑郁症状的研究 [J]. 南京中医药大学学报， 2020 , 36 ( 5 ): 667 － 674 .

北京中医药学会男科疾病专家共识组 . 早泄中西医融合药物治疗专家共识 [J]. 中国男科学杂志， 2021 , 35 ( 6 ): 93 － 96 .

Views

165

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Treating premature ejaculation combined with anxiety and depression based on the "four-dimensional integration" of the "holism of body and spirit" theory

Mechanism of Qishen Yiqi Dropping Pills in regulating gut microbiota and ROS/TXNIP/NLRP3 signaling pathway to improve chronic heart failure in rats

The hemostatic effect and its mechanism of modified Sijunzi Decoction on the zebrafish intestinal bleeding model through 5-hydroxytryptamine and its receptors

Discussion on the microscopic syndrome differentiation of phlegm syndrome in metabolic syndrome based on gut microbiota associated with lipid metabolism

Anti-atherosclerotic mechanism of phlegm-transforming and stasis-resolving Chinese medicinals

Related Author

ZHOU Wenbin

WANG Quan

ZENG Yangling

KUANG Hao

CHEN Zilong

QIU Junfeng

HONG Zhiming

WEI Yi

Related Institution

The Fourth Clinical Medical College of Guangzhou University of Chinese Medicine

Department of Andrology, Shenzhen Traditional Chinese Medicine Hospital

Guang′anmen Hospital, China Academy of Chinese Medical Sciences

The First Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Provincial Hospital of Chinese Medicine

Hunter Biotechnology, Inc

AI问答

Postal code：100029
Tel：(010)53911857 Email：jbutcm@bucm.edu.cn
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备09064830号-19 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰