The pathological mechanism and treatment principle of depression based on qi-collaterals theory

LIAN Kun; LUO Peng; YE Jiahao; NING Bo; HU Zhixi

doi:10.3969/j.issn.1006-2157.2023.10.017

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The pathological mechanism and treatment principle of depression based on qi-collaterals theory

Clinical Studies | 更新时间：2023-11-06

- The pathological mechanism and treatment principle of depression based on qi-collaterals theory
- Journal of Beijing University of Traditional Chinese Medicine Vol. 46, Issue 10, Pages: 1449-1453(2023)
- 作者机构：
  
  1.湖南中医药大学　长沙　410208
  2.陕西中医药大学　咸阳　712046
- 作者简介：
  
  Prof. HU Zhixi, Ph. D., Doctoral Supervisor. Hunan University of Chinese Medicine, No. 300, Xueshi Road, Yuelu District, Changsha 410208. E-mail: 003405@hnucm.edu.cn
- 基金信息：
  
  National Natural Science Foundation of China(82274412);Guangdong Key Field Research and Development Project(2020B1111100001);Hunan Natural Science Foundation(2023JJ30453;2020JJ4062;2020JJ5408);Changsha Natural Science Foundation(kq2208185)
- DOI：10.3969/j.issn.1006-2157.2023.10.017
  CLC： R277.7
- Received：29 May 2023，
  
  Published Online：29 August 2023，
  
  Published：30 October 2023
- 稿件说明：
移动端阅览
LIAN Kun, LUO Peng, YE Jiahao, et al. The pathological mechanism and treatment principle of depression based on qi-collaterals theory[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(10): 1449-1453.
DOI：

LIAN Kun, LUO Peng, YE Jiahao, et al. The pathological mechanism and treatment principle of depression based on qi-collaterals theory[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(10): 1449-1453. DOI： 10.3969/j.issn.1006-2157.2023.10.017.

摘要

抑郁症是发病率逐年上升的一类心身疾病，西医学对其病因和病理机制尚无定论，提出了神经递质、肠道菌群、下丘脑－垂体－肾上腺轴功能异常等假说；临床治疗以应用各类抗抑郁药为主。本文从气络理论出发，分析抑郁症中医病机治法，认为本病的病机是脑络失养、络气虚滞，肝络郁滞、气络不和；治疗原则为络虚通补、扶正补气而滋养脑络，以辛泄络、疏肝解郁而畅达络气，调神祛邪、脏腑同治而和谐气络。进一步完善抑郁症的病机和治法，更好地解释和指导抑郁症的临床辨证与治疗。

Abstract

Depression is a psychosomatic disease with a yearly increasing incidence. Western medicine has not reached an agreement on its etiology and pathological mechanism

and many hypotheses have been proposed

such as monoamine neurotransmitter deficiency

intestinal flora imbalance

and hypothalamic-pituitary-adrenal axis dysfunction. Clinical treatment method are dominated by antidepressants. Based on the qi-collaterals theory

this study points out that this disease is caused by a lack of brain collaterals nourishment

qi deficiency

liver collaterals stagnation

and disharmony between qi and collaterals. The principles of treatment are relieving the deficiency of collaterals

tonifying qi and nourishing the brain collaterals

unblocking collaterals with pungent flavor

soothing the liver and regulating qi

regulating spirit and eliminating pathogenic factors

treating zang-fu organs

and harmonizing qi and collaterals. Our ultimate aim is to improve the treatment of depression by further elucidating its pathogenesis.

关键词

Keywords

references

HUANG YQ , WANG Y , WANG H , et al . Prevalence of mental disorders in China: a cross-sectional epidemiological study [J]. Lancet Psychiat , 2019 , 6 ( 3 ): 211 － 224 .

COVID－19 MENTAL DISORDERS COLLABORATORS . Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic [J]. Lancet , 2021 , 398 ( 10312 ): 1700 － 1712 .

LI HY , LUO XN , KE XY , et al . Major depressive disorder and suicide risk among adult outpatients at several general hospitals in a Chinese Han population [J/OL]. PLoS One , 2017 , 12 ( 10 ): e0186143 [ 2023－03－19 ]. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186143 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0186143 .

王喜红，韩振蕴，陈家旭，等 . 基于重阳理论探讨光照疗法治疗抑郁症 [J]. 中华中医药杂志， 2022 , 37 ( 4 ): 2010 － 2013 .

马小雅，丁敏芮，施侠威，等 . 中药复方辨证治疗抑郁症的现代数据研究 [J]. 世界科学技术—中医药现代化， 2019 , 21 ( 7 ): 1418 － 1423 .

郭蓉娟 . 论抑郁症“虚气流滞”病机 [J]. 北京中医药大学学报， 2023 , 46 ( 1 ): 5 － 11 .

宁博，赵明君，葛腾，等 . 基于气络学说辨治心血管神经症 [J]. 中国中医药信息杂志， 2023 , 30 ( 3 ): 148 － 151 .

仝小林 . 中医肺毒疫辨识 [J]. 中医杂志， 2003 , 44 ( 12 ): 885 － 887 .

王永炎，常富业，杨宝琴 . 病络与络病对比研究 [J]. 北京中医药大学学报， 2005 , 28 ( 3 ): 1 － 6 .

李澎，张占军，王永炎 . 论脑气络含义及在老年认知障碍疾病中的作用 [J]. 中国中医基础医学杂志， 2016 , 22 ( 3 ): 316 － 319 .

吴以岭 . 中医络病学说与三维立体网络系统 [J]. 中医杂志， 2003 , 44 ( 6 ): 407 － 409 .

吴以岭，魏聪，赵珊珊 . 气与气络学说探讨 [J]. 中医杂志， 2017 , 58 ( 21 ): 1801 － 1807 .

吴以岭 . 气络—NEI网络相关性探析 [J]. 中医杂志， 2005 , 46 ( 10 ): 723 － 726 .

王香君，夏小雯，马明钰，等 . 基于抑郁症病理机制探讨芦丁抗抑郁作用 [J]. 中国现代应用药学， 2022 , 39 ( 14 ): 1895 － 1900 .

唐启盛．抑郁障碍中西医研究进展述评 [J]. 北京中医药大学学报， 2022 ， 45 ( 9 )： 871 － 877 .

陈抒鹏，唐娜娜，王思梦，等 . 肝郁脾虚方对抑郁失眠模型大鼠结肠组织GABA能信号系统及肠道菌群的影响 [J]. 中医杂志， 2023 , 64 ( 12 ): 1273 － 1281 .

郑洪新 . 中医基础理论 [M]. 4版 . 北京：中国中医药出版社， 2016 : 145 － 150 .

金雨静，翟吴剑文，黄世敬 . 从“脑－心－三焦”关联探讨抑郁症病机 [J]. 中国实验方剂学杂志， 2022 , 28 ( 4 ): 219 － 226 .

韩雪菲，刘泽华，王豆，等 . 从络病学说论治卒中后抑郁 [J]. 现代中西医结合杂志， 2021 , 30 ( 22 ): 2446 － 2448 .

李欣，王立伟，李敬伟，等 . 基于抑郁、焦虑、躯体形式障碍的郁证特质研究 [J]. 北京中医药大学学报， 2019 , 42 ( 3 ): 226 － 234 .

吴以岭，赵珊珊，魏聪，等 . 试论气络病变治疗十法 [J]. 中国实验方剂学杂志， 2018 , 24 ( 9 ): 1 － 8 .

程冬梅，李鹏，马家伟 . 基于扶阳固本理念探讨加味补阳还五汤治疗缺血性脑卒中后抑郁症疗效与安全性评价 [J]. 贵州医药， 2019 , 43 ( 12 ): 1934 － 1936 .

卞伟煜，韩俊萍，单永琳，等 . 加味补阳还五汤联合经颅磁刺激治疗卒中后抑郁临床疗效及安全性分析 [J]. 四川中医， 2022 , 40 ( 6 ): 124 － 128 .

王睿，费洪新，王琪，等 . 补阳还五汤对慢性不可预知性温和应激抑郁模型小鼠行为及脑海马CA3区病理形态学影响 [J]. 中国实验方剂学杂志， 2017 , 23 ( 1 ): 158 － 162 .

马小俊，陈澈，王全年 . 从扶阳论治抑郁症的学术思想探析 [J]. 云南中医中药杂志， 2022 , 43 ( 6 ): 18 － 20 .

冯璐，董鹤婷，王乃娴，等 . 养心汤加减联合心理疗法治疗抑郁症的临床效果 [J]. 中华中医药学刊， 2022 , 40 ( 12 ): 197 － 200 .

潘瑾，潘文超，迟显苏，等 . 百合地黄汤治疗阴虚内热型抑郁症的机制 [J]. 中国实验方剂学杂志， 2022 , 28 ( 12 ): 31 － 38 .

刘佳蕾，王宇亮，赵宏，等 . 百合多糖与黄芪多糖联用对慢性应激小鼠抑郁行为的影响及机制 [J]. 中国实验方剂学杂志， 2022 , 28 ( 5 ): 62 － 70 .

雷昌，凌成利，黄丹，等 . 人参配伍贯叶金丝桃对抑郁症模型大鼠行为学及海马组织GR、SGK1表达的影响 [J]. 中国中医药信息杂志， 2022 , 29 ( 10 ): 73 － 78 .

朱爽，姜涛，张洪长，等 . 人参皂苷Rg3对UVB致抑郁模型大鼠行为学的影响 [J]. 中成药， 2021 , 43 ( 11 ): 3143 － 3147 .

胡霜，马义泽 . 石菖蒲等五味中药抗抑郁作用的实验研究 [J]. 山东中医杂志， 2009 , 28 ( 11 ): 799 － 800 .

张辰，王蕊，余亚倩，等 . 基于网络药理学预测青皮治疗抑郁症的作用机制 [J]. 湖南中医杂志， 2022 , 38 ( 7 ): 133 － 137, 152 .

张晓南，黄世敬 . 枳实、枳壳的抗抑郁作用 [J]. 环球中医药， 2014 , 7 ( 1 ): 77 － 80 .

袁培，周昌乐，许家佗 . 中医情志疗法在抑郁症诊疗中的应用 [J]. 中华中医药杂志， 2021 , 36 ( 8 ): 4853 － 4856 .

霍野 . 疏肝健脾汤联合中药脐贴治疗失眠伴抑郁临床观察 [J]. 中国中医药现代远程教育， 2021 , 19 ( 16 ): 108 － 110 .

邓颖，袁昌文，王欣彤 . 疏肝养心安神法治疗抑郁症临床研究 [J]. 内蒙古中医药， 2016 , 35 ( 8 ): 4 － 5 .

张雅绚，张二仝 . 温阳宣肺疏肝法治疗抑郁症临床观察 [J]. 光明中医， 2019 , 34 ( 14 ): 2159 － 2160 .

刘舰遥，任路，杨洋 . 基于少阳枢机理论探讨肾阳虚型抑郁的病机与治疗 [J]. 中华中医药杂志， 2023 , 38 ( 2 ): 537 － 540 .

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