Comment on the research of chronic aplastic anemia treatment with traditional Chinese medicine
Hematology and Oncology|更新时间:2023-11-06
|
Comment on the research of chronic aplastic anemia treatment with traditional Chinese medicine
Journal of Beijing University of Traditional Chinese MedicineVol. 46, Issue 10, Pages: 1461-1466(2023)
作者机构:
浙江中医药大学附属第一医院/浙江省中医院 杭州 310006
作者简介:
Prof. ZHOU Yuhong, Chief Physician, Doctoral Supervisor. The First Affiliated Hospital of Zhejiang Chinese Medical University/Zhejiang Provincial Hosptial of Chinese Medicine, No.54, Youdian Road, Hangzhou 310006. E-mail: zyhblood@163.com
基金信息:
National Natural Science Foundation of China(82274273;82174138);Health Technology Plan of Zhejiang Province(2022RC216);Zhejiang Scientifc Research Fund of Traditional Chinese Medicine(2022ZB085);Project of Academic Inheritance Studio of Famous and Aged Chinese Medicine Experts in Zhejiang Province(GZS2021022)
ZHOU Yuhong. Comment on the research of chronic aplastic anemia treatment with traditional Chinese medicine[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(10): 1461-1466.
DOI:
ZHOU Yuhong. Comment on the research of chronic aplastic anemia treatment with traditional Chinese medicine[J]. Journal of beijing university of traditional chinese medicine, 2023, 46(10): 1461-1466. DOI: 10.3969/j.issn.1006-2157.2023.10.019.
Comment on the research of chronic aplastic anemia treatment with traditional Chinese medicine
Aplastic anemia is a bone marrow hematopoietic failure disease
characterized as a decrease in bone marrow hematopoietic stem cells and pancytopenia. This disease belongs to the categories of "blood syndrome"
"deficiency and fatigue"
"marrow necrosis"
and "blood deficiency" in traditional Chinese medicine. In recent years
the incidence rate of aplastic anemia has gradually increased
but the existing western medicine treatment methods are limited
with poor long-term efficacy and larger adverse reactions. Conversely
traditional Chinese medicine has unique advantages in the treatment of this disease. The traditional Chinese medicine treatment of aplastic anemia began in the 1950 s and has developed for more than 70 years. Through the exploration of many physicians theory and practice
the basic treatment principles have gradually been formed
with tonifying the kidney as the core strategy
and with strengthening the spleen and replenishing qi
activating blood circulation for removing blood stasis
purging fire and regulating the liver
and dispelling phlegm as auxiliary strategies. This article summarizes the theoretical origin
evolution of syndrome types
treatment research
and experimental progress of traditional Chinese medicine in the treatment of aplastic anemia
and puts forward suggestions for the existing problems in order to contribute to the development of traditional Chinese medicine in the treatment of aplastic anemia.
YANG X , HUANG CG , DU SY , et al . Effect of Danggui Buxue Tang on immune-mediated aplastic anemia bone marrow proliferation mice [J]. Phytomedicine , 2014 , 21 ( 5 ): 640 - 646 .
ZHOU JW , LI X , DENG PY , et al . Chinese Herbal Formula, Modified Danggui Buxue Tang, Attenuates Apoptosis of Hematopoietic Stem Cells in Immune-Mediated Aplastic Anemia Mouse Model [J/OL]. J Immunol Res , 2017 , 2017 : 9786972 [ 2023-02-16 ]. https://www.hindawi.com/journals/jir/2017/9786972/ https://www.hindawi.com/journals/jir/2017/9786972/ .
ZHANG L , NI RF , LI JN , et al . Dioscin Regulating Bone Marrow Apoptosis in Aplastic Anemia [J]. Drug Des Devel Ther , 2022 , 16 : 3041 - 3053 .
EDOUARD MJ , MIAO L , FAN GW , et al . Yang-tonifying traditional Chinese medicinal plants and their potential phytoandrogenic activity [J]. Chin J Nat Med , 2014 , 12 ( 5 ): 321 - 324 .
LI HC , JI LN , SHEN YY , et al . Bushen Jianpi Quyu Formula Alleviates Myelosuppression of an Immune-Mediated Aplastic Anemia Mouse Model via Inhibiting Expression of the PI3K/AKT/NF-kappaB Signaling Pathway [J/OL]. Evid Based Complement Alternat Med , 2022 , 2022 : 9033297 [ 2023-02-16 ]. https://www.hindawi.com/journals/ecam/2022/9033297/ https://www.hindawi.com/journals/ecam/2022/9033297/ .
YE BD , CHEN D , WU DJ , et al . Effect of kidney-reinforcing, blood-activating and stasis-removing recipes on adhesion molecule expression of bone marrow mesenchymal stem cells from chronic aplastic anemia patients [J]. J Tradit Chin Med , 2012 , 32 ( 4 ): 596 - 603 .